Dynamics and biological relevance of DNA demethylation in Arabidopsis antibacterial defense.

abstract：:Genes that are up- and down-regulated by thyroid hormone in the tail resorption program of Xenopus laevis have been isolated by a gene expression screen, sequenced, and identified in the GenBank data base. The entire program is estimated to consist of fewer than 35 up-regulated and fewer than 10 down-regulated genes; ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown DD,Wang Z,Furlow JD,Kanamori A,Schwartzman RA,Remo BF,Pinder A

更新日期：1996-03-05 00:00:00

abstract：:The cAMP receptor protein (CRP) of Escherichia coli needs cAMP for an allosteric change to regulate gene expression by binding to specific DNA sites. The hinge region connecting the DNA-binding domain to the cAMP-binding domain has been proposed to participate in the cAMP-induced allosteric change necessary to adjust ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ryu S,Kim J,Adhya S,Garges S

更新日期：1993-01-01 00:00:00

abstract：:Thermus thermophilus possesses an aspartyl-tRNA synthetase (AspRS2) able to aspartylate efficiently tRNAAsp and tRNAAsn. Aspartate mischarged on tRNAAsn then is converted into asparagine by an omega amidase that differs structurally from all known asparagine synthetases. However, aspartate is not misincorporated into ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Becker HD,Kern D

更新日期：1998-10-27 00:00:00

abstract：:Vascular endothelial cells (ECs) sense and respond to hemodynamic shear stress, which is critical for circulatory homeostasis and the pathophysiology of vascular diseases. The mechanisms of shear stress mechanotransduction, however, remain elusive. We previously demonstrated a direct role of mitochondria in the purine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamamoto K,Nogimori Y,Imamura H,Ando J

更新日期：2020-12-29 00:00:00

abstract：:Adult human brains retain the capacity to undergo tissue reorganization during second-language learning. Brain-imaging studies show a relationship between neuroanatomical properties and learning for adults exposed to a second language. However, the role of genetic factors in this relationship has not been investigated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mamiya PC,Richards TL,Coe BP,Eichler EE,Kuhl PK

更新日期：2016-06-28 00:00:00

abstract：:The enzyme tryptophan 2,3-dioxygenase [EC 1.13.11.11; L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)] first appears in the livers of young rats around the 15th postnatal day, and increases to the adult level by the 22nd day. Studies have shown that the appearance and subsequent development of the enzyme activity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Killewich LA,Feigelson P

更新日期：1977-12-01 00:00:00

abstract：:Cardiotoxin VII4 from Naja mossambica mossambica crystallizes in space group P61 (a = b = 73.9 A; c = 59.0 A) with two molecules of toxin (molecular mass = 6715 Da) in the asymmetric unit. The structure was solved by using a combination of multiple isomorphous replacement and density modification methods. Model buildi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rees B,Samama JP,Thierry JC,Gilibert M,Fischer J,Schweitz H,Lazdunski M,Moras D

更新日期：1987-05-01 00:00:00

abstract：:Mitochondrial protein kinases (mPKs) are molecular switches that down-regulate the oxidation of branched-chain alpha-ketoacids and pyruvate. Elevated levels of these metabolites are implicated in disease states such as insulin-resistant Type II diabetes, branched-chain ketoaciduria, and primary lactic acidosis. We rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Machius M,Chuang JL,Wynn RM,Tomchick DR,Chuang DT

更新日期：2001-09-25 00:00:00

abstract：:We have isolated, cloned, and characterized two cDNAs corresponding to the mRNAs for cationic peroxidases synthesized by cultured peanut cells. The first clone was obtained from a phage lambda gt11 library screened with antibodies directed against the major secreted isozyme. Its predicted amino acid sequence, deduced ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buffard D,Breda C,van Huystee RB,Asemota O,Pierre M,Ha DB,Esnault R

更新日期：1990-11-01 00:00:00

abstract：:Patent ductus arteriosus (PDA) is a common congenital heart disease that results when the ductus arteriosus, a muscular artery, fails to remodel and close after birth. A syndromic form of this disorder, Char syndrome, is caused by mutation in TFAP2B, the gene encoding a neural crest-derived transcription factor. Estab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mani A,Radhakrishnan J,Farhi A,Carew KS,Warnes CA,Nelson-Williams C,Day RW,Pober B,State MW,Lifton RP

更新日期：2005-02-22 00:00:00

abstract：:Primary HIV-1 isolates were evaluated for their sensitivity to inhibition by beta-chemokines RANTES (regulated upon activation, normal T-cell expressed and secreted), macrophage inflammatory protein 1 alpha (MIP-1 alpha), and MIP-1 beta. Virus isolates of both nonsyncytium-inducing (NSI) and syncytium-inducing (SI) bi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jansson M,Popovic M,Karlsson A,Cocchi F,Rossi P,Albert J,Wigzell H

更新日期：1996-12-24 00:00:00

abstract：:Sequencing of a 360-nucleotide segment of the mitochondrial control region for 63 individuals from an Amerindian tribe, the Nuu-Chah-Nulth of the Pacific Northwest, revealed the existence of 28 lineages defined by 26 variable positions. This represents a substantial level of mitochondrial diversity for a small local p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ward RH,Frazier BL,Dew-Jager K,Pääbo S

更新日期：1991-10-01 00:00:00

abstract：:Climate change impacts island communities all over the world. Sea-level rise, an increase in the frequency and intensity of severe weather events, and changes in distribution and health of marine organisms are among the most significant processes affecting island communities worldwide. On islands of the Caribbean and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Douglass K,Cooper J

更新日期：2020-04-14 00:00:00

abstract：:The hydrodynamic properties of the detergent-solubilized, terminal membrane complex of serum complement components C5-C9 [C5b-9(m)] were studied to obtain an estimate of its molecular weight. In a solution of Triton X-100/deoxycholate, the protein complex binds 17% Triton X-100 and 11% deoxycholate by weight. The sedi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhakdi S,Tranum-Jensen J

更新日期：1981-03-01 00:00:00

abstract：:The electronic absorption spectra of oxidized and reduced spinach ferredoxins have been measured between 1200 and 600 nm at low temperature in D(2)O/ethylene glycol glasses. Relatively weak absorption bands are observed at 720, 820, and 920 nm in oxidized ferredoxin, and at 652, 820, and 920 nm in reduced ferredoxin. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rawlings J,Siiman O,Gray HB

更新日期：1974-01-01 00:00:00

abstract：:Compared with the U.S., Japan is believed to have a collectivist culture that nurtures high trust. Results from laboratory and survey research, however, show that Americans are more likely to trust strangers than are Japanese. Why would trust be lower in a collectivist culture? We use an agent-based computational mode...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Macy MW,Sato Y

更新日期：2002-05-14 00:00:00

abstract：:The nuclear receptor Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) is an important coordinator of glucose homeostasis through its function in different organs such as the endocrine pancreas, adipose tissue, skeletal muscle, and liver. Recently we have demonstrated that COUP-TFII expression in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sabra-Makke L,Maritan M,Planchais J,Boutant M,Pégorier JP,Even PC,Vasseur-Cognet M,Bossard P

更新日期：2013-03-12 00:00:00

abstract：:The Landau spectrum of bismuth is complex and includes many angle-dependent lines in the extreme quantum limit. The adequacy of single-particle theory to describe this spectrum in detail has been an open issue. Here, we present a study of angle-resolved Nernst effect in bismuth, which maps the angle-resolved Landau sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu Z,Fauqué B,Malone L,Antunes AB,Fuseya Y,Behnia K

更新日期：2012-09-11 00:00:00

abstract：:To understand the basis for T-cell-specific induction of interleukin 2 (IL-2), we have analyzed nuclear factors from the Jurkat T-lymphoid leukemia cell, which can be induced to secrete IL-2. We have used an electrophoretic mobility shift assay to examine binding of proteins to the upstream regulatory region, before a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nabel GJ,Gorka C,Baltimore D

更新日期：1988-05-01 00:00:00

abstract：:Stressor exposure biases decision-making strategies from those based on the relationship between actions and their consequences to others restricted by stimulus-response associations. Chronic stressor exposure also desensitizes glucocorticoid receptors (GR) and diminishes motivation to acquire food reinforcement, alth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gourley SL,Swanson AM,Jacobs AM,Howell JL,Mo M,Dileone RJ,Koleske AJ,Taylor JR

更新日期：2012-12-11 00:00:00

abstract：:Deficiency in PTEN (phosphatase and tensin homolog deleted on chromosome 10) is the underlying cause of PTEN hamartoma tumor syndrome and a wide variety of human cancers. In skin epidermis, we have previously identified an autocrine FGF signaling induced by loss of Pten in keratinocytes. In this study, we demonstrate ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mathew G,Hannan A,Hertzler-Schaefer K,Wang F,Feng GS,Zhong J,Zhao JJ,Downward J,Zhang X

更新日期：2016-11-15 00:00:00

abstract：:Many multifunctional tumor suppressor proteins have low stability, a property linked to cancer development. The von Hippel-Lindau tumor suppressor protein (pVHL) is one of these proteins. pVHL forms part of the E3 ubiquitin ligase complex that regulates the degradation of the hypoxia-inducible factor (HIF). Under nati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu J,Nussinov R

更新日期：2008-01-22 00:00:00

abstract：:The virulence of many pathogens depends upon their ability to cope with immune-generated nitric oxide (NO·). In Escherichia coli, the major NO· detoxification systems are Hmp, an NO· dioxygenase (NOD), and NorV, an NO· reductase (NOR). It is well established that Hmp is the dominant system under aerobic conditions, wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robinson JL,Brynildsen MP

更新日期：2016-03-22 00:00:00

abstract：:Cerebral malaria is the most deadly manifestation of infection with Plasmodium falciparum. The pathology of cerebral malaria is characterized by the accumulation of infected erythrocytes (IEs) in the microvasculature of the brain caused by parasite adhesins on the surface of IEs binding to human receptors on microvasc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Claessens A,Adams Y,Ghumra A,Lindergard G,Buchan CC,Andisi C,Bull PC,Mok S,Gupta AP,Wang CW,Turner L,Arman M,Raza A,Bozdech Z,Rowe JA

更新日期：2012-06-26 00:00:00

abstract：:The ability to instantly create a state of immunity as achieved in the passive transfer of hyperimmune globulin has had a tremendous impact on public health. Unlike passive immunization, active immunization, which is the foundation of vaccinology, is an anticipatory strategy with inherent limitations. Here we show tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Popkov M,Gonzalez B,Sinha SC,Barbas CF 3rd

更新日期：2009-03-17 00:00:00

abstract：:An electron density map at 3 angstrom resolution has been calculated for Cu2+, Zn2+ superoxide dismutase from bovine erythrocytes, and the course of the main chain has been traced. The dominant structural feature is an 8-stranded barrel of antiparallel beta-pleated sheet. There is one very short helical section and tw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richardson J,Thomas KA,Rubin BH,Richardson DC

更新日期：1975-04-01 00:00:00

abstract：:Metal detoxification is essential for bacteria's survival in adverse environments and their pathogenesis in hosts. Understanding the underlying mechanisms is crucial for devising antibacterial treatments. In the Gram-negative bacterium Escherichia coli, membrane-bound sensor CusS and its response regulator CusR togeth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu B,Sengupta K,Genova LA,Santiago AG,Jung W,Krzemiński Ł,Chakraborty UK,Zhang W,Chen P

更新日期：2020-06-16 00:00:00

abstract：:Insects, as a group, have been remarkably successful in adapting to a great range of physical and biological environments, in large part because of their ability to fly. The evolution of flight in small insects was accompanied by striking adaptations of the thoracic musculature that enabled very high wing beat frequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swank DM,Vishnudas VK,Maughan DW

更新日期：2006-11-14 00:00:00

abstract：:Hepatocytes polarize by forming functionally distinct sinusoidal (basolateral) and canalicular (apical) plasma membrane domains. Two distinct routes are used for delivery of membrane proteins to the canaliculus. Proteins having glycosylphosphatidylinositol anchors or single transmembrane domains are targeted to the si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wakabayashi Y,Dutt P,Lippincott-Schwartz J,Arias IM

更新日期：2005-10-18 00:00:00

abstract：:Recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) was found to increase the adherence of purified peripheral blood monocytes to plastic surfaces and to monolayers of human umbilical vein endothelial cells. With plastic surfaces as a model 9-hr culture with GM-CSF was necessary for enhancement...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gamble JR,Elliott MJ,Jaipargas E,Lopez AF,Vadas MA

更新日期：1989-09-01 00:00:00