The heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through tissue.

abstract：:NK cells are promising effectors for tumor adoptive immunotherapy, particularly when considering the targeting of MHC class I low or negative tumors. Yet, NK cells cannot respond to many tumors, which is particularly the case for nonhematopoietic tumors such as carcinomas or melanoma even when these cells lose MHC cla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kruschinski A,Moosmann A,Poschke I,Norell H,Chmielewski M,Seliger B,Kiessling R,Blankenstein T,Abken H,Charo J

更新日期：2008-11-11 00:00:00

abstract：:The role of the serum proteolytic system plasminogen/plasminogen activator as a biochemical tool used by the glia or neurons, or both, for maintaining their temporary and flexible cellular interactions during histogenesis of the nervous system is under study. The present report identifies a glia cell type, the Schwann...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kalderon N

更新日期：1984-11-01 00:00:00

abstract：:A cDNA sequence coding for murine granulocyte colony-stimulating factor (G-CSF) has been isolated from a cDNA library prepared with mRNA derived from murine fibrosarcoma NFSA cells, which produce G-CSF constitutively. Identification of murine G-CSF cDNA was based on the cross-hybridization with human G-CSF cDNA under ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsuchiya M,Asano S,Kaziro Y,Nagata S

更新日期：1986-10-01 00:00:00

abstract：:In the present work, we investigated the role of natural killer (NK) cells in combination therapy with oncolytic virus (OV) and bortezomib, a proteasome inhibitor. NK cells display rapid and potent immunity to metastatic and hematological cancers, and they overcome immunosuppressive effects of tumor microenvironment. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim Y,Yoo JY,Lee TJ,Liu J,Yu J,Caligiuri MA,Kaur B,Friedman A

更新日期：2018-05-08 00:00:00

abstract：:Multiple protein subcomplexes of the kinetochore cooperate as a cohesive molecular unit that forms load-bearing microtubule attachments that drive mitotic chromosome movements. There is intriguing evidence suggesting that central kinetochore components influence kinetochore-microtubule attachment, but the mechanism re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kudalkar EM,Scarborough EA,Umbreit NT,Zelter A,Gestaut DR,Riffle M,Johnson RS,MacCoss MJ,Asbury CL,Davis TN

更新日期：2015-10-13 00:00:00

abstract：:The C terminus of transcription factor NusA from Escherichia coli comprises two repeat units, which bind during antitermination to protein N from phage lambda. To delineate the structural basis of the NusA-lambdaN interaction, we attempted to crystallize the NusA C-terminal repeats in complex with a lambdaN peptide (r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonin I,Mühlberger R,Bourenkov GP,Huber R,Bacher A,Richter G,Wahl MC

更新日期：2004-09-21 00:00:00

abstract：:Frogs (Anura) are one of the most diverse groups of vertebrates and comprise nearly 90% of living amphibian species. Their worldwide distribution and diverse biology make them well-suited for assessing fundamental questions in evolution, ecology, and conservation. However, despite their scientific importance, the evol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feng YJ,Blackburn DC,Liang D,Hillis DM,Wake DB,Cannatella DC,Zhang P

更新日期：2017-07-18 00:00:00

abstract：:We present an automated laser tracking and optogenetic manipulation system (ALTOMS) for studying social memory in fruit flies (Drosophila melanogaster). ALTOMS comprises an intelligent central control module for high-speed fly behavior analysis and feedback laser scanning (∼40 frames per second) for targeting two lase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu MC,Chu LA,Hsiao PY,Lin YY,Chi CC,Liu TH,Fu CC,Chiang AS

更新日期：2014-04-08 00:00:00

abstract：:The amount of extra-pair paternity in socially monogamous bird species varies from 0% to 76% extra-pair offspring. The causes of this remarkable interspecific variation are largely unknown, although intraspecific analyses suggest that females seek extra-pair matings to improve the genetic quality of their offspring. I...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrie M,Doums C,Moller AP

更新日期：1998-08-04 00:00:00

abstract：:Although sexual selection theory has proved successful in explaining a wide array of male ornaments, the function of ornaments occurring in females is largely unknown. Traditionally, female ornaments have been considered nonfunctional, being merely a genetically correlated response to selection for male ornamentation....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amundsen T,Forsgren E

更新日期：2001-11-06 00:00:00

abstract：:Bone mineralization is an essential step during the embryonic development of vertebrates, and bone serves vital functions in human physiology. To systematically identify unique gene functions essential for osteogenesis, we performed a forward genetic screen in zebrafish and isolated a mutant, no bone (nob), that does ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huitema LF,Apschner A,Logister I,Spoorendonk KM,Bussmann J,Hammond CL,Schulte-Merker S

更新日期：2012-12-26 00:00:00

abstract：:Genes that are up- and down-regulated by thyroid hormone in the tail resorption program of Xenopus laevis have been isolated by a gene expression screen, sequenced, and identified in the GenBank data base. The entire program is estimated to consist of fewer than 35 up-regulated and fewer than 10 down-regulated genes; ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown DD,Wang Z,Furlow JD,Kanamori A,Schwartzman RA,Remo BF,Pinder A

更新日期：1996-03-05 00:00:00

abstract：:It has been reported that an insulin 2 gene knockout, when bred onto nonobese diabetic (NOD) mice, accelerates diabetes. We produced insulin 1 gene knockout congenic NOD mice. In contrast to insulin 2, diabetes and insulitis were markedly reduced in insulin 1 knockout mice, with decreased and delayed diabetes in heter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moriyama H,Abiru N,Paronen J,Sikora K,Liu E,Miao D,Devendra D,Beilke J,Gianani R,Gill RG,Eisenbarth GS

更新日期：2003-09-02 00:00:00

abstract：:It is well established that exposure to solar UVB (290-320 nm) gives rise to mutations in oncogenes and tumor suppressor genes that initiate the molecular cascade toward skin cancer. Although UVA (320-400 nm) has also been implicated in multistage photocarcinogenesis, its potential contribution to sunlight mutagenesis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Drobetsky EA,Turcotte J,Châteauneuf A

更新日期：1995-03-14 00:00:00

abstract：:Cardiotoxin VII4 from Naja mossambica mossambica crystallizes in space group P61 (a = b = 73.9 A; c = 59.0 A) with two molecules of toxin (molecular mass = 6715 Da) in the asymmetric unit. The structure was solved by using a combination of multiple isomorphous replacement and density modification methods. Model buildi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rees B,Samama JP,Thierry JC,Gilibert M,Fischer J,Schweitz H,Lazdunski M,Moras D

更新日期：1987-05-01 00:00:00

abstract：:The visual (retinoid) cycle, the enzymatic pathway that regenerates chromophore after light absorption, is located primarily in the retinal pigment epithelium (RPE) and is essential for rod photoreceptor survival. Whether this pathway also is essential for cone photoreceptor survival is unknown, and there are no data ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jacobson SG,Aleman TS,Cideciyan AV,Heon E,Golczak M,Beltran WA,Sumaroka A,Schwartz SB,Roman AJ,Windsor EA,Wilson JM,Aguirre GD,Stone EM,Palczewski K

更新日期：2007-09-18 00:00:00

abstract：:In this era of continued emergence of zoonotic virus infections, the rapid development of rodent models represents a critical barrier to public health preparedness, including the testing of antivirus therapy and vaccines. The Middle East respiratory syndrome coronavirus (MERS-CoV) was recently identified as the causat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao J,Li K,Wohlford-Lenane C,Agnihothram SS,Fett C,Zhao J,Gale MJ Jr,Baric RS,Enjuanes L,Gallagher T,McCray PB Jr,Perlman S

更新日期：2014-04-01 00:00:00

abstract：:With decreasing temperature, liquids generally freeze into a solid state, losing entropy in the process. However, exceptions to this trend exist, such as quantum liquids, which may remain unfrozen down to absolute zero owing to strong quantum entanglement effects that stabilize a disordered state with zero entropy. Ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Katayama N,Kimura K,Han Y,Nasu J,Drichko N,Nakanishi Y,Halim M,Ishiguro Y,Satake R,Nishibori E,Yoshizawa M,Nakano T,Nozue Y,Wakabayashi Y,Ishihara S,Hagiwara M,Sawa H,Nakatsuji S

更新日期：2015-07-28 00:00:00

abstract：:MscS is a mechanosensitive channel that is ubiquitous among bacteria. Recent progress in the genome projects has revealed that homologs of MscS are also present in eukaryotes, but whether they operate as ion channels is unknown. In this study we cloned MSC1, a homolog of MscS in Chlamydomonas, and examined its functio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakayama Y,Fujiu K,Sokabe M,Yoshimura K

更新日期：2007-04-03 00:00:00

abstract：:Specific antibodies against types I and III collagens and procollagens were used to localize these proteins in cultured human cells. These studies indicate that the same cell makes both proteins. No type III procollagen synthesis was observed in cells from two patients with two patients with the Ehlers-Danlos type IV ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gay S,Martin GR,Muller PK,Timpl R,Kuhn K

更新日期：1976-11-01 00:00:00

abstract：:The venoms from three spider species, Araneus gemma, Neoscona arabesca, and Argiope aurantia, were shown to inhibit the high-affinity, sodium-independent L-glutamate-binding sites in rat brain synaptic membranes. The same three venoms caused concentration-dependent inhibition of the activity of the glutamate-binding g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Michaelis EK,Galton N,Early SL

更新日期：1984-09-01 00:00:00

abstract：:Leucine-rich repeat kinase 2 (LRRK2) has been associated with a variety of human diseases, including Parkinson's disease and Crohn's disease, whereas LRRK2 deficiency leads to accumulation of abnormal lysosomes in aged animals. However, the cellular roles and mechanisms of LRRK2-mediated lysosomal regulation have rema...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eguchi T,Kuwahara T,Sakurai M,Komori T,Fujimoto T,Ito G,Yoshimura SI,Harada A,Fukuda M,Koike M,Iwatsubo T

更新日期：2018-09-25 00:00:00

abstract：:Little is known about how chromatin folds in its native state. Using optimized in situ hybridization and live imaging techniques have determined compaction ratios and fiber flexibility for interphase chromatin in budding yeast. Unlike previous studies, ours examines nonrepetitive chromatin at intervals short enough to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bystricky K,Heun P,Gehlen L,Langowski J,Gasser SM

更新日期：2004-11-23 00:00:00

abstract：:Despite significant infiltration into tumors and atherosclerotic plaques, the role of T lymphocytes in these pathological conditions is still unclear. We have demonstrated that tumor-infiltrating lymphocytes (TILs) and plaque-infiltrating lymphocytes (PILs) produce heparin-binding epidermal growth factor-like growth f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peoples GE,Blotnick S,Takahashi K,Freeman MR,Klagsbrun M,Eberlein TJ

更新日期：1995-07-03 00:00:00

abstract：:The cationic conductances of purified bovine retinal rod membranes were studied by incorporation of vesicles into planar lipid bilayers. When the membranes were stripped of all peripheral proteins [guanine nucleotide-binding protein (G protein) and cGMP phosphodiesterase (3',5'-cyclic-GMP 5'-nucleotidohydrolase), EC 3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bennett N,Ildefonse M,Crouzy S,Chapron Y,Clerc A

更新日期：1989-05-01 00:00:00

abstract：:Organelles in the axoplasm from the squid giant axon move along exogenous actin filaments toward their barbed ends. An approximately 235-kDa protein, the only band recognized by a pan-myosin antibody in Western blots of isolated axoplasmic organelles, has been previously proposed to be a motor for these movements. Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bearer EL,DeGiorgis JA,Jaffe H,Medeiros NA,Reese TS

更新日期：1996-06-11 00:00:00

abstract：:The effect of pH on the membrane-fusion activity of Sendai virus was examined (pH 5.0-9.5) by using, as assays of activity, hemolysis of chicken erythrocytes and the fusion of baby hamster kidney (BHK-21) cells. Exposure of virus to basic pH increased fusion activity; the optimum pH was found to be approximately equal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu MC,Scheid A,Choppin PW

更新日期：1982-10-01 00:00:00

abstract：:The mammalian AML/CBFalpha runt domain (RD) transcription factors regulate hematopoiesis and osteoblast differentiation. Like their Drosophila counterparts, most mammalian RD proteins terminate in a common pentapeptide, VWRPY, which serves to recruit the corepressor Groucho (Gro). Using a yeast two-hybrid assay, in vi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levanon D,Goldstein RE,Bernstein Y,Tang H,Goldenberg D,Stifani S,Paroush Z,Groner Y

更新日期：1998-09-29 00:00:00

abstract：:l-tryptophan (Trp), an essential amino acid for mammals, is the precursor of a wide array of immunomodulatory metabolites produced by the kynurenine and serotonin pathways. The kynurenine pathway is a paramount source of several immunoregulatory metabolites, including l-kynurenine (Kyn), the main product of indoleamin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mondanelli G,Coletti A,Greco FA,Pallotta MT,Orabona C,Iacono A,Belladonna ML,Albini E,Panfili E,Fallarino F,Gargaro M,Manni G,Matino D,Carvalho A,Cunha C,Maciel P,Di Filippo M,Gaetani L,Bianchi R,Vacca C,Iamandii

更新日期：2020-02-18 00:00:00

abstract：:The spleen from a patient with adult Gaucher's disease was shown to be deficient in a beta-glucosidase (EC 3.2.1.21) isoenzyme that has optimal activity at pH 4.0-4.3, and is stimulated by 0.02% Triton X-100. A mixture of spleen homogenates from a control and from the patient contained beta-glucosidase activity equiva...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ho MW,O'Brien JS

更新日期：1971-11-01 00:00:00