High-frequency expression of a conserved kappa light-chain variable-region gene in chronic lymphocytic leukemia.

abstract：:Cytotactin is an extracellular matrix protein that is dynamically and transiently expressed in a place-dependent fashion during development by glial cells, fibroblasts, and several other cell types. In the present study, the effects of cytotactin on cell proliferation were examined in fibroblastic cells in culture. NI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crossin KL

更新日期：1991-12-15 00:00:00

abstract：:Oligosaccharyltransferase transfers an oligosaccharide chain to the asparagine residues in proteins. The archaeal and eubacterial oligosaccharyltransferases are single subunit membrane enzymes, referred to as "AglB" (archaeal glycosylation B) and "PglB" (protein glycosylation B), respectively. Only one crystal structu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matsumoto S,Shimada A,Nyirenda J,Igura M,Kawano Y,Kohda D

更新日期：2013-10-29 00:00:00

abstract：:Plant metabolites are crucial for both plant life and human nutrition. Despite recent advance in metabolomics, the genetic control of plant metabolome remains largely unknown. Here, we performed a genetic analysis of the rice metabolome that provided over 2,800 highly resolved metabolic quantitative trait loci for 900...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gong L,Chen W,Gao Y,Liu X,Zhang H,Xu C,Yu S,Zhang Q,Luo J

更新日期：2013-12-10 00:00:00

abstract：:Methods to accurately predict potential drug target mutations in response to early-stage leads could drive the design of more resilient first generation drug candidates. In this study, a structure-based protein design algorithm (K* in the OSPREY suite) was used to prospectively identify single-nucleotide polymorphisms...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reeve SM,Gainza P,Frey KM,Georgiev I,Donald BR,Anderson AC

更新日期：2015-01-20 00:00:00

abstract：:Mutations of MECP2 (Methyl-CpG Binding Protein 2) cause Rett syndrome. As a chromatin-associated multifunctional protein, how MeCP2 integrates external signals and regulates neuronal function remain unclear. Although neuronal activity-induced phosphorylation of MeCP2 at serine 421 (S421) has been reported, the full sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tao J,Hu K,Chang Q,Wu H,Sherman NE,Martinowich K,Klose RJ,Schanen C,Jaenisch R,Wang W,Sun YE

更新日期：2009-03-24 00:00:00

abstract：:Chlorpromazine (3 x 10(-4)M) prevents the stimulation of adenyl cyclase activity in thyroid membranes produced by thyrotropin and prostaglandin, ACTH stimulation of adenyl cyclase in adrenal tissue, and glucagon- and epinephrine-stimulation of adenyl cyclase activity in liver. Baseline activity is unaffected. Parathyr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wolff J,Jones AB

更新日期：1970-02-01 00:00:00

abstract：:Low passage Fischer rat embryo cultures, which are normally very resistant to transformation by 3-methylcholanthrene but are highly susceptible when chronically infected with the Rauscher murine leukemia virus, were completely protected from transformation by methylcholanthrene when treated with neutralizing antibody ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Price PJ,Bellew TM,King MP,Freeman AE,Gilden RV,Huebner RJ

更新日期：1976-01-01 00:00:00

abstract：:The importance of Gly-93 and Gly-94 in transmembrane segment M1 of the Na+,K+-ATPase for interaction with Na+ and K+ was demonstrated by functional analysis of mutants Gly-93-Ala and Gly-94-Ala. In the crystal structures of the Ca2+-ATPase, the corresponding residues, Asp-59 and Leu-60, are located exactly where M1 be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Einholm AP,Toustrup-Jensen M,Andersen JP,Vilsen B

更新日期：2005-08-09 00:00:00

abstract：:The question was addressed whether the risk of cancer of an individual in a heterogeneous population can be predicted on the basis of measurable biochemical and biological variables postulated to be associated with the process of chemical carcinogenesis. Using the skin tumor model with outbred male NMRI mice, the late...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fischer WH,Lutz WK

更新日期：1995-06-20 00:00:00

abstract：:Streptococcus groups A and B cause serious infections, including early onset sepsis and meningitis in newborns. Rib domain-containing surface proteins are found associated with invasive strains and elicit protective immunity in animal models. Yet, despite their apparent importance in infection, the structure of the Ri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Whelan F,Lafita A,Griffiths SC,Cooper REM,Whittingham JL,Turkenburg JP,Manfield IW,St John AN,Paci E,Bateman A,Potts JR

更新日期：2019-12-09 00:00:00

abstract：:Because neurogenesis persists in the adult mammalian brain and can be regulated by physiological and pathological events, we investigated its possible involvement in the brain's response to focal cerebral ischemia. Ischemia was induced by occlusion of the middle cerebral artery in the rat for 90 min, and proliferating...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin K,Minami M,Lan JQ,Mao XO,Batteur S,Simon RP,Greenberg DA

更新日期：2001-04-10 00:00:00

abstract：:We present here direct evidence for the preservation of a transcriptional initiation sequence in a eukaryotic rRNA precursor: the 5'-end group for precursor to 17S rRNA (p17S RNA) from Dictyostelium discoideum is identified as the triphosphate residue pppA-. We also show that mature 5S RNA form Dictyostelium bears a d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Batts-Young B,Lodish HF

更新日期：1978-02-01 00:00:00

abstract：:rap1/Krev-1 is a p21ras-related GTP-binding protein that has been implicated in the reversion of the ras-transformed cell phenotype. We have identified a GTPase-activating protein (GAP) specific for rap in plasma membranes isolated from differentiated HL60 cells. The rap GAP activity remained quantitatively associated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polakis PG,Rubinfeld B,Evans T,McCormick F

更新日期：1991-01-01 00:00:00

abstract：:The cytoskeleton provides structural integrity to cells and serves as a key component in mechanotransduction. Tensins are thought to provide a force-bearing linkage between integrins and the actin cytoskeleton; yet, direct evidence of tensin's role in mechanotransduction is lacking. We here report that local force app...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheah JS,Jacobs KA,Heinrich V,Lo SH,Yamada S

更新日期：2019-10-01 00:00:00

abstract：:Systemic amyloid A (AA) amyloidosis is a serious complication of chronic inflammation. Serum AA protein (SAA), an acute phase plasma protein, is deposited extracellularly as insoluble amyloid fibrils that damage tissue structure and function. Clinical AA amyloidosis is typically preceded by many years of active inflam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simons JP,Al-Shawi R,Ellmerich S,Speck I,Aslam S,Hutchinson WL,Mangione PP,Disterer P,Gilbertson JA,Hunt T,Millar DJ,Minogue S,Bodin K,Pepys MB,Hawkins PN

更新日期：2013-10-01 00:00:00

abstract：:At meiotic prophase, chromatin loops around a proteinaceous core, with the sizes of these loops varying between species. Comparison of the morphology of sequence-related inserts at different sites in transgenic mice demonstrates that loop size also varies with chromosomal geography. Similarly, chromatin loop lengths d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heng HH,Chamberlain JW,Shi XM,Spyropoulos B,Tsui LC,Moens PB

更新日期：1996-04-02 00:00:00

abstract：:Blindsight is a phenomenon in which human patients with damage to striate cortex deny any visual sensation in the resultant visual field defect but can nonetheless detect and localize stimuli when persuaded to guess. Although monkeys with striate lesions have also been shown to exhibit some residual vision, it is not ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moore T,Rodman HR,Repp AB,Gross CG

更新日期：1995-08-29 00:00:00

abstract：:The action of calmodulin (CaM) on target proteins is important for a variety of cellular functions. We demonstrate here, however, that the presence of a CaM-binding site on a protein does not necessarily imply a functional effect. The alpha-subunit of the cGMP-gated cation channel of human retinal cones has a CaM-bind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grunwald ME,Zhong H,Lai J,Yau KW

更新日期：1999-11-09 00:00:00

abstract：:The covalent linkage of supramolecular monomers provides a powerful strategy for constructing dynamic polymeric materials whose properties can be readily tuned either by the selection of monomers or the choice of functional linkers. In this strategy, the stabilities of the supramolecular monomers and the reactions use...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang M,Li S,Yan X,Zhou Z,Saha ML,Wang YC,Stang PJ

更新日期：2016-10-04 00:00:00

abstract：:Virus-specific or group-specific antibody probes to potyviruses can be produced by targeting the immune response to the virus-specific, N-terminal region of the capsid protein (29-95 amino acids depending on the virus) or to the conserved core region (216 amino acids) of the capsid protein, respectively. Immunochemica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shukla DD,Tribbick G,Mason TJ,Hewish DR,Geysen HM,Ward CW

更新日期：1989-11-01 00:00:00

abstract：:Electron spectroscopic imaging, a new technique that permits the quantitative detection of the spatial distributions of atomic elements at high resolution, has been applied to the epiphyseal zone of hypertrophy in the mouse for the visualization of calcium, phosphorus, and sulfur. Longitudinally sectioned epiphyseal g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arsenault AL,Ottensmeyer FP

更新日期：1983-03-01 00:00:00

abstract：:The number of large intramembrane particles associated with sites of synaptic vesicle release at the squid giant synapse was determined and compared to the average maximal presynaptic calcium current in order to derive an estimate of the conductance each particle would have if it were a calcium channel. This value, 0....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pumplin DW,Reese TS,Llinás R

更新日期：1981-11-01 00:00:00

abstract：:Understanding the pathways that control epithelial carcinogenesis is vital to the development of effective treatments. The Polycomb group family member Bmi1 is overexpressed in numerous epithelial tumors, but its role in their development has not been established. We now show a key role for Bmi1 in lung adenocarcinoma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dovey JS,Zacharek SJ,Kim CF,Lees JA

更新日期：2008-08-19 00:00:00

abstract：:The "protein only" hypothesis states that the infectious agent causing transmissible spongiform encephalopathies is a conformational isomer of PrP, a host protein predominantly expressed in brain, and is strongly supported by many lines of evidence. Prion diseases are so far unique among conformational diseases in tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weissmann C,Enari M,Klöhn PC,Rossi D,Flechsig E

更新日期：2002-12-10 00:00:00

abstract：:Motifs of neural circuitry seem surprisingly conserved over different areas of neocortex or of paleocortex, while performing quite different sensory processing tasks. This apparent paradox may be resolved by the fact that seemingly different problems in sensory information processing are related by transformations (ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hopfield JJ

更新日期：1996-12-24 00:00:00

abstract：:Superhard metals are of interest as possible replacements with enhanced properties over the metal carbides commonly used in cutting, drilling, and wear-resistant tooling. Of the superhard metals, the highest boride of tungsten--often referred to as WB4 and sometimes as W(1-x)B3--is one of the most promising candidates...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lech AT,Turner CL,Mohammadi R,Tolbert SH,Kaner RB

更新日期：2015-03-17 00:00:00

abstract：:Murine mastocytoma cells treated with calcium ionophore A23187 produced a slow-reacting substance (SRS) that caused guinea pig ileum to contract. The response was reversed by the SRS antagonist FPL 55712. On the basis of isotope incorporation experiments, spectroscopy, and chemical degradations, the SRS was identified...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murphy RC,Hammarström S,Samuelsson B

更新日期：1979-09-01 00:00:00

abstract：:A synthetic polyribonucleotide, poly(U5,G), was used to study the codon specificity of wild-type and UGA suppressor tRNATrp from Escherichia coli. Phe (UUU) incorporation directed by this synthetic messenger is reduced somewhat by omission from the incubation mixtures of Val (GUU), Leu (UUG), or Cys (UGU). In contrast...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buckingham RH,Kurland CG

更新日期：1977-12-01 00:00:00

abstract：:Activity-dependent means of altering calcium (Ca(2)(+)) influx are assumed to be of great physiological consequence, although definitive tests of this assumption have only begun to emerge. Facilitation and inactivation offer two opposing, activity-dependent means of altering Ca(2+) influx via cardiac Ca(v)1.2 calcium ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blaich A,Welling A,Fischer S,Wegener JW,Köstner K,Hofmann F,Moosmang S

更新日期：2010-06-01 00:00:00

abstract：:Protein acetylation, especially histone acetylation, is the subject of both research and clinical investigation. At least four small-molecule histone deacetylase inhibitors are currently in clinical trials for the treatment of cancer. These and other inhibitors also affect microtubule acetylation. A multidimensional, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haggarty SJ,Koeller KM,Wong JC,Grozinger CM,Schreiber SL

更新日期：2003-04-15 00:00:00