Association of mouse liver adenosine 3':5'-cyclic monophosphate (cyclic AMP) levels with histocompatibility-2 genotype.

abstract：:We previously isolated from mouse spleen an octapeptide (LSPFPFDL) that in association with the class I major histocompatibility complex protein Ld is recognized by the antigen-specific receptor of an alloreactive CD8+ T-cell clone (2C). Guided by an assay dependent upon the same 2C T-cell receptor, we have now isolat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Udaka K,Tsomides TJ,Walden P,Fukusen N,Eisen HN

更新日期：1993-12-01 00:00:00

abstract：:The adult repertoire of antibody specificities is acquired in a developmentally programmed fashion that, in mouse and man, parallels the ordered rearrangement of a limited number of germ-line heavy chain variable region (VH) gene segments during development. It has been hypothesized that this developmental bias is a c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Willems van Dijk K,Milner LA,Sasso EH,Milner EC

更新日期：1992-11-01 00:00:00

abstract：:Borrelia burgdorferi (Bb), the causative agent of Lyme disease, is transmitted to mammalian hosts through an arthropod (tick) vector. To establish infection, Bb must acquire essential nutrients, including transition metals, from its mammalian and tick hosts. Thus far, no metal transporter has been identified in Bb. He...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ouyang Z,He M,Oman T,Yang XF,Norgard MV

更新日期：2009-03-03 00:00:00

abstract：:Establishing quantitative relationships between molecular structure and broad biological effects has been a longstanding challenge in science. Currently, no method exists for forecasting broad biological activity profiles of medicinal agents even within narrow boundaries of structurally similar molecules. Starting fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fliri AF,Loging WT,Thadeio PF,Volkmann RA

更新日期：2005-01-11 00:00:00

abstract：:Vascular endothelial cells (ECs) at arterial branches and curvatures experience disturbed blood flow and induce a quiescent-to-activated phenotypic transition of the adjacent smooth muscle cells (SMCs) and a subsequent smooth muscle hyperplasia. However, the mechanism underlying the flow pattern-specific initiation of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu JJ,Liu YF,Zhang YP,Zhao CR,Yao WJ,Li YS,Wang KC,Huang TS,Pang W,Wang XF,Wang X,Chien S,Zhou J

更新日期：2017-08-01 00:00:00

abstract：:The incidence of pediatric adrenal cortical carcinoma (ACC) in southern Brazil is 10-15 times higher than that of pediatric ACC worldwide. Because childhood ACC is associated with Li-Fraumeni syndrome, we examined the cancer history and p53 status of 36 Brazilian patients and their families. Remarkably, 35 of 36 patie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ribeiro RC,Sandrini F,Figueiredo B,Zambetti GP,Michalkiewicz E,Lafferty AR,DeLacerda L,Rabin M,Cadwell C,Sampaio G,Cat I,Stratakis CA,Sandrini R

更新日期：2001-07-31 00:00:00

abstract：:Expression of the transcription factor FOXC2 is induced and necessary for successful epithelial-mesenchymal transition, a developmental program that when activated in cancer endows cells with metastatic potential and the properties of stem cells. As such, identifying agents that inhibit the growth of FOXC2-transformed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bollong MJ,Pietilä M,Pearson AD,Sarkar TR,Ahmad I,Soundararajan R,Lyssiotis CA,Mani SA,Schultz PG,Lairson LL

更新日期：2017-11-14 00:00:00

abstract：:Acidification of the extracellular milieu of malignant tumors is reported to increase the invasive behavior of cancer cells. In normal tissues, production of acid is catalyzed by carbonic anhydrases (CAs), some of which are known to be overexpressed in certain cancers. To investigate the functional role of CA activity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parkkila S,Rajaniemi H,Parkkila AK,Kivela J,Waheed A,Pastorekova S,Pastorek J,Sly WS

更新日期：2000-02-29 00:00:00

abstract：:In this paper I review the ways in which the glassy state is obtained both in nature and in materials science and highlight a "new twist"--the recent recognition of polymorphism within the glassy state. The formation of glass by continuous cooling (viscous slowdown) is then examined, the strong/fragile liquids classif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Angell CA

更新日期：1995-07-18 00:00:00

abstract：:Thermotaxis by individual amoebae of Dictyostelium discoideum on a temperature gradient is described. These amoebae show positive thermotaxis at temperatures between 14 degrees C and 28 degrees C shortly (3 hr) after food depletion. Increasing time on the gradient reduces the positive thermotactic response at the lowe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong CB,Fontana DR,Poff KL

更新日期：1983-09-01 00:00:00

abstract：:A unique neuronal system was detected in the rat central nervous system by immunohistochemistry and radioimmunoassay with antibodies to salmon melanin-concentrating hormone (MCH). MCH-like immunoreactive (MCH-LI) cell bodies were confined to the hypothalamus. MCH-LI fibers were found throughout the brain but were most...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zamir N,Skofitsch G,Bannon MJ,Jacobowitz DM

更新日期：1986-03-01 00:00:00

abstract：:Predicting whether and how populations will adapt to rapid climate change is a critical goal for evolutionary biology. To examine the genetic basis of fitness and predict adaptive evolution in novel climates with seasonal variation, we grew a diverse panel of the annual plant Arabidopsis thaliana (multiparent advanced...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fournier-Level A,Perry EO,Wang JA,Braun PT,Migneault A,Cooper MD,Metcalf CJ,Schmitt J

更新日期：2016-05-17 00:00:00

abstract：:Langerhans cells are a subset of dendritic cells (DCs) found in the human epidermis with unique morphological and molecular properties that enable their function as "sentinels" of the immune system. DCs are pivotal in the initiation and regulation of primary MHC class I restricted T lymphocyte immune responses and are...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： MacAry PA,Lindsay M,Scott MA,Craig JI,Luzio JP,Lehner PJ

更新日期：2001-03-27 00:00:00

abstract：:The alpha and beta subunits of Na-K-ATPase are up-regulated by hypertonicity in inner-medullary collecting duct cells adapted to survive in hypertonic conditions. We examined the regulation of the gamma subunit by hypertonicity. Although cultured inner-medullary collecting duct cells lacked the gamma subunits, both va...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Capasso JM,Rivard C,Berl T

更新日期：2001-11-06 00:00:00

abstract：:Nitrogen limitation imposes a major transition in the lifestyle of nondiazotrophic cyanobacteria that is controlled by a complex interplay of regulatory factors involving the pervasive signal processor PII Immediately upon nitrogen limitation, newly fixed carbon is redirected toward glycogen synthesis. How the metabol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Orthwein T,Scholl J,Spät P,Lucius S,Koch M,Macek B,Hagemann M,Forchhammer K

更新日期：2021-02-09 00:00:00

abstract：:Degeneracy, the ability of elements that are structurally different to perform the same function or yield the same output, is a well known characteristic of the genetic code and immune systems. Here, we point out that degeneracy is a ubiquitous biological property and argue that it is a feature of complexity at geneti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edelman GM,Gally JA

更新日期：2001-11-20 00:00:00

abstract：:The Na/K pump is a P-type ATPase that exchanges three intracellular Na(+) ions for two extracellular K(+) ions through the plasmalemma of nearly all animal cells. The mechanisms involved in cation selection by the pump's ion-binding sites (site I and site II bind either Na(+) or K(+); site III binds only Na(+)) are po...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ratheal IM,Virgin GK,Yu H,Roux B,Gatto C,Artigas P

更新日期：2010-10-26 00:00:00

abstract：:Enteritis caused by Clostridium difficile toxin (Tx) is a nosocomial disease of increasing clinical concern, but the local mediators of C. difficile TxA inflammation are unknown. The potent vasodilator calcitonin gene-related peptide mediates neurogenic inflammation via the calcitonin receptor-like receptor (CLR). Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhargava A,Clifton MS,Mhaske P,Liao M,Pothoulakis C,Leeman SE,Grady EF

更新日期：2013-01-08 00:00:00

abstract：:Femtosecond and subfemtosecond time scales typically rule electron dynamics at metal surfaces. Recent advance in experimental techniques permits now remarkable precision in the description of these processes. In particular, shorter time scales, smaller system sizes, and spin-dependent effects are current targets of in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muiño RD,Sánchez-Portal D,Silkin VM,Chulkov EV,Echenique PM

更新日期：2011-01-18 00:00:00

abstract：:Recent studies show that plant organ positioning may be mediated by localized concentrations of the plant hormone auxin. Auxin patterning in the shoot apical meristem is in turn brought about by the subcellular polar distribution of the putative auxin efflux mediator, PIN1. However, the question of what signals determ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jönsson H,Heisler MG,Shapiro BE,Meyerowitz EM,Mjolsness E

更新日期：2006-01-31 00:00:00

abstract：:We have constructed and characterized a polyoma virus-based plasmid that is maintained as an autonomously replicating extrachromosomal element (episome) in mouse embryonic stem (ES) cells. Plasmid pMGD20neo contains the polyoma origin of replication harboring a mutated enhancer (PyF101), a modified polyoma early regio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gassmann M,Donoho G,Berg P

更新日期：1995-02-28 00:00:00

abstract：:Fibroblasts can be reprogrammed to induced pluripotent stem cells (iPSCs) by application of transcription factors octamer-binding protein 4 (Oct4), SRY-box containing gene 2 (Sox2), Kruppel-like factor 4 (Klf4), and c-Myelocytomatosis oncogene (c-Myc) (OSKM), but the underlying mechanisms remain unclear. Here, we repo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang G,Guo X,Hong W,Liu Q,Wei T,Lu C,Gao L,Ye D,Zhou Y,Chen J,Wang J,Wu M,Liu H,Kang J

更新日期：2013-02-19 00:00:00

abstract：:The interaction of human high density lipoproteins (HDL) with isolated human monocytes from control and Tangier patients was studied in tissue culture experiments. It was observed that normal monocytes, similar to mouse peritoneal macrophages, bind HDL to a cell surface receptor, internalize the bound HDL particles, t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmitz G,Assmann G,Robenek H,Brennhausen B

更新日期：1985-09-01 00:00:00

abstract：:DNA fragmentation is a hallmark of apoptosis (programmed cell death). However, the biological function of apoptotic DNA fragmentation remains unclear. Here, we show that DNA fragmentation factor plays an important role for maintaining genomic stability. Inhibition or loss of the DNA fragmentation factor (DFF)/caspase-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan B,Wang H,Peng Y,Hu Y,Wang H,Zhang X,Chen Q,Bedford JS,Dewhirst MW,Li CY

更新日期：2006-01-31 00:00:00

abstract：:Node characteristics and behaviors are often correlated with the structure of social networks over time. While evidence of this type of assortative mixing and temporal clustering of behaviors among linked nodes is used to support claims of peer influence and social contagion in networks, homophily may also explain suc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aral S,Muchnik L,Sundararajan A

更新日期：2009-12-22 00:00:00

abstract：:A central role for phenotypic plasticity in adaptive evolution is often posited yet lacks empirical support. Selection for the stable production of an induced phenotype is hypothesized to modify the regulation of preexisting developmental pathways, producing rapid adaptive change. We examined the role of plasticity in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scoville AG,Pfrender ME

更新日期：2010-03-02 00:00:00

abstract：:We have investigated the biochemical basis for negative regulation of interleukin 2 receptor alpha-chain (IL-2R alpha) gene expression. Transient transfection studies employing internally deleted forms of the IL-2R alpha promoter localized a negative regulatory element (NRE) between nucleotides -400 and -368 relative ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith MR,Greene WC

更新日期：1989-11-01 00:00:00

abstract：:We propose that protein translocation across membranes is driven by biased random thermal motion. This "Brownian ratchet" mechanism depends on chemical asymmetries between the cis and trans sides of the membrane. Several mechanisms could contribute to rectifying the thermal motion of the protein, such as binding and d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simon SM,Peskin CS,Oster GF

更新日期：1992-05-01 00:00:00

abstract：:The underlying structure is taken as a strongly superharmonic cone [unk], defined as a partially ordered abelian semigroup with identity 0 which admits a multiplication by nonnegative scalars and satisfies two fundamental axioms of a potentialtheoretic character. In terms of a fixed nonzero element e there is introduc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arsove M,Leutwiler H

更新日期：1975-07-01 00:00:00

abstract：:Conjugative DNA transfer of the self-transmissible broad-host-range plasmid RP4 is initiated by strand- and site-specific cleavage at the nick site (nic) of the transfer origin (oriT). Cleavage results in covalent attachment of the plasmid-encoded relaxase (TraI) to the 5'-terminal 2'-deoxycytidine residue at nic. We ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pansegrau W,Schröder W,Lanka E

更新日期：1993-04-01 00:00:00