Varicella-zoster virus infection of human dorsal root ganglia in vivo.

abstract：:Helicobacter pylori is a Gram-negative bacterial pathogen with a small genome of 1.64-1.67 Mb. More than 20 putative DNA restriction-modification (R-M) systems, comprising more than 4% of the total genome, have been identified in the two completely sequenced H. pylori strains, 26695 and J99, based on sequence similari...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin LF,Posfai J,Roberts RJ,Kong H

更新日期：2001-02-27 00:00:00

abstract：:Local inhomogeneities in lipid composition play a crucial role in regulation of signal transduction and membrane traffic. Nevertheless, most evidence for microdomains in cells remains indirect, and the nature of membrane inhomogeneities has been difficult to characterize. We used lipid analogs and lipid-anchored prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hao M,Mukherjee S,Maxfield FR

更新日期：2001-11-06 00:00:00

abstract：:Calcium/phospholipid-dependent protein kinase (protein kinase C, PKC) has been suggested to play a role in the sensitivity of gamma-aminobutyrate type A (GABAA) receptors to ethanol. We tested a line of null mutant mice that lacks the gamma isoform of PKC (PKC gamma) to determine the role of this brain-specific isoenz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harris RA,McQuilkin SJ,Paylor R,Abeliovich A,Tonegawa S,Wehner JM

更新日期：1995-04-25 00:00:00

abstract：:Much experimental work has been devoted in comparing the folding behavior of proteins sharing the same fold but different sequence. The recent design of proteins displaying very high sequence identities but different 3D structure allows the unique opportunity to address the protein-folding problem from a complementary...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giri R,Morrone A,Travaglini-Allocatelli C,Jemth P,Brunori M,Gianni S

更新日期：2012-10-30 00:00:00

abstract：:Natural ecosystems contain many individuals and species interacting with each other and with their abiotic environment. Such systems can be expected to exhibit complex dynamics in which small perturbations can be amplified to cause large changes. Here, we document the reorganization of an arid ecosystem that has occur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown JH,Valone TJ,Curtin CG

更新日期：1997-09-02 00:00:00

abstract：:Osedax is a recently discovered group of siboglinid annelids that consume bones on the seafloor and whose evolutionary origins have been linked with Cretaceous marine reptiles or to the post-Cretaceous rise of whales. Here we present whale bones from early Oligocene bathyal sediments exposed in Washington State, which...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kiel S,Goedert JL,Kahl WA,Rouse GW

更新日期：2010-05-11 00:00:00

abstract：:The polypeptide chain initiation factor 2 (eIF-2) binds phospholipid (PL) and becomes a potent inhibitor of translation in hemin-supplemented reticulocyte lysates. This binding is markedly reduced by prior treatment of eIF-2 with N-ethylmaleimide. Although PL is probably bound by all three eIF-2 subunits, our results ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Haro C,de Herreros AG,Ochoa S

更新日期：1986-09-01 00:00:00

abstract：:Nannofossils section sign here described are from the middle Proterozoic Paradise Creek Formation, along Paradise Creek in northwestern Queensland, Australia. These fossils, in chert blebs associated with branched stromatolites, comprise cubic colonies analogous to living Eucapsis, a member of the blue-green algal fam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Licari GR,Cloud PE,Smith WD

更新日期：1969-01-01 00:00:00

abstract：:We investigated the influence of interareal distance on connectivity patterns in a database obtained from the injection of retrograde tracers in 29 areas distributed over six regions (occipital, temporal, parietal, frontal, prefrontal, and limbic). One-third of the 1,615 pathways projecting to the 29 target areas were...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Markov NT,Ercsey-Ravasz M,Lamy C,Ribeiro Gomes AR,Magrou L,Misery P,Giroud P,Barone P,Dehay C,Toroczkai Z,Knoblauch K,Van Essen DC,Kennedy H

更新日期：2013-03-26 00:00:00

abstract：:Previous studies have identified an ATP-dependent DNA helicase activity intrinsic to the human minichromosome maintenance (MCM) complex, composed of MCM subunits 4, 6, and 7 [Ishimi, Y. (1997) J. Biol. Chem. 272, 24508-24513]. In contrast to the presence of multiple MCM genes (at least six) in eukaryotes, the archaeon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kelman Z,Lee JK,Hurwitz J

更新日期：1999-12-21 00:00:00

abstract：:How genome divergence eventually leads to speciation is a topic of prime evolutionary interest. Genomic islands of elevated divergence are frequently reported between diverging lineages, and their size is expected to increase with time and gene flow under the speciation-with-gene-flow model. However, such islands can ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma T,Wang K,Hu Q,Xi Z,Wan D,Wang Q,Feng J,Jiang D,Ahani H,Abbott RJ,Lascoux M,Nevo E,Liu J

更新日期：2018-01-09 00:00:00

abstract：:Combined effects of two drugs present simultaneously are usually expressed as summation, synergism or potentiation, and antagonism. When the sum of the effects of each drug present separately equals the combined effect of the two drugs present simultaneously, the action is called additive or summation. However, the ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kamaya H,Ueda I,Eyring H

更新日期：1976-06-01 00:00:00

abstract：:We have isolated and partially sequenced a M(r) 160,000 glycoprotein whose rate of cycling to and from the adipocyte cell surface is enhanced by insulin in a manner apparently identical to the effect of insulin on GLUT4 cycling. Based on the protein sequence, we have prepared an antipeptide antibody against this prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kandror KV,Pilch PF

更新日期：1994-08-16 00:00:00

abstract：:The term quantum turbulence denotes the turbulent motion of quantum fluids, systems such as superfluid helium and atomic Bose-Einstein condensates, which are characterized by quantized vorticity, superfluidity, and, at finite temperatures, two-fluid behavior. This article introduces their basic properties, describes t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barenghi CF,Skrbek L,Sreenivasan KR

更新日期：2014-03-25 00:00:00

abstract：:F1-ATPase, the catalytic domain of ATP synthase, synthesizes most of the ATP in living organisms. Running in reverse powered by ATP hydrolysis, this hexameric ring-shaped molecular motor formed by three αβ-dimers creates torque on its central γ-subunit. This reverse operation enables detailed explorations of the mecha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okazaki K,Hummer G

更新日期：2013-10-08 00:00:00

abstract：:RNA molecules perform diverse regulatory functions in natural biological systems, and numerous synthetic RNA-based control devices that integrate sensing and gene-regulatory functions have been demonstrated, predominantly in bacteria and yeast. Despite potential advantages of RNA-based genetic control strategies in cl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YY,Jensen MC,Smolke CD

更新日期：2010-05-11 00:00:00

abstract：:The three lipin phosphatidate phosphatase (PAP) enzymes catalyze a step in glycerolipid biosynthesis, the conversion of phosphatidate to diacylglycerol. Lipin-1 is critical for lipid synthesis and homeostasis in adipose tissue, liver, muscle, and peripheral nerves. Little is known about the physiological role of lipin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dwyer JR,Donkor J,Zhang P,Csaki LS,Vergnes L,Lee JM,Dewald J,Brindley DN,Atti E,Tetradis S,Yoshinaga Y,De Jong PJ,Fong LG,Young SG,Reue K

更新日期：2012-09-11 00:00:00

abstract：:Mitochondrial dysfunction is implicated in the pathophysiology of Parkinson's disease (PD), a common age-associated neurodegenerative disease characterized by intraneuronal inclusions (Lewy bodies) and progressive degeneration of the nigrostriatal dopamine (DA) system. It has recently been demonstrated that midbrain D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ekstrand MI,Terzioglu M,Galter D,Zhu S,Hofstetter C,Lindqvist E,Thams S,Bergstrand A,Hansson FS,Trifunovic A,Hoffer B,Cullheim S,Mohammed AH,Olson L,Larsson NG

更新日期：2007-01-23 00:00:00

abstract：:Antibodies that modulate receptor function have great untapped potential in the control of stem cell differentiation. In contrast to many natural ligands, antibodies are stable, exquisitely specific, and are unaffected by the regulatory mechanisms that act on natural ligands. Here we describe an innovative system for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Melidoni AN,Dyson MR,Wormald S,McCafferty J

更新日期：2013-10-29 00:00:00

abstract：:Although Africa is the origin of modern humans, the pattern and distribution of genetic variation and correlations with cultural and linguistic diversity in Africa have been understudied. Recent advances in genomic technology, however, have led to genomewide studies of African samples. In this article, we discuss gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scheinfeldt LB,Soi S,Tishkoff SA

更新日期：2010-05-11 00:00:00

abstract：:A climate/vegetation model simulates episodic wetter and drier periods at the 21,000-y precession period in eastern North Africa, the Arabian Peninsula, and the Levant over the past 140,000 y. Large orbitally forced wet/dry extremes occur during interglacial time, ∼130 to 80 ka, and conditions between these two extrem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kutzbach JE,Guan J,He F,Cohen AS,Orland IJ,Chen G

更新日期：2020-02-04 00:00:00

abstract：:Embryonal rhabdomyosarcoma (ERMS) is a common pediatric malignancy of muscle, with relapse being the major clinical challenge. Self-renewing tumor-propagating cells (TPCs) drive cancer relapse and are confined to a molecularly definable subset of ERMS cells. To identify drugs that suppress ERMS self-renewal and induce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen EY,DeRan MT,Ignatius MS,Grandinetti KB,Clagg R,McCarthy KM,Lobbardi RM,Brockmann J,Keller C,Wu X,Langenau DM

更新日期：2014-04-08 00:00:00

abstract：:The effect of pH on the membrane-fusion activity of Sendai virus was examined (pH 5.0-9.5) by using, as assays of activity, hemolysis of chicken erythrocytes and the fusion of baby hamster kidney (BHK-21) cells. Exposure of virus to basic pH increased fusion activity; the optimum pH was found to be approximately equal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu MC,Scheid A,Choppin PW

更新日期：1982-10-01 00:00:00

abstract：:Within the scientific community, much attention has focused on improving communications between scientists, policy makers, and the public. To date, efforts have centered on improving the content, accessibility, and delivery of scientific communications. Here we argue that in the current political and media environment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iyengar S,Massey DS

更新日期：2019-04-16 00:00:00

abstract：:The crystal structure of human angiogenin (reported in the preceding paper in this issue) reveals that the site that corresponds to the pyrimidine binding site of RNase A is obstructed by Gln-117. Mutation of this residue to Ala and Gly is here found to increase activity 11- to 18-fold and 21- to 30-fold, respectively...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Russo N,Shapiro R,Acharya KR,Riordan JF,Vallee BL

更新日期：1994-04-12 00:00:00

abstract：:Focal cerebral ischemia and traumatic brain injury induce an escalating amount of cell death because of harmful mediators diffusing from the original lesion site. Evidence suggests that healthy cells surrounding these lesions attempt to protect themselves by producing endocannabinoids (eCBs) and activating cannabinoid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Witting A,Chen L,Cudaback E,Straiker A,Walter L,Rickman B,Möller T,Brosnan C,Stella N

更新日期：2006-04-18 00:00:00

abstract：:The suprachiasmatic nucleus (SCN), the master circadian clock in mammals, sends major output signals to the subparaventricular zone (SPZ) and further to the paraventricular nucleus (PVN), the neural mechanism of which is largely unknown. In this study, the intracellular calcium levels were measured continuously in cul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu YE,Enoki R,Oda Y,Huang ZL,Honma KI,Honma S

更新日期：2018-10-02 00:00:00

abstract：:We recently have shown that mice deficient for the 86-kDa component (Ku80) of the DNA-dependent protein kinase exhibit growth retardation and a profound deficiency in V(D)J (variable, diversity, and joining) recombination. These defects may be related to abnormalities in DNA metabolism that arise from the inability of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nussenzweig A,Sokol K,Burgman P,Li L,Li GC

更新日期：1997-12-09 00:00:00

abstract：:3-Hydroxykynurenine (3-HK) is a tryptophan metabolite whose level in the brain is markedly elevated under several pathological conditions, including Huntington disease and human immunodeficiency virus infection. Here we demonstrate that micromolar concentrations (1-100 microM) of 3-HK cause cell death in primary neuro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okuda S,Nishiyama N,Saito H,Katsuki H

更新日期：1996-10-29 00:00:00

abstract：:Protein kinases play key roles in the induction by human interferon alpha (IFN-alpha) of specific gene expression and biological activity in various human cell lines. We now report that IFN-alpha increased the 7-kb transcript for the epsilon isotype of protein kinase C (PKC-epsilon) and the cellular content of PKC-eps...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang C,Constantinescu SN,MacEwan DJ,Strulovici B,Dekker LV,Parker PJ,Pfeffer LM

更新日期：1993-08-01 00:00:00