Plant neighbor detection through touching leaf tips precedes phytochrome signals.

abstract：:The internal promoter of the Xenopus laevis oocyte-type 5S RNA gene is preferentially cleaved by S1 and Bal-31 nucleases in plasmid DNA. S1 nuclease sensitivity is largely dependent on supercoiling; however, Bal-31 cleaves within the 5S RNA gene in linear as well as in supercoiled DNA. The S1 nuclease-hypersensitive s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reynolds WF,Gottesfeld JM

更新日期：1985-06-01 00:00:00

abstract：:Reactions of a membrane-bound multienzyme complex (electron-transport chain of rat-liver microsomes) suspended in aqueous-organic solvent used as antifreeze at temperatures below 0 degrees were studied. In the presence of a relatively high concentration of ethylene glycol, electron transfer can still be observed and s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Debey P,Balny C,Douzou P

更新日期：1973-09-01 00:00:00

abstract：:Marine viruses are the most abundant biological entities in the oceans shaping community structure and nutrient cycling. The interaction between the bloom-forming alga Emiliania huxleyi and its specific large dsDNA virus (EhV) is a major factor determining the fate of carbon in the ocean, thus serving as a key host-pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ziv C,Malitsky S,Othman A,Ben-Dor S,Wei Y,Zheng S,Aharoni A,Hornemann T,Vardi A

更新日期：2016-03-29 00:00:00

abstract：:The Drosophila clock genes period (per) and timeless (tim) have been studied behaviorally and biochemically, but to date there has been no viable culture system for studying the cell biology of the Drosophila clock. We have cultured pupal ring glands attached to the central nervous system and observed rhythms of perio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Emery IF,Noveral JM,Jamison CF,Siwicki KK

更新日期：1997-04-15 00:00:00

abstract：:The study of photoinitiated electron transfer in donor-bridge-acceptor molecules has helped elucidate the distance dependence of electron transfer rates and behavior of various electron transfer mechanisms. In all reported cases, the energies of the bridge electronic states involved in the electron transfer change dra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldsmith RH,Sinks LE,Kelley RF,Betzen LJ,Liu W,Weiss EA,Ratner MA,Wasielewski MR

更新日期：2005-03-08 00:00:00

abstract：:A five-helix secondary structural model is proposed for eukaryotic cytoplasmic 5S rRNA. All available sequence data are consistent with this model including those from Chlorella 5S rRNA whose sequence is revised by data included here. Various architectural features of eukaryotic 5S rRNA are summarized in terms of this...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luehrsen KR,Fox GE

更新日期：1981-04-01 00:00:00

abstract：:A clone for the iron-responsive element (IRE)-binding protein (IRE-BP) has been transfected and expressed in mouse fibroblasts. The IRE-BP gene product binds IREs with high affinity and specificity. Amino acid alignments reveal that the IRE-BP is 30% identical to mitochondrial aconitase. The 18 active site residues of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaptain S,Downey WE,Tang C,Philpott C,Haile D,Orloff DG,Harford JB,Rouault TA,Klausner RD

更新日期：1991-11-15 00:00:00

abstract：:Infection of Swiss mouse 3T3FL cells with a clonal isolate of Moloney leukemia virus (MLV-IC) resulted in virus progeny composed of at least three different murine helper oncornaviruses. Each entity was purified in appropriate cells by several sequential terminal dilution isolations and was grouwn to high titers. Besi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fischinger PJ,Nomura S,Bolognesi DP

更新日期：1975-12-01 00:00:00

abstract：:Charge transport (CT) through the DNA base pairs provides a means to promote redox reactions at a remote site and potentially to effect signaling between molecules bound to DNA. Here we describe the oxidation of a cell-cycle regulatory protein, p53, from a distance through DNA-mediated CT. A consensus p53 binding site...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Augustyn KE,Merino EJ,Barton JK

更新日期：2007-11-27 00:00:00

abstract：:The plant hormone indole-acetic acid (auxin) is essential for many aspects of plant development. Auxin-mediated growth regulation typically involves the establishment of an auxin concentration gradient mediated by polarly localized auxin transporters. The localization of auxin carriers and their amount at the plasma m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boutté Y,Jonsson K,McFarlane HE,Johnson E,Gendre D,Swarup R,Friml J,Samuels L,Robert S,Bhalerao RP

更新日期：2013-10-01 00:00:00

abstract：:Telomeres are specialized structures located at the ends of linear eukaryotic chromosomes that ensure their complete replication and protect them from fusion and degradation. We report here the characterization of the telomeres of the nematode Caenorhabditis elegans. We show that the chromosomes terminate in 4-9 kb of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wicky C,Villeneuve AM,Lauper N,Codourey L,Tobler H,Müller F

更新日期：1996-08-20 00:00:00

abstract：:Defining the virus-host interactions responsible for HIV-1 transmission, including the phenotypic requirements of viruses capable of establishing de novo infections, could be important for AIDS vaccine development. Previous analyses have failed to identify phenotypic properties other than chemokine receptor 5 (CCR5) a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parrish NF,Gao F,Li H,Giorgi EE,Barbian HJ,Parrish EH,Zajic L,Iyer SS,Decker JM,Kumar A,Hora B,Berg A,Cai F,Hopper J,Denny TN,Ding H,Ochsenbauer C,Kappes JC,Galimidi RP,West AP Jr,Bjorkman PJ,Wilen CB,Doms RW

更新日期：2013-04-23 00:00:00

abstract：:An examination of life expectancy in 1963 reveals twin peaks in the empirical distribution across countries: one group of countries clustered around a life expectancy of 40 years and a second group clustered around a life expectancy of 65 years. By 2003, the mode of each cluster had moved up by approximately 10 years....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bloom DE,Canning D

更新日期：2007-10-09 00:00:00

abstract：:Fibroblasts cultured from the skin of a patient with metachromatic leukodystrophy have been found to manifest the biochemical defect of this inborn error of metabolism, a deficiency of arylsulfatase A. Diseased cells had less than five per cent of normal arylsulfatase-A activity, while activities of other lysosomal en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Porter MT,Fluharty AL,Kihara H

更新日期：1969-03-01 00:00:00

abstract：:The isolation and biochemical properties of a Saccharomyces cerevisiae mutant (acc1-167) defective in acetyl-CoA carboxylase [acetyl-CoA:carbon-dioxide ligase (ADP forming), EC 6.4.1.2] activity are described. The mutant is deficient in de novo biosynthesis of long-chain fatty acids and specifically requires a saturat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roggenkamp R,Numa S,Schweizer E

更新日期：1980-04-01 00:00:00

abstract：:A major challenge of cancer immunotherapy is the persistence and outgrowth of subpopulations that lose expression of the target antigen. IL-15 is a potent cytokine that can promote organ-specific autoimmunity when up-regulated on tissue cells. Here we report that T cells eradicated 2-wk-old solid tumors that expressed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu RB,Engels B,Schreiber K,Ciszewski C,Schietinger A,Schreiber H,Jabri B

更新日期：2013-05-14 00:00:00

abstract：:Release of formylmethionine from the reticulocyte ribosomal substrate, f[(3)H]Met-tRNA.ribosome, is promoted by reticulocyte release factor (RF). The initial rate of this reaction is stimulated by GTP but inhibited by GDPCP. Formation of an RF.UA[(3)H]A(2).ribosome complex is a measure of the binding of reticulocyte R...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tate WP,Beaudet AL,Caskey CT

更新日期：1973-08-01 00:00:00

abstract：:In healthy adults, activation of γ-aminobutyric acid (GABA)(A) and glycine receptors inhibits neurons as a result of low intracellular chloride concentration ([Cl(-)](i)), which is maintained by the potassium-chloride cotransporter KCC2. A reduction of KCC2 expression or function is implicated in the pathogenesis of s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bos R,Sadlaoud K,Boulenguez P,Buttigieg D,Liabeuf S,Brocard C,Haase G,Bras H,Vinay L

更新日期：2013-01-02 00:00:00

abstract：:Vertebrae are derived from the sclerotomal moities of the somites. Sclerotomal cells migrate ventrally to surround the notochord, where they form the vertebral body, and dorsolaterally to form the neural arch, which is dorsally closed by the spinous process. Precursor cells of the spinous process as well as superficia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Monsoro-Burq AH,Bontoux M,Teillet MA,Le Douarin NM

更新日期：1994-10-25 00:00:00

abstract：:The expression and integration of membrane proteins into vesicle membranes is a critical step in the design of cell-mimetic biosensors, bioreactors, and artificial cells. While membrane proteins have been integrated into a variety of nonnatural membranes, the effects of the chemical and physical properties of these ve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jacobs ML,Boyd MA,Kamat NP

更新日期：2019-03-05 00:00:00

abstract：:Two mouse monoclonal anti-anti-idiotopic antibodies (anti-anti-Id, Ab3), AF14 and AF52, were prepared by immunizing BALB/c mice with rabbit polyclonal anti-idiotypic antibodies (anti-Id, Ab2) raised against antibody D1.3 (Ab1) specific for the antigen hen egg lysozyme. AF14 and AF52 react with an "internal image" mono...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldbaum FA,Velikovsky CA,Dall'Acqua W,Fossati CA,Fields BA,Braden BC,Poljak RJ,Mariuzza RA

更新日期：1997-08-05 00:00:00

abstract：:Saccharomyces cerevisiae is one of the most important model organisms and has been a valuable asset to human civilization. However, despite its extensive use in the last 9,000 y, the existence of a seasonal cycle outside human-made environments has not yet been described. We demonstrate the role of social wasps as vec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stefanini I,Dapporto L,Legras JL,Calabretta A,Di Paola M,De Filippo C,Viola R,Capretti P,Polsinelli M,Turillazzi S,Cavalieri D

更新日期：2012-08-14 00:00:00

abstract：:Chromosomal RNA was isolated from several rat tissues by a new technique. It is shown by RNA-DNA hybridization that each tissue contains a distinct population of chromosomal RNA sequences. This finding is compatible with the proposal that chromosomal RNA is involved in the process of gene activation. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mayfield JE,Bonner J

更新日期：1971-11-01 00:00:00

abstract：:The problem of demonstrating hemoglobin binding to the erythrocyte membrane in intact cells was approached by observing the quenching of fluorescent membrane probes by hemoglobin as a function of pH. This quenching was studied by measuring fluorescence intensities and decay rates of membrane-bound donors by both right...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eisinger J,Flores J,Salhany JM

更新日期：1982-01-01 00:00:00

abstract：:Synaptically released glutamate has been identified as a signal coupling excitatory neuronal activity to increased glucose utilization. The proposed mechanism of this coupling involves glutamate uptake into astrocytes resulting in increased intracellular Na+ (Nai+) and activation of the Na+/K+-ATPase. Increased metabo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chatton JY,Pellerin L,Magistretti PJ

更新日期：2003-10-14 00:00:00

abstract：:Cognitive flexibility depends on a fast neural learning mechanism for enhancing momentary relevant over irrelevant information. A possible neural mechanism realizing this enhancement uses fast spiking interneurons (FSIs) in the striatum to train striatal projection neurons to gate relevant and suppress distracting cor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Banaie Boroujeni K,Oemisch M,Hassani SA,Womelsdorf T

更新日期：2020-07-28 00:00:00

abstract：:During endoplasmic reticulum-associated degradation, the multifunctional AAA ATPase p97 is part of a protein degradation complex. p97 associates via its N-terminal domain with various cofactors to recruit ubiquitinated substrates. It also interacts with alternative substrate-processing cofactors, such as Ufd2, Ufd3, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao G,Zhou X,Wang L,Li G,Schindelin H,Lennarz WJ

更新日期：2007-05-22 00:00:00

abstract：:We prepared a stable cell line expressing the glucagon receptor to characterize the effect of G(s)-coupled receptor stimulation on extracellular signal-regulated protein kinase 1/2 (ERK1/2) activity. Glucagon treatment of the cell line caused a dose-dependent increase in cAMP concentration, activation of cAMP-dependen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang Y,Cypess AM,Muse ED,Wu CR,Unson CG,Merrifield RB,Sakmar TP

更新日期：2001-08-28 00:00:00

abstract：:Cancer stem-like cells (CSCs) are a highly tumorigenic cell type present as a minority population in developmentally diverse tumors and cell lines. Using a genetic screen in an inducible model of CSC formation in a breast cell line, we identify microRNAs (miRNAs) that inhibit CSC growth and are down-regulated in CSCs....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polytarchou C,Iliopoulos D,Struhl K

更新日期：2012-09-04 00:00:00

abstract：:A role for Notch in the elaboration of existing neural processes is emerging that is distinct from the increasingly well understood function of this gene in binary cell-fate decisions. Several research groups, by using a variety of organisms, have shown that Notch is important in the development of neural ultrastructu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Presente A,Boyles RS,Serway CN,de Belle JS,Andres AJ

更新日期：2004-02-10 00:00:00