Elevated mutagenesis and decreased DNA repair at a transgene are associated with proliferation but not apoptosis in p53-deficient cells.

abstract：:We present the complete nucleotide and deduced amino acid sequences of a mouse epidermal keratin subunit of 60,000 Da. The keratin possesses a central alpha-helical domain of four tracts (termed 1A, 1B, 2A, and 2B) that can form coiled-coils, interspersed by short linker sequences, and has non-alpha-helical terminal d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steinert PM,Parry DA,Racoosin EL,Idler WW,Steven AC,Trus BL,Roop DR

更新日期：1984-09-01 00:00:00

abstract：:Cigarette smoke is the major cause of lung cancer, the leading cause of cancer death, and of chronic obstructive pulmonary disease, the fourth leading cause of death in the United States. Using high-density gene expression arrays, we describe genes that are normally expressed in a subset of human airway epithelial cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spira A,Beane J,Shah V,Liu G,Schembri F,Yang X,Palma J,Brody JS

更新日期：2004-07-06 00:00:00

abstract：:T-helper 17 (Th17) cells have important functions in adaptor immunity and have also been implicated in inflammatory disorders. The bromodomain and extraterminal domain (BET) family proteins regulate gene transcription during lineage-specific differentiation of naïve CD4+ T cells to produce mature T-helper cells. Inhib...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung K,Lu G,Sharma R,Vincek A,Zhang R,Plotnikov AN,Zhang F,Zhang Q,Ju Y,Hu Y,Zhao L,Han X,Meslamani J,Xu F,Jaganathan A,Shen T,Zhu H,Rusinova E,Zeng L,Zhou J,Yang J,Peng L,Ohlmeyer M,Walsh MJ,Zhang DY,

更新日期：2017-03-14 00:00:00

abstract：:Type C retroviruses are endogenous in most vertebrate species. These viruses generally are of low pathogenicity in their natural hosts. Variants that contain cell-derived transforming genes have been isolated infrequently in the past upon continued passage in vivo. We report here a procedure that allows the isolation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rapp UR,Todaro GJ

更新日期：1980-01-01 00:00:00

abstract：:There is no theoretical limit in using molecular networks to harvest diffusive sun photons on large areas and funnel them onto much smaller areas of highly efficient but also precious energy-converting materials. The most effective concept reported so far is based on a pool of randomly oriented, light-harvesting donor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Willich MM,Wegener L,Vornweg J,Hohgardt M,Nowak J,Wolter M,Jacob CR,Walla PJ

更新日期：2020-12-29 00:00:00

abstract：:In eukaryotic photosynthetic organisms, the conversion of solar into chemical energy occurs in thylakoid membranes in the chloroplast. How thylakoid membranes are formed and maintained is poorly understood. However, previous observations of vesicles adjacent to the stromal side of the inner envelope membrane of the ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hertle AP,García-Cerdán JG,Armbruster U,Shih R,Lee JJ,Wong W,Niyogi KK

更新日期：2020-04-21 00:00:00

abstract：:Extracts of insect cells infected with baculoviruses recombinant for the herpes simplex virus 1 (HSV-1)-encoded enzymes that are required for its replication can promote the rolling circle replication of circular plasmid templates. Replication is independent of a HSV-1 origin of replication (oris) or the HSV-1 origin ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skaliter R,Lehman IR

更新日期：1994-10-25 00:00:00

abstract：:Most class I MHC ligands are generated from the vast majority of cellular proteins by proteolysis within the ubiquitin-proteasome pathway and are presented on the cell surface by MHC class I molecules. Here, we present the crystallographic analysis of yeast 20S proteasome in complex with the inhibitor homobelactosin C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Groll M,Larionov OV,Huber R,de Meijere A

更新日期：2006-03-21 00:00:00

abstract：:Both mammals and birds use the interaural time difference (ITD) for localization of sound in the horizontal plane. They may localize either real or phantom sound sources, when the signal consists of a narrow frequency band. This ambiguity does not occur with broadband signals. A plot of impulse rates or amplitude of e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peña JL,Konishi M

更新日期：2000-10-24 00:00:00

abstract：:Production of mature erythrocytes requires multiple growth factors, but we do not know how their actions are coordinated. Here we show that erythroid progenitors from erythropoietin receptor (Epo-R)-/- fetal livers, infected in vitro with a retrovirus expressing the wild-type Epo-R, require addition of both Epo and st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu H,Klingmüller U,Acurio A,Hsiao JG,Lodish HF

更新日期：1997-03-04 00:00:00

abstract：:Plant-made vaccines have been the subject of intense interest because they can be produced economically in large scale without the use of animal-derived components. Plant-made therapeutic vaccines against challenging chronic diseases, such as cancer, have received little research attention, and no previous human clini...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCormick AA,Reddy S,Reinl SJ,Cameron TI,Czerwinkski DK,Vojdani F,Hanley KM,Garger SJ,White EL,Novak J,Barrett J,Holtz RB,Tusé D,Levy R

更新日期：2008-07-22 00:00:00

abstract：:The Arctic Ocean already experiences areas of low pH and high CO2, and it is expected to be most rapidly affected by future ocean acidification (OA). Copepods comprise the dominant Arctic zooplankton; hence, their responses to OA have important implications for Arctic ecosystems, yet there is little data on their curr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lewis CN,Brown KA,Edwards LA,Cooper G,Findlay HS

更新日期：2013-12-17 00:00:00

abstract：:Burkitt's lymphomas, linked by previous studies with the DNA-containing Epstein-Barr virus, contain an RNA related in sequence to that of Rauscher leukemia virus. The present study establishes that the viral-related RNA found in Burkitt's tumors is a 70S component encapsulated with RNA-instructed DNA polymerase in a p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kufe D,Magrath IT,Ziegler JL,Spiegelman S

更新日期：1973-03-01 00:00:00

abstract：:We present a method for studying multiple retroviral integration events into a small DNA target in vivo. Episomal simian virus 40 (SV40) genomes established by infection of CV-1 cells served as integration targets during subsequent infection with murine leukemia virus (MLV). Using a PCR-based assay for the abundance a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pryciak PM,Müller HP,Varmus HE

更新日期：1992-10-01 00:00:00

abstract：:In vitro translation of Rous sarcoma virus (RSV) virion RNA in the messenger-dependent reticulocyte lysate system yielded polypeptides that were not synthesized by translation of RNA from a transformation-defective deletion mutant of RSV. These RSV-specific products migrated on sodium dodecyl sulfate/polyacrylamide ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beemon K,Hunter T

更新日期：1977-08-01 00:00:00

abstract：:The p53 protein is an attractive target for immunotherapy, because mutations in the p53 gene are the most common genetic alterations found in human tumors. These mutations result in high levels of p53 protein in the tumor cell, whereas the expression level of wild-type p53 in nonmalignant tissue is usually much lower....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roth J,Dittmer D,Rea D,Tartaglia J,Paoletti E,Levine AJ

更新日期：1996-05-14 00:00:00

abstract：:In biosynthesis of the pancreatic cancer drug streptozotocin, the tridomain nonheme-iron oxygenase SznF hydroxylates Nδ and Nω' of Nω-methyl-l-arginine before oxidatively rearranging the triply modified guanidine to the N-methyl-N-nitrosourea pharmacophore. A previously published structure visualized the monoiron cofa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McBride MJ,Pope SR,Hu K,Okafor CD,Balskus EP,Bollinger JM Jr,Boal AK

更新日期：2021-01-26 00:00:00

abstract：:Human skeletal muscle is composed of various muscle fiber types. We hypothesized that differences in metabolism between fiber types could be detected noninvasively with 31P nuclear magnetic resonance spectroscopy during maximal exercise. This assumes that during maximal exercise all fiber types are recruited and all v...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vandenborne K,McCully K,Kakihira H,Prammer M,Bolinger L,Detre JA,De Meirlier K,Walter G,Chance B,Leigh JS

更新日期：1991-07-01 00:00:00

abstract：:The Eemian (last interglacial, 130-115 ka) was likely the warmest of all interglacials of the last 800 ka, with summer Arctic temperatures 3-5 °C above present. Here, we present improved Eemian climate records from central Greenland, reconstructed from the base of the Greenland Ice Sheet Project 2 (GISP2) ice core. Ou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yau AM,Bender ML,Robinson A,Brook EJ

更新日期：2016-08-30 00:00:00

abstract：:Tropical diversity has generally exceeded temperate diversity in the present and at points in the past, but whether measured differences have remained relatively constant through time has been unknown. Here we examine tropical vs. temperate diversities from the Neogene to Recent using the within-habitat diversity meas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buzas MA,Collins LS,Culver SJ

更新日期：2002-06-11 00:00:00

abstract：:Class I phosphoinositide 3-kinase contains four isoforms of the catalytic subunit, p110alpha, -beta, -gamma, and -delta. At physiological levels of expression, the wild-type p110alpha isoform lacks oncogenic potential, but gain-of-function mutations and overexpression of p110alpha are correlated with oncogenicity. The...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kang S,Denley A,Vanhaesebroeck B,Vogt PK

更新日期：2006-01-31 00:00:00

abstract：:Terminal oligopyrimidine (TOP) motifs are sequences at the 5' ends of mRNAs that link their translation to the mTOR Complex 1 (mTORC1) nutrient-sensing signaling pathway. They are commonly regarded as discrete elements that reside on ∼100 mRNAs that mostly encode translation factors. However, the full spectrum of TOP ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Philippe L,van den Elzen AMG,Watson MJ,Thoreen CC

更新日期：2020-03-10 00:00:00

abstract：:Current structural genomics projects are yielding structures for proteins whose functions are unknown. Accordingly, there is a pressing requirement for computational methods for function prediction. Here we present PHUNCTIONER, an automatic method for structure-based function prediction using automatically extracted f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pazos F,Sternberg MJ

更新日期：2004-10-12 00:00:00

abstract：:Alzheimer's disease (AD) and other neurodegenerative disorders are associated with the cytoplasmic aggregation of microtubule-associated protein tau. Recent evidence supports transcellular transfer of tau misfolding (seeding) as the mechanism of spread within an affected brain, a process reminiscent of viral infection...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McEwan WA,Falcon B,Vaysburd M,Clift D,Oblak AL,Ghetti B,Goedert M,James LC

更新日期：2017-01-17 00:00:00

abstract：:A brilliant, coarsely granular nuclear antigen was detected by anti-complement immunofluorescence in the nuclei of acute myeloid leukemia myeloblasts. Designated as LANA (leukemia-associated nuclear antigen), the reactivity differs from that of the Epstein-Barr-virus-determined nuclear antigen (EBNA) in immunological ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klein G,Steiner M,Wiener F,Klein E

更新日期：1974-03-01 00:00:00

abstract：:In a field study, we show that a young song sparrow (i) selects his songs from three or four older birds who have neighboring territories, (ii) preferentially learns song types that these tutor neighbors share, and (iii) ultimately sets up his territory next to, or replaces, one of these tutor neighbors. The consequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beecher MD,Campbell SE,Stoddard PK

更新日期：1994-02-15 00:00:00

abstract：:A mouse cDNA clone has been isolated that contains the complete coding region of a protein highly homologous to the delta subunit of the Torpedo acetylcholine receptor (AcChoR). The cDNA library was constructed in the vector lambda 10 from membrane-associated poly(A)+ RNA from BC3H-1 mouse cells. Surprisingly, the del...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： LaPolla RJ,Mayne KM,Davidson N

更新日期：1984-12-01 00:00:00

abstract：:The heterogeneous RNA of the HeLa cell nucleus contains short internal poly(A) sequences which, in contrast to the longer poly(A) sequences at the 3' ends, are not found in messenger RNA of the cytoplasm. A distinct origin for each of these homologous sequences is evident when the effects of actinomycin D and 3'-deoxy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakazato H,Edmonds M,Kopp DW

更新日期：1974-01-01 00:00:00

abstract：:Saccharopolyspora erythraea makes erythromycin, an antibiotic commonly used in human medicine. Unusually, the erythromycin biosynthetic (ery) cluster lacks a pathway-specific regulatory gene. We isolated a transcriptional regulator of the ery biosynthetic genes from S. erythraea and found that this protein appears to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chng C,Lum AM,Vroom JA,Kao CM

更新日期：2008-08-12 00:00:00

abstract：:For many years, the Neanderthals have been recognized as a distinctive extinct hominid group that occupied Europe and western Asia between about 200,000 and 30,000 years ago. It is still debated, however, whether these hominids belong in their own species, Homo neanderthalensis, or represent an extinct variant of Homo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwartz JH,Tattersall I

更新日期：1996-10-01 00:00:00