Fusion of dipalmitoylphosphatidylcholine vesicle membranes induced by concanavalin A.

abstract：:Because RNAs fold as they are being synthesized, their transcription rate can affect their folding. Here, we report the results of single-molecule fluorescence studies that characterize the ligand-dependent cotranscriptional folding of the Escherichia coli thiM riboswitch that regulates translation. We found that the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uhm H,Kang W,Ha KS,Kang C,Hohng S

更新日期：2018-01-09 00:00:00

abstract：:Arguably the most foundational principle in perception research is that our experience of the world goes beyond the retinal image; we perceive the distal environment itself, not the proximal stimulation it causes. Shape may be the paradigm case of such "unconscious inference": When a coin is rotated in depth, we infer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morales J,Bax A,Firestone C

更新日期：2020-06-30 00:00:00

abstract：:Previous attempts to express functional DNA cytosine methyltransferase (EC 2.1.1.37) in cells transfected with the available Dnmt cDNAs have met with little or no success. We show that the published Dnmt sequence encodes an amino terminal-truncated protein that is tolerated only at very low levels when stably expresse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tucker KL,Talbot D,Lee MA,Leonhardt H,Jaenisch R

更新日期：1996-11-12 00:00:00

abstract：:One of the earliest detectable events during plant-pathogen interaction is a rapid increase in ethylene biosynthesis. This gaseous plant stress hormone may be a signal for plants to activate defense mechanisms against invading pathogens such as bacteria, fungi, and viruses. The effect of ethylene on four plant genes i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ecker JR,Davis RW

更新日期：1987-08-01 00:00:00

abstract：:The ion transport properties of the rough endoplasmic reticulum (RER) from liver have been defined by using measurements of active and potential gradient-driven transport. The Ca2+ pump is shown to be electrogenic, and both ATP and potential difference is able to drive vanadate-inhibitable Ca2+ uptake into the RER. AT...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muallem S,Schoeffield M,Pandol S,Sachs G

更新日期：1985-07-01 00:00:00

abstract：:Melanocyte stimulating hormone coupled to Sepharose effects an increase in tryosinase (EC 1.14.18.1; monophenol monoxygenase) activity of cultivated mouse melanoma cells. Synchronized cells are found to respond to melanocyte stimulating hormone only in the G2 phase of the cell cycle, although their response to cyclic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Varga JM,Dipasquale A,Pawelek J,McGuire JS,Lerner AB

更新日期：1974-05-01 00:00:00

abstract：:A compound of simple structure, 2,4-dichlorobenzyl thiocyanate (DCBT), is an antimitotic agent with a number of unusual properties. The drug causes an extreme reorganization of microtubules in cells in culture. Most normal microtubules disappear, and remaining tubulin-containing structures appear to be bundled or aggr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abraham I,Dion RL,Chi DM,Gottesman MM,Hamel E

更新日期：1986-09-01 00:00:00

abstract：:The positive transcription elongation factor b (P-TEFb) is involved in physiological and pathological events including inflammation, cancer, AIDS, and cardiac hypertrophy. The balance between its active and inactive form is tightly controlled to ensure cellular integrity. We report that the transcriptional repressor C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cherrier T,Le Douce V,Eilebrecht S,Riclet R,Marban C,Dequiedt F,Goumon Y,Paillart JC,Mericskay M,Parlakian A,Bausero P,Abbas W,Herbein G,Kurdistani SK,Grana X,Van Driessche B,Schwartz C,Candolfi E,Benecke AG,Van Lin

更新日期：2013-07-30 00:00:00

abstract：:In a well networked community, there is intense social interaction, and information disseminates briskly and broadly. This is important if the environment is volatile (i.e., keeps changing) and individuals never stop searching for fresh opportunities. Here, we present a simple model that attributes the rise of a dynam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marsili M,Vega-Redondo F,Slanina F

更新日期：2004-02-10 00:00:00

abstract：:After pollen grains germinate on the stigma, pollen tubes traverse the extracellular matrix of the style on their way to the ovules. We previously characterized two pollen-specific, receptor-like kinases, LePRK1 and LePRK2, from tomato (Lycopersicon esculentum). Their structure and immunolocalization pattern and the s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wengier D,Valsecchi I,Cabanas ML,Tang WH,McCormick S,Muschietti J

更新日期：2003-05-27 00:00:00

abstract：:Under conditions (0.2% CO2; 1% O2) that allow high rates of photosynthesis, chlorophyll fluorescence was measured simultaneously with carbon assimilation at various light intensities in spinach (Spinacia oleracea) leaves. Using a stoichiometry of 3 ATP/CO2 and the known relationship between ATP synthesis rate and driv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schönknecht G,Neimanis S,Katona E,Gerst U,Heber U

更新日期：1995-12-19 00:00:00

abstract：:Substance P prohormones were identified in the caudate nucleus, hypothalamus, and substantia nigra of human brain. A polypeptide fraction of acidic brain extracts was fractionated on Sephadex G-50. The lyophilized fractions were sequentially treated with trypsin and a substance P-degrading enzyme with strong preferenc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nyberg F,le Grevés P,Terenius L

更新日期：1985-06-01 00:00:00

abstract：:Of the four major types of Ca channel described in vertebrate cells (designated T, L, N, and P), N-type Ca channels are unique in that they are found specifically in neurons, have been correlated with control of neurotransmitter release, and are blocked by omega-conotoxin, a neuropeptide toxin isolated from the marine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dubel SJ,Starr TV,Hell J,Ahlijanian MK,Enyeart JJ,Catterall WA,Snutch TP

更新日期：1992-06-01 00:00:00

abstract：:Molecular mechanisms that initiate meiosis have been studied in fungi and mammals, but little is known about the mechanisms directing the meiosis transition in other organisms. To elucidate meiosis initiation in plants, we characterized and cloned the ameiotic1 (am1) gene, which affects the transition to meiosis and p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pawlowski WP,Wang CJ,Golubovskaya IN,Szymaniak JM,Shi L,Hamant O,Zhu T,Harper L,Sheridan WF,Cande WZ

更新日期：2009-03-03 00:00:00

abstract：:Muscle wasting is a debilitating consequence of fasting, inactivity, cancer, and other systemic diseases that results primarily from accelerated protein degradation by the ubiquitin-proteasome pathway. To identify key factors in this process, we have used cDNA microarrays to compare normal and atrophying muscles and f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gomes MD,Lecker SH,Jagoe RT,Navon A,Goldberg AL

更新日期：2001-12-04 00:00:00

abstract：:The use of proteasome inhibitors to target cancer's dependence on altered protein homeostasis has been greatly limited by intrinsic and acquired resistance. Analyzing data from thousands of cancer lines and tumors, we find that those with suppressed expression of one or more 19S proteasome subunits show intrinsic prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsvetkov P,Sokol E,Jin D,Brune Z,Thiru P,Ghandi M,Garraway LA,Gupta PB,Santagata S,Whitesell L,Lindquist S

更新日期：2017-01-10 00:00:00

abstract：:A promoterless trp-lac fusion fragment was inserted near one end of the bacterial transposon Tn5 in the correct orientation to fuse lacZ gene expression to promoters outside Tn5. The resulting transposon, Tn5 lac, retains the kanamycin-resistance gene of Tn5 and transposes in Escherichia coli at 6% the frequency of Tn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kroos L,Kaiser D

更新日期：1984-09-01 00:00:00

abstract：:We have isolated a lymphoid cell line, MDS, from the pleural exudate of a patient with chronic myelomonocytic leukemia. The cells are biphenotypic, containing various T-cell and myeloid markers, and are surface negative for CD4 and CD8 but have low CD4 mRNA. The cells grow in suspension with a doubling time of 15 hr, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Banerjee R,Bekesi JG,Tarcsafalvi A,Sperber K,Deak G,Choi HS,Paronetto F,Holland JF,Acs G

更新日期：1992-11-01 00:00:00

abstract：:Viruses have been implicated in the development of neurodegenerative diseases, such as Alzheimer's, Parkinson's, and multiple sclerosis. Human herpesvirus-6 (HHV-6) is a neurotropic virus that has been associated with a wide variety of neurologic disorders, including encephalitis, mesial temporal lobe epilepsy, and mu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harberts E,Yao K,Wohler JE,Maric D,Ohayon J,Henkin R,Jacobson S

更新日期：2011-08-16 00:00:00

abstract：:Cytochrome P450(BioI) (CYP107H1) from the biotin operon of Bacillus subtilis forms a seven-carbon diacid through a multistep oxidative cleavage of a fatty acid linked to acyl carrier protein (ACP). Crystal structures of P450(BioI) in complex with three different length fatty acyl-ACP (Escherichia coli) ligands show th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cryle MJ,Schlichting I

更新日期：2008-10-14 00:00:00

abstract：:The Alu element has been a major source of new exons during primate evolution. Thousands of human genes contain spliced exons derived from Alu elements. However, identifying Alu exons that have acquired genuine biological functions remains a major challenge. We investigated the creation and establishment of Alu exons ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen S,Lin L,Cai JJ,Jiang P,Kenkel EJ,Stroik MR,Sato S,Davidson BL,Xing Y

更新日期：2011-02-15 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor, a subtype of excitatory amino acid receptor, mediates synaptic responses in many regions of the central nervous system. This receptor plays a critical role in the mechanisms of both synaptic plasticity and excitotoxicity. Although these receptors were generally thought to be a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Monaghan DT,Olverman HJ,Nguyen L,Watkins JC,Cotman CW

更新日期：1988-12-01 00:00:00

abstract：:Within the trimeric HIV-1 envelope (Env) spike, the first and second variable loops (V1V2 region) and the third variable loop (V3) of the gp120 subunit play dual roles in antibody recognition, because they contain neutralization epitopes and also participate in epitope masking. The spatial relationships between V1V2 a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu L,Cimbro R,Lusso P,Berger EA

更新日期：2011-12-13 00:00:00

abstract：:Interleukin (IL)-1beta is a pluripotent proinflammatory cytokine that signals through the type-I IL-1 receptor (IL-1RI), a member of the Toll-like receptor family. In hypothalamic neurons, binding of IL-1beta to IL-1RI mediates transcription-dependent changes that depend on the recruitment of the cytosolic adaptor pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis CN,Mann E,Behrens MM,Gaidarova S,Rebek M,Rebek J Jr,Bartfai T

更新日期：2006-02-21 00:00:00

abstract：:Signaling in the nervous system requires matching of neurotransmitter receptors with cognate neurotransmitters at synapses. The vertebrate neuromuscular junction is the best studied cholinergic synapse, but the mechanisms by which acetylcholine is matched with acetylcholine receptors are not fully understood. Because ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Borodinsky LN,Spitzer NC

更新日期：2007-01-02 00:00:00

abstract：:In Saccharomyces cerevisiae Mediator, a subgroup of proteins (Srb8, Srb9, Srb10, and Srb11) form a module, which is involved in negative regulation of transcription. Homologues of Srb10 and Srb11 are found in some mammalian Mediator preparations, whereas no clear homologues have been reported for Srb8 and Srb9. Here, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Samuelsen CO,Baraznenok V,Khorosjutina O,Spahr H,Kieselbach T,Holmberg S,Gustafsson CM

更新日期：2003-05-27 00:00:00

abstract：:The Bam complex assembles β-barrel proteins into the outer membrane (OM) of Gram-negative bacteria. These proteins comprise cylindrical β-sheets with long extracellular loops and create pores to allow passage of nutrients and waste products across the membrane. Despite their functional importance, several questions re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wzorek JS,Lee J,Tomasek D,Hagan CL,Kahne DE

更新日期：2017-03-07 00:00:00

abstract：:Selective autophagy of damaged mitochondria requires autophagy receptors optineurin (OPTN), NDP52 (CALCOCO2), TAX1BP1, and p62 (SQSTM1) linking ubiquitinated cargo to autophagic membranes. By using quantitative proteomics, we show that Tank-binding kinase 1 (TBK1) phosphorylates all four receptors on several autophagy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richter B,Sliter DA,Herhaus L,Stolz A,Wang C,Beli P,Zaffagnini G,Wild P,Martens S,Wagner SA,Youle RJ,Dikic I

更新日期：2016-04-12 00:00:00

abstract：:Despite their small size, some insects, such as crickets, can produce high amplitude mating songs by rubbing their wings together. By exploiting structural resonance for sound radiation, crickets broadcast species-specific songs at a sharply tuned frequency. Such songs enhance the range of signal transmission, contain...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mhatre N,Montealegre-Z F,Balakrishnan R,Robert D

更新日期：2012-05-29 00:00:00

abstract：:The serine protease autotransporters of Enterobacteriaceae (SPATEs) are secreted by pathogenic Gram-negative bacteria through the autotransporter pathway. We previously classified SPATE proteins into two classes: cytotoxic (class 1) and noncytotoxic (class 2). Here, we show that Pic, a class 2 SPATE protein produced b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruiz-Perez F,Wahid R,Faherty CS,Kolappaswamy K,Rodriguez L,Santiago A,Murphy E,Cross A,Sztein MB,Nataro JP

更新日期：2011-08-02 00:00:00