Noradrenergic and serotonergic fibers innervate complementary layers in monkey primary visual cortex: an immunohistochemical study.

abstract：:Type IV pili (Tfp) are highly conserved macromolecular structures that fulfill diverse cellular functions, such as adhesion to host cells, the import of extracellular DNA, kin recognition, and cell motility (twitching). Outstandingly, twitching motility enables a poorly understood process by which highly coordinated g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mercier R,Bautista S,Delannoy M,Gibert M,Guiseppi A,Herrou J,Mauriello EMF,Mignot T

更新日期：2020-11-10 00:00:00

abstract：:Coxsackievirus causes severe disease in adult mice subjected to sustained post-weaning undernutrition (marasmus). Virus-infected marasmic mice have an increased incidence of mortality, severe lesions, and elevated and persistent viral in target organs. Transfer of immune lymphoid cells 30 min or 24 hr after viral chal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Woodruff JF,Woodruff JJ

更新日期：1971-09-01 00:00:00

abstract：:The immunophilin FK506 binding protein 12 (FKBP12) is associated with and modulates the ryanodine receptor calcium release channel of skeletal muscle. Ryanodine receptor has amino acid homology and functional similarity with another intracellular Ca2+ release channel, the inositol 1,4,5-trisphosphate receptor (IP3R). ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cameron AM,Steiner JP,Sabatini DM,Kaplin AI,Walensky LD,Snyder SH

更新日期：1995-02-28 00:00:00

abstract：:Colocalization of proteins that are part of the same signal transduction pathway via compartmentalization, scaffold, or anchor proteins is an essential aspect of the signal transduction system in eukaryotic cells. If interaction must occur via free diffusion, then the spatial separation between the sources of the two ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Batada NN,Shepp LA,Siegmund DO

更新日期：2004-04-27 00:00:00

abstract：:Repeat proteins contain short, tandem arrays of simple structural motifs (20-40 aa). These stack together to form nonglobular structures that are stabilized by short-range interactions from residues close in primary sequence. Unlike globular proteins, they have few, if any, long-range nonlocal stabilizing interactions...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Javadi Y,Main ER

更新日期：2009-10-13 00:00:00

abstract：:Integration sites for many retrotransposons and retroviruses are determined by interactions between retroelement-encoded integrases and specific DNA-bound proteins. The Saccharomyces retrotransposon Ty5 preferentially integrates into heterochromatin because of interactions between Ty5 integrase and the heterochromatin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baller JA,Gao J,Voytas DF

更新日期：2011-12-20 00:00:00

abstract：:The c-Raf-1 protein kinase plays a central role in the mitogenic response of cells to growth factors, cytokines, and many oncogenes. Despite the critical importance of this enzyme, very little is known of its biochemical properties or mechanisms of regulation. In these experiments, we used the only candidate physiolog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Force T,Bonventre JV,Heidecker G,Rapp U,Avruch J,Kyriakis JM

更新日期：1994-02-15 00:00:00

abstract：:Many discoveries in cell biology rely on making specific proteins visible within their native cellular environment. There are various genetically encoded tags, such as fluorescent proteins, developed for fluorescence microscopy (FM). However, there are almost no genetically encoded tags that enable cellular proteins t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doh JK,White JD,Zane HK,Chang YH,López CS,Enns CA,Beatty KE

更新日期：2018-12-18 00:00:00

abstract：:A synchronized heart beat is controlled by pacemaking impulses conducted through Purkinje fibers. In chicks, these impulse-conducting cells are recruited during embryogenesis from myocytes in direct association with developing coronary arteries. In culture, the vascular cytokine endothelin converts embryonic myocytes ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hyer J,Johansen M,Prasad A,Wessels A,Kirby ML,Gourdie RG,Mikawa T

更新日期：1999-11-09 00:00:00

abstract：:Inactivation of the recently identified murMN operon in penicillin-resistant strains of Streptococcus pneumoniae was shown already to cause two major effects: elimination of branched-structured muropeptides from the cell wall and complete loss of penicillin resistance. We now show that cells with inactivated murMN als...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Filipe SR,Severina E,Tomasz A

更新日期：2002-02-05 00:00:00

abstract：:Hydrogen/deuterium exchange followed by trapping of the labeled species in the aprotic solvent DMSO has been used to elucidate structure in both the burst-phase molten globule-folding intermediate of apomyoglobin and in an equilibrium intermediate that models the kinetic intermediate. Precise estimates can be made of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nishimura C,Dyson HJ,Wright PE

更新日期：2005-03-29 00:00:00

abstract：:Efficient computation of geophysical turbulence, such as occurs in the atmosphere and ocean, is a formidable challenge for the following reasons: the complex combination of waves, jets, and vortices; significant energetic backscatter from unresolved small scales to resolved large scales; a lack of dynamical scale sepa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grooms I,Majda AJ

更新日期：2013-03-19 00:00:00

abstract：:We present the complete nucleotide and deduced amino acid sequences of a mouse epidermal keratin subunit of 60,000 Da. The keratin possesses a central alpha-helical domain of four tracts (termed 1A, 1B, 2A, and 2B) that can form coiled-coils, interspersed by short linker sequences, and has non-alpha-helical terminal d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steinert PM,Parry DA,Racoosin EL,Idler WW,Steven AC,Trus BL,Roop DR

更新日期：1984-09-01 00:00:00

abstract：:Phenotypic alterations induced by the cytokinin 6-benzylaminopurine in cell suspensions of Nicotiana plumbaginifolia were studied at the level of the NH(2)-terminal sequence of the constituent proteins. Total protein extracts were separated by classical two-dimensional PAGE, and the proteins were recovered by electrob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bauw G,De Loose M,Inzé D,Van Montagu M,Vandekerckhove J

更新日期：1987-07-01 00:00:00

abstract：:Tadpole collagenase (EC 3.4.24.3) cleaved chick cranial bone procollagen into two triple-stranded fragments, PCA and PCB. Only PCB, with an estimated molecular weight of about 60,000 for each component chain after reduction, was found to contain interchain disulfide bonds. The analogous cleavage of collagen is known t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Byers PH,Click EM,Harper E,Bornstein P

更新日期：1975-08-01 00:00:00

abstract：:Targeted drug delivery critically depends on the binding selectivity of cargo-transporting colloidal particles. Extensive theoretical work has shown that two factors are necessary to achieve high selectivity for a threshold receptor density: multivalency and weak interactions. Here, we study a model system of DNA-coat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scheepers MRW,van IJzendoorn LJ,Prins MWJ

更新日期：2020-09-15 00:00:00

abstract：:Mitotic recombination between homologous chromosomes is a genetic technique for mosaic analysis in model organisms. The general application of this technique in the mouse depends on establishment of effective recombination systems for individual chromosomes and reliable and sensitive methods for detection of recombina...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun L,Wu X,Han M,Xu T,Zhuang Y

更新日期：2008-03-18 00:00:00

abstract：:A cylindrical detonating explosive behaves like a non-Newtonian viscous fluid emerging from a cylindrical pipe. The expression for non-Newtonian viscous flow has been applied to detonating explosives. The resultant fit to emerging flame fronts from detonation is excellent for a wide variety of detonating explosives bo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coon N,Ma SM,Redington PK,Brown B,Eyring H

更新日期：1980-10-01 00:00:00

abstract：:In cultures of spleen cells from normal mice, recombinant human granulocyte colony-stimulating factor (G-CSF) supported the formation of multipotential blast cell colonies. Serial replating of the blast cell colonies in the presence of G-CSF, however, failed to demonstrate any direct effect of G-CSF on murine multipot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ikebuchi K,Clark SC,Ihle JN,Souza LM,Ogawa M

更新日期：1988-05-01 00:00:00

abstract：:The delta-subspecies of protein kinase C (delta PKC) was purified to near homogeneity from the Triton X-100 extract of the rat brain particulate fraction by successive chromatographies on S-Sepharose fast flow, phenyl 5PW, heparin 5PW, hydroxyapatite, and Mono Q columns. The purified enzyme was a doublet with molecula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ogita K,Miyamoto S,Yamaguchi K,Koide H,Fujisawa N,Kikkawa U,Sahara S,Fukami Y,Nishizuka Y

更新日期：1992-03-01 00:00:00

abstract：:Expression of the homeobox protein CDX1 is lost or reduced in a significant proportion of colorectal carcinomas (CRCs) but the underlying mechanism for this is unclear. We have demonstrated absence of CDX1 mRNA expression in 7 of 37 CRC cell lines and shown that all 7 cell lines have a methylated CDX1 promoter. Twenty...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wong NA,Britton MP,Choi GS,Stanton TK,Bicknell DC,Wilding JL,Bodmer WF

更新日期：2004-01-13 00:00:00

abstract：:During performance of attention-demanding cognitive tasks, certain regions of the brain routinely increase activity, whereas others routinely decrease activity. In this study, we investigate the extent to which this task-related dichotomy is represented intrinsically in the resting human brain through examination of s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fox MD,Snyder AZ,Vincent JL,Corbetta M,Van Essen DC,Raichle ME

更新日期：2005-07-05 00:00:00

abstract：:The T cell alphabeta receptor (TCR) recognizes foreign peptide antigens bound to proteins encoded in the MHC. The MHC portion of this complex contributes much to the footprint of the TCR on the ligand, yet T cells are usually very specific for individual foreign peptides. Here, we show that the development of peptide-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huseby ES,Crawford F,White J,Kappler J,Marrack P

更新日期：2003-09-30 00:00:00

abstract：:Partial, unilateral nigrostriatal lesions of varying severity were produced in rats by injecting graded doses of 6-hydroxydopamine into the substantia nigra. Formation of the dopamine metabolites dihydroxyphenylacetic acid and homovanillic acid in each surviving nigrostriatal neuron (estimated by the ratios of dihydro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Melamed E,Hefti F,Wurtman RJ

更新日期：1980-07-01 00:00:00

abstract：:In all but the poorest countries of South Asia and Africa, the supply and quality of food will rise to meet the demand. Biotechnology, accelerated by genomics, will create wealth for both producers and consumers by reducing the cost and increasing the quality of food. Famine and malnutrition in the poorest countries m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Briggs SP

更新日期：1998-03-03 00:00:00

abstract：:We outline a theory to quantify the interplay of entropic and selective forces on nucleotide organization and apply it to the genomes of single-stranded RNA viruses. We quantify these forces as intensive variables that can easily be compared between sequences, outline a computationally efficient transfer-matrix method...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greenbaum BD,Cocco S,Levine AJ,Monasson R

更新日期：2014-04-01 00:00:00

abstract：:Two independently arising alpha heavy chain mutants have been found to synthesize heavy chains with CH1 deletions of approximately equal extent. Both were isolated from heavy chain-producing variants of the mouse myeloma W3129 and demonstrate that it is possible to arrive at the heavy chain disease phenotype by the pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dackowski W,Morrison SL

更新日期：1981-11-01 00:00:00

abstract：:A discussion of the range of applicability of Forster long-range energy transfer in the determination of macromolecular dimensions and conformational dynamics is given. Emphasis is laid on the effect of restrictions in the orientational freedom of donor and acceptor and on the importance of the orientational averaging...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dale RE,Eisinger J

更新日期：1976-02-01 00:00:00

abstract：:Unlike αβ-T lineage cells, where the role of ligand in intrathymic selection is well established, the role of ligand in the development of γδ-T cells remains controversial. Here we provide evidence for the role of a bona fide selecting ligand in shaping the γδ-T cell-receptor (TCR) repertoire. Reactivity of the γδ-TCR...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fahl SP,Coffey F,Kain L,Zarin P,Dunbrack RL Jr,Teyton L,Zúñiga-Pflücker JC,Kappes DJ,Wiest DL

更新日期：2018-02-20 00:00:00

abstract：:The S(N)2 displacement of Cl(-) from 1,2-dichloroethane by acetate (CH(3)CO(2)(-)) in water and by the carboxylate of the active site aspartate in the haloalkane dehalogenase of Xanthobacter autothropicus have been compared by using molecular dynamics simulations. In aqueous solution, six families of contact-pair stru...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hur S,Kahn K,Bruice TC

更新日期：2003-03-04 00:00:00