Differing levels of dispersed repetitive DNA among closely related species of Drosophila.

abstract：:Through a process called "bioturbation," burrowing macrofauna have altered the seafloor habitat and modified global carbon cycling since the Cambrian. However, the impact of macrofauna on the community structure of microorganisms is poorly understood. Here, we show that microbial communities across bioturbated, but ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deng L,Bölsterli D,Kristensen E,Meile C,Su CC,Bernasconi SM,Seidenkrantz MS,Glombitza C,Lagostina L,Han X,Jørgensen BB,Røy H,Lever MA

更新日期：2020-07-07 00:00:00

abstract：:When the content of cyclic AMP (cAMP) was compared in livers of a series of congenic mouse strains differing at the H-2 locus, significant variation in concentration of cAMP per unit wet weight was found among strains, and also for animals of a given strain with increasing age. For a given age, from 8 to 22 weeks, cAM...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meruelo D,Edidin M

更新日期：1975-07-01 00:00:00

abstract：:Using data from the Fragile Families and Child Wellbeing Study, this study examined the effects of the Great Recession on maternal harsh parenting. We found that changes in macroeconomic conditions, rather than current conditions, affected harsh parenting, that declines in macroeconomic conditions had a stronger impac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee D,Brooks-Gunn J,McLanahan SS,Notterman D,Garfinkel I

更新日期：2013-08-20 00:00:00

abstract：:A "projection function," P(x,z), is defined as the partial integral of the molecular electron density, rho(x,y,z), over the region -infinity < y < +infinity. The projection provides a three-dimensional representation of molecular electron distributions. Chemically useful information can be discerned from graphical dis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Streitwieser A,Collins JB,McKelvey JM,Grier D,Sender J,Toczko AG

更新日期：1979-06-01 00:00:00

abstract：:Introduction and expression of multiple transgenes is frequently required for basic and applied studies. However, at present, multigene transformation is very difficult due to technical limitations of existing methods. Here, we describe a vector system for efficient multigene assembly and transformation. The system co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin L,Liu YG,Xu X,Li B

更新日期：2003-05-13 00:00:00

abstract：:The addition of insulin to a mixture of plasma membrane and mitochondrial fractions from rat adipocytes results in a decrease in the phosphorylation of a mitochondrial protein identified as the alpha subunit of pyruvate dehydrogenase [pyruvate:lipoamide oxidoreductase (decarboxylating and acceptor-acetylating), EC 1.2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seals JR,Jarett L

更新日期：1980-01-01 00:00:00

abstract：:Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes present in mammals with 16 isoforms that differ in terms of catalytic activity as well as cellular and tissue distribution. CAs catalyze the conversion of CO2 to bicarbonate and protons and are involved in various physiological processes, including learning and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmidt SD,Costa A,Rani B,Godfried Nachtigall E,Passani MB,Carta F,Nocentini A,de Carvalho Myskiw J,Furini CRG,Supuran CT,Izquierdo I,Blandina P,Provensi G

更新日期：2020-07-07 00:00:00

abstract：:The alphavbeta3 integrins are linked to human bleeding disorders, and pathogenic hantaviruses regulate the function of alphavbeta3 integrins and cause acute vascular diseases. alphavbeta3 integrins are present in either extended (active) or dramatically bent (inactive) structures, and interconversion of alphavbeta3 co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raymond T,Gorbunova E,Gavrilovskaya IN,Mackow ER

更新日期：2005-01-25 00:00:00

abstract：:Usual human livers contain two major aldehyde dehydrogenase [(ALDH) aldehyde:NAD+ oxidoreductase] isozymes--i.e., a cytosolic ALDH1 component and a mitochondrial ALDH2 component--whereas approximately equal to 50% of Orientals are "atypical" and have only the ALDH1 isozyme and are missing the ALDH2 isozyme. We previou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoshida A,Huang IY,Ikawa M

更新日期：1984-01-01 00:00:00

abstract：:Infective stages of the protozoan parasite Leishmania spp. accumulate a class of beta-1,2-mannan oligosaccharides as their major carbohydrate reserve material. Here, we describe the biosynthesis of Leishmania mannan. Mannan precursors were identified by metabolic labeling of Leishmania mexicana promastigotes with [(3)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sernee MF,Ralton JE,Dinev Z,Khairallah GN,O'Hair RA,Williams SJ,McConville MJ

更新日期：2006-06-20 00:00:00

abstract：:We present the complete nucleotide and deduced amino acid sequences of a mouse epidermal keratin subunit of 60,000 Da. The keratin possesses a central alpha-helical domain of four tracts (termed 1A, 1B, 2A, and 2B) that can form coiled-coils, interspersed by short linker sequences, and has non-alpha-helical terminal d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steinert PM,Parry DA,Racoosin EL,Idler WW,Steven AC,Trus BL,Roop DR

更新日期：1984-09-01 00:00:00

abstract：:We describe five individuals who have constitutional deletions of the short arm of one chromosome 11, including all or part of the band p13. All of these individuals suffer from aniridia; two have had a Wilms tumor removed. We have established lymphoblastoid cell lines from these and in three cases constructed somatic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Heyningen V,Boyd PA,Seawright A,Fletcher JM,Fantes JA,Buckton KE,Spowart G,Porteous DJ,Hill RE,Newton MS

更新日期：1985-12-01 00:00:00

abstract：:We show in climate model experiments that large-scale afforestation in northern mid-latitudes warms the Northern Hemisphere and alters global circulation patterns. An expansion of dark forests increases the absorption of solar energy and increases surface temperature, particularly in regions where the land surface is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swann AL,Fung IY,Chiang JC

更新日期：2012-01-17 00:00:00

abstract：:Induced pluripotent stem cells (iPS cells) represent a unique tool for the study of the pathophysiology of human disease, because these cells can be differentiated into multiple cell types in vitro and used to generate patient- and tissue-specific disease models. Given the critical role for skeletal muscle insulin res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iovino S,Burkart AM,Warren L,Patti ME,Kahn CR

更新日期：2016-02-16 00:00:00

abstract：:CD45, a protein tyrosine phosphatase that regulates Src family kinases, is important for regulating T cell and B cell receptor signaling; however, little is known about how CD45 regulates immunoreceptor tyrosine-based activation motif (ITAM)-dependent natural killer (NK) cell receptor signaling and the resulting effec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hesslein DG,Takaki R,Hermiston ML,Weiss A,Lanier LL

更新日期：2006-05-02 00:00:00

abstract：:Restricted fetal growth is associated with postnatal mortality and morbidity and may be directly related to alterations in the capacity of the placenta to supply nutrients. We proposed previously that imprinted genes can regulate nutrient supply by the placenta. Here, we tested the hypothesis that the insulin-like gro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sibley CP,Coan PM,Ferguson-Smith AC,Dean W,Hughes J,Smith P,Reik W,Burton GJ,Fowden AL,Constância M

更新日期：2004-05-25 00:00:00

abstract：:Although NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) and long-term depression (LTD) of glutamatergic transmission are candidate mechanisms for long-term spatial memory, the precise contributions of LTP and LTD remain poorly understood. Here, we report that LTP and LTD in the hippocampal CA1 region of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ge Y,Dong Z,Bagot RC,Howland JG,Phillips AG,Wong TP,Wang YT

更新日期：2010-09-21 00:00:00

abstract：:Photosystem II (PSII) is an intrinsic membrane protein complex that functions as a light-driven water:plastoquinone oxidoreductase in oxygenic photosynthesis. Electron transport in PSII is associated with formation of reactive oxygen species (ROS) responsible for oxidative modifications of PSII proteins. In this study...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumar A,Prasad A,Sedlářová M,Kale R,Frankel LK,Sallans L,Bricker TM,Pospíšil P

更新日期：2021-01-26 00:00:00

abstract：:A method is proposed for analyzing fast (10 μs) single-molecule rotation trajectories in F1 adenosinetriphosphatase ([Formula: see text]-ATPase). This method is based on the distribution of jumps in the rotation angle that occur in the transitions during the steps between subsequent catalytic dwells. The method is com...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volkán-Kacsó S,Le LQ,Zhu K,Su H,Marcus RA

更新日期：2019-12-17 00:00:00

abstract：:In vitro studies have demonstrated that glia can express functional receptors for a variety of neurotransmitters. To determine whether similar neurotransmitter receptors are also expressed by glia in vivo, we examined the glial scar in the transected optic nerve of the albino rabbit by quantitative receptor autoradiog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mantyh PW,Johnson DJ,Boehmer CG,Catton MD,Vinters HV,Maggio JE,Too HP,Vigna SR

更新日期：1989-07-01 00:00:00

abstract：:Signaling through Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) is central to the responses to the majority of cytokines and some growth factors, including the interferons (IFNs) and the IL-6 family of cytokines. The biological responses to stimulation through the widely distribut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Costa-Pereira AP,Tininini S,Strobl B,Alonzi T,Schlaak JF,Is'harc H,Gesualdo I,Newman SJ,Kerr IM,Poli V

更新日期：2002-06-11 00:00:00

abstract：:Small molecules produced by Actinobacteria have played a prominent role in both drug discovery and organic chemistry. As part of a larger study of the actinobacterial symbionts of fungus-growing ants, we discovered a small family of three previously unreported piperazic acid-containing cyclic depsipeptides, gerumycins...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sit CS,Ruzzini AC,Van Arnam EB,Ramadhar TR,Currie CR,Clardy J

更新日期：2015-10-27 00:00:00

abstract：:Amber suppressor tRNA genes were constructed by site-specific mutagenesis of the anticodons of human lysine-inserting tRNA (tRNA(Lys)) and glutamine-inserting tRNA (tRNA(Gln)) genes, and a Xenopus laevis tyrosine-inserting tRNA (tRNA(Tyr)) gene. As previous in vitro studies in prokaryotes have shown that substitution ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ho YS,Kan YW

更新日期：1987-04-01 00:00:00

abstract：:Mechanical robustness of the cell under different modes of stress and deformation is essential to its survival and function. Under tension, mechanical rigidity is provided by the cytoskeletal network; with increasing stress, this network stiffens, providing increased resistance to deformation. However, a cell must als...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou EH,Trepat X,Park CY,Lenormand G,Oliver MN,Mijailovich SM,Hardin C,Weitz DA,Butler JP,Fredberg JJ

更新日期：2009-06-30 00:00:00

abstract：:The reactivities of N-iodosuccinimide and iodine with various goitrogenic compounds were studied with dimethylsulfoxide through which nitrogen had been bubbled as a solvent. Although iodine does not react with all of the compounds, N-iodosuccinimide does react with all of them. N-Iodosuccinimide may, therefore, serve ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jirousek L,Soodak M

更新日期：1973-05-01 00:00:00

abstract：:BSC-1 cells, epithelial cells of African green monkey kidney origin, show pronounced density-dependent regulation of growth in cell culture. Growth of the cells is rapid to a density of approximately 1.5 x 10(5) cells/per cm(2) in Dulbecco-modified Eagle's medium supplemented with 10% calf serum. Above this "saturatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holley RW,Armour R,Baldwin JH

更新日期：1978-01-01 00:00:00

abstract：:We have shown recently that the temporal order of antioxidant consumption in human blood plasma exposed to a constant flux of aqueous peroxyl radicals is ascorbate = protein thiols greater than bilirubin greater than urate greater than alpha-tocopherol and that detectable lipid peroxidation starts only after ascorbate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frei B,England L,Ames BN

更新日期：1989-08-01 00:00:00

abstract：:Previous reports have shown that γδ T cells are important for the elimination of malaria parasites in humans and mice. However, how γδ T cells are involved in protective immunity against blood-stage malaria remains unknown. We infected γδ T-cell-deficient (TCRδ-KO) mice and control wild-type mice with Plasmodium bergh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inoue S,Niikura M,Takeo S,Mineo S,Kawakami Y,Uchida A,Kamiya S,Kobayashi F

更新日期：2012-07-24 00:00:00

abstract：:The six individual catalytic polypeptide chains within the two catalytic trimers of Escherichia coli aspartate transcarbamoylase (ATCase; EC 2.1.3.2) are folded into two discrete structural domains interconnected in part by helix 12, which comprises residues 285-305 and is located near the carboxyl terminus of the cha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peterson CB,Schachman HK

更新日期：1991-01-15 00:00:00

abstract：:Saccades are rapid eye movements that orient the visual axis toward objects of interest to allow their processing by the central, high-acuity retina. Our ability to collect visual information efficiently relies on saccadic accuracy, which is limited by a combination of uncertainty in the location of the target and mot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lisi M,Solomon JA,Morgan MJ

更新日期：2019-08-06 00:00:00