Abstract:
:DNA methylation is an epigenetic mark that silences transposable elements (TEs) and repeats. Whereas the establishment and maintenance of DNA methylation are relatively well understood, little is known about their dynamics and biological relevance in plant and animal innate immunity. Here, we show that some TEs are demethylated and transcriptionally reactivated during antibacterial defense in Arabidopsis. This effect is correlated with the down-regulation of key transcriptional gene silencing factors and is partly dependent on an active demethylation process. DNA demethylation restricts multiplication and vascular propagation of the bacterial pathogen Pseudomonas syringae in leaves and, accordingly, some immune-response genes, containing repeats in their promoter regions, are negatively regulated by DNA methylation. This study provides evidence that DNA demethylation is part of a plant-induced immune response, potentially acting to prime transcriptional activation of some defense genes linked to TEs/repeats.
journal_name
Proc Natl Acad Sci U S Aauthors
Yu A,Lepère G,Jay F,Wang J,Bapaume L,Wang Y,Abraham AL,Penterman J,Fischer RL,Voinnet O,Navarro Ldoi
10.1073/pnas.1211757110subject
Has Abstractpub_date
2013-02-05 00:00:00pages
2389-94issue
6eissn
0027-8424issn
1091-6490pii
1211757110journal_volume
110pub_type
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