Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation.

abstract：:Sinuous patterns traced by fluid flows are a ubiquitous feature of physical landscapes on Earth, Mars, the volcanic floodplains of the Moon and Venus, and other planetary bodies. Typically discussed as a consequence of migration processes in meandering rivers, sinuosity is also expressed in channel types that show lit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lazarus ED,Constantine JA

更新日期：2013-05-21 00:00:00

abstract：:Intrinsic horizontal axon collaterals in the striate cortex of adult cats specifically link columns having the same preferred orientation; consequently, retrograde tracer injections result in intrinsic labeling that is sharply clustered. We have previously shown that the normal development of this circuitry involves t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Callaway EM,Katz LC

更新日期：1991-02-01 00:00:00

abstract：:The electron spin resonance spectrum of the triplet excited state of Rhodopseudomonas spheroides R-26 reaction centers has been studied after excitation with the polarized narrow-bandwidth output of a tunable dye laser from 520 to 670 nm. A theory is developed relating experimental observables to the angles between th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boxer SG,Roelofs MG

更新日期：1979-11-01 00:00:00

abstract：:Prior incubation of quiescent cultures of Swiss 3T3 cells with vasopressin leads to loss of mitogenic stimulation on its subsequent addition in the presence of a synergistic growth factor. This desensitization is selective for vasopressin, requires prolonged incubation (half-maximal desensitization after 12 hr of trea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collins MK,Rozengurt E

更新日期：1983-04-01 00:00:00

abstract：:Activation-induced cytidine deaminase (AID) is essential to class-switch recombination (CSR) and somatic hypermutation (SHM) in both V region SHM and S region SHM (s-SHM). Uracil DNA glycosylase (UNG), a member of the base excision repair (BER) complex, is required for CSR. Strikingly, however, UNG deficiency causes a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yousif AS,Stanlie A,Mondal S,Honjo T,Begum NA

更新日期：2014-03-18 00:00:00

abstract：:The detailed molecular dynamics of an actual bond-breaking event in a fluctuating enzyme substrate complex is simulated. The method developed allows one to explore what type of fluctuations are involved in enzymatic reactions and to evaluate entropic contributions to enzyme catalysis. The fluctuations of the enzyme el...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warshel A

更新日期：1984-01-01 00:00:00

abstract：:Reactive oxygen species (ROS)-mediated oxidative stress and DNA damage have recently been recognized as contributing to the efficacy of most bactericidal antibiotics, irrespective of their primary macromolecular targets. Inhibitors of targets involved in both combating oxidative stress as well as being required for in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tiwari S,van Tonder AJ,Vilchèze C,Mendes V,Thomas SE,Malek A,Chen B,Chen M,Kim J,Blundell TL,Parkhill J,Weinrick B,Berney M,Jacobs WR Jr

更新日期：2018-09-25 00:00:00

abstract：:The serine proteases sequentially activated to form a fibrin clot are inhibited primarily by members of the serpin family, which use a unique beta-sheet expansion mechanism to trap and destroy their targets. Since the discovery that serpins were a family of serine protease inhibitors there has been controversy as to t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baglin TP,Carrell RW,Church FC,Esmon CT,Huntington JA

更新日期：2002-08-20 00:00:00

abstract：:Pulmonary pathologies including adult respiratory distress syndrome are characterized by disruption of pulmonary integrity and edema compromising respiratory function. Sphingosine 1-phosphate (S1P) is a lipid mediator synthesized and/or stored in mast cells, platelets, and epithelial cells, with production up-regulate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gon Y,Wood MR,Kiosses WB,Jo E,Sanna MG,Chun J,Rosen H

更新日期：2005-06-28 00:00:00

abstract：:The fluorescence of the supposedly buried tryptophan in ribonuclease T1 has been found to be collisionally quenched by acrylamide with a rate constant of 3 X 10(8) M--1 sec--1. Only a slight decrease in the quenching rate is observed upon a 5-fold increase in the viscosity of the solution. For this to be the case, the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eftink MR,Ghiron CA

更新日期：1975-09-01 00:00:00

abstract：:The conjugal transmission of plasmid ColE1 and its derivatives can lead to recA-independent recombination. The recombination is not observed during vegetative growth and takes place specifically between the sequences that are thought to represent the transfer origin of ColE1. This provides genetic evidence for breakag...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warren GJ,Clark AJ

更新日期：1980-11-01 00:00:00

abstract：:Bovine milk lipoprotein lipase was subjected to amino acid sequence analysis. The first 19 amino-terminal residues were Asp-Arg-Ile-Thr-Gly-Gly-Lys-Asp-Phe-Arg-Asp-Ile-Glu-Ser-Lys-Phe-Ala-Leu- Arg. In addition, reversed-phase high-performance liquid chromatography of a tryptic digest of reduced and alkylated lipase re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ben-Avram CM,Ben-Zeev O,Lee TD,Haaga K,Shively JE,Goers J,Pedersen ME,Reeve JR Jr,Schotz MC

更新日期：1986-06-01 00:00:00

abstract：:The Ser52Pro variant of transthyretin (TTR) produces aggressive, highly penetrant, autosomal-dominant systemic amyloidosis in persons heterozygous for the causative mutation. Together with a minor quantity of full-length wild-type and variant TTR, the main component of the ex vivo fibrils was the residue 49-127 fragme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mangione PP,Porcari R,Gillmore JD,Pucci P,Monti M,Porcari M,Giorgetti S,Marchese L,Raimondi S,Serpell LC,Chen W,Relini A,Marcoux J,Clatworthy IR,Taylor GW,Tennent GA,Robinson CV,Hawkins PN,Stoppini M,Wood SP,Pepys

更新日期：2014-01-28 00:00:00

abstract：:Isolated developing plastids from greening cucumber cotyledons or from photoperiodically grown pea seedlings incorporated (14)C-labeled 5-aminolevulinic acid (ALA) into chlorophyll (Chl). Incorporation was light dependent, enhanced by S-adenosylmethionine, and linear for 1 hr. The in vitro rate of Chl synthesis from A...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhaya D,Castelfranco PA

更新日期：1985-08-01 00:00:00

abstract：:Translational initiation factor 2 (IF2) is a guanine nucleotide-binding protein that can bind guanosine 3',5'-(bis) diphosphate (ppGpp), an alarmone involved in stringent response in bacteria. In cells growing under optimal conditions, the GTP concentration is very high, and that of ppGpp very low. However, under stre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milon P,Tischenko E,Tomsic J,Caserta E,Folkers G,La Teana A,Rodnina MV,Pon CL,Boelens R,Gualerzi CO

更新日期：2006-09-19 00:00:00

abstract：:Amide linkages are among the most important chemical bonds in living systems, constituting the connections between amino acids in peptides and proteins. We demonstrate the controlled formation of amide bonds between amino acids or peptides in the gas phase using ion/ion reactions in a mass spectrometer. Individual ami...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McGee WM,McLuckey SA

更新日期：2014-01-28 00:00:00

abstract：:The Fas/APO-1 cytotoxic pathway plays an important role in the regulation of peripheral immunity. Recent evidence indicates that this regulatory function operates through deletion of activated T and B lymphocytes by CD4+ T cells expressing the Fas ligand. Because macrophages play a key role in peripheral immunity, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ashany D,Song X,Lacy E,Nikolic-Zugic J,Friedman SM,Elkon KB

更新日期：1995-11-21 00:00:00

abstract：:The major auxin-binding protein in maize membranes is thought to function as a physiological receptor. From earlier information, including the use of site-directed irreversible inhibitors, several of the amino acids likely to form part of the active auxin-binding site were provisionally assigned. Inspection of the ami...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Venis MA,Napier RM,Barbier-Brygoo H,Maurel C,Perrot-Rechenmann C,Guern J

更新日期：1992-08-01 00:00:00

abstract：:Five different selectively deuterated analogs of staphylococcal nuclease (Foggi) were prepared having all but a selected few hydrogen atoms in the enzyme molecule replaced by deuterium. The (1)H-NMR spectra of these analogs are extremely simplified, since they consist of lines arising only from the remaining protonate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Putter I,Barreto A,Markley JL,Jardetzky O

更新日期：1969-12-01 00:00:00

abstract：:The techniques of in vivo magnetic resonance (MR) imaging and spectroscopy have been established over the past two decades. Recent applications of these methods to study human brain function have become a rapidly growing area of research. The development of methods using standard MR contrast agents within the cerebral...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shulman RG,Blamire AM,Rothman DL,McCarthy G

更新日期：1993-04-15 00:00:00

abstract：:Tissue cultures of Actinidia kolomikta can be maintained as callus through repeated passages on a nutrient medium devoid of cytokinin but containing inorganic nutrients, sucrose, and other basal organics plus auxin. Under these conditions, actively growing callus contained 2 and 0.5 nmol of the cytokinins zeatin [io(6...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Einset JW

更新日期：1986-02-01 00:00:00

abstract：:The subcellular localization of cathepsin B activity (EC 3.4.22.1) in three murine melanomas of increasing metastatic potential (Cloudman less than B16-F1 less than B16 amelanotic) was determined. Cathepsin B activity was localized in the heavy mitochondrial fraction of normal murine liver but in the light mitochondri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sloane BF,Rozhin J,Johnson K,Taylor H,Crissman JD,Honn KV

更新日期：1986-04-01 00:00:00

abstract：:Stat3 protein has an important role in oncogenesis and is a promising anticancer target. Indirubin, the active component of a traditional Chinese herbal medicine, has been shown previously to inhibit cyclin-dependent kinases, resulting in cell cycle arrest. Here, we show that the indirubin derivatives E564, E728, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nam S,Buettner R,Turkson J,Kim D,Cheng JQ,Muehlbeyer S,Hippe F,Vatter S,Merz KH,Eisenbrand G,Jove R

更新日期：2005-04-26 00:00:00

abstract：:We have isolated several lines of rat embryo cells transformed by simian virus 40. All these lines are fully transformed with regard to saturation density and serum sensitivity, but they differ greatly in their anchorage dependence, as assayed by efficiency of plating in methyl cellulose suspension. This set of lines ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pollack R,Risser R,Conlon S,Rifkin D

更新日期：1974-12-01 00:00:00

abstract：:The Ca(2+)-binding protein calbindin D28k (CB) is vital for the normal function of the central nervous system but its specific functional role is largely unclear. CB is typically described as a mobile Ca(2+)buffer that shapes the spatiotemporal extent of cellular Ca(2+)signals. Recent biochemical data, however, indica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmidt H,Schwaller B,Eilers J

更新日期：2005-04-19 00:00:00

abstract：:Interaction of the estrogen receptor/ligand complex with a DNA estrogen response element is known to regulate gene transcription. In turn, specific conformations of the receptor-ligand complex have been postulated to influence unique subsets of estrogen-responsive genes resulting in differential modulation and, ultima...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grese TA,Sluka JP,Bryant HU,Cullinan GJ,Glasebrook AL,Jones CD,Matsumoto K,Palkowitz AD,Sato M,Termine JD,Winter MA,Yang NN,Dodge JA

更新日期：1997-12-09 00:00:00

abstract：:We have measured the angle-resolved transverse resistivity (ARTR), a sensitive indicator of electronic anisotropy, in high-quality thin films of the unconventional superconductor Sr2RuO4 grown on various substrates. The ARTR signal, heralding the electronic nematicity or a large nematic susceptibility, is present and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu J,Nair HP,Bollinger AT,He X,Robinson I,Schreiber NJ,Shen KM,Schlom DG,Božović I

更新日期：2020-05-19 00:00:00

abstract：:High-resolution magnetic resonance microscopy (MRM) was used to determine regional brain volumetric changes in a mouse model of Alzheimer's disease. These transgenic (Tg) mice overexpress human mutant amyloid precursor protein (APP) V717F under control of platelet-derived growth factor promoter (PDAPP mice), and corti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Redwine JM,Kosofsky B,Jacobs RE,Games D,Reilly JF,Morrison JH,Young WG,Bloom FE

更新日期：2003-02-04 00:00:00

abstract：:p38 mitogen-activated protein kinase (MAPK) regulates cytokines in arthritis and is, in turn, regulated by MAPK kinase (MKK) 3 and MKK6. To modulate p38 function but potentially minimize toxicity, we evaluated the utility of targeting MKK3 by using MKK3(-/-) mice. These studies showed that TNF-alpha increased phosphor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inoue T,Boyle DL,Corr M,Hammaker D,Davis RJ,Flavell RA,Firestein GS

更新日期：2006-04-04 00:00:00

abstract：:A protein-free nucleic acid preparation method for electron microscopy is described. The basic procedure is very similar to the classical protein monolayer spreading techniques. The carrier protein (usually cytochrome c) is replaced by benzyldimethylalkylammonium chloride. Both the hypophase method and the microdiffus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vollenweider HJ,Sogo JM,Koller T

更新日期：1975-01-01 00:00:00