Olfactory neuroblastoma is a peripheral primitive neuroectodermal tumor related to Ewing sarcoma.

abstract：:Infected cell protein 0 (ICP0) is a 775-residue multifunctional herpes simplex virus protein associated with numerous functions related to transactivation of gene expression and repression of host defenses to infection. We report that an uncharted domain of ICP0 located between residues 245 and 510 contains multiple S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liang Y,Kurakin A,Roizman B

更新日期：2005-04-19 00:00:00

abstract：:31P nuclear magnetic relaxation rates for phosphocreatine in intact frog gastrocnemius were compared with those observed in model solutions at 4 degrees, a temperature at which muscle maintains its physiological state for at least 5 hr. Both nuclear Overhauser effect and spin-lattice relaxation rate (1/T1) experiments...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen SM,Burt CT

更新日期：1977-10-01 00:00:00

abstract：:Animal development is remarkably robust; cell fates are specified with spatial and temporal precision despite physiological and environmental contingencies. Favorable conditions cause Caenorhabditis elegans to develop rapidly through four larval stages (L1-L4) to the reproductive adult. In unfavorable conditions, L2 l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hammell CM,Karp X,Ambros V

更新日期：2009-11-03 00:00:00

abstract：:Colloidal particles with directional interactions are key in the realization of new colloidal materials with possibly unconventional phase behaviors. Here we exploit DNA self-assembly to produce bulk quantities of "DNA stars" with three or four sticky terminals, mimicking molecules with controlled limited valence. Sol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biffi S,Cerbino R,Bomboi F,Paraboschi EM,Asselta R,Sciortino F,Bellini T

更新日期：2013-09-24 00:00:00

abstract：:There is considerable interest in engineering plant cell wall components, particularly lignin, to improve forage quality and biomass properties for processing to fuels and bioproducts. However, modifying lignin content and/or composition in transgenic plants through down-regulation of lignin biosynthetic enzymes can i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gallego-Giraldo L,Liu C,Pose-Albacete S,Pattathil S,Peralta AG,Young J,Westpheling J,Hahn MG,Rao X,Knox JP,De Meester B,Boerjan W,Dixon RA

更新日期：2020-02-11 00:00:00

abstract：:Amide linkages are among the most important chemical bonds in living systems, constituting the connections between amino acids in peptides and proteins. We demonstrate the controlled formation of amide bonds between amino acids or peptides in the gas phase using ion/ion reactions in a mass spectrometer. Individual ami...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McGee WM,McLuckey SA

更新日期：2014-01-28 00:00:00

abstract：:Ascidians are hermaphrodites releasing sperm and eggs simultaneously, but many species are self-sterile because of a self/nonself-recognition system in spermegg interaction. Here, we show that a 70-kDa vitelline coat protein, HrVC70, consisting of 12 epidermal growth factor-like repeats, plays a key role in self/nonse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sawada H,Tanaka E,Ban S,Yamasaki C,Fujino J,Ooura K,Abe Y,Matsumoto K,Yokosawa H

更新日期：2004-11-02 00:00:00

abstract：:Bones from a stratified sedimentary deposit in the Puu Naio Cave site on Maui, Hawaiian Islands, reveal the late Holocene extinction of 19 species of birds. The age of the sediment and associated fauna was determined by direct radiocarbon dating (tandem particle accelerator-mass spectrometer; TAMS) of amino acids extr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： James HF,Stafford TW Jr,Steadman DW,Olson SL,Martin PS,Jull AJ,McCoy PC

更新日期：1987-04-01 00:00:00

abstract：:Oxygen isotherms of human hemoglobin measured in distilled water and in solutions of sodium chloride in the concentration range from 0.02 to 3.0 M indicate that the oxygen affinity decreases up to about 1 M salt and then begins to increase. The isotherms obtained in the range from 0.02 to 0.6 M sodium chloride, at 37 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haire RN,Hedlund BE

更新日期：1977-10-01 00:00:00

abstract：:In biosynthesis of the pancreatic cancer drug streptozotocin, the tridomain nonheme-iron oxygenase SznF hydroxylates Nδ and Nω' of Nω-methyl-l-arginine before oxidatively rearranging the triply modified guanidine to the N-methyl-N-nitrosourea pharmacophore. A previously published structure visualized the monoiron cofa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McBride MJ,Pope SR,Hu K,Okafor CD,Balskus EP,Bollinger JM Jr,Boal AK

更新日期：2021-01-26 00:00:00

abstract：:Using defined oligomers of IgE, our group previously studied the quantitative relationship between the aggregation of the high affinity receptors for IgE (Fc epsilonRI) and the earliest signals initiated by such aggregation: the phosphorylation of tyrosines on the receptor. Notably, at certain doses of the oligomers s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Torigoe C,Goldstein B,Wofsy C,Metzger H

更新日期：1997-02-18 00:00:00

abstract：:We demonstrate that poly(dA-dT) can adopt two conformations in solution, with the relative proportions dependent on the nature and concentration of the counter ion and cationic ligands. The synthetic DNA exhibits a dinucleotide repeat conformation on addition of CsF and Me4NCl at molar concentrations, with the NMR spe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patel DJ,Kozlowski SA,Suggs JW,Cox SD

更新日期：1981-07-01 00:00:00

abstract：:The regulatory mechanisms underlying the uptake and utilization of multiple types of carbohydrates in actinomycetes remain poorly understood. In this study, we show that GlnR (central regulator of nitrogen metabolism) serves as a universal regulator of nitrogen metabolism and plays an important, previously unknown rol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liao CH,Yao L,Xu Y,Liu WB,Zhou Y,Ye BC

更新日期：2015-12-22 00:00:00

abstract：:Lineage specification is thought to be largely regulated at the level of transcription, where lineage-specific transcription factors drive specific cell fates. MicroRNAs (miR), vital to many cell functions, act posttranscriptionally to decrease the expression of target mRNAs. MLL-AF4 acute lymphocytic leukemia exhibit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okuyama K,Ikawa T,Gentner B,Hozumi K,Harnprasopwat R,Lu J,Yamashita R,Ha D,Toyoshima T,Chanda B,Kawamata T,Yokoyama K,Wang S,Ando K,Lodish HF,Tojo A,Kawamoto H,Kotani A

更新日期：2013-08-13 00:00:00

abstract：:This study demonstrates the presence of an N-acetyl-D-galactosaminyltransferase in human serum and in erythrocyte membranes. This enzyme catalyzes the transfer of N-acetyl-D-galactosamine from UDP-N-acetyl-D-galactosamine to a mucin receptor and 2'-fucosyllactose that have blood group H activity and may be responsible...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim YS,Perdomo J,Bella A Jr,Nordberg J

更新日期：1971-08-01 00:00:00

abstract：:Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are prototypic growth factors and receptor tyrosine kinases which have critical functions in development. We show that PDGFs share a conserved region in their prodomain sequences which can remain noncovalently associated with the mature cystine-knot ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shim AH,Liu H,Focia PJ,Chen X,Lin PC,He X

更新日期：2010-06-22 00:00:00

abstract：:The Ipl (Tssc3) gene lies in an extended imprinted region of distal mouse chromosome 7, which also contains the Igf2 gene. Expression of Ipl is highest in placenta and yolk sac, where its mRNA is derived almost entirely from the maternal allele. Ipl encodes a small cytoplasmic protein with a pleckstrin-homology (PH) d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frank D,Fortino W,Clark L,Musalo R,Wang W,Saxena A,Li CM,Reik W,Ludwig T,Tycko B

更新日期：2002-05-28 00:00:00

abstract：:In North America there are two generally recognized pathotypes (pathotypes 1 and 2) of the fungus Entomophaga grylli which show host-preferential infection of grasshopper subfamilies. Pathotype 3, discovered in Australia, has a broader grasshopper host range and was considered to be a good biocontrol agent. Between 19...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bidochka MJ,Walsh SR,Ramos ME,St Leger RJ,Silver JC,Roberts DW

更新日期：1996-01-23 00:00:00

abstract：:The GTP/GDP nucleotide switch in Ras superfamily GTPases generally involves differential affinity toward downstream effectors, with the GTP-bound state having a higher affinity for effector than the GDP-bound state. We have developed a quantitative model of allosteric regulation of the Wiskott-Aldrich syndrome protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leung DW,Rosen MK

更新日期：2005-04-19 00:00:00

abstract：:Over the past five decades, ultra high vacuum (uhv) techniques applied to well-defined single-crystal samples (the "surface science paradigm") have transformed our understanding of fundamental surface chemistry. To translate this success to the world of realistic heterogeneous catalysis, however, requires one seriousl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iyngaran P,Madden DC,Jenkins SJ,King DA

更新日期：2011-01-18 00:00:00

abstract：:X-ray diffraction studies have produced a low resolution image and also located the iron atoms of a monomeric hemerythrin from muscles of a sipunculan worm. These results reveal the course of the polypeptide chain and some details of the active center. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hendrickson WA,Klippenstein GL,Ward KB

更新日期：1975-06-01 00:00:00

abstract：:A cDNA expression library in lambda gt11 was screened with affinity-purified polyclonal anti-rat cytochrome b5 reductase antibodies. One positive clone out of 450,000 clones was isolated and found to be incomplete. This clone was used to rescreen the library, and a second, overlapping clone that contained the entire c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pietrini G,Carrera P,Borgese N

更新日期：1988-10-01 00:00:00

abstract：:We propose and test a theoretical perspective in which a universal hallmark of successful literacy acquisition is the convergence of the speech and orthographic processing systems onto a common network of neural structures, regardless of how spoken words are represented orthographically in a writing system. During fun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rueckl JG,Paz-Alonso PM,Molfese PJ,Kuo WJ,Bick A,Frost SJ,Hancock R,Wu DH,Mencl WE,Duñabeitia JA,Lee JR,Oliver M,Zevin JD,Hoeft F,Carreiras M,Tzeng OJ,Pugh KR,Frost R

更新日期：2015-12-15 00:00:00

abstract：:The spatiotemporal regulation of neurotransmitter transporters involves proteins that interact with their intracellular domains. Using a proteomic approach, we identified several proteins that interact with the C terminus of the serotonin transporter (SERT). These included neuronal nitric oxide synthase (nNOS), a PSD-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chanrion B,Mannoury la Cour C,Bertaso F,Lerner-Natoli M,Freissmuth M,Millan MJ,Bockaert J,Marin P

更新日期：2007-05-08 00:00:00

abstract：:Adenosine, dibutyryl cyclic AMP, monobutyryl cyclic AMP, cyclic AMP, and 5'-AMP have a remarkable morphogenetic effect on cultured iris epithelial cells obtained from adult newt. They alter the broad undulating membrane of the cell into branching strands of cytoplasm, a configuration that has been named "stellate." Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ortiz JR,Yamada T,Hsie AW

更新日期：1973-08-01 00:00:00

abstract：:Emotional signals are crucial for sharing important information, with conspecifics, for example, to warn humans of danger. Humans use a range of different cues to communicate to others how they feel, including facial, vocal, and gestural signals. We examined the recognition of nonverbal emotional vocalizations, such a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sauter DA,Eisner F,Ekman P,Scott SK

更新日期：2010-02-09 00:00:00

abstract：:Neonates are highly susceptible to infectious diseases and, in general, respond poorly to conventional vaccines due to immaturity of the immune system. In the present study, we hypothesized that the anti-tetanus toxoid (TT) vaccine response of neonatal mice could be enhanced by retinoic acid (RA), a bioactive retinoid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma Y,Ross AC

更新日期：2005-09-20 00:00:00

abstract：:Tactile-foraging ducks are specialist birds known for their touch-dependent feeding behavior. They use dabbling, straining, and filtering to find edible matter in murky water, relying on the sense of touch in their bill. Here, we present the molecular characterization of embryonic duck bill, which we show contains a h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schneider ER,Anderson EO,Mastrotto M,Matson JD,Schulz VP,Gallagher PG,LaMotte RH,Gracheva EO,Bagriantsev SN

更新日期：2017-12-05 00:00:00

abstract：:We recently reported the hemochromatosis-like phenotype observed in our Usf2 knockout mice. In these mice, as in murine models of hemochromatosis and patients with hereditary hemochromatosis, iron accumulates in parenchymal cells (in particular, liver and pancreas), whereas the reticuloendothelial system is spared fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nicolas G,Bennoun M,Porteu A,Mativet S,Beaumont C,Grandchamp B,Sirito M,Sawadogo M,Kahn A,Vaulont S

更新日期：2002-04-02 00:00:00

abstract：:Epilepsy, a disease characterized by abnormal brain activity, is a disabling and potentially life-threatening condition for nearly 1% of the world population. Unfortunately, modulation of brain excitability using available antiepileptic drugs can have serious side effects, especially in the developing brain, and some ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baraban SC,Southwell DG,Estrada RC,Jones DL,Sebe JY,Alfaro-Cervello C,García-Verdugo JM,Rubenstein JL,Alvarez-Buylla A

更新日期：2009-09-08 00:00:00