The X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activation.

abstract：:Since at least the 1920s, it has been reported that common chimpanzees (Pan troglodytes) differ from humans in being capable of exceptional feats of "super strength," both in the wild and in captive environments. A mix of anecdotal and more controlled studies provides some support for this view; however, a critical re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Neill MC,Umberger BR,Holowka NB,Larson SG,Reiser PJ

更新日期：2017-07-11 00:00:00

abstract：:Visual development is thought to be completed at an early age. We suggest that the maturation of the visual brain is not homogeneous: functions with greater need for early availability, such as visuomotor control, mature earlier, and the development of other visual functions may extend well into childhood. We found si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kovács I,Kozma P,Fehér A,Benedek G

更新日期：1999-10-12 00:00:00

abstract：:In the central nervous system, glycogen-derived bioenergetic resources in astrocytes help promote tissue survival in response to focal neuronal stress. However, our understanding of the extent to which these resources are mobilized and utilized during neurodegeneration, especially in nearby regions that are not active...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cooper ML,Pasini S,Lambert WS,D'Alessandro KB,Yao V,Risner ML,Calkins DJ

更新日期：2020-08-04 00:00:00

abstract：:Exercise promotes longevity and ameliorates type 2 diabetes mellitus and insulin resistance. However, exercise also increases mitochondrial formation of presumably harmful reactive oxygen species (ROS). Antioxidants are widely used as supplements but whether they affect the health-promoting effects of exercise is unkn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ristow M,Zarse K,Oberbach A,Klöting N,Birringer M,Kiehntopf M,Stumvoll M,Kahn CR,Blüher M

更新日期：2009-05-26 00:00:00

abstract：:Iron/sulfur cluster (ISC)-containing proteins are essential components of cells. In most eukaryotes, Fe/S clusters are synthesized by the mitochondrial ISC machinery, the cytosolic iron/sulfur assembly system, and, in photosynthetic species, a plastid sulfur-mobilization (SUF) system. Here we show that the anaerobic h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsaousis AD,Ollagnier de Choudens S,Gentekaki E,Long S,Gaston D,Stechmann A,Vinella D,Py B,Fontecave M,Barras F,Lukeš J,Roger AJ

更新日期：2012-06-26 00:00:00

abstract：:Hypnotic analgesia in some respects resembles opiate analgesia. We tested the hypothesis that some features of hypnotic analgesia are mediated through neuronal pathways activating specific opiate receptors in brain. The opiate antagonist naloxone had no effect on hypnotic analgesia in three subjects. Thus, the hypothe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldstein A,Hilgard ER

更新日期：1975-06-01 00:00:00

abstract：:After treatment with nitrite, Japanese soy sauce was strongly mutagenic to Salmonella typhimurium TA100 without S9 mixture. Two precursors of the mutagen were isolated from Japanese soy sauce, and these were identified as (-)-(1S,3S)-1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid [(-)-(1S,3S)-MTCA] and i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wakabayashi K,Ochiai M,Saitô H,Tsuda M,Suwa Y,Nagao M,Sugimura T

更新日期：1983-05-01 00:00:00

abstract：:Addition of antisense oligonucleotides to cell cultures has been used to specifically inhibit gene expression. We have investigated the mechanism by which oligonucleotides enter living cells. These compounds are taken up by cells in a saturable, size-dependent manner compatible with receptor-mediated endocytosis. Poly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loke SL,Stein CA,Zhang XH,Mori K,Nakanishi M,Subasinghe C,Cohen JS,Neckers LM

更新日期：1989-05-01 00:00:00

abstract：:A new type of self-assembling peptide (sapeptide) scaffolds that serve as substrates for neurite outgrowth and synapse formation is described. These peptide-based scaffolds are amenable to molecular design by using chemical or biotechnological syntheses. They can be tailored to a variety of applications. The sapeptide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmes TC,de Lacalle S,Su X,Liu G,Rich A,Zhang S

更新日期：2000-06-06 00:00:00

abstract：:Microviscosity (n) of the cell membrane lipid layer was determined in synchronized C1300 mouse neuroblastoma cells (clone Neuro-2A) by fluorescence polarization of 1,6-diphenystratum. The determined n value was maximal in mitosis, decreased markedly in the G1 phase, remained constant at a low level during the S phase,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Laat SW,van der Saag PT,Shinitzky M

更新日期：1977-10-01 00:00:00

abstract：:MicroRNAs are predicted to regulate approximately 30% of all human genes by targeting sequences in their 3' UTR. Polymorphisms in 3' UTR of several genes have been reported to affect gene expression, but the mechanism is not fully understood. Here, we demonstrate that 829C-->T, a naturally occurring SNP, near the miR-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mishra PJ,Humeniuk R,Mishra PJ,Longo-Sorbello GS,Banerjee D,Bertino JR

更新日期：2007-08-14 00:00:00

abstract：:Recent advances in cell-free expression protocols have opened a new avenue toward high-resolution structural investigations of membrane proteins by x-ray crystallography and NMR spectroscopy. One of the biggest challenges for liquid-state NMR-based structural investigations of membrane proteins is the significant peak...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reckel S,Sobhanifar S,Schneider B,Junge F,Schwarz D,Durst F,Löhr F,Güntert P,Bernhard F,Dötsch V

更新日期：2008-06-17 00:00:00

abstract：:We have employed a combination of temperature-dependent UV absorption spectroscopy, circular dichroism, and batch calorimetry to characterize the binding of actinomycin D to a series of oligomeric DNA duplexes. We find the duplex [d(CGTCGACG)]2 to be unique in its ability to bind actinomycin D strongly despite the abs...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Snyder JG,Hartman NG,D'Estantoit BL,Kennard O,Remeta DP,Breslauer KJ

更新日期：1989-06-01 00:00:00

abstract：:Mucosal surfaces are a main entry point for pathogens and the principal sites of defense against infection. Both bacteria and phage are associated with this mucus. Here we show that phage-to-bacteria ratios were increased, relative to the adjacent environment, on all mucosal surfaces sampled, ranging from cnidarians t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barr JJ,Auro R,Furlan M,Whiteson KL,Erb ML,Pogliano J,Stotland A,Wolkowicz R,Cutting AS,Doran KS,Salamon P,Youle M,Rohwer F

更新日期：2013-06-25 00:00:00

abstract：:The RNA world hypothesis presumes that RNA will be competent for varied essential cellular functions. One such indispensable cell function is regulation of membrane permeability. Though this was not a known RNA activity, selection-amplification yielded RNAs that bound phosphatidylcholine:cholesterol liposomes. At leas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khvorova A,Kwak YG,Tamkun M,Majerfeld I,Yarus M

更新日期：1999-09-14 00:00:00

abstract：:In the prostate gland of adult mammals, most epithelial cells are in a state of proliferative quiescence. Androgens regulate this effect by inducing cell cycle arrest in the G(0)/G(1) phase. Potential mediators of this androgen-induced proliferative shutoff were identified by means of subtracted cDNA libraries. The ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geck P,Maffini MV,Szelei J,Sonnenschein C,Soto AM

更新日期：2000-08-29 00:00:00

abstract：:The genomic concentrations of certain middle repetitive DNA sequences vary considerably among closely related species of Drosophila. In fact, the chromosomes of D. melanogaster appear to carry approximately 3 times as much middle repetitive DNA as those of the sibling species D. simulans. Although most of the middle r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dowsett AP,Young MW

更新日期：1982-08-01 00:00:00

abstract：:The biosynthesis of rebeccamycin, an antitumor compound, involves the remarkable eight-electron oxidation of chlorinated chromopyrrolic acid. Although one rebeccamycin biosynthetic enzyme is capable of generating low levels of the eight-electron oxidation product on its own, a second protein, RebC, is required to acce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ryan KS,Howard-Jones AR,Hamill MJ,Elliott SJ,Walsh CT,Drennan CL

更新日期：2007-09-25 00:00:00

abstract：:High-quality and high-throughput prediction of enzyme commission (EC) numbers is essential for accurate understanding of enzyme functions, which have many implications in pathologies and industrial biotechnology. Several EC number prediction tools are currently available, but their prediction performance needs to be f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ryu JY,Kim HU,Lee SY

更新日期：2019-07-09 00:00:00

abstract：:Coimmunoprecipitation of members of the phytochrome red/farred photoreceptor family from plant extracts has been used to analyze their heteromeric binding interactions. Phytochrome (phy)B or phyD apoproteins with six myc epitopes fused to their N termini are biologically active when expressed in Arabidopsis. Immunopre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharrock RA,Clack T

更新日期：2004-08-03 00:00:00

abstract：:Identification of the genetic basis of common disease may require comprehensive sequence analysis of coding regions and regulatory elements in patients and controls to find genetic effects caused by rare or heterogeneous mutations. In this study, we demonstrate how mismatch repair detection on tag arrays can be applie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Faham M,Zheng J,Moorhead M,Fakhrai-Rad H,Namsaraev E,Wong K,Wang Z,Chow SG,Lee L,Suyenaga K,Reichert J,Boudreau A,Eberle J,Bruckner C,Jain M,Karlin-Neumann G,Jones HB,Willis TD,Buxbaum JD,Davis RW

更新日期：2005-10-11 00:00:00

abstract：:Benzophenones are among the most useful photocrosslinking agents in biology. We have evolved an orthogonal aminoacyl-tRNA synthetase/tRNA pair that makes possible the in vivo incorporation of p-benzoyl-l-phenylalanine into proteins in Escherichia coli in response to the amber codon, TAG. This unnatural amino acid was ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chin JW,Martin AB,King DS,Wang L,Schultz PG

更新日期：2002-08-20 00:00:00

abstract：:Thyroid hormone is a critical mediator of central nervous system (CNS) development, acting through nuclear receptors to modulate the expression of specific genes. Transcription of the rat hairless (hr) gene is highly up-regulated by thyroid hormone in the developing CNS; we show here that hr is directly induced by thy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson CC,Bottcher MC

更新日期：1997-08-05 00:00:00

abstract：:Reactive oxygen species (ROS)-mediated oxidative stress and DNA damage have recently been recognized as contributing to the efficacy of most bactericidal antibiotics, irrespective of their primary macromolecular targets. Inhibitors of targets involved in both combating oxidative stress as well as being required for in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tiwari S,van Tonder AJ,Vilchèze C,Mendes V,Thomas SE,Malek A,Chen B,Chen M,Kim J,Blundell TL,Parkhill J,Weinrick B,Berney M,Jacobs WR Jr

更新日期：2018-09-25 00:00:00

abstract：:Myofibril formation was visualized in cultured live cardiomyocytes that were transfected with plasmids expressing green fluorescent protein (GFP) linked to the Z-band protein, alpha-actinin. The expression of this fluorescent protein provided an in vivo label for structures containing alpha-actinin. The GFP-alpha-acti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dabiri GA,Turnacioglu KK,Sanger JM,Sanger JW

更新日期：1997-08-19 00:00:00

abstract：:The molecular weight of the major glycoprotein from the human erythrocyte membrane is 29,000, of which 55% is carbohydrate and 45% is protein. The binding of sodium dodecyl sulfate to this glycoprotein is anomalous when compared to water soluble proteins and leads to migration rates in sodium dodecyl sulfate-polyacryl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grefrath SP,Reynolds JA

更新日期：1974-10-01 00:00:00

abstract：:An artificial charge pair buried in the hydrophobic core of staphylococcal nuclease was engineered by making the V23E and L36K substitutions. Buried individually, Glu-23 and Lys-36 both titrate with pKa values near 7. When buried together their pKa values appear to be normal. The ionizable moieties of the buried Glu-L...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robinson AC,Castañeda CA,Schlessman JL,García-Moreno EB

更新日期：2014-08-12 00:00:00

abstract：:An inborn deficiency in the ability of aldolase B to split fructose 1-phosphate is found in humans with hereditary fructose intolerance (HFI). A stable isotope procedure to elucidate the mechanism of conversion of fructose to glucose in normal children and in HFI children has been developed. A constant infusion of D-[...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gopher A,Vaisman N,Mandel H,Lapidot A

更新日期：1990-07-01 00:00:00

abstract：:Campylobacter jejuni is the leading cause of acute bacterial diarrhea worldwide and is implicated in development of Guillain-Barré syndrome. Two major surface features, the outer membrane lipooligosaccharide and flagella, are highly variable and are often targets for modification. Presumably, these modifications provi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cullen TW,Trent MS

更新日期：2010-03-16 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) most frequently occurs in southern China and southeast Asia. Epidemiology studies link NPC to genetic predisposition, Epstein-Barr virus (EBV) infection, and environmental factors. Genetic studies indicate that mutations in chromatin-modifying enzymes are the most frequent genetic altera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ke L,Zhou H,Wang C,Xiong G,Xiang Y,Ling Y,Khabir A,Tsao GS,Zeng Y,Zeng M,Busson P,Kieff E,Guo X,Zhao B

更新日期：2017-09-05 00:00:00