Impact and cost-effectiveness of new tuberculosis vaccines in low- and middle-income countries.

abstract：:Glioblastoma is the most common primary malignant brain tumor of adults and one of the most lethal of all cancers. Patients with this disease have a median survival of 15 months from the time of diagnosis despite surgery, radiation, and chemotherapy. New treatment approaches are needed. Recent works suggest that gliob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horvath S,Zhang B,Carlson M,Lu KV,Zhu S,Felciano RM,Laurance MF,Zhao W,Qi S,Chen Z,Lee Y,Scheck AC,Liau LM,Wu H,Geschwind DH,Febbo PG,Kornblum HI,Cloughesy TF,Nelson SF,Mischel PS

更新日期：2006-11-14 00:00:00

abstract：:Using morphometrical methods, we investigated variation in the skeletons of more than 400 offspring of C57BL/6J and DBA/2J male mice that had received either a 250 mg/kg dose of the mutagen ethylnitrosourea or a solvent control. Sperm involved in the matings developed from cells in the spermatogonial stage at the time...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lovell DP,Willis DB,Johnson FM

更新日期：1985-05-01 00:00:00

abstract：:Landscape-scale reconstructions of ancient environments within the cradle of humanity may reveal insights into the relationship between early hominins and the changing resources around them. Many studies of Olduvai Gorge during Pliocene-Pleistocene times have revealed the presence of precession-driven wet-dry cycles a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sistiaga A,Husain F,Uribelarrea D,Martín-Perea DM,Ferland T,Freeman KH,Diez-Martín F,Baquedano E,Mabulla A,Domínguez-Rodrigo M,Summons RE

更新日期：2020-10-06 00:00:00

abstract：:With every pair of bounded self-adjoint operators {U,V} on Hilbert space such that VU - UV = (1/pii)C, where C is trace class, there is associated a certain function of two complex variables called the determining function of the pair. It was previously shown how the determining function can be obtained as the solutio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pincus JD

更新日期：1971-08-01 00:00:00

abstract：:We found that two markers of differentiation, tyrosinase (monophenol, dihydroxyphenylalanine:oxygen oxidoreductase, EC 1.14.18.1) activity and melanin synthesis, are induced by diazepam in B16/C3 mouse melanoma cells. We also demonstrated high-affinity binding sites for [3H]diazepam in these cells by radioreceptor ass...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matthew E,Laskin JD,Zimmerman EA,Weinstein IB,Hsu KC,Engelhardt DL

更新日期：1981-06-01 00:00:00

abstract：:To characterize the region on human IgG1 responsible for its high-affinity interaction with the human Fc gamma receptor class I (Fc gamma RI), we have analyzed the binding properties of a series of genetically engineered chimeric antidinitrophenyl antibodies with identical murine antibody combining sites and hybrid Ig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chappel MS,Isenman DE,Everett M,Xu YY,Dorrington KJ,Klein MH

更新日期：1991-10-15 00:00:00

abstract：:The signal-transducing guanine nucleotide-binding regulatory (G) proteins are heterotrimers composed of three subunits--alpha, beta, and gamma. Although multiple distinctive forms of the alpha subunit have been described, only two forms of the beta subunits of the G proteins have been identified. To investigate furthe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levine MA,Smallwood PM,Moen PT Jr,Helman LJ,Ahn TG

更新日期：1990-03-01 00:00:00

abstract：:Conventional wisdom regarding mechanisms of bacterial pathogenesis holds that pathogens arise by external acquisition of distinct virulence factors, whereas determinants shared by pathogens and commensals are considered to be functionally equivalent and have been ignored as genes that could become adapted specifically...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sokurenko EV,Chesnokova V,Dykhuizen DE,Ofek I,Wu XR,Krogfelt KA,Struve C,Schembri MA,Hasty DL

更新日期：1998-07-21 00:00:00

abstract：:Current chemotherapeutic approaches for cancer are in part limited by the inability of drugs to destroy neoplastic cells within poorly vascularized compartments of tumors. We have here systematically assessed anaerobic bacteria for their capacity to grow expansively within avascular compartments of transplanted tumors...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dang LH,Bettegowda C,Huso DL,Kinzler KW,Vogelstein B

更新日期：2001-12-18 00:00:00

abstract：:B-1 B cells have been proposed to be preferentially generated from fetal progenitors, but this view is challenged by studies concluding that B-1 production is sustained throughout adult life. To address this controversy, we compared the efficiency with which hematopoietic stem cells (HSCs) and common lymphoid progenit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barber CL,Montecino-Rodriguez E,Dorshkind K

更新日期：2011-08-16 00:00:00

abstract：:8-L-Arginine vasopressin ([Arg8]VP) receptors are expressed transiently in the rat facial nucleus during the perinatal period. Electrophysiological studies suggest that at least part of these receptors is located on facial motoneurones. In the present study we report that, in the adult rat, unilateral section of a fac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tribollet E,Arsenijevic Y,Marguerat A,Barberis C,Dreifuss JJ

更新日期：1994-09-27 00:00:00

abstract：:The switch from membrane-bound to secreted IgM is accomplished by producing alternative forms of mRNA from a single mu heavy-chain gene. This process might be controlled at any of three steps--transcription termination, RNA splicing, or RNA cleavage/poly(A) addition. To distinguish between these possibilities, we have...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Danner D,Leder P

更新日期：1985-12-01 00:00:00

abstract：:Endothelial cell growth factor (ECGF) binds specifically in vitro to membrane receptors present on the surface of several cell types, including murine and human endothelial cells and fibroblasts. Monoclonal antibodies prepared against ECGF that inhibit the mitogenic activity of the growth factor prevent receptor occup...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schreiber AB,Kenney J,Kowalski WJ,Friesel R,Mehlman T,Maciag T

更新日期：1985-09-01 00:00:00

abstract：:Thiazides and related diuretics inhibit NaCl reabsorption in the distal tubule through an unknown mechanism. We report here that [3H]metolazone, a diuretic with a thiazide-like mechanism of action, labels a site in rat kidney membranes that has characteristics of the thiazide-sensitive ion transporter. [3H]Metolazone ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beaumont K,Vaughn DA,Fanestil DD

更新日期：1988-04-01 00:00:00

abstract：:Epstein-Barr nuclear antigen 1 (EBNA1) plays a vital role in the maintenance of the viral genome and is the only viral protein expressed in nearly all forms of Epstein-Barr virus (EBV) latency and EBV-associated diseases, including numerous cancer types. To our knowledge, no specific agent against EBV genes or protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang L,Lung HL,Huang T,Lan R,Zha S,Chan LS,Thor W,Tsoi TH,Chau HF,Boreström C,Cobb SL,Tsao SW,Bian ZX,Law GL,Wong WT,Tai WC,Chau WY,Du Y,Tang LHX,Chiang AKS,Middeldorp JM,Lo KW,Mak NK,Long NJ,Wong KL

更新日期：2019-12-10 00:00:00

abstract：:The polymerization of mixtures of Hb S with hemoglobins A, A2, and F has been investigated by analysis of the proportions of S and non-S hemoglobin both in the supernate and in the pellet after centrifugation. In all cases the non-S hemoglobin was incorporated into the polymer even in the absence of hybrids in the ord...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benesch RE,Edalji R,Benesch R,Kwong S

更新日期：1980-09-01 00:00:00

abstract：:Many bacteria use N-acyl homoserine lactone (AHL) signals to coordinate the behavior of individual cells in a local population. The successful infection of eukaryotic hosts by bacteria seems to depend particularly on such AHL-mediated "quorum-sensing" regulation. We have used proteome analysis to show that a eukaryoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mathesius U,Mulders S,Gao M,Teplitski M,Caetano-Anolles G,Rolfe BG,Bauer WD

更新日期：2003-02-04 00:00:00

abstract：:The endbrain (telencephalon) is at the rostral end of the central nervous system and is primarily responsible for supporting cognition and affect. Structurally, it consists of right and left cerebral hemispheres, each parceled into multiple cortical and nuclear gray matter regions. The global network organization of a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swanson LW,Hahn JD,Jeub LGS,Fortunato S,Sporns O

更新日期：2018-07-17 00:00:00

abstract：:NRSF/REST is a protein that silences transcription of a number of genes that contain a DNA element called the neuron-restrictive silencer element (NRSE). During embryogenesis, REST is expressed ubiquitously in nonneural cells, but is down-regulated during differentiation of neural progenitors into neurons. REST is als...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koenigsberger C,Chicca JJ 2nd,Amoureux MC,Edelman GM,Jones FS

更新日期：2000-02-29 00:00:00

abstract：:Ca2+/calmodulin-dependent protein kinase enriched in cerebellar granule cells (CaM kinase Gr) is a neuronal calmodulin-dependent protein kinase whose purification and partial cloning from rat brain has been described. A combination of the polymerase chain reaction and cDNA library screening was used to determine the D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohmstede CA,Bland MM,Merrill BM,Sahyoun N

更新日期：1991-07-01 00:00:00

abstract：:Like other guanine nucleotide-exchange proteins (GEPs) that activate ADP-ribosylation factor (ARF) GTPases, brefeldin A-inhibited GEP2, BIG2, contains an approximately 200-aa Sec7 domain that is responsible for this catalytic activity and its inhibition by brefeldin A. The Sec7 domain is located near the center of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li H,Adamik R,Pacheco-Rodriguez G,Moss J,Vaughan M

更新日期：2003-02-18 00:00:00

abstract：:Marine viruses are the most abundant biological entities in the oceans shaping community structure and nutrient cycling. The interaction between the bloom-forming alga Emiliania huxleyi and its specific large dsDNA virus (EhV) is a major factor determining the fate of carbon in the ocean, thus serving as a key host-pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ziv C,Malitsky S,Othman A,Ben-Dor S,Wei Y,Zheng S,Aharoni A,Hornemann T,Vardi A

更新日期：2016-03-29 00:00:00

abstract：:RNA helicases play roles in various essential biological processes such as RNA splicing and editing. Recent in vitro studies show that RNA helicases are involved in immune responses toward viruses, serving as viral RNA sensors or immune signaling adaptors. However, there is still a lack of in vivo data to support the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,He K,Sheng B,Lei X,Tao W,Zhu X,Wei Z,Fu R,Wang A,Bai S,Zhang Z,Hong N,Ye C,Tian Y,Wang J,Li M,Zhang K,Li L,Yang H,Li HB,Flavell RA,Zhu S

更新日期：2021-01-26 00:00:00

abstract：:The eukaryotic microorganism Saccharomyces cerevisiae contains 50-100 copies per cell of a circular plasmid called 2-micrometer DNA. The intracellular structure of these molecules, which represent about 4% of the total DNA, was examined by digestion of total cellular chromatin with micrococcal nuclease (nucleate 3'-ol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nelson RG,Fangman WL

更新日期：1979-12-01 00:00:00

abstract：:Ezrin and moesin are components of actin-rich cell surface structures that are thought to function as membrane-cytoskeletal linking proteins. Here we show that a stable complex of ezrin and moesin can be isolated from cultured cells by immunoprecipitation with specific antibodies. The capacity of these two proteins to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gary R,Bretscher A

更新日期：1993-11-15 00:00:00

abstract：:In the last decade, a number of quantitative epidemiological studies of specific diseases have been done in developing countries that for the first time allow estimation of the total burden of disease (mortality and morbidity) attributable to use of solid fuels in adult women and young children, who jointly receive th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith KR

更新日期：2000-11-21 00:00:00

abstract：:Reconnections of coherent filamentary structures play a key role in the dynamics of fluids, redistributing energy and helicity among the length scales, triggering dissipative effects, and inducing fine-scale mixing. Unlike ordinary (classical) fluids where vorticity is a continuous field, in superfluid helium and in a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galantucci L,Baggaley AW,Parker NG,Barenghi CF

更新日期：2019-06-18 00:00:00

abstract：:We use quantized molecular dynamics simulations to characterize the role of enzyme vibrations in facilitating dihydrofolate reductase hydride transfer. By sampling the full ensemble of reactive trajectories, we are able to quantify and distinguish between statistical and dynamical correlations in the enzyme motion. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boekelheide N,Salomón-Ferrer R,Miller TF 3rd

更新日期：2011-09-27 00:00:00

abstract：:A protein fraction from B. subtilis infected with phage SP01 (fraction LGG) stimulates the activity of RNA polymerase (EC 2.7.7.6; nucleosidetriphosphate:RNA nucleotidyltransferase) core from uninfected bacteria. Fraction LGG contains a protein (P-28, molecular weight 28,000) that is labeled after phage infection and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duffy JJ,Petrusek RL,Geiduschek EP

更新日期：1975-06-01 00:00:00

abstract：:Strain OU122, a dnaB mutant of HfrH which stops vegetative DNA synthesis immediately when the temperature is shifted to 43 degrees, was mated at 43 degrees with minicells with and without 1 mM Zn2+. Synthesis of DNA was detected in the mating mixture containing minicells derived from either Fchi925 or F+chi115 cells, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ou JT

更新日期：1975-09-01 00:00:00