Molecular weight of the membrane C5b-9 complex of human complement: characterization of the terminal complex as a C5b-9 monomer.

abstract：:Malignant B lymphocytes from several patients with chronic lymphocytic leukemia (CLL) were examined for reactivity with murine monoclonal antibody 17.109. This antibody, prepared against the rheumatoid factor (RF) paraprotein Sie, recognizes a crossreactive idiotype on 48% of human IgM RF paraproteins, but does not re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kipps TJ,Fong S,Tomhave E,Chen PP,Goldfien RD,Carson DA

更新日期：1987-05-01 00:00:00

abstract：:The economic and ecological costs of wildfire in the United States have risen substantially in recent decades. Although climate change has likely enabled a portion of the increase in wildfire activity, the direct role of people in increasing wildfire activity has been largely overlooked. We evaluate over 1.5 million g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balch JK,Bradley BA,Abatzoglou JT,Nagy RC,Fusco EJ,Mahood AL

更新日期：2017-03-14 00:00:00

abstract：:Recent work with prion diseases and synucleinopathies indicates that accurate diagnostic methods for protein-folding diseases can be based on the ultrasensitive, amplified measurement of pathological aggregates in biospecimens. A better understanding of the physicochemical factors that control the seeded polymerizatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metrick MA 2nd,do Carmo Ferreira N,Saijo E,Hughson AG,Kraus A,Orrú C,Miller MW,Zanusso G,Ghetti B,Vendruscolo M,Caughey B

更新日期：2019-11-12 00:00:00

abstract：:The regulation of glycogen metabolism is critical for the maintenance of glucose and energy homeostasis in mammals. Glycogen synthase, the enzyme responsible for glycogen production, is regulated by multisite phosphorylation in yeast and mammals. We have previously identified PAS kinase as a physiological regulator of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilson WA,Skurat AV,Probst B,de Paoli-Roach A,Roach PJ,Rutter J

更新日期：2005-11-15 00:00:00

abstract：:Immobilization antigens of stock 51 of Paramecium tetraurelia were subjected to electrophoresis in NaDodSO(4)/polyacrylamide gels. Type A is estimated to have a molecular size of 300,000 daltons; H is estimated to be 288,000, D to be 280,000, E to be 270,000, B to be 253,000, and C to be 250,000. Poly(A)(+)RNAs have b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Preer JR,Preer LB,Rudman BM

更新日期：1981-11-01 00:00:00

abstract：:Huntington disease stems from a mutation of the protein huntingtin and is characterized by selective loss of discrete neuronal populations in the brain. Despite a massive loss of neurons in the corpus striatum, NO-generating neurons are intact. We recently identified a brain-specific protein that associates with hunti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li XJ,Sharp AH,Li SH,Dawson TM,Snyder SH,Ross CA

更新日期：1996-05-14 00:00:00

abstract：:Mitochondrial dysfunctions cause numerous human disorders. A platform technology based on biodegradable polymers for carrying bioactive molecules to the mitochondrial matrix could be of enormous potential benefit in treating mitochondrial diseases. Here we report a rationally designed mitochondria-targeted polymeric n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marrache S,Dhar S

更新日期：2012-10-02 00:00:00

abstract：:p53, the most commonly mutated gene in human tumors, is believed to play a crucial role in the prevention of cancer by protecting cells from mutation, a theory commonly known as the "Guardian of the Genome" hypothesis. There are two hypotheses as to how this can occur. In the first, p53 protects the genome by retardin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bielas JH,Heddle JA

更新日期：2003-10-28 00:00:00

abstract：:Two independently arising alpha heavy chain mutants have been found to synthesize heavy chains with CH1 deletions of approximately equal extent. Both were isolated from heavy chain-producing variants of the mouse myeloma W3129 and demonstrate that it is possible to arrive at the heavy chain disease phenotype by the pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dackowski W,Morrison SL

更新日期：1981-11-01 00:00:00

abstract：:Voltage gating of hyperpolarization-activated cation (HCN) channels is potentiated by direct binding of cAMP to a cytoplasmic cAMP-sensing domain (CSD). When unliganded, the CSD inhibits hyperpolarization-dependent opening of the HCN channel gate; cAMP binding relieves this autoinhibition so that opening becomes more ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wicks NL,Wong T,Sun J,Madden Z,Young EC

更新日期：2011-01-11 00:00:00

abstract：:Beckwith-Wiedemann syndrome (BWS) involves fetal overgrowth and predisposition to a wide variety of embryonal tumors of childhood. We have previously found that BWS is genetically linked to 11p15 and that this same band shows loss of heterozygosity in the types of tumors to which children with BWS are susceptible. How...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoovers JM,Kalikin LM,Johnson LA,Alders M,Redeker B,Law DJ,Bliek J,Steenman M,Benedict M,Wiegant J,Lengauer C,Taillon-Miller P,Schlessinger D,Edwards MC,Elledge SJ,Ivens A,Westerveld A,Little P,Mannens M,Feinberg AP

更新日期：1995-12-19 00:00:00

abstract：:The mechanisms that regulate insulin secretion were investigated using capacitance measurements of exocytosis in single beta cells maintained in tissue culture. Exocytosis was stimulated by voltage-clamp depolarizations to activate the voltage-dependent Ca2+ channels that mediate Ca2+ influx into the beta cell. Under ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ammälä C,Eliasson L,Bokvist K,Berggren PO,Honkanen RE,Sjöholm A,Rorsman P

更新日期：1994-05-10 00:00:00

abstract：:By using both double-colony hybridization and an in situ immunostaining assay for transformants, 39 cDNA clones (clone p-16 alpha) encoding mouse liver microsomal testosterone 16 alpha-hydroxylase (cytochrome P-450(16) alpha) were isolated from a cDNA library constructed in the cloning vector pUC-9 with poly(A)+ RNA i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harada N,Negishi M

更新日期：1985-04-01 00:00:00

abstract：:Forebrain cholinergic neurons play important roles as striatal local circuit neurons and basal telencephalic projection neurons. The genetic mechanisms that control development of these neurons suggest that most of them are derived from the basal telencephalon where Lhx8, a LIM-homeobox gene, is expressed. Here we rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao Y,Marín O,Hermesz E,Powell A,Flames N,Palkovits M,Rubenstein JL,Westphal H

更新日期：2003-07-22 00:00:00

abstract：:With continued debate over the functional significance of adult neurogenesis, identifying an in vivo correlate of neurogenesis has become an important goal. Here we rely on the coupling between neurogenesis and angiogenesis and test whether MRI measurements of cerebral blood volume (CBV) provide an imaging correlate o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pereira AC,Huddleston DE,Brickman AM,Sosunov AA,Hen R,McKhann GM,Sloan R,Gage FH,Brown TR,Small SA

更新日期：2007-03-27 00:00:00

abstract：:During the developmental process of the Gram-negative soil bacterium Myxococcus xanthus, vegetatively growing rod cells differentiate to ultimately become metabolically quiescent and environmentally resistant myxospores encased within fruiting bodies. This program, initiated by nutrient deprivation, is propagated by b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tzeng L,Singer M

更新日期：2005-10-04 00:00:00

abstract：:The global configuration of individual, surface-adsorbed molecules of the giant muscle protein titin, labeled with rhodamine conjugates, was followed with confocal microscopy. Fluorescence-emission intensity was reduced because of self-quenching caused by the close spacing between rhodamine dye molecules that formed d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grama L,Somogyi B,Kellermayer MS

更新日期：2001-12-04 00:00:00

abstract：:The dansyl-conjugated (Dns) peptides Dns-Pro-Gly-Gly-Gln-Gln-Ile-Val and Dns-Ala-Gln-Gln-Ile-Val, patterned on the N-terminal sequence of fibronectin, were synthesized and used for the transglutaminase (protein-glutamine:amine gamma-glutamyltransferase, EC 2.3.2.13)-directed selective blocking of lens proteins that ot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lorand L,Parameswaran KN,Velasco PT

更新日期：1991-01-01 00:00:00

abstract：:The GroE chaperonins assist substrate protein (SP) folding by cycling through several conformational states. With each cycle the SP is, in turn, captured, unfolded, briefly encapsulated (t1/2 ∼ 1 s), and released by the chaperonin complex. The protein-folding functional form is the US-football-shaped GroEL:GroES2 comp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fei X,Ye X,LaRonde NA,Lorimer GH

更新日期：2014-09-02 00:00:00

abstract：:The importance of dystrophin and its associated proteins in normal muscle function is now well established. Many of these proteins are expressed in nonmuscle tissues, particularly the brain. Here we describe the characterization of beta-dystrobrevin, a dystrophin-related protein that is abundantly expressed in brain a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blake DJ,Nawrotzki R,Loh NY,Górecki DC,Davies KE

更新日期：1998-01-06 00:00:00

abstract：:Genetically engineered mice with targeted disruption of the neuronal nitric oxide synthase (nNOS) gene established the inhibitory role of nitric oxide (NO) in male impulsive aggressive behavior. This was later confirmed by using selective nNOS inhibitors in male wild-type mice. The molecular mechanisms accounting for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chiavegatto S,Dawson VL,Mamounas LA,Koliatsos VE,Dawson TM,Nelson RJ

更新日期：2001-01-30 00:00:00

abstract：:To examine the role of breast cancer stem cells (BCSCs) in metastasis, we generated human-in-mouse breast cancer orthotopic models using patient tumor specimens, labeled with optical reporter fusion genes. These models recapitulate human cancer features not captured with previous models, including spontaneous metastas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu H,Patel MR,Prescher JA,Patsialou A,Qian D,Lin J,Wen S,Chang YF,Bachmann MH,Shimono Y,Dalerba P,Adorno M,Lobo N,Bueno J,Dirbas FM,Goswami S,Somlo G,Condeelis J,Contag CH,Gambhir SS,Clarke MF

更新日期：2010-10-19 00:00:00

abstract：:Clostridium difficile has rapidly emerged as the leading cause of antibiotic-associated diarrheal disease, with the transcontinental spread of various PCR ribotypes, including 001, 017, 027 and 078. However, the genetic basis for the emergence of C. difficile as a human pathogen is unclear. Whole genome sequencing was...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He M,Sebaihia M,Lawley TD,Stabler RA,Dawson LF,Martin MJ,Holt KE,Seth-Smith HM,Quail MA,Rance R,Brooks K,Churcher C,Harris D,Bentley SD,Burrows C,Clark L,Corton C,Murray V,Rose G,Thurston S,van Tonder A,Walker D

更新日期：2010-04-20 00:00:00

abstract：:Variation in the masticatory behavior of hunter-gatherer and agricultural populations is hypothesized to be one of the major forces affecting the form of the human mandible. However, this has yet to be analyzed at a global level. Here, the relationship between global mandibular shape variation and subsistence economy ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： von Cramon-Taubadel N

更新日期：2011-12-06 00:00:00

abstract：:Effective therapies for most solid cancers, especially those that have progressed to metastasis, remain elusive because of inherent and acquired resistance of tumor cells to conventional treatments. Additionally, the effective therapeutic window for many protocols can be very narrow, frequently resulting in toxicity. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lebedeva IV,Washington I,Sarkar D,Clark JA,Fine RL,Dent P,Curiel DT,Turro NJ,Fisher PB

更新日期：2007-02-27 00:00:00

abstract：:The POT1-TPP1 heterodimer, the major telomere-specific single-stranded DNA-binding protein in mammalian cells, protects chromosome ends and contributes to the regulation of telomerase. The recent discovery of telomeric RNA raises the question of how POT1 faithfully binds telomeric ssDNA and avoids illicit RNA binding ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nandakumar J,Podell ER,Cech TR

更新日期：2010-01-12 00:00:00

abstract：:Electron micrographs of replicating lambda DNA molecules, during the period of progeny-particle DNA formation, show single-tailed circular structures. The tails are, predominantly, shorter than one viral genome. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kiger JA Jr,Sinsheimer RL

更新日期：1971-01-01 00:00:00

abstract：:Spontaneous reciprocal mitotic recombination in the yeast Saccharomyces cerevisiae, associated with heteroallelic recombination, occurs almost exclusively at the two-strand stage and involves recombination of unduplicated chromosomes (i.e., during G1) or the unduplicated regions of chromosomes during the S phase of mi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Esposito MS

更新日期：1978-09-01 00:00:00

abstract：:A stable complex between pentaammineruthenium(III) and histidine-33 in horse heart ferricytochrome c is formed in the reaction between aquopentaammineruthenium(II) and the protein at pH 7. HPLC of the tryptic hydrolysate of the modified protein was employed to identify the pentaammineruthenium binding site. Spectrosco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yocom KM,Shelton JB,Shelton JR,Schroeder WA,Worosila G,Isied SS,Bordignon E,Gray HB

更新日期：1982-11-01 00:00:00

abstract：:The S-M checkpoint delays mitosis until DNA replication is complete; cells defective in this checkpoint lose viability when DNA replication is inhibited. This inviability can be suppressed in fission yeast by overexpression of Cid1 or the related protein Cid13. Fission yeast contain six cid1/cid13-like genes, whereas ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Read RL,Martinho RG,Wang SW,Carr AM,Norbury CJ

更新日期：2002-09-17 00:00:00