Abstract:
:Despite significant infiltration into tumors and atherosclerotic plaques, the role of T lymphocytes in these pathological conditions is still unclear. We have demonstrated that tumor-infiltrating lymphocytes (TILs) and plaque-infiltrating lymphocytes (PILs) produce heparin-binding epidermal growth factor-like growth factor (HB-EGF) and basic fibroblast growth factor (bFGF) in vitro under nonspecific conditions and in vivo in tumors by immunohistochemical staining. HB-EGF and bFGF derived from TILs and PILs directly stimulated tumor cells and vascular smooth muscle cells (SMCs) in vitro, respectively, while bFGF displayed angiogenic properties. Therefore, T cells may play a critical role in the SMC hyperplasia of atherosclerosis and support tumor progression by direct stimulation and angiogenesis.
journal_name
Proc Natl Acad Sci U S Aauthors
Peoples GE,Blotnick S,Takahashi K,Freeman MR,Klagsbrun M,Eberlein TJdoi
10.1073/pnas.92.14.6547subject
Has Abstractpub_date
1995-07-03 00:00:00pages
6547-51issue
14eissn
0027-8424issn
1091-6490journal_volume
92pub_type
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