Trafficking of gap junction channels at a vertebrate electrical synapse in vivo.

abstract：:The genomic concentrations of certain middle repetitive DNA sequences vary considerably among closely related species of Drosophila. In fact, the chromosomes of D. melanogaster appear to carry approximately 3 times as much middle repetitive DNA as those of the sibling species D. simulans. Although most of the middle r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dowsett AP,Young MW

更新日期：1982-08-01 00:00:00

abstract：:Controlling topological defects in 3D liquid crystal phases is a crucial element in the development of novel devices, from blue-phase displays to passive biochemical sensors. However, it remains challenging to realize the 3D topological conditions necessary to robustly and arbitrarily direct the formation of defects. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Honglawan A,Beller DA,Cavallaro M Jr,Kamien RD,Stebe KJ,Yang S

更新日期：2013-01-02 00:00:00

abstract：:We have isolated cold-sensitive mutations in two genes of the yeast Saccharomyces cerevisiae, BIN2 and BIN3, that cause aberrant chromosome segregation in vivo. BIN2 and BIN3 encode essential proteins that are similar to each other and to TCP-1. TCP-1 and TCP-1-like proteins are components of the eukaryotic cytoplasmi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen X,Sullivan DS,Huffaker TC

更新日期：1994-09-13 00:00:00

abstract：:Ca(2+) is known to have important roles in sperm chemotaxis, although the relationship between intracellular Ca(2+) concentration ([Ca(2+)](i)) and modulation of the swimming and chemotactic behavior of spermatozoa has not been elucidated. Using a high-speed Ca(2+) imaging system, we examined the chemotactic behavior ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shiba K,Baba SA,Inoue T,Yoshida M

更新日期：2008-12-09 00:00:00

abstract：:Despite substantial evidence that nitric oxide (NO) and/or endogenous S-nitrosothiols (SNOs) exert protective effects in a variety of cardiovascular diseases, the molecular details are largely unknown. Here we show that following left coronary artery ligation, mice with a targeted deletion of the S-nitrosoglutathione ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lima B,Lam GK,Xie L,Diesen DL,Villamizar N,Nienaber J,Messina E,Bowles D,Kontos CD,Hare JM,Stamler JS,Rockman HA

更新日期：2009-04-14 00:00:00

abstract：:We use sequential large-scale crawl data to empirically investigate and validate the dynamics that underlie the evolution of the structure of the web. We find that the overall structure of the web is defined by an intricate interplay between experience or entitlement of the pages (as measured by the number of inbound ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kong JS,Sarshar N,Roychowdhury VP

更新日期：2008-09-16 00:00:00

abstract：:CCR5 encodes a cell surface chemokine receptor molecule that serves as the principal coreceptor, with CD4, for HIV-type 1 (HIV-1). Varied HIV-1 susceptibility and time to progression to AIDS have been associated with polymorphisms in CCR5. Many of these polymorphisms are located in the 5' cis-regulatory region of CCR5...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bamshad MJ,Mummidi S,Gonzalez E,Ahuja SS,Dunn DM,Watkins WS,Wooding S,Stone AC,Jorde LB,Weiss RB,Ahuja SK

更新日期：2002-08-06 00:00:00

abstract：:The Esx secretion pathway is conserved across Gram-positive bacteria. Esx-1, the best-characterized system, is required for virulence of Mycobacterium tuberculosis, although its precise function during infection remains unclear. Esx-3, a paralogous system present in all mycobacterial species, is required for growth in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Siegrist MS,Unnikrishnan M,McConnell MJ,Borowsky M,Cheng TY,Siddiqi N,Fortune SM,Moody DB,Rubin EJ

更新日期：2009-11-03 00:00:00

abstract：:By using differential display PCR, we have identified 98 cDNA fragments from the rat dorsal hippocampus that are expressed differentially between the fast learners and slow learners in the water maze learning task. One of these cDNA fragments encodes the rat serum- and glucocorticoid-inducible kinase (sgk) gene. North...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsai KJ,Chen SK,Ma YL,Hsu WL,Lee EH

更新日期：2002-03-19 00:00:00

abstract：:A majority of the total protein synthesis in host cell cytoplasm is inhibited by cycloheximide. Because leghemoglobin represents a large proportion of total cellular protein in the nodule, this observation suggests that leghemoglobin may be translated on the 80S-type ribosomes. Analysis of the nascent peptides isolate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Verma DP,Bal AK

更新日期：1976-11-01 00:00:00

abstract：:Actin polymerization provides a powerful propulsion force for numerous types of cell motility. Although tremendous progress has been made in identifying the biochemical components necessary for actin-based motility, the precise biophysical mechanisms of force generation remain unclear. To probe the polymerization forc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Upadhyaya A,Chabot JR,Andreeva A,Samadani A,van Oudenaarden A

更新日期：2003-04-15 00:00:00

abstract：:The magnetic circular dichroism of benzene and indole derivatives was measured down to 190 nM. The following pairs of molecules have magnetic circular dichroisms of the opposite sign in the B(2u) absorption region: aniline and benzonitrile, indene and indoline, indole and 4-aminoindole, and 4-aminoindole and 5-aminoin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miles DW,Eyring H

更新日期：1973-12-01 00:00:00

abstract：:The DNA binding activity of p53 is crucial for its tumor suppressor function and is subject to tight regulation. Previous studies revealed that the inhibitory function of the p53 C terminus is implicated in the latent, low affinity sequence-specific DNA binding activity of p53 in the uninduced state. Sequence-specific...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Müller-Tiemann BF,Halazonetis TD,Elting JJ

更新日期：1998-05-26 00:00:00

abstract：:Two issues long debated among Pacific and American prehistorians are (i) whether there was a pre-Columbian introduction of chicken (Gallus gallus) to the Americas and (ii) whether Polynesian contact with South America might be identified archaeologically, through the recovery of remains of unquestionable Polynesian or...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Storey AA,Ramírez JM,Quiroz D,Burley DV,Addison DJ,Walter R,Anderson AJ,Hunt TL,Athens JS,Huynen L,Matisoo-Smith EA

更新日期：2007-06-19 00:00:00

abstract：:Ventriculo-cisternal perfusion of horseradish peroxidase (HRP) in the mouse brain has demonstrated that a brain-blood barrier exists at the microvascular endothelium in brain parenchyma but not in the median eminence of the hypothalamus. The brain-blood barrier is similar to the blood-brain barrier in that: tight junc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Broadwell RD,Balin BJ,Salcman M,Kaplan RS

更新日期：1983-12-01 00:00:00

abstract：:Plants in dense vegetation compete for resources, including light, and optimize their growth based on neighbor detection cues. The best studied of such behaviors is the shade-avoidance syndrome that positions leaves in optimally lit zones of a vegetation. Although proximate vegetation is known to be sensed through a r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Wit M,Kegge W,Evers JB,Vergeer-van Eijk MH,Gankema P,Voesenek LA,Pierik R

更新日期：2012-09-04 00:00:00

abstract：:Retroviral Gag polyproteins have specific regions, commonly referred to as late assembly (L) domains, which are required for the efficient separation of assembled virions from the host cell. The L domain of HIV-1 is in the C-terminal p6(gag) domain and contains an essential P(T/S)AP core motif that is widely conserved...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strack B,Calistri A,Accola MA,Palu G,Gottlinger HG

更新日期：2000-11-21 00:00:00

abstract：:The primary structure of about half of the protein chain of yeast alcohol dehydrogenase has been determined and compared with the amino-acid sequences of other dehydrogenases. The enzyme is found to be distantly related to horse-liver alcohol dehydrogenase, although these two proteins have different quaternary structu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jörnvall H

更新日期：1973-08-01 00:00:00

abstract：:Influenza hemagglutinin (HA) glycoprotein is the primary surface antigen targeted by the host immune response and a focus for development of novel vaccines, broadly neutralizing antibodies (bnAbs), and therapeutics. HA enables viral entry into host cells via receptor binding and membrane fusion and is a validated targ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yao Y,Kadam RU,Lee CD,Woehl JL,Wu NC,Zhu X,Kitamura S,Wilson IA,Wolan DW

更新日期：2020-08-04 00:00:00

abstract：:XMAP215/Dis1 family proteins positively regulate microtubule growth. Repeats at their N termini, called TOG domains, are important for this function. While TOG domains directly bind tubulin dimers, it is unclear how this interaction translates to polymerase activity. Understanding the functional roles of TOG domains i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Widlund PO,Stear JH,Pozniakovsky A,Zanic M,Reber S,Brouhard GJ,Hyman AA,Howard J

更新日期：2011-02-15 00:00:00

abstract：:Is the pathway of protein folding determined by the relative stability of folding intermediates, or by the relative height of the activation barriers leading to these intermediates? This is a fundamental question for resolving the Levinthal paradox, which stated that protein folding by a random search mechanism would ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Su ZD,Arooz MT,Chen HM,Gross CJ,Tsong TY

更新日期：1996-03-19 00:00:00

abstract：:Functional reconstitution of membrane proteins within lipid bilayers is crucial for understanding their biological function in living cells. While this strategy has been extensively used with liposomes, reconstitution of membrane proteins in lipidic cubic mesophases presents significant challenges related to the struc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Speziale C,Salvati Manni L,Manatschal C,Landau EM,Mezzenga R

更新日期：2016-07-05 00:00:00

abstract：:Although the unifying hallmark of prion diseases is CNS neurodegeneration caused by conformational corruption of host prion protein (PrP) to its infective counterpart, contagious transmission of chronic wasting disease (CWD) results from shedding of prions produced at high titers in the periphery of diseased cervids. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bian J,Christiansen JR,Moreno JA,Kane SJ,Khaychuk V,Gallegos J,Kim S,Telling GC

更新日期：2019-06-18 00:00:00

abstract：:Of nine established murine haplotypes, mice of three types (H-2d, H-2u, and H-2q) possess major histocompatibility complex class I glycoproteins able to present an identical viral peptide for recognition and lysis by virus-specific cytotoxic T lymphocytes. Incorporation of this viral epitope into a recombinant vaccini...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oldstone MB,Tishon A,Geckeler R,Lewicki H,Whitton JL

更新日期：1992-04-01 00:00:00

abstract：:A central tenet of evolutionary social science holds that behaviors, such as those associated with social dominance, produce fitness effects that are subject to cultural selection. However, evidence for such selection is inconclusive because it is based on short-term statistical associations between behavior and ferti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lansing JS,Watkins JC,Hallmark B,Cox MP,Karafet TM,Sudoyo H,Hammer MF

更新日期：2008-08-19 00:00:00

abstract：:Clinical data showing correlations between low thyroid-stimulating hormone (TSH) levels and high bone turnover markers, low bone mineral density, and an increased risk of osteoporosis-related fractures are buttressed by mouse genetic and pharmacological studies identifying a direct action of TSH on the skeleton. Here ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun L,Zhu LL,Lu P,Yuen T,Li J,Ma R,Baliram R,Moonga SS,Liu P,Zallone A,New MI,Davies TF,Zaidi M

更新日期：2013-06-11 00:00:00

abstract：:Genetic switches based on the [Formula: see text] system are master regulators of an array of cellular responses. Recent kinetic experiments have shown that [Formula: see text] can actively remove NF-κB bound to its genetic sites via a process called "molecular stripping." This allows the [Formula: see text] switch to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Potoyan DA,Zheng W,Komives EA,Wolynes PG

更新日期：2016-01-05 00:00:00

abstract：:The DNA-containing Epstein-Barr herpesvirus has been implicated in the etiology of Burkitt's lymphoma, a malignant tumor of children in Africa. Recently, however, particles possessing four biochemical characteristics of RNA tumor viruses have also been identified in these tumors. The fact that both types of viruses ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peters WP,Kufe D,Schlom J,Frankel JW,Prickett CO,Groupé V,Spiegelman S

更新日期：1973-11-01 00:00:00

abstract：:The thin layer of airway surface liquid (ASL) contains antimicrobial substances that kill the small numbers of bacteria that are constantly being deposited in the lungs. An increase in ASL salt concentration inhibits the activity of airway antimicrobial factors and may partially explain the pathogenesis of cystic fibr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zabner J,Seiler MP,Launspach JL,Karp PH,Kearney WR,Look DC,Smith JJ,Welsh MJ

更新日期：2000-10-10 00:00:00

abstract：:After the start of transcription, the 5' ends of eukaryotic mRNA molecules are modified by the addition of a guanylyl residue to form a cap structure, G(5')ppp(5')N. The guanylyltransferase (GTP:mRNA guanylyltransferase, EC 2.7.7.50) reaction responsible for cap formation usually proceeds via a covalent enzyme-GMP int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahola T,Kääriäinen L

更新日期：1995-01-17 00:00:00