Abstract:
:The X-ray crystal structure of the Head module, one-third of the Mediator of transcriptional regulation, has been determined as a complex with the C-terminal domain (CTD) of RNA polymerase II. The structure reveals multiple points of interaction with an extended conformation of the CTD; it suggests a basis for regulation by phosphorylation of the CTD. Biochemical studies show a requirement for Mediator-CTD interaction for transcription.
journal_name
Proc Natl Acad Sci U S Aauthors
Robinson PJ,Bushnell DA,Trnka MJ,Burlingame AL,Kornberg RDdoi
10.1073/pnas.1215241109subject
Has Abstractpub_date
2012-10-30 00:00:00pages
17931-5issue
44eissn
0027-8424issn
1091-6490pii
1215241109journal_volume
109pub_type
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