Abstract:
:Targeted drug delivery critically depends on the binding selectivity of cargo-transporting colloidal particles. Extensive theoretical work has shown that two factors are necessary to achieve high selectivity for a threshold receptor density: multivalency and weak interactions. Here, we study a model system of DNA-coated particles with multivalent and weak interactions that mimics ligand-receptor interactions between particles and cells. Using an optomagnetic cluster experiment, particle aggregation rates are measured as a function of ligand and receptor densities. The measured aggregation rates show that the binding becomes more selective for shorter DNA ligand-receptor pairs, proving that multivalent weak interactions lead to enhanced selectivity in interparticle binding. Simulations confirm the experimental findings and show the role of ligand-receptor dissociation in the selectivity of the weak multivalent binding.
journal_name
Proc Natl Acad Sci U S Aauthors
Scheepers MRW,van IJzendoorn LJ,Prins MWJdoi
10.1073/pnas.2003968117subject
Has Abstractpub_date
2020-09-15 00:00:00pages
22690-22697issue
37eissn
0027-8424issn
1091-6490pii
2003968117journal_volume
117pub_type
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