Abstract:
:In the present work, we investigated the role of natural killer (NK) cells in combination therapy with oncolytic virus (OV) and bortezomib, a proteasome inhibitor. NK cells display rapid and potent immunity to metastatic and hematological cancers, and they overcome immunosuppressive effects of tumor microenvironment. We developed a mathematical model to address the question of how the density of NK cells affects the growth of the tumor. We found that the antitumor efficacy increases when the endogenous NKs are depleted and also when exogenous NK cells are injected into the tumor. These predictions were validated by our in vivo and in vitro experiments.
journal_name
Proc Natl Acad Sci U S Aauthors
Kim Y,Yoo JY,Lee TJ,Liu J,Yu J,Caligiuri MA,Kaur B,Friedman Adoi
10.1073/pnas.1715295115subject
Has Abstractpub_date
2018-05-08 00:00:00pages
4927-4932issue
19eissn
0027-8424issn
1091-6490pii
1715295115journal_volume
115pub_type
杂志文章abstract::The properties of a recently synthesized photolabile chelator for divalent cations are described, the affinity of which for Ca2+ changes by some 5 orders of magnitude on illumination. The compound 1-(2-nitro-4,5-dimethoxyphenyl)-N,N,N',N'-tetrakis[(oxycarbonyl)me thyl]-1,2-ethanediamine (DM-nitrophen) binds Ca2+ (Kd a...
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