当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Nasopharyngeal carcinoma super-enhancer-driven ETV6 correlates with prognosis.

Nasopharyngeal carcinoma super-enhancer-driven ETV6 correlates with prognosis.

Abstract：

:Nasopharyngeal carcinoma (NPC) most frequently occurs in southern China and southeast Asia. Epidemiology studies link NPC to genetic predisposition, Epstein-Barr virus (EBV) infection, and environmental factors. Genetic studies indicate that mutations in chromatin-modifying enzymes are the most frequent genetic alterations in NPC. Here, we used H3K27ac chromatin immune precipitation followed by deep sequencing (ChIP-seq) to define the NPC epigenome in primary NPC biopsies, NPC xenografts, and an NPC cell line, and compared them to immortalized normal nasopharyngeal or oral epithelial cells. We identified NPC-specific enhancers and found these enhancers were enriched with nuclear factor κB (NF-κB), IFN-responsive factor 1 (IRF1) and IRF2, and ETS family members ETS1 motifs. Normal cell-specific enhancers were enriched with basic leucine zipper family members and TP53 motifs. NPC super-enhancers with extraordinarily broad and high H3K27ac signals were also identified, and they were linked to genes important for oncogenesis including ETV6. ETV6 was also highly expressed in NPC biopsies by immunohistochemistry. High ETV6 expression correlated with a poor prognosis. Furthermore, we defined the EBV episome epigenetic landscapes in primary NPC tissue.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Ke L,Zhou H,Wang C,Xiong G,Xiang Y,Ling Y,Khabir A,Tsao GS,Zeng Y,Zeng M,Busson P,Kieff E,Guo X,Zhao B

doi

10.1073/pnas.1705236114

subject

Has Abstract

pub_date

2017-09-05 00:00:00

pages

9683-9688

issue

36

eissn

0027-8424

issn

1091-6490

pii

1705236114

journal_volume

114

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Mast cells synthesize, store, and release nerve growth factor.

    abstract：:Mast cells and nerve growth factor (NGF) have both been reported to be involved in neuroimmune interactions and tissue inflammation. In many peripheral tissues, mast cells interact with the innervating fibers. Changes in the behaviors of both of these elements occur after tissue injury/inflammation. As such conditions...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.91.9.3739

    authors： Leon A,Buriani A,Dal Toso R,Fabris M,Romanello S,Aloe L,Levi-Montalcini R

    更新日期：1994-04-26 00:00:00

  • Evolution of global marine fishing fleets and the response of fished resources.

    abstract：:Previous reconstructions of marine fishing fleets have aggregated data without regard to the artisanal and industrial sectors. Engine power has often been estimated from subsets of the developed world, leading to inflated results. We disaggregated data into three sectors, artisanal (unpowered/powered) and industrial, ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 历史文章,杂志文章

    doi：10.1073/pnas.1820344116

    authors： Rousseau Y,Watson RA,Blanchard JL,Fulton EA

    更新日期：2019-06-18 00:00:00

  • Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells.

    abstract：:Nonsteroidal antiinflammatory drugs reduce the risk of colon cancer, possibly via cyclooxygenase (COX) inhibition. The growth factor-inducible COX-2, which is overexpressed in neoplastic colonic tissue, is an attractive target to mediate this effect. Herein we have exploited the ability of a human colon cancer cell li...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.94.2.657

    authors： Coffey RJ,Hawkey CJ,Damstrup L,Graves-Deal R,Daniel VC,Dempsey PJ,Chinery R,Kirkland SC,DuBois RN,Jetton TL,Morrow JD

    更新日期：1997-01-21 00:00:00

  • Carbonic anhydrase inhibitor suppresses invasion of renal cancer cells in vitro.

    abstract：:Acidification of the extracellular milieu of malignant tumors is reported to increase the invasive behavior of cancer cells. In normal tissues, production of acid is catalyzed by carbonic anhydrases (CAs), some of which are known to be overexpressed in certain cancers. To investigate the functional role of CA activity...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.040554897

    authors： Parkkila S,Rajaniemi H,Parkkila AK,Kivela J,Waheed A,Pastorekova S,Pastorek J,Sly WS

    更新日期：2000-02-29 00:00:00

  • Ecological character displacement in Plethodon: biomechanical differences found from a geometric morphometric study.

    abstract：:Ecological character displacement describes a pattern where morphological differences between sympatric species are enhanced through interspecific competition. Although widely considered a pervasive force in evolutionary ecology, few clear-cut examples have been documented. Here we report a case of ecological characte...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.97.8.4106

    authors： Adams DC,Rohlf FJ

    更新日期：2000-04-11 00:00:00

  • Effect of Ca2+ on weak cross-bridge interaction with actin in the presence of adenosine 5'-[gamma-thio]triphosphate).

    abstract：:In the presence of the nucleotide analog adenosine 5'-[gamma-thio]triphosphate (ATP[gamma S]), effects of Ca2+ on stiffness and equatorial x-ray diffraction patterns of single skinned fibers of the rabbit psoas muscle were studied. It is shown that cross-bridges in the presence of ATP[gamma S] have properties of the w...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.89.23.11362

    authors： Kraft T,Yu LC,Kuhn HJ,Brenner B

    更新日期：1992-12-01 00:00:00

  • A widely expressed betaIII spectrin associated with Golgi and cytoplasmic vesicles.

    abstract：:Spectrin is an important structural component of the plasma membrane skeleton. Heretofore-unidentified isoforms of spectrin also associate with Golgi and other organelles. We have discovered another member of the beta-spectrin gene family by homology searches of the GenBank databases and by 5' rapid amplification of c...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.95.24.14158

    authors： Stankewich MC,Tse WT,Peters LL,Ch'ng Y,John KM,Stabach PR,Devarajan P,Morrow JS,Lux SE

    更新日期：1998-11-24 00:00:00

  • The heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through tissue.

    abstract：:The Lyme disease spirochete Borrelia burgdorferi exists in nature in an enzootic cycle that involves the arthropod vector Ixodes scapularis and mammalian reservoirs. To disseminate within and between these hosts, spirochetes must migrate through complex, polymeric environments such as the basement membrane of the tick...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1114362109

    authors： Harman MW,Dunham-Ems SM,Caimano MJ,Belperron AA,Bockenstedt LK,Fu HC,Radolf JD,Wolgemuth CW

    更新日期：2012-02-21 00:00:00

  • DNA-mediated engineering of multicomponent enzyme crystals.

    abstract：:The ability to predictably control the coassembly of multiple nanoscale building blocks, especially those with disparate chemical and physical properties such as biomolecules and inorganic nanoparticles, has far-reaching implications in catalysis, sensing, and photonics, but a generalizable strategy for engineering sp...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1503533112

    authors： Brodin JD,Auyeung E,Mirkin CA

    更新日期：2015-04-14 00:00:00

  • Glucocorticoid and cAMP induction mechanisms are differentially affected by the p85gag-mos oncoprotein.

    abstract：:The inability to perceive and coordinate both internal and external signals that function to regulate cellular growth and proliferation is a hallmark of oncogenic transformation. To examine the effects of the v-mos oncogene on distinct signal transduction pathways, the 6m2 cell line was used, in which expression of th...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.86.2.597

    authors： Hamilton BJ,DeFranco D

    更新日期：1989-01-01 00:00:00

  • CRISPR-Cas9-guided oncogenic chromosomal translocations with conditional fusion protein expression in human mesenchymal cells.

    abstract：:Gene editing techniques have been extensively used to attempt to model recurrent genomic rearrangements found in tumor cells. These methods involve the induction of double-strand breaks at endogenous loci followed by the identification of breakpoint junctions within a population, which typically arise by nonhomologous...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1700622114

    authors： Vanoli F,Tomishima M,Feng W,Lamribet K,Babin L,Brunet E,Jasin M

    更新日期：2017-04-04 00:00:00

  • Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13.

    abstract：:A polyclonal antiserum directed against the C-terminal domain of dystrophin was used to isolate a cDNA clone encoding an antigenically cross-reactive protein, microtubule-associated protein 1B (MAP-1B). Physical mapping of the human MAP-1B locus places its chromosomal location at 5q13, in proximity to the spinal muscu...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.17.7873

    authors： Lien LL,Boyce FM,Kleyn P,Brzustowicz LM,Menninger J,Ward DC,Gilliam TC,Kunkel LM

    更新日期：1991-09-01 00:00:00

  • An evolutionary process that assembles phenotypes through space rather than through time.

    abstract：:In classical evolutionary theory, traits evolve because they facilitate organismal survival and/or reproduction. We discuss a different type of evolutionary mechanism that relies upon differential dispersal. Traits that enhance rates of dispersal inevitably accumulate at expanding range edges, and assortative mating b...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1018989108

    authors： Shine R,Brown GP,Phillips BL

    更新日期：2011-04-05 00:00:00

  • Regulation of the self-renewal probability in Hydra stem cell clones.

    abstract：:Hydra interstitial stem cells continuously give rise to daughter stem cells as well as precursors for nerve and nematocyte differentiation. Growth of the stem cell population is controlled by the self-renewal probability (Ps): Ps is the fraction of stem cell daughters that remain stem cells in each generation. We have...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.75.2.886

    authors： David CN,MacWilliams H

    更新日期：1978-02-01 00:00:00

  • The presumed ginkgophyte Umaltolepis has seed-bearing structures resembling those of Peltaspermales and Umkomasiales.

    abstract：:The origins of the five groups of living seed plants, including the single relictual species Ginkgo biloba, are poorly understood, in large part because of very imperfect knowledge of extinct seed plant diversity. Here we describe well-preserved material from the Early Cretaceous of Mongolia of the previously enigmati...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1621409114

    authors： Herrera F,Shi G,Ichinnorov N,Takahashi M,Bugdaeva EV,Herendeen PS,Crane PR

    更新日期：2017-03-21 00:00:00

  • Insulin resistance in skeletal muscles of caveolin-3-null mice.

    abstract：:Type 2 diabetes is preceded by the development of insulin resistance, in which the action of insulin is impaired, largely in skeletal muscles. Caveolin-3 (Cav3) is a muscle-specific subtype of caveolin, an example of a scaffolding protein found within membranes. Cav is also known as growth signal inhibitor, although i...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0402053101

    authors： Oshikawa J,Otsu K,Toya Y,Tsunematsu T,Hankins R,Kawabe J,Minamisawa S,Umemura S,Hagiwara Y,Ishikawa Y

    更新日期：2004-08-24 00:00:00

  • Galacturonosyltransferase (GAUT)1 and GAUT7 are the core of a plant cell wall pectin biosynthetic homogalacturonan:galacturonosyltransferase complex.

    abstract：:Plant cell wall pectic polysaccharides are arguably the most complex carbohydrates in nature. Progress in understanding pectin synthesis has been slow due to its complex structure and difficulties in purifying and expressing the low-abundance, Golgi membrane-bound pectin biosynthetic enzymes. Arabidopsis galacturonosy...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1112816108

    authors： Atmodjo MA,Sakuragi Y,Zhu X,Burrell AJ,Mohanty SS,Atwood JA 3rd,Orlando R,Scheller HV,Mohnen D

    更新日期：2011-12-13 00:00:00

  • "Conjugal" transfer of plasmid DNA among oral streptococci.

    abstract：:The beta plasmid from Streptococcus faecalis strain DS5, which codes for resistance to erythromycin and lincomycin, was introduced into a Lancefield group F streptococcus, strain DR1501, by transformation. This strain, DR1501 (beta), was found to be an excellent donor of the beta plasmid and readily transferred the re...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.75.7.3484

    authors： LeBlanc DJ,Hawley RJ,Lee LN,St Martin EJ

    更新日期：1978-07-01 00:00:00

  • A defined minimal medium for axenic strains of Dictyostelium discoideum.

    abstract：:A defined, minimal medium for the cellular slime mold Dictyostelium discoideum is reported. ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.74.5.2157

    authors： Franke J,Kessin R

    更新日期：1977-05-01 00:00:00

  • Direct observation of protonation reactions during the catalytic cycle of cytochrome c oxidase.

    abstract：:Cytochrome c oxidase, the terminal protein in the respiratory chain, converts oxygen into water and helps generate the electrochemical gradient used in the synthesis of ATP. The catalytic action of cytochrome c oxidase involves electron transfer, proton transfer, and O2 reduction. These events trigger specific molecul...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1530408100

    authors： Nyquist RM,Heitbrink D,Bolwien C,Gennis RB,Heberle J

    更新日期：2003-07-22 00:00:00

  • Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses.

    abstract：:Actin polymerization and assembly into stress fibers (SFs) is central to many cellular processes. However, how SFs form in response to the mechanical interaction of cells with their environment is not fully understood. Here we have identified Piezo2 mechanosensitive cationic channel as a transducer of environmental ph...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1718177115

    authors： Pardo-Pastor C,Rubio-Moscardo F,Vogel-González M,Serra SA,Afthinos A,Mrkonjic S,Destaing O,Abenza JF,Fernández-Fernández JM,Trepat X,Albiges-Rizo C,Konstantopoulos K,Valverde MA

    更新日期：2018-02-20 00:00:00

  • Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation.

    abstract：:There is controversy over the nature of the disturbance in brain development that underpins attention-deficit/hyperactivity disorder (ADHD). In particular, it is unclear whether the disorder results from a delay in brain maturation or whether it represents a complete deviation from the template of typical development....

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0707741104

    authors： Shaw P,Eckstrand K,Sharp W,Blumenthal J,Lerch JP,Greenstein D,Clasen L,Evans A,Giedd J,Rapoport JL

    更新日期：2007-12-04 00:00:00

  • Primary structure and tissue distribution of the orphanin FQ precursor.

    abstract：:The heptadecapeptide orphanin FQ (OFQ) is a recently discovered neuropeptide that exhibits structural features reminiscent of the opioid peptides and that is an endogenous ligand to a G protein-coupled receptor sequentially related to the opioid receptors. We have cloned both the human and rat cDNAs encoding the OFQ p...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.93.16.8677

    authors： Nothacker HP,Reinscheid RK,Mansour A,Henningsen RA,Ardati A,Monsma FJ Jr,Watson SJ,Civelli O

    更新日期：1996-08-06 00:00:00

  • Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristics.

    abstract：:Ovulation induces cyclic rupture and regenerative repair of the ovarian coelomic epithelium. This process of repeated disruption and repair accompanied by complex remodeling typifies a somatic stem/progenitor cell-mediated process. Using BrdU incorporation and doxycycline inducible histone2B-green fluorescent protein ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0805012105

    authors： Szotek PP,Chang HL,Brennand K,Fujino A,Pieretti-Vanmarcke R,Lo Celso C,Dombkowski D,Preffer F,Cohen KS,Teixeira J,Donahoe PK

    更新日期：2008-08-26 00:00:00

  • Induction and properties of beta-adrenergic receptors during erythroid differentiation of Friend leukemic cells.

    abstract：:beta-Adrenergic receptors on Friend erythroleukemic cells were identified by the use of 125I-labeled hydroxybenzylpindolol, a potent beta-adrenergic antagonist. Binding of this ligand was saturable and stereospecific. The relative orders of potency of isoproterenol, epinephrine, and norepinephrine to displace bound hy...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.77.7.4065

    authors： Schmitt H,Guyaux M,Pochet R,Kram R

    更新日期：1980-07-01 00:00:00

  • The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation.

    abstract：:The nuclear LIM domain protein LMO2, a T cell oncoprotein, is essential for embryonic erythropoiesis. LIM-only proteins are presumed to act primarily through protein-protein interactions. We, and others, have identified a widely expressed protein, Ldb1, whose C-terminal 76-residues are sufficient to mediate interactio...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.94.25.13707

    authors： Visvader JE,Mao X,Fujiwara Y,Hahm K,Orkin SH

    更新日期：1997-12-09 00:00:00

  • Insect feeding mobilizes a unique plant defense protease that disrupts the peritrophic matrix of caterpillars.

    abstract：:Plants frequently respond to herbivorous insect attack by synthesizing defense proteins that deter insect feeding and prevent additional herbivory. Maize (Zea mays L.) lines, resistant to feeding by a number of lepidopteran species, rapidly mobilize a unique 33-kDa cysteine protease in response to caterpillar feeding....

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.202224899

    authors： Pechan T,Cohen A,Williams WP,Luthe DS

    更新日期：2002-10-01 00:00:00

  • MerTK regulates thymic selection of autoreactive T cells.

    abstract：:T cell-mediated autoimmune diseases such as type 1 diabetes (T1D) are believed to be the result in part of inefficient negative selection of self-specific thymocytes. However, the events regulating thymic negative selection are not fully understood. In the current study, we demonstrate that nonobese diabetic (NOD) mic...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0900683106

    authors： Wallet MA,Flores RR,Wang Y,Yi Z,Kroger CJ,Mathews CE,Earp HS,Matsushima G,Wang B,Tisch R

    更新日期：2009-03-24 00:00:00

  • Control of time-dependent biological processes by temporally patterned input.

    abstract：:Temporal patterning of biological variables, in the form of oscillations and rhythms on many time scales, is ubiquitous. Altering the temporal pattern of an input variable greatly affects the output of many biological processes. We develop here a conceptual framework for a quantitative understanding of such pattern de...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.94.19.10444

    authors： Brezina V,Orekhova IV,Weiss KR

    更新日期：1997-09-16 00:00:00

  • nanos function is essential for development and regeneration of planarian germ cells.

    abstract：:Germ cells are required for the successful propagation of sexually reproducing species. Understanding the mechanisms by which these cells are specified and how their totipotency is established and maintained has important biomedical and evolutionary implications. Freshwater planarians serve as fascinating models for s...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0609708104

    authors： Wang Y,Zayas RM,Guo T,Newmark PA

    更新日期：2007-04-03 00:00:00