Schwann cell proliferation and localized proteolysis: expression of plasminogen-activator activity predominates in the proliferating cell populations.

abstract：:Most marine organisms disperse via ocean currents as larvae, so it is often assumed that larval-stage duration is the primary determinant of geographic range size. However, empirical tests of this relationship have yielded mixed results, and alternative hypotheses have rarely been considered. Here we assess the relati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luiz OJ,Allen AP,Robertson DR,Floeter SR,Kulbicki M,Vigliola L,Becheler R,Madin JS

更新日期：2013-10-08 00:00:00

abstract：:Studies in mice indicate that the gut microbiota promotes energy harvest and storage from components of the diet when these components are plentiful. Here we examine how the microbiota shapes host metabolic and physiologic adaptations to periods of nutrient deprivation. Germ-free (GF) mice and mice who had received a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crawford PA,Crowley JR,Sambandam N,Muegge BD,Costello EK,Hamady M,Knight R,Gordon JI

更新日期：2009-07-07 00:00:00

abstract：:Mechanisms by which macrophages discriminate between "mature-self" and "senescent-self" were investigated using the human red blood cell (RBC) system as a model. Conditions simulating those encountered in situ were adhered to as closely as possible by using short term culture techniques and incubating with autologous ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kay MM

更新日期：1975-09-01 00:00:00

abstract：:LTRs of endogenous retroviruses are known to affect expression of several human genes, typically as a relatively minor alternative promoter. Here, we report that an endogenous retrovirus LTR acts as one of at least two alternative promoters for the human beta1,3-galactosyltransferase 5 gene, involved in type 1 Lewis a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dunn CA,Medstrand P,Mager DL

更新日期：2003-10-28 00:00:00

abstract：:The aspartate receptor involved in chemotaxis is modified by methyl esterification at four distinct glutamate residues during the adaptive response of this receptor. To explain the high degree of specificity of this modification, it has been proposed that the methyltransferase recognizes the sequence Glu-Glu-Xaa-Xaa-A...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Terwilliger TC,Wang JY,Koshland DE Jr

更新日期：1986-09-01 00:00:00

abstract：:Using data from the North American Breeding Bird Survey, we determined that most neotropical migrant bird species that breed in forests of the eastern United States and Canada have recently (1978-1987) declined in abundance after a period of stable or increasing populations. Most permanent residents and temperate-zone...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robbins CS,Sauer JR,Greenberg RS,Droege S

更新日期：1989-10-01 00:00:00

abstract：:Ribonucleoside diphosphate reductase from Escherichia coli and mammalian cells provides the deoxyribonucleoside triphosphates for DNA synthesis. The active enzyme contains a tyrosyl free radical whose formation requires oxygen. Earlier genetic evidence suggested that the enzyme is not required for anaerobic growth of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fontecave M,Eliasson R,Reichard P

更新日期：1989-04-01 00:00:00

abstract：:A pentapeptide open reading frame equipped with a canonical ribosome-binding site is present in the Escherichia coli 23S rRNA. Overexpression of 23S rRNA fragments containing the mini-gene renders cells resistant to the ribosome-inhibiting antibiotic erythromycin. Mutations that change either the initiator or stop cod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tenson T,DeBlasio A,Mankin A

更新日期：1996-05-28 00:00:00

abstract：:Thiamin diphosphate, the vitamin B1 coenzyme, plays critical roles in fundamental metabolic pathways that require acyl carbanion equivalents. Studies on chemical models and enzymes had suggested that these carbanions are resonance-stabilized as enamines. A crystal structure of this intermediate in pyruvate oxidase at ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyer D,Neumann P,Koers E,Sjuts H,Lüdtke S,Sheldrick GM,Ficner R,Tittmann K

更新日期：2012-07-03 00:00:00

abstract：:The Bill and Melinda Gates Foundation supports an ambitious portfolio of novel vaccines, drug regimens, and diagnostic tools for tuberculosis (TB). We elicited the expected efficacies and improvements of the novel interventions in discussions with the foundations managing their development. Using an age-structured mat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abu-Raddad LJ,Sabatelli L,Achterberg JT,Sugimoto JD,Longini IM Jr,Dye C,Halloran ME

更新日期：2009-08-18 00:00:00

abstract：:In animals and in man, diverse immunologic functions are mediated by specialized T-cell (thymus-derived lymphocyte) subsets that are distinguishable from one another on the basis of differences in cell surface determinants. Unfortunately, in humans, subset-specific antibodies have been difficult to generate. In this s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Engleman EG,Benike C,Osborne B,Goldsby R

更新日期：1980-03-01 00:00:00

abstract：:A full-length placental alkaline phosphatase (PLAP) cDNA was used to identify and clone the PLAP-like Nagao isozyme gene from human genomic libraries. The entire nucleotide sequence of the gene reveals the existence of 11 exons interrupted by 10 small introns (76-427 base pairs). Putative regulatory sequences have bee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Millán JL,Manes T

更新日期：1988-05-01 00:00:00

abstract：:Understanding the mechanisms of Salmonella virulence is an important challenge. The capacity of this intracellular bacterial pathogen to cause diseases depends on the expression of virulence factors including the second type III secretion system (TTSS-2), which is used to translocate into the eukaryotic cytosol a set ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henry T,Couillault C,Rockenfeller P,Boucrot E,Dumont A,Schroeder N,Hermant A,Knodler LA,Lecine P,Steele-Mortimer O,Borg JP,Gorvel JP,Méresse S

更新日期：2006-09-05 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) is synthesized in the brain, and a single type of cloned receptor for the N-terminal portion of PTHrP and PTH is present in the central nervous system. Nothing is known about the physiological actions or signaling pathways used by PTHrP in the brain. Using cultured rat hippo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fukayama S,Tashjian AH Jr,Davis JN,Chisholm JC

更新日期：1995-10-24 00:00:00

abstract：:The protein kinase A stimulator cAMP can potentiate the ability of progestins to induce the transactivation function of the human progesterone receptor (hPR). We questioned in the present study whether cAMP could functionally cooperate with the progestin antagonist RU486. In T47D human breast cancer cells, RU486 behav...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beck CA,Weigel NL,Moyer ML,Nordeen SK,Edwards DP

更新日期：1993-05-15 00:00:00

abstract：:ADP ribosylation factor (ARF) is a small guanosine triphosphate (GTP)-binding protein that regulates the binding of coat proteins to membranes and is required for several stages of vesicular transport. ARF also stimulates phospholipase D (PLD) activity, which can alter the lipid content of membranes by conversion of p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ktistakis NT,Brown HA,Sternweis PC,Roth MG

更新日期：1995-05-23 00:00:00

abstract：:Down-regulation of mitogenic signaling in mammalian cells relies in part on endosomal trafficking of activated receptors into lysosomes, where the receptors are degraded. These events are mediated by ubiquitination of the endosomal cargo and its consequent sorting into multivesicular bodies that form at the surfaces o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu Q,Hope LW,Brasch M,Reinhard C,Cohen SN

更新日期：2003-06-24 00:00:00

abstract：:Inflammation plays an important role in pathological angiogenesis. Receptor-interacting protein 1 (RIP1) is highly expressed in inflammatory cells and is known to play an important role in the regulation of apoptosis, necroptosis, and inflammation; however, a comprehensive description of its role in angiogenesis remai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ueta T,Ishihara K,Notomi S,Lee JJ,Maidana DE,Efstathiou NE,Murakami Y,Hasegawa E,Azuma K,Toyono T,Paschalis EI,Aihara M,Miller JW,Vavvas DG

更新日期：2019-11-19 00:00:00

abstract：:The molecular and cellular basis of selective motor neuron (MN) vulnerability in amyotrophic lateral sclerosis (ALS) is not known. In genetically distinct mouse models of familial ALS expressing mutant superoxide dismutase-1 (SOD1), TAR DNA-binding protein 43 (TDP-43), and fused in sarcoma (FUS), we demonstrate select...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lalancette-Hebert M,Sharma A,Lyashchenko AK,Shneider NA

更新日期：2016-12-20 00:00:00

abstract：:The RNA synthesized in vitro by the virion-associated RNA-instructed RNA polymerase of purified vesicular stomatitis virus contains polyadenylate sequences. These have been demonstrated by their partial resistance to pancreatic and T(1) ribonucleases and their capacity to bind to poly(U) filters and oligo(dT)-cellulos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Banerjee AK,Rhodes DP

更新日期：1973-12-01 00:00:00

abstract：:The heat-stable enterotoxin B (STB) of Escherichia coli is a 48-amino acid extracellular peptide that induces rapid fluid accumulation in animal intestinal models. Unlike other E. coli enterotoxins that elicit cAMP or cGMP responses in the gut [heat-labile toxin (LT) and heat-stable toxin A (STA), respectively], STB i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dreyfus LA,Harville B,Howard DE,Shaban R,Beatty DM,Morris SJ

更新日期：1993-04-15 00:00:00

abstract：:A mammalian A-type cyclin, cyclin A1, is highly expressed in testes of both human and mouse and targeted mutagenesis in the mouse has revealed the unique requirement for cyclin A1 in the progression of male germ cells through the meiotic cell cycle. While very low levels of cyclin A1 have been reported in the human he...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liao C,Wang XY,Wei HQ,Li SQ,Merghoub T,Pandolfi PP,Wolgemuth DJ

更新日期：2001-06-05 00:00:00

abstract：:The X-ray crystal structure of the Head module, one-third of the Mediator of transcriptional regulation, has been determined as a complex with the C-terminal domain (CTD) of RNA polymerase II. The structure reveals multiple points of interaction with an extended conformation of the CTD; it suggests a basis for regulat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robinson PJ,Bushnell DA,Trnka MJ,Burlingame AL,Kornberg RD

更新日期：2012-10-30 00:00:00

abstract：:DNA polymerases from Xenopus laevis oocytes, unfertilized eggs, and kidney cells grown in culture have been characterized. The same three major DNA polymerase activities are present in all cell types examined. We attempt to relate the characteristics of amphibian enzymes to those of mammalian polymerases. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tatò F,Gandini DA,Tocchini-Valentini GP

更新日期：1974-09-01 00:00:00

abstract：:An integral mitochondrial membrane protein (p32) of yeast has previously been molecularly cloned and sequenced and suggested to function as a mitochondrial import receptor. However, this protein has also been proposed to function as phosphate translocator [Guérin, B., Bukusoglu, C., Rakotomanana, F. & Wohlrab, H. (199...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murakami H,Blobel G,Pain D

更新日期：1993-04-15 00:00:00

abstract：:Leukocyte adherence to endothelium is in part mediated by the transient expression of endothelial-leukocyte adhesion molecule 1 (ELAM-1) on endothelial surfaces stimulated by tumor necrosis factor alpha (TNF), interleukin (IL) 1, or bacterial lipopolysaccharide (LPS). The intracellular factors controlling induction of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Montgomery KF,Osborn L,Hession C,Tizard R,Goff D,Vassallo C,Tarr PI,Bomsztyk K,Lobb R,Harlan JM

更新日期：1991-08-01 00:00:00

abstract：:Injection of antisense oligonucleotides was used to investigate the function of c-mos in murine oocytes. Oocytes injected with antisense c-mos oligonucleotides completed the first meiotic division but failed to initiate meiosis II. Instead, loss of c-mos function led to chromosome decondensation, reformation of a nucl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Keefe SJ,Wolfes H,Kiessling AA,Cooper GM

更新日期：1989-09-01 00:00:00

abstract：:Amorphous silicon oxycarbide polymer-derived ceramics (PDCs), synthesized from organometallic precursors, contain carbon- and silica-rich nanodomains, the latter with extensive substitution of carbon for oxygen, linking Si-centered SiO(x)C(4-x) tetrahedra. Calorimetric studies demonstrated these PDCs to be thermodynam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sen S,Widgeon SJ,Navrotsky A,Mera G,Tavakoli A,Ionescu E,Riedel R

更新日期：2013-10-01 00:00:00

abstract：:Two mouse monoclonal anti-anti-idiotopic antibodies (anti-anti-Id, Ab3), AF14 and AF52, were prepared by immunizing BALB/c mice with rabbit polyclonal anti-idiotypic antibodies (anti-Id, Ab2) raised against antibody D1.3 (Ab1) specific for the antigen hen egg lysozyme. AF14 and AF52 react with an "internal image" mono...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldbaum FA,Velikovsky CA,Dall'Acqua W,Fossati CA,Fields BA,Braden BC,Poljak RJ,Mariuzza RA

更新日期：1997-08-05 00:00:00

abstract：:In vitro data show that the adenomatous polyposis coli (APC) protein associates with the mitotic spindle and that mouse embryonic stem cells with biallelic Apc mutations are karyotypically unstable. These findings led to suggestions that APC acts in chromosomal segregation and that APC inactivation leads to chromosoma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sieber OM,Heinimann K,Gorman P,Lamlum H,Crabtree M,Simpson CA,Davies D,Neale K,Hodgson SV,Roylance RR,Phillips RK,Bodmer WF,Tomlinson IP

更新日期：2002-12-24 00:00:00