Calbindin D28k targets myo-inositol monophosphatase in spines and dendrites of cerebellar Purkinje neurons.

abstract：:Retroviruses undergo a high frequency of genetic alterations during the process of copying their RNA genomes. However, little is known about the replication fidelity of other elements that transpose via reverse transcription of an RNA intermediate. The complete sequence of 29 independently integrated copies of the yea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gabriel A,Willems M,Mules EH,Boeke JD

更新日期：1996-07-23 00:00:00

abstract：:There are numerous studies on the immune response against malignant human tumors. This study was aimed to address the complexity and specificity of humoral immune response against a benign human tumor. We assembled a panel of 62 meningioma-expressed antigens that show reactivity with serum antibodies of meningioma pat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Comtesse N,Zippel A,Walle S,Monz D,Backes C,Fischer U,Mayer J,Ludwig N,Hildebrandt A,Keller A,Steudel WI,Lenhof HP,Meese E

更新日期：2005-07-05 00:00:00

abstract：:The effects of predator intimidation on habitat use and behavior of prey species are rarely quantified for large marine vertebrates over ecologically relevant scales. Using state space movement models followed by a series of step selection functions, we analyzed movement data of concurrently tracked prey, bowhead whal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matthews CJD,Breed GA,LeBlanc B,Ferguson SH

更新日期：2020-03-24 00:00:00

abstract：:Food is a powerful entrainment cue for circadian clocks in peripheral tissues, and changes in the composition of nutrients have been demonstrated to metabolically reprogram peripheral clocks. However, how food challenges may influence circadian metabolism of the master clock in the suprachiasmatic nucleus (SCN) or in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tognini P,Samad M,Kinouchi K,Liu Y,Helbling JC,Moisan MP,Eckel-Mahan KL,Baldi P,Sassone-Corsi P

更新日期：2020-11-24 00:00:00

abstract：:Classical eyeblink conditioning is a well-characterized model paradigm that engages the septohippocampal cholinergic system. This form of associative learning is impaired in normal aging and severely disrupted in Alzheimer's disease (AD). Some nicotinic cholinergic receptor subtypes are lost in AD, making the use of n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Woodruff-Pak DS,Vogel RW 3rd,Wenk GL

更新日期：2001-02-13 00:00:00

abstract：:The major protein extracted from anyloid deposits induced in mice by injection of either Candida albicans cells or sodium caseinate was found to have chromatographic and electrophoretic properties and an amino-acid compostiion characteristic of the AA class of amyloid proteins. The homology of the mouse protein with p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eriksen N,Ericsson LH,Pearsall N,Lagunoff D,Benditt EP

更新日期：1976-03-01 00:00:00

abstract：:Ring-shaped hexameric helicases and translocases support essential DNA-, RNA-, and protein-dependent transactions in all cells and many viruses. How such systems coordinate ATPase activity between multiple subunits to power conformational changes that drive the engagement and movement of client substrates is a fundame...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomsen ND,Lawson MR,Witkowsky LB,Qu S,Berger JM

更新日期：2016-11-29 00:00:00

abstract：:Adaptive radiation is the evolution of ecological and phenotypic diversity within a rapidly multiplying lineage. Recent studies have identified general patterns in adaptive radiation and inferred that resource competition is a primary factor driving phenotypic divergence. The role and importance of other processes, su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nosil P,Crespi BJ

更新日期：2006-06-13 00:00:00

abstract：:Translational initiation factor 2 (IF2) is a guanine nucleotide-binding protein that can bind guanosine 3',5'-(bis) diphosphate (ppGpp), an alarmone involved in stringent response in bacteria. In cells growing under optimal conditions, the GTP concentration is very high, and that of ppGpp very low. However, under stre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milon P,Tischenko E,Tomsic J,Caserta E,Folkers G,La Teana A,Rodnina MV,Pon CL,Boelens R,Gualerzi CO

更新日期：2006-09-19 00:00:00

abstract：:Epilepsy, a disease characterized by abnormal brain activity, is a disabling and potentially life-threatening condition for nearly 1% of the world population. Unfortunately, modulation of brain excitability using available antiepileptic drugs can have serious side effects, especially in the developing brain, and some ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baraban SC,Southwell DG,Estrada RC,Jones DL,Sebe JY,Alfaro-Cervello C,García-Verdugo JM,Rubenstein JL,Alvarez-Buylla A

更新日期：2009-09-08 00:00:00

abstract：:By employing the nuclear DNA of the African rice Oryza glaberrima as a reference genome, the timing, natures, mechanisms, and specificities of recent sequence evolution in the indica and japonica subspecies of Oryza sativa were identified. The data indicate that the genome sizes of both indica and japonica have increa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma J,Bennetzen JL

更新日期：2004-08-24 00:00:00

abstract：:We have screened about 1.4 million colonies of Escherichia coli K-12 for their ability to grow on nutrient agar at 30 degrees and 41 degrees. Among the 2266 temperature-sensitive mutants found, 110 were defective in DNA synthesis but not in protein synthesis at 41 degrees. Three of these dna mutations mapped at two pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sevastopoulos CG,Wehr CT,Glaser DA

更新日期：1977-08-01 00:00:00

abstract：:Reactive oxygen species (ROS)-mediated oxidative stress and DNA damage have recently been recognized as contributing to the efficacy of most bactericidal antibiotics, irrespective of their primary macromolecular targets. Inhibitors of targets involved in both combating oxidative stress as well as being required for in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tiwari S,van Tonder AJ,Vilchèze C,Mendes V,Thomas SE,Malek A,Chen B,Chen M,Kim J,Blundell TL,Parkhill J,Weinrick B,Berney M,Jacobs WR Jr

更新日期：2018-09-25 00:00:00

abstract：:Quinate:NAD(+) 3-oxidoreductase (EC 1.1.1.24) from carrot cell suspension cultures has previously been shown to be activated by phosphorylation and inactivated by dephosphorylation. Here it is shown that the reactivation of the inactivated quinate:NAD(+) oxidoreductase is an enzyme-mediated process that requires ATP a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ranjeva R,Refeno G,Boudet AM,Marmé D

更新日期：1983-09-01 00:00:00

abstract：:Sexual arousal is a dynamical, highly coordinated neurophysiological process that is often induced by visual stimuli. Numerous studies have proposed that the cognitive processing stage of responding to sexual stimuli is the first stage, in which sex differences occur, and the divergence between men and women has been ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitricheva E,Kimura R,Logothetis NK,Noori HR

更新日期：2019-07-30 00:00:00

abstract：:Language and analytic processing are currently thought to be represented in the left hemisphere, whereas spatial and holistic processing would involve primarily the right hemisphere in man. An experimental paradigm for engaging the nonlanguage hemisphere (generally the right) is described. This involves active touch e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Desmedt JE

更新日期：1977-09-01 00:00:00

abstract：:Morphine produces analgesia at opiate receptors expressed in nociceptive circuits. mu, delta, and kappa opiate receptor subtypes are expressed in circuits that can modulate nociception and receive inputs from endogenous opioid neuropeptide ligands. The roles played by each receptor subtype in nociceptive processing in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sora I,Takahashi N,Funada M,Ujike H,Revay RS,Donovan DM,Miner LL,Uhl GR

更新日期：1997-02-18 00:00:00

abstract：:Rabbit chondrocyte cultures on plastic dishes are capable of depositing a cartilaginous matrix, although the matrix does not calcify unless high levels of phosphate are added to the medium. In the present study, we cultivated a pelleted mass of rabbit growth-plate chondrocytes in the presence of Eagle's minimum essent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kato Y,Iwamoto M,Koike T,Suzuki F,Takano Y

更新日期：1988-12-01 00:00:00

abstract：:Despite an important role in vascular development and repair, the origin of endothelial progenitors remains unknown. Accumulating evidence indicates that cells derived from the hematopoietic system participate in angiogenesis. However, the identity and functional role of these cells remain controversial. Here we show ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bailey AS,Willenbring H,Jiang S,Anderson DA,Schroeder DA,Wong MH,Grompe M,Fleming WH

更新日期：2006-08-29 00:00:00

abstract：:Receptor activator of NF-κB (RANK), known for controlling bone mass, has been recognized for its role in epithelial cell activation of the mammary gland. Because bone and the epidermo-pilosebaceous unit of the skin share a lifelong renewal activity where similar molecular players operate, and because mammary glands an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duheron V,Hess E,Duval M,Decossas M,Castaneda B,Klöpper JE,Amoasii L,Barbaroux JB,Williams IR,Yagita H,Penninger J,Choi Y,Lézot F,Groves R,Paus R,Mueller CG

更新日期：2011-03-29 00:00:00

abstract：:Olfactory neuroblastoma (ONB) is a malignant tumor of the nasal mucosa whose histogenesis is unclear. A relationship to neuroblastoma (NB), a pediatric tumor of the sympathetic nervous system, is based on morphologic similarities and the expression of similar neural antigens. However, the clinical presentation of ONB ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sorensen PH,Wu JK,Berean KW,Lim JF,Donn W,Frierson HF,Reynolds CP,López-Terrada D,Triche TJ

更新日期：1996-02-06 00:00:00

abstract：:Plant litter decomposition is a critical step in the formation of soil organic matter, the mineralization of organic nutrients, and the carbon balance in terrestrial ecosystems. Biotic decomposition in mesic ecosystems is generally negatively correlated with the concentration of lignin, a group of complex aromatic pol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Austin AT,Ballaré CL

更新日期：2010-03-09 00:00:00

abstract：:Overexpression of the receptor tyrosine kinase (RTK) erbB2 (also designated neu or HER2) was implicated in causing a variety of human cancers, including mammary and ovarian carcinomas. Ligand-induced receptor dimerization is critical for stimulation of the intrinsic protein tyrosine kinase (PTK) of RTKs. It was theref...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fleishman SJ,Schlessinger J,Ben-Tal N

更新日期：2002-12-10 00:00:00

abstract：:Zooxanthellae are unicellular algae that occur as endosymbionts in many hundreds of common marine invertebrates. The issue of zooxanthella diversity has been difficult to address. Most zooxanthellae have been placed in the dinoflagellate genus Symbiodinium as one or several species that are not easily distinguished. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rowan R,Powers DA

更新日期：1992-04-15 00:00:00

abstract：:HeLa cells grown in the presence of [methyl-3H]thymidine contained large amounts of 5-hydroxymethyl-2'-deoxyuridine (HMdU) in their DNA. When the cells were grown in [6-3H]thymidine and their DNA was labeled to the same specific activity, no HMdU was present. When such [6-3H]thymidine-labeled cells were exposed to inc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teebor GW,Frenkel K,Goldstein MS

更新日期：1984-01-01 00:00:00

abstract：:Characteristic classes for the index of the Dirac family [unk](A) are computed in terms of differential forms on the orbit space of vector potentials under gauge transformations. They represent obstructions to the existence of a covariant Dirac propagator. The first obstruction is related to a chiral anomaly. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Atiyah MF,Singer IM

更新日期：1984-04-01 00:00:00

abstract：:Over the past years, family 18 chitinases have been validated as potential targets for the design of drugs against human pathogens that contain or interact with chitin during their normal life cycles. Thus far, only one potent chitinase inhibitor has been described in detail, the pseudotrisaccharide allosamidin. Recen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Houston DR,Shiomi K,Arai N,Omura S,Peter MG,Turberg A,Synstad B,Eijsink VG,van Aalten DM

更新日期：2002-07-09 00:00:00

abstract：:Chaperones of the Hsp70 family bind to unfolded or partially folded polypeptides to facilitate many cellular processes. ATP hydrolysis and substrate binding, the two key molecular activities of this chaperone, are modulated by the cochaperone DnaJ. By using both genetic and biochemical approaches, we provide evidence ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suh WC,Burkholder WF,Lu CZ,Zhao X,Gottesman ME,Gross CA

更新日期：1998-12-22 00:00:00

abstract：:The heptadecapeptide orphanin FQ (OFQ) is a recently discovered neuropeptide that exhibits structural features reminiscent of the opioid peptides and that is an endogenous ligand to a G protein-coupled receptor sequentially related to the opioid receptors. We have cloned both the human and rat cDNAs encoding the OFQ p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nothacker HP,Reinscheid RK,Mansour A,Henningsen RA,Ardati A,Monsma FJ Jr,Watson SJ,Civelli O

更新日期：1996-08-06 00:00:00

abstract：:The attachment of chondrocytes to collagen substrates is stimulated by serum but not by fibronectin. The active material in serum was partially purified and was shown to be a protein by its sensitivity to trypsin and heat and its chromatographic properties. This factor, which we have named chondronectin, is distinct f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hewitt AT,Kleinman HK,Pennypacker JP,Martin GR

更新日期：1980-01-01 00:00:00