A ubiquitous protein is the source of naturally occurring peptides that are recognized by a CD8+ T-cell clone.

abstract：:Previous studies imply that the intracellular domain of Notch1 must translocate to the nucleus for its activity. In this study, we demonstrate that a mNotch1 mutant protein that lacks its extracellular domain but retains its membrane-spanning region becomes proteolytically processed on its intracellular surface and, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kopan R,Schroeter EH,Weintraub H,Nye JS

更新日期：1996-02-20 00:00:00

abstract：:Three criteria have been used to distinguish among different systems of embryonic cell adhesion: dependence on Ca2+, involvement of particular cell-surface molecules, and binding specificity. The characterization of the adhesion with respect to cell-surface molecules was carried out by using specific antibodies agains...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brackenbury R,Rutishauser U,Edelman GM

更新日期：1981-01-01 00:00:00

abstract：:Stopping an action in response to an unexpected event requires both that the event is attended to, and that the action is inhibited. Previous neuroimaging investigations of stopping have failed to adequately separate these cognitive elements. Here we used a version of the widely used Stop Signal Task that controls for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharp DJ,Bonnelle V,De Boissezon X,Beckmann CF,James SG,Patel MC,Mehta MA

更新日期：2010-03-30 00:00:00

abstract：:Sialic acid-recognizing Ig-like lectins (Siglecs) are signaling receptors that modulate immune responses, and are targeted for interactions by certain pathogens. We describe two primate Siglecs that were rendered nonfunctional by single genetic events during hominin evolution after our common ancestor with the chimpan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang X,Mitra N,Secundino I,Banda K,Cruz P,Padler-Karavani V,Verhagen A,Reid C,Lari M,Rizzi E,Balsamo C,Corti G,De Bellis G,Longo L,NISC Comparative Sequencing Program.,Beggs W,Caramelli D,Tishkoff SA,Hayakawa T,Gree

更新日期：2012-06-19 00:00:00

abstract：:Active immunization using tumor antigen-loaded dendritic cells holds promise for the adjuvant treatment of cancer to eradicate or control residual disease, but so far, most dendritic cell trials have been performed in end-stage cancer patients with high tumor loads. Here, in a phase I/II trial, we investigated the eff...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Tendeloo VF,Van de Velde A,Van Driessche A,Cools N,Anguille S,Ladell K,Gostick E,Vermeulen K,Pieters K,Nijs G,Stein B,Smits EL,Schroyens WA,Gadisseur AP,Vrelust I,Jorens PG,Goossens H,de Vries IJ,Price DA,Oji Y

更新日期：2010-08-03 00:00:00

abstract：:Reestablishment of vascular homeostasis following ex vivo preservation is a critical determinant of successful organ transplantation. Because the nitric oxide (NO) pathway modulates pulmonary vascular tone and leukocyte/endothelial interactions, we hypothesized that reactive oxygen intermediates would lead to decrease...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pinsky DJ,Naka Y,Chowdhury NC,Liao H,Oz MC,Michler RE,Kubaszewski E,Malinski T,Stern DM

更新日期：1994-12-06 00:00:00

abstract：:Mutations in the presenilin 1 (PS1) and presenilin 2 (PS2) genes increase the production of the highly amyloidogenic 42-residue form of amyloid beta-protein (Abeta42) in a variety of cell lines and transgenic mice. To elucidate the molecular mechanism of this effect, wild-type (wt) or mutant PS1 and PS2 genes were sta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xia W,Zhang J,Perez R,Koo EH,Selkoe DJ

更新日期：1997-07-22 00:00:00

abstract：:Gelation of colloidal nanocrystals emerged as a strategy to preserve inherent nanoscale properties in multiscale architectures. However, available gelation methods to directly form self-supported nanocrystal networks struggle to reliably control nanoscale optical phenomena such as photoluminescence and localized surfa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saez Cabezas CA,Ong GK,Jadrich RB,Lindquist BA,Agrawal A,Truskett TM,Milliron DJ

更新日期：2018-09-04 00:00:00

abstract：:Antisera directed against human dopamine beta-hydroxylase or serotonin were used to characterize the noradrenergic and serotonergic innervation patterns within the primary visual cortex of the squirrel monkey. The noradrenergic and serotonergic projections exhibit a high degree of laminar complementarity: layers V and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morrison JH,Foote SL,Molliver ME,Bloom FE,Lidov HG

更新日期：1982-04-01 00:00:00

abstract：:The super-enhancers (SEs) of lineage-specific genes in B cells are off-target sites of somatic hypermutation. However, the inability to detect sufficient numbers of mutations in normal human B cells has precluded the generation of a high-resolution mutational landscape of SEs. Here we captured and sequenced 12 B cell ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen JC,Kamath-Loeb AS,Kohrn BF,Loeb KR,Preston BD,Loeb LA

更新日期：2019-12-03 00:00:00

abstract：:The c-rings of ATP synthases consist of individual c-subunits, all of which harbor a conserved motif of repetitive glycine residues (GxGxGxG) important for tight transmembrane α-helix packing. The c-ring stoichiometry determines the number of ions transferred during enzyme operation and has a direct impact on the ion-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Preiss L,Klyszejko AL,Hicks DB,Liu J,Fackelmayer OJ,Yildiz Ö,Krulwich TA,Meier T

更新日期：2013-05-07 00:00:00

abstract：:The gene encoding the rice transcription factor, REB (rice endosperm bZIP) was cloned from a bacterial artificial chromosome library of rice. The cloned 6,227-bp-long Reb gene is composed of six exons and five introns and is flanked by a 1.2-kb 5' promoter and a 1.2-kb 3' terminator region. The function of the Reb gen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang D,Wu L,Hwang YS,Chen L,Huang N

更新日期：2001-09-25 00:00:00

abstract：:T cells are essential for immune defenses against pathogens, such that viability of naïve T cells before antigen encounter is critical to preserve a polyclonal repertoire and prevent immunodeficiencies. The viability of naïve T cells before antigen recognition is ensured by IL-7, which drives expression of the prosurv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller ML,Mashayekhi M,Chen L,Zhou P,Liu X,Michelotti M,Tramontini Gunn N,Powers S,Zhu X,Evaristo C,Alegre ML,Molinero LL

更新日期：2014-05-20 00:00:00

abstract：:The total amount of noncoding sequences on chromosomes of contemporary organisms varies significantly from species to species. We propose a hypothesis for the origin of these noncoding sequences that assumes that (i) an approximately equal to 0.55-kilobase (kb)-long reading frame composed the primordial gene and (ii) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naora H,Miyahara K,Curnow RN

更新日期：1987-09-01 00:00:00

abstract：:The sequence of spontaneous Epstein-Barr virus activation was studied in P3HR-1 carrier cells and in P3HR-1(BrdU) cells made resistant to 5-bromodeoxyuridine. Virus activation was initiated during the normal cell cycle, and recruitment of additional virus-activated cells was prevented by the DNA inhibitors, 1-beta-D-a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hampar B,Derge JG,Martos LM,Tagamets MA,Burroughs MA

更新日期：1972-09-01 00:00:00

abstract：:An array of photoreceptors including cryptochromes, phototropin, and phytochromes regulates various light responses in plants. Among these photoreceptors, phytochromes perceive red and far-red light by switching between two interconvertible spectral forms (Pr and Pfr). The Pfr form promotes light responses partly by d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paik I,Yang S,Choi G

更新日期：2012-01-24 00:00:00

abstract：:Abnormal H2O2 levels are closely related to many diseases, including inflammation and cancers. Herein, we simultaneously load HRP and its substrate, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), into liposomal nanoparticles, obtaining a Lipo@HRP&ABTS optical nanoprobe for in vivo H2O2-responsive chrom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Q,Liang C,Sun X,Chen J,Yang Z,Zhao H,Feng L,Liu Z

更新日期：2017-05-23 00:00:00

abstract：:Incubation of chicken embryo fibroblasts with mitogenic concentrations of insulin for 24 hr or with the tumor promoter phorbol 12-myristate 13-acetate for 6 hr stimulated lactate release and 3-O-methylglucose uptake. Insulin also increased the Vmax of 6-phosphofructo-1-kinase (ATP:D-fructose-6-phosphate 1-phosphotrans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bosca L,Rousseau GG,Hue L

更新日期：1985-10-01 00:00:00

abstract：:The phosphoprotein (NS) of vesicular stomatitis virus is an indispensable subunit of the virion-associated RNA polymerase (L). NS consists of a highly acidic NH2-terminal domain and a basic COOH-terminal domain. Unlike the latter, the amino acid sequences of the NH2-terminal regions are highly dissimilar among differe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chattopadhyay D,Banerjee AK

更新日期：1988-11-01 00:00:00

abstract：:Here, using further optimized 3D culture that allows highly selective induction and long-term growth of human ES cell (hESC)-derived cortical neuroepithelium, we demonstrate unique aspects of self-organization in human neocorticogenesis. Self-organized cortical tissue spontaneously forms a polarity along the dorsocaud...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kadoshima T,Sakaguchi H,Nakano T,Soen M,Ando S,Eiraku M,Sasai Y

更新日期：2013-12-10 00:00:00

abstract：:Members of the POU-homeodomain gene family encode transcriptional regulatory molecules that play important roles in terminal differentiation of many organ systems. Sperm-1 (Sprm-1) is a POU domain factor that is exclusively expressed in the differentiating male germ cell. We show here that the Sprm-1 protein is expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pearse RV 2nd,Drolet DW,Kalla KA,Hooshmand F,Bermingham JR Jr,Rosenfeld MG

更新日期：1997-07-08 00:00:00

abstract：:Treatment of human fibroblast cells with human fibroblast (beta)interferon for up to 8 hr resulted in the accumulation of at least four mRNAs. The mRNAs were isolated from cellular polysomes and characterized by stimulation of translation in a wheat germ cell-free protein synthesis system. The mRNAs appear as early as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colonno RJ

更新日期：1981-08-01 00:00:00

abstract：:The intermediates and the rate-limiting step in the crystallization of deoxygenated sickle hemoglobin have been determined by a kinetic study with the use of electron microscopy. In slowly stirred solutions of deoxygenated hemoglobin S [Pumphrey, J. & Steinhardt, J. (1977) J. Mol. Biol. 112, 359--375], the sequential ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilson SM,Makinen MW

更新日期：1980-02-01 00:00:00

abstract：:Analogy-the ability to find and apply deep structural patterns across domains-has been fundamental to human innovation in science and technology. Today there is a growing opportunity to accelerate innovation by moving analogy out of a single person's mind and distributing it across many information processors, both hu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kittur A,Yu L,Hope T,Chan J,Lifshitz-Assaf H,Gilon K,Ng F,Kraut RE,Shahaf D

更新日期：2019-02-05 00:00:00

abstract：:Levinthal's paradox is that finding the native folded state of a protein by a random search among all possible configurations can take an enormously long time. Yet proteins can fold in seconds or less. Mathematical analysis of a simple model shows that a small and physically reasonable energy bias against locally unfa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zwanzig R,Szabo A,Bagchi B

更新日期：1992-01-01 00:00:00

abstract：:During or immediately after synthesis in vertebrate cells, the oncogenic protein-tyrosine kinase pp60v-src associates with the approximately 90-kDa heat-shock protein (hsp90). In this complex, pp60v-src is not functional as a kinase. When pp60v-src is subsequently found inserted into the plasma membrane, it is active ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu Y,Lindquist S

更新日期：1993-08-01 00:00:00

abstract：:Proopiomelanocortin (POMC), a major pituitary product, is also present in the adult mouse testis. We have shown previously that POMC mRNAs are most abundant in a subpopulation of Leydig cells associated with tubules in specific stages of the cycle of the seminiferous epithelium. In the present study, we examined the e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gizang-Ginsberg E,Wolgemuth DJ

更新日期：1987-03-01 00:00:00

abstract：:Mitogen-activated protein (MAP) kinase kinase is an enzyme that activates the growth factor-regulated MAP kinase in vitro by a mechanism that involves direct phosphorylation of MAP kinase on tyrosine and threonine residues. MAP kinase kinase is stimulated by growth factor treatment of cells and has been shown to be in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahn NG,Campbell JS,Seger R,Jensen AL,Graves LM,Krebs EG

更新日期：1993-06-01 00:00:00

abstract：:The toxic, mutagenic, and carcinogenic effects of alkylating agents have been attributed to their ability to damage DNA. Reaction at the O6 position of guanine results in miscoding during DNA replication, has been shown to be mutagenic in both bacteriophage and bacteria, and may be responsible for malignant transforma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brennand J,Margison GP

更新日期：1986-09-01 00:00:00

abstract：:Rat cortical astrocytes in pure culture are functionally coupled to neighboring cells via connexin (Cx) 43 gap junctions under ordinary conditions. Small fluorescent molecules such as Lucifer yellow (LY) pass between cell interiors via gap junctions, but do not enter the cells when externally applied. Subjecting rat a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Contreras JE,Sánchez HA,Eugenin EA,Speidel D,Theis M,Willecke K,Bukauskas FF,Bennett MV,Sáez JC

更新日期：2002-01-08 00:00:00