Killer whale presence drives bowhead whale selection for sea ice in Arctic seascapes of fear.

abstract：:The aryl hydrocarbon receptor (AhR) knockout mice raised in the laboratory of Fujii-Kuriyama have been under investigation for several years because of the presence in their urinary bladder of large, yellowish stones. The stones are composed of uric acid and become apparent in the bladders as tiny stones when mice are...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Butler R,Inzunza J,Suzuki H,Fujii-Kuriyama Y,Warner M,Gustafsson JÅ

更新日期：2012-01-24 00:00:00

abstract：:Although it is accepted that regulatory T cells (T regs) contribute to cancer progression, most studies in the field consider nonantigen-specific suppression. Here, we show the presence of tumor antigen-specific CD4(+) T regs in the blood of patients with metastatic melanoma. These CD4(+) T regs recognize a broad rang...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vence L,Palucka AK,Fay JW,Ito T,Liu YJ,Banchereau J,Ueno H

更新日期：2007-12-26 00:00:00

abstract：:Metallothionein (MT) has several putative roles in metal detoxification, in Zn and Cu homeostasis, in scavenging free radicals, and in the acute phase response. Mice of mixed 129/Ola and C57BL/6J background with targeted disruption of MT-I and MT-II genes are more sensitive to toxic metals and oxidative stress. We not...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beattie JH,Wood AM,Newman AM,Bremner I,Choo KH,Michalska AE,Duncan JS,Trayhurn P

更新日期：1998-01-06 00:00:00

abstract：:Phosphocholine (PC) is an abundant primary form of organic phosphate that is transported in plant xylem sap. Addition of PC to the perfusate of compressed Pi-starved sycamore cells monitored by 31P NMR spectroscopy resulted in an accumulation of PC and all the other phosphate esters in the cytoplasmic compartment. Add...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gout E,Bligny R,Roby C,Douce R

更新日期：1990-06-01 00:00:00

abstract：:IL-17 is a T cell-derived, proinflammatory cytokine that is suspected to be involved in the development of various inflammatory diseases. Although there are elevated levels of IL-17 in synovial fluid of patients with rheumatoid arthritis, the pathogenic role of IL-17 in the development of rheumatoid arthritis remains ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakae S,Saijo S,Horai R,Sudo K,Mori S,Iwakura Y

更新日期：2003-05-13 00:00:00

abstract：:The hypothetical scanning (HS) method is a general approach for calculating the absolute entropy and free energy by analyzing Boltzmann samples obtained by Monte Carlo (MC) or molecular dynamics techniques. With HS applied to a fluid, each configuration i of the sample is reconstructed by adding its atoms gradually to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： White RP,Meirovitch H

更新日期：2004-06-22 00:00:00

abstract：:Tata Element Modulatory Factor (TMF/ARA160) is a multifunctional Golgi-associated protein, which accumulates in colonic enterocytes and goblet cells. Mice lacking TMF/ARA160 (TMF(-/-)) produce thick and uniform colonic mucus that resists adherent bacterial colonization and diminishes susceptibility of these mice to in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bel S,Elkis Y,Elifantz H,Koren O,Ben-Hamo R,Lerer-Goldshtein T,Rahimi R,Ben Horin S,Nyska A,Shpungin S,Nir U

更新日期：2014-04-01 00:00:00

abstract：:Bcl-2 family proteins play a crucial role in tissue homeostasis and apoptosis (programmed cell death). Bid is a proapoptotic member of the Bcl-2 family, promoting cell death when activated by caspase-8. Following an NMR-based approach (structure-activity relationships by interligand NOE) we were able to identify two c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Becattini B,Culmsee C,Leone M,Zhai D,Zhang X,Crowell KJ,Rega MF,Landshamer S,Reed JC,Plesnila N,Pellecchia M

更新日期：2006-08-15 00:00:00

abstract：:The clonal rat pituitary cell line GH4C1 expresses the genes for several voltage-dependent potassium channels including Kv1.5 and Kv1.4. Dexamethasone, a glucocorticoid agonist, induces a slowly inactivating potassium current in these cells but does not alter the amplitude of a rapidly inactivating component of potass...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung S,Saal DB,Kaczmarek LK

更新日期：1995-06-20 00:00:00

abstract：:The redox siblings nitroxyl (HNO) and nitric oxide (NO) have often been assumed to undergo casual redox reactions in biological systems. However, several recent studies have demonstrated distinct pharmacological effects for donors of these two species. Here, infusion of the HNO donor Angeli's salt into normal dogs res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miranda KM,Paolocci N,Katori T,Thomas DD,Ford E,Bartberger MD,Espey MG,Kass DA,Feelisch M,Fukuto JM,Wink DA

更新日期：2003-08-05 00:00:00

abstract：:Antibody-coated latex beads (Ab-beads) were attached to Leptospira interrogans serovars illini 3055 and icterohaemorrhagiae SC1157. The movement of the Ab-beads relative to the motion of the cells was observed by direct darkfield microscopy or was recorded on videotape. When the Ab-beads were attached to the front end...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Charon NW,Lawrence CW,O'Brien S

更新日期：1981-11-01 00:00:00

abstract：:Abelson murine leukemia virus (A-MuLV) is derived from the thymotropic Moloney leukemia virus. However, injection of mice with A-MuLV by conventional routes results in rapidly arising peripheral and bone marrow lymphomas, not thymomas or T cell tumors. In this study thymomas have been induced by intrathymic injection ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cook WD

更新日期：1982-05-01 00:00:00

abstract：:We used a sensitive and specific cDNA polymerase chain reaction assay to detect hepatitis C virus (HCV) RNA in serum samples from 128 unselected southern African Blacks with hepatocellular carcinoma (HCC) and found HCV RNA in 26 (20.3%) of these patients. Antibodies to HCV (anti-HCV) were detected in 59 patients (46.1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bukh J,Miller RH,Kew MC,Purcell RH

更新日期：1993-03-01 00:00:00

abstract：:By combining the pairwise interactions between proteins, as predicted by the conserved co-occurrence of their genes in operons, we obtain protein interaction networks. Here we study the properties of such networks to identify functional modules: sets of proteins that together are involved in a biological process. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Snel B,Bork P,Huynen MA

更新日期：2002-04-30 00:00:00

abstract：:The covalent linkage of supramolecular monomers provides a powerful strategy for constructing dynamic polymeric materials whose properties can be readily tuned either by the selection of monomers or the choice of functional linkers. In this strategy, the stabilities of the supramolecular monomers and the reactions use...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang M,Li S,Yan X,Zhou Z,Saha ML,Wang YC,Stang PJ

更新日期：2016-10-04 00:00:00

abstract：:The use of profiling by ethnicity or nationality to trigger secondary security screening is a controversial social and political issue. Overlooked is the question of whether such actuarial methods are in fact mathematically justified, even under the most idealized assumptions of completely accurate prior probabilities...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Press WH

更新日期：2009-02-10 00:00:00

abstract：:Human herpesvirus 6 (HHV-6) like other herpesviruses, expresses sequentially immediate early (IE), early, and late genes during lytic infection. Evidence of ability to establish latent infection has not been available, but by analogy with other herpesviruses it could be expected that IE genes that regulate and transac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rotola A,Ravaioli T,Gonelli A,Dewhurst S,Cassai E,Di Luca D

更新日期：1998-11-10 00:00:00

abstract：:Controlled maturation of ovarian follicles is necessary for fertility. Follicles are restrained at an immature stage until stimulated by FSH secreted by pituitary gonadotropes. FSH acts on granulosa cells within the immature follicle to inhibit apoptosis, promote proliferation, stimulate production of steroid and prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hunzicker-Dunn ME,Lopez-Biladeau B,Law NC,Fiedler SE,Carr DW,Maizels ET

更新日期：2012-10-30 00:00:00

abstract：:We analyzed gene expression patterns in human gastric cancers by using cDNA microarrays representing approximately equal 30,300 genes. Expression of PLA2G2A, a gene previously implicated as a modifier of the Apc(Min/+) (multiple intestinal neoplasia 1) mutant phenotype in the mouse, was significantly correlated with p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leung SY,Chen X,Chu KM,Yuen ST,Mathy J,Ji J,Chan AS,Li R,Law S,Troyanskaya OG,Tu IP,Wong J,So S,Botstein D,Brown PO

更新日期：2002-12-10 00:00:00

abstract：:Chemical labeling of proteins inside of living cells can enable studies of the location, movement, and function of proteins in vivo. Here we demonstrate an approach for chemical labeling of proteins that uses the high-affinity interaction between an FKBP12 mutant (F36V) and a synthetic, engineered ligand (SLF'). A flu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marks KM,Braun PD,Nolan GP

更新日期：2004-07-06 00:00:00

abstract：:The innate immune system detects viral nucleic acids and induces type I interferon (IFN) responses. The RNA- and DNA-sensing pathways converge on the protein kinase TANK-binding kinase 1 (TBK1) and the transcription factor IFN-regulatory factor 3 (IRF3). Activation of the IFN signaling pathway is known to trigger the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seo M,Lee SO,Kim JH,Hong Y,Kim S,Kim Y,Min DH,Kong YY,Shin J,Ahn K

更新日期：2016-12-13 00:00:00

abstract：:We report here the reconstitution of a pathway that leads to the apoptotic changes in nuclei by using recombinant DNA fragmentation factor (DFF), a heterodimeric protein of 40 and 45 kDa. Coexpression of DFF40 and DFF45 is required to generate recombinant DFF, which becomes activated when DFF45 is cleaved by caspase-3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu X,Li P,Widlak P,Zou H,Luo X,Garrard WT,Wang X

更新日期：1998-07-21 00:00:00

abstract：:Retroviral Gag polyproteins have specific regions, commonly referred to as late assembly (L) domains, which are required for the efficient separation of assembled virions from the host cell. The L domain of HIV-1 is in the C-terminal p6(gag) domain and contains an essential P(T/S)AP core motif that is widely conserved...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strack B,Calistri A,Accola MA,Palu G,Gottlinger HG

更新日期：2000-11-21 00:00:00

abstract：:The phagocyte NADPH oxidase, dormant in resting cells, is activated during phagocytosis to produce superoxide, a precursor of microbicidal oxidants. The activated oxidase is a complex of membrane-integrated cytochrome b558, composed of 91-kDa (gp91phox) and 22-kDa (p22phox) subunits, and two cytosolic factors (p47phox...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sumimoto H,Kage Y,Nunoi H,Sasaki H,Nose T,Fukumaki Y,Ohno M,Minakami S,Takeshige K

更新日期：1994-06-07 00:00:00

abstract：:Biomimetic nanopores based on membrane-spanning single-walled carbon nanotubes have been designed to include selectivity filters based on combinations of anionic and cationic groups mimicking those present in bacterial porins and in voltage-gated sodium and calcium channels. The ion permeation and selectivity properti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： García-Fandiño R,Sansom MS

更新日期：2012-05-01 00:00:00

abstract：:Most proteins are in equilibrium with partially and globally unfolded conformations. In contrast, kinetically stable proteins (KSPs) are trapped by an energy barrier in a specific state, unable to transiently sample other conformations. Among many potential roles, it appears that kinetic stability (KS) is a feature us...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xia K,Manning M,Hesham H,Lin Q,Bystroff C,Colón W

更新日期：2007-10-30 00:00:00

abstract：:Isolated rat kidney glomeruli converted octatritiated arachidonic acid to several prostaglandins whose production was inhibited by meclofenamate. These were, in order of decreasing abundance, prostaglandin F2 alpha, prostaglandin E2, 6-oxo-prostaglandin F1 alpha, thromboxane B2, and prostaglandin D2. These products we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hassid A,Konieczkowski M,Dunn MJ

更新日期：1979-03-01 00:00:00

abstract：:The β-1,3-glucan chrysolaminarin is the main storage polysaccharide of diatoms. In contrast to plants and green algae, diatoms and most other algal groups do not accumulate storage polysaccharides in their plastids. The diatom Phaeodactylum tricornutum possesses only a single gene encoding a putative β-1,3-glucan synt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang W,Haferkamp I,Lepetit B,Molchanova M,Hou S,Jeblick W,Río Bártulos C,Kroth PG

更新日期：2018-05-01 00:00:00

abstract：:The reactivities of N-iodosuccinimide and iodine with various goitrogenic compounds were studied with dimethylsulfoxide through which nitrogen had been bubbled as a solvent. Although iodine does not react with all of the compounds, N-iodosuccinimide does react with all of them. N-Iodosuccinimide may, therefore, serve ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jirousek L,Soodak M

更新日期：1973-05-01 00:00:00

abstract：:Leaf-cutting ants combine large-scale herbivory with fungus farming to sustain advanced societies. Their stratified colonies are major evolutionary achievements and serious agricultural pests, but the crucial adaptations that allowed this mutualism to become the prime herbivorous component of neotropical ecosystems ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Fine Licht HH,Schiøtt M,Rogowska-Wrzesinska A,Nygaard S,Roepstorff P,Boomsma JJ

更新日期：2013-01-08 00:00:00