Studies on peptide:N-glycanase-p97 interaction suggest that p97 phosphorylation modulates endoplasmic reticulum-associated degradation.

abstract：:Whereas several apoptosis-related proteins have been linked to the antiapoptotic effects of Akt serine-threonine kinase, the search continues to explain the Akt signaling role in promoting cell survival via antiapoptotic effects. Here, we demonstrate that Akt phosphorylates the androgen receptor (AR) at Ser-210 and Se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin HK,Yeh S,Kang HY,Chang C

更新日期：2001-06-19 00:00:00

abstract：:We give a functional generalization of fractal scaling laws applied to response problems as well as to probability distributions. We consider excitations and responses, which are functions of a given state vector. Based on scaling arguments, we derive a general nonlinear response functional scaling law, which expresse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vlad MO,Morán F,Popa VT,Szedlacsek SE,Ross J

更新日期：2007-03-20 00:00:00

abstract：:Mutations in WNK1 and WNK4 lead to familial hyperkalemic hypertension (FHHt). Because FHHt associates net positive Na(+) balance together with K(+) and H(+) renal retention, the identification of WNK1 and WNK4 led to a new paradigm to explain how aldosterone can promote either Na(+) reabsorption or K(+) secretion in a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hadchouel J,Soukaseum C,Büsst C,Zhou XO,Baudrie V,Zürrer T,Cambillau M,Elghozi JL,Lifton RP,Loffing J,Jeunemaitre X

更新日期：2010-10-19 00:00:00

abstract：:We have previously identified by cDNA cloning 5 mRNAs that appear in resting BALB/c 3T3 cells soon after growth stimulation by serum or platelet-derived growth factor. Five additional mRNAs of this class are described in this report. The mRNAs reached peak levels between 40 and 120 min after serum addition and rapidly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lau LF,Nathans D

更新日期：1987-03-01 00:00:00

abstract：:The hammerhead ribozyme, as engineered by J. Haseloff and W. L. Gerlach [(1988) Nature (London) 334, 585-591], is an RNA molecule containing two regions of conserved nucleotides, a double helix, called helix II, which connects the two conserved regions, and flanking arms of variable sequence, which hybridize the riboz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCall MJ,Hendry P,Jennings PA

更新日期：1992-07-01 00:00:00

abstract：:Zfp57 is a maternal-zygotic effect gene that maintains genomic imprinting. Here we report that Zfp57 mutants exhibited a variety of cardiac defects including atrial septal defect (ASD), ventricular septal defect (VSD), thin myocardium, and reduced trabeculation. Zfp57 maternal-zygotic mutant embryos displayed more sev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shamis Y,Cullen DE,Liu L,Yang G,Ng SF,Xiao L,Bell FT,Ray C,Takikawa S,Moskowitz IP,Cai CL,Yang X,Li X

更新日期：2015-04-21 00:00:00

abstract：:The neural crest (NC) emerges from combinatorial inductive events occurring within its progenitor domain, the neural border (NB). Several transcription factors act early at the NB, but the initiating molecular events remain elusive. Recent data from basal vertebrates suggest that ap2 might have been critical for NC em...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Crozé N,Maczkowiak F,Monsoro-Burq AH

更新日期：2011-01-04 00:00:00

abstract：:The transcription factor interferon regulatory factor 5 (IRF5) is essential for the induction of inflammatory cytokines, but the mechanism by which IRF5 is activated is not well understood. Here we present evidence that the kinase IKKβ phosphorylates and activates IRF5 in response to stimulation in several inflammator...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ren J,Chen X,Chen ZJ

更新日期：2014-12-09 00:00:00

abstract：:The 24 human chromosome types of normal diploid fibroblast cell strain were classified into 15 groups by high-resolution flow cytometry on the basis of 33258 Hoechst fluorescence. Chromosomes associated with each group were flow sorted onto microscope slides and identified by quinacrine banding analysis. DNA cytophoto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrano AV,Gray JW,Langlois RG,Burkhart-Schultz KJ,Van Dilla MA

更新日期：1979-03-01 00:00:00

abstract：:Monosynaptic excitatory connections between cerebellar granule and Purkinje cells were studied in dissociated cell cultures, and identification of the transmitter and the postsynaptic receptor at this synapse was pharmacologically investigated. The presynaptic granule cell and the postsynaptic Purkinje cell were volta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirano T,Hagiwara S

更新日期：1988-02-01 00:00:00

abstract：:We deal with the issue of quantifying and optimizing the rotation dynamics of synthetic molecular motors. For this purpose, the continuous four-stage rotation behavior of a typical light-activated molecular motor was measured in detail. All reaction constants were determined empirically. Next, we developed a Markov mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geertsema EM,van der Molen SJ,Martens M,Feringa BL

更新日期：2009-10-06 00:00:00

abstract：:Positively acting, rate-limiting regulatory factors that influence tissue-specific expression of the human cardiac alpha-actin gene in a mouse muscle cell line are shown by in vivo competition and gel mobility-shift assays to bind to upstream regions of its promoter but to neither vector DNA nor a beta-globin promoter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miwa T,Boxer LM,Kedes L

更新日期：1987-10-01 00:00:00

abstract：:Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is a frequent occurrence in human cancers and a major promoter of chemotherapeutic resistance. Inhibition of one downstream target in this pathway, mTORC1, has shown potential to improve chemosensitivity. However, the mechanisms and genetic m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mills JR,Hippo Y,Robert F,Chen SM,Malina A,Lin CJ,Trojahn U,Wendel HG,Charest A,Bronson RT,Kogan SC,Nadon R,Housman DE,Lowe SW,Pelletier J

更新日期：2008-08-05 00:00:00

abstract：:Earth's water cycle enables the incorporation of water (hydration) in mantle minerals that can influence the physical properties of the mantle. Lattice thermal conductivity of mantle minerals is critical for controlling the temperature profile and dynamics of the mantle and subducting slabs. However, the effect of hyd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang YY,Hsieh WP,Tan E,Chen J

更新日期：2017-04-18 00:00:00

abstract：:Do people judge hurricane risks in the context of gender-based expectations? We use more than six decades of death rates from US hurricanes to show that feminine-named hurricanes cause significantly more deaths than do masculine-named hurricanes. Laboratory experiments indicate that this is because hurricane names lea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jung K,Shavitt S,Viswanathan M,Hilbe JM

更新日期：2014-06-17 00:00:00

abstract：:The rpoS gene of Escherichia coli encodes a putative RNA polymerase sigma factor that is considered to be the central regulator of gene expression in stationary phase. The gene product (sigma 38) was overproduced using the cloned rpoS gene and purified to homogeneity. Reconstituted RNA polymerase holoenzyme (E sigma 3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tanaka K,Takayanagi Y,Fujita N,Ishihama A,Takahashi H

更新日期：1993-04-15 00:00:00

abstract：:2-Acetylpyridine 5-[(dimethylamino)thiocarbonyl]thiocarbonohydrazone (A1110U) was found to be a potent inactivator of the ribonucleotide reductases (EC 1.17.4.1) encoded by herpes simplex virus types 1 and 2 and by varicella-zoster virus and to be a weaker inactivator of human ribonucleotide reductase. It also markedl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spector T,Harrington JA,Morrison RW Jr,Lambe CU,Nelson DJ,Averett DR,Biron K,Furman PA

更新日期：1989-02-01 00:00:00

abstract：:Oriented cell division is critical for cell fate specification, tissue organization, and tissue homeostasis, and relies on proper orientation of the mitotic spindle. The molecular mechanisms underlying the regulation of spindle orientation remain largely unknown. Herein, we identify a critical role for cylindromatosis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Y,Liu M,Li D,Ran J,Gao J,Suo S,Sun SC,Zhou J

更新日期：2014-02-11 00:00:00

abstract：:Adipose triglyceride lipase (ATGL) initiates intracellular triglyceride (TG) catabolism. In humans, ATGL deficiency causes neutral lipid storage disease with myopathy (NLSDM) characterized by a systemic TG accumulation. Mice with a genetic deletion of ATGL (AKO) also accumulate TG in many tissues. However, neither NLS...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schreiber R,Hofer P,Taschler U,Voshol PJ,Rechberger GN,Kotzbeck P,Jaeger D,Preiss-Landl K,Lord CC,Brown JM,Haemmerle G,Zimmermann R,Vidal-Puig A,Zechner R

更新日期：2015-11-10 00:00:00

abstract：:Managing excess nutrients remains a major obstacle to improving ecosystem service benefits of urban waters. To inform more ecologically based landscape nutrient management, we compared watershed inputs, outputs, and retention for nitrogen (N) and phosphorus (P) in seven subwatersheds of the Mississippi River in St. Pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hobbie SE,Finlay JC,Janke BD,Nidzgorski DA,Millet DB,Baker LA

更新日期：2017-04-18 00:00:00

abstract：:A mouse cDNA clone has been isolated that contains the complete coding region of a protein highly homologous to the delta subunit of the Torpedo acetylcholine receptor (AcChoR). The cDNA library was constructed in the vector lambda 10 from membrane-associated poly(A)+ RNA from BC3H-1 mouse cells. Surprisingly, the del...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： LaPolla RJ,Mayne KM,Davidson N

更新日期：1984-12-01 00:00:00

abstract：:Arsenate is an abundant oxyanion that, because of its ability to mimic the phosphate group, is toxic to cells. Arsenate reductase (EC; encoded by the arsC gene in bacteria) participates to achieve arsenate resistance in both prokaryotes and yeast by reducing arsenate to arsenite; the arsenite is then exported by a spe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bennett MS,Guan Z,Laurberg M,Su XD

更新日期：2001-11-20 00:00:00

abstract：:In the normal development of retinotectal connections, the site in the tectum at which an optic fiber synapses is related to the position of its ganglion-cell body in the retina. How and when the ganglion cells acquire information about their positions is unknown, but the positional information that each ganglion cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hunt RK,Jacobson M

更新日期：1972-10-01 00:00:00

abstract：:Homing endonucleases stimulate gene conversion by generating site-specific DNA double-strand breaks that are repaired by homologous recombination. These enzymes are potentially valuable tools for targeted gene correction and genome engineering. We have engineered a variant of the I-AniI homing endonuclease that nicks ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McConnell Smith A,Takeuchi R,Pellenz S,Davis L,Maizels N,Monnat RJ Jr,Stoddard BL

更新日期：2009-03-31 00:00:00

abstract：:We have isolated an Arabidopsis thaliana gene that codes for a receptor related to antifungal pathogenesis-related (PR) proteins. The PR5K gene codes for a predicted 665-amino acid polypeptide that comprises an extracellular domain related to the PR5 proteins, a central transmembrane-spanning domain, and an intracellu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang X,Zafian P,Choudhary M,Lawton M

更新日期：1996-03-19 00:00:00

abstract：:Hydrogen bonds and their relative strengths in proteins are of importance for understanding protein structure and protein motions. The correct strength of such hydrogen bonds is experimentally known to vary greatly from approximately 5-6 kcal/mol for the isolated bond to approximately 0.5-1.5 kcal/mol for proteins in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sheu SY,Yang DY,Selzle HL,Schlag EW

更新日期：2003-10-28 00:00:00

abstract：:The O(2) reduction site of cytochrome c oxidase (CcO), comprising iron (Fe(a3)) and copper (Cu(B)) ions, is probed by x-ray structural analyses of CO, NO, and CN(-) derivatives to investigate the mechanism of the complete reduction of O(2). Formation of the derivative contributes to the trigonal planar coordination of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muramoto K,Ohta K,Shinzawa-Itoh K,Kanda K,Taniguchi M,Nabekura H,Yamashita E,Tsukihara T,Yoshikawa S

更新日期：2010-04-27 00:00:00

abstract：:The interleukin 2 (IL-2) receptor (IL-2R) is a multisubunit receptor that includes three major IL-2 binding subunits, the IL-2R alpha, beta, and gamma chains. We have detected and analyzed cooperative interactions between the IL-2R alpha and beta chains (IL-2R alpha and IL-2R beta, respectively) in COS cells transfect...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roessler E,Grant A,Ju G,Tsudo M,Sugamura K,Waldmann TA

更新日期：1994-04-12 00:00:00

abstract：:The C terminus of transcription factor NusA from Escherichia coli comprises two repeat units, which bind during antitermination to protein N from phage lambda. To delineate the structural basis of the NusA-lambdaN interaction, we attempted to crystallize the NusA C-terminal repeats in complex with a lambdaN peptide (r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonin I,Mühlberger R,Bourenkov GP,Huber R,Bacher A,Richter G,Wahl MC

更新日期：2004-09-21 00:00:00

abstract：:A methylcholanthrene-induced glioblastoma of the C57BL/6 inbred mouse strain was used to raise antibodies in C57BL/6 and C57BL/10 inbred mice and in (C57BL/6 x DBA/2) and (C57BL/6 x Balb/c) F(1) hybrids. When examined by the cytotoxicity test, these antibodies define a cell-surface component (or components) found excl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schachner M

更新日期：1974-05-01 00:00:00