Interaction of the Hsp70 molecular chaperone, DnaK, with its cochaperone DnaJ.

abstract：:Glutamate release activates multiple receptors that interact with each other and thus determine the response of the cell. Exploring these interactions is critical to developing an understanding of the functional consequences of synaptic transmission. Activation of metabotropic glutamate receptors (mGluRs) inhibits N-m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colwell CS,Altemus KL,Cepeda C,Levine MS

更新日期：1996-02-06 00:00:00

abstract：:Children whose parents divorce tend to have worse educational outcomes than children whose parents stay married. However, not all children respond identically to their parents divorcing. We focus on how the impact of parental divorce on children's education varies by how likely or unlikely divorce was for those parent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brand JE,Moore R,Song X,Xie Y

更新日期：2019-04-09 00:00:00

abstract：:Sympatric speciation (SS), i.e., speciation within a freely breeding population or in contiguous populations, was first proposed by Darwin [Darwin C (1859) On the Origins of Species by Means of Natural Selection] and is still controversial despite theoretical support [Gavrilets S (2004) Fitness Landscapes and the Orig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li K,Hong W,Jiao H,Wang GD,Rodriguez KA,Buffenstein R,Zhao Y,Nevo E,Zhao H

更新日期：2015-09-22 00:00:00

abstract：:A series of recombinant plasmids was generated in Escherichia coli in which the TEM beta-lactamase translocon (TnA) was inserted into the small plasmid RSF1010. RSF1010 is a 5.5 X 10(6) dalton nonconjugative plasmid which confers resistance to streptomycin and sulfonamide. The recombinant plasmids can be classified in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heffron F,Rubens C,Falkow S

更新日期：1975-09-01 00:00:00

abstract：:Mice prefer to mate with individuals expressing different MHC genes from their own. Volatile components presenting MHC-dependent odor types are present in urine and can be detected by mice, as shown by extensive behavioral studies. Similar odor types are suspected to influence human behavior as well. Although a recent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Montag S,Frank M,Ulmer H,Wernet D,Göpel W,Rammensee HG

更新日期：2001-07-31 00:00:00

abstract：:Cell variants resistant to the cytotoxic effect of mycophenolic acid, an inhibitor of IMP dehydrogenase (IMP:NAD+ oxidoreductase, EC 1.2.1.14), were selected by a one-step procedure from Chinese hamster V79 cells. The frequency of these variants was increased in a dose-dependent manner after treatment with the mutagen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huberman E,McKeown CK,Friedman J

更新日期：1981-05-01 00:00:00

abstract：:Although neural circuits mediating various simple behaviors have been delineated, those generating more complex behaviors are less well described. The discrete structure of avian song control nuclei promises that circuits controlling complex behaviors, such as birdsong, can also be understood. To this end, we develope...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mooney R,Konishi M

更新日期：1991-05-15 00:00:00

abstract：:From the types of ring chromosomes induced in x-irradiated Chinese hamster ovary (CHO) cells, we deduce the existence of switches in the polarity of chromosomal DNA; if there is a continuous DNA double helix along the full length of the chromosome then the polarity switches imply 3'-3' and 5'-5' phosphodiester linkage...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wolff S,Lindsley DL,Peacock WJ

更新日期：1976-03-01 00:00:00

abstract：:Collectivistic cultures have been characterized as having harmonious, cooperative ingroup relationships. However, we find evidence that people in collectivistic cultures are more vigilant toward ingroup members, mindful of their possible unethical intentions. Study 1 found that Chinese participants were more vigilant ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu SS,Morris MW,Talhelm T,Yang Q

更新日期：2019-07-16 00:00:00

abstract：:The structure of the proline-specific aminopeptidase (EC 3.4.11.9) from Escherichia coli has been solved and refined for crystals of the native enzyme at a 2.0-A resolution, for a dipeptide-inhibited complex at 2.3-A resolution, and for a low-pH inactive form at 2.7-A resolution. The protein crystallizes as a tetramer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilce MC,Bond CS,Dixon NE,Freeman HC,Guss JM,Lilley PE,Wilce JA

更新日期：1998-03-31 00:00:00

abstract：:High molecular weight RNA (35S) isolated from avian myeloblastosis virus directs the cell-free synthesis of two prominent polypeptides of 180,000 and 76,000 molecular weight. The latter polypeptide has previously been identified as the precursor to the group-specific antigens of the virus ("gag" proteins) [Vogt, V. M....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paterson BM,Marciani DJ,Papas TS

更新日期：1977-11-01 00:00:00

abstract：:The suppressor of Hairy-wing [su(Hw)] protein exerts a polar effect on gene expression by repressing the function of transcriptional enhancers located distally from the promoter with respect to the location of su(Hw) binding sequences. The directionality of this effect suggests that the su(Hw) protein specifically int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Georgiev PG,Corces VG

更新日期：1995-05-23 00:00:00

abstract：:Concepts organize the relationship among individual stimuli or events by highlighting shared features. Often, new goals require updating conceptual knowledge to reflect relationships based on different goal-relevant features. Here, our aim is to determine how hippocampal (HPC) object representations are organized and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mack ML,Love BC,Preston AR

更新日期：2016-11-15 00:00:00

abstract：:NGC 7027 shows the richest spectrum of any known gaseous nebula. In the region of the spectrum surveyed we have measured lines of ions of H, He, C, N, O, F, Ne, Mg, Si, P, S, Cl, Ar, K, Ca, Mn, and Fe using the new Hamilton Echelle Spectrograph of Lick Observatory with a charge-coupled device (CCD) detector. Since a C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aller LH,Keyes CD

更新日期：1988-04-01 00:00:00

abstract：:Analyses of amino-acid sequences of the total cell-free products programmed by the mRNA of MOPC-104E gamma light (L)-chain show that over 95% of the products have sequences of a distinct protein that correspond to the L-chain precursor. In this precursor an extra piece is coupled to the NH2-terminus of the mature L-ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burstein Y,Kantour F,Schechter I

更新日期：1976-08-01 00:00:00

abstract：:Avian reovirus S1133 penetrates and uncoats in suspension cultures of mouse L cells. The multiple species of viral transcripts are produced in the cytoplasm of the infected cell, but they fail to associate with polysomes, consistent with the absence of viral protein synthesis. The selective block in avian virus mRNA t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benavente J,Shatkin AJ

更新日期：1988-06-01 00:00:00

abstract：:rev-regulated expression of HIV-1 envelope proteins from a simian virus 40 late replacement vector was found to be dependent on the presence of a 5' splice site in the env mRNA in spite of the fact that this mRNA remains unspliced. When the 5' splice site upstream of the env open reading frame was deleted or mutated, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu XB,Heimer J,Rekosh D,Hammarskjöld ML

更新日期：1990-10-01 00:00:00

abstract：:Established T cell dysfunction is a barrier to antitumor responses, and checkpoint blockade presumably reverses this. Many patients fail to respond to treatment and/or develop autoimmune adverse events. The underlying reason for T cell responsiveness remains elusive. Here, we show that susceptibility to checkpoint blo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nelson CE,Mills LJ,McCurtain JL,Thompson EA,Seelig DM,Bhela S,Quarnstrom CF,Fife BT,Vezys V

更新日期：2019-02-12 00:00:00

abstract：:A 105-kilobase bacterial artificial chromosome (BAC) clone from the ovate-containing region of tomato chromosome 2 was sequenced and annotated. The tomato BAC sequence was then compared, gene by gene, with the sequenced portions of the Arabidopsis thaliana genome. Rather than matching a single portion of the Arabidops...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ku HM,Vision T,Liu J,Tanksley SD

更新日期：2000-08-01 00:00:00

abstract：:Covariance analysis of protein sequence alignments uses coevolving pairs of sequence positions to predict features of protein structure and function. However, current methods ignore the phylogenetic relationships between sequences, potentially corrupting the identification of covarying positions. Here, we use random m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qin C,Colwell LJ

更新日期：2018-01-23 00:00:00

abstract：:The classical Euler-Poisson equations describing the motion of a heavy rigid body about a fixed point are generalized to arbitrary Lie algebras as Hamiltonian systems on coad-joint orbits of a tangent bundle Lie group. the N-dimensional Lagrange and symmetric heavy top are thereby shown to be completely integrable. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ratiu T

更新日期：1981-03-01 00:00:00

abstract：:This perspective addresses recent advances in lipid transport across the Gram-negative inner and outer membranes. While we include a summary of previously existing literature regarding this topic, we focus on the maintenance of lipid asymmetry (Mla) pathway. Discovered in 2009 by the Silhavy group [J. C. Malinverni, T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Powers MJ,Trent MS

更新日期：2019-08-27 00:00:00

abstract：:Dendritic spines are of major importance in information processing and memory formation in central neurons. Estradiol has been shown to induce an increase of dendritic spine density on hippocampal neurons in vivo and in vitro. The neurotrophin brain-derived neurotrophic factor (BDNF) recently has been implicated in ne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murphy DD,Cole NB,Segal M

更新日期：1998-09-15 00:00:00

abstract：:Women outnumber men in undergraduate enrollments, but they are much less likely than men to major in mathematics or science or to choose a profession in these fields. This outcome often is attributed to the effects of negative sex-based stereotypes. We studied the effect of such stereotypes in an experimental market, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reuben E,Sapienza P,Zingales L

更新日期：2014-03-25 00:00:00

abstract：:Ribonucleotide reductase provides deoxynucleotides for nuclear and mitochondrial (mt) DNA replication and repair. The mammalian enzyme consists of a catalytic (R1) and a radical-generating (R2 or p53R2) subunit. During S-phase, a R1/R2 complex is the major provider of deoxynucleotides. p53R2 is induced by p53 after DN...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pontarin G,Fijolek A,Pizzo P,Ferraro P,Rampazzo C,Pozzan T,Thelander L,Reichard PA,Bianchi V

更新日期：2008-11-18 00:00:00

abstract：:The recently characterized corticosteroid receptor on amphibian neuronal membranes appears to mediate rapid, stress-induced changes in male reproductive behaviors. Because the transduction mechanisms associated with this receptor are unknown, we performed radioligand binding studies to determine whether this steroid r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Orchinik M,Murray TF,Franklin PH,Moore FL

更新日期：1992-05-01 00:00:00

abstract：:An integral mitochondrial membrane protein (p32) of yeast has previously been molecularly cloned and sequenced and suggested to function as a mitochondrial import receptor. However, this protein has also been proposed to function as phosphate translocator [Guérin, B., Bukusoglu, C., Rakotomanana, F. & Wohlrab, H. (199...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murakami H,Blobel G,Pain D

更新日期：1993-04-15 00:00:00

abstract：:Respiratory cytochrome c has been found to be phosphorylated at tyrosine 97 in the postischemic brain upon neuroprotective insulin treatment, but how such posttranslational modification affects mitochondrial metabolism is unclear. Here, we report the structural features and functional behavior of a phosphomimetic cyto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guerra-Castellano A,Díaz-Quintana A,Pérez-Mejías G,Elena-Real CA,González-Arzola K,García-Mauriño SM,De la Rosa MA,Díaz-Moreno I

更新日期：2018-07-31 00:00:00

abstract：:Two major problems have to be solved in studies of genes near breakpoints of chromosome abnormalities and in large-scale genomic mapping projects: (i) the identification of genes within the large amount on nontranscribed DNA and (ii) the determination of the tissues in which the identified genes are transcribed. In si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boehm T,Gonzalez-Sarmiento R,Kennedy M,Rabbitts TH

更新日期：1991-05-01 00:00:00

abstract：:The phosphatidylinositol 3-kinase subunit PIK3CA is frequently mutated in human cancers. Here we used gene targeting to "knock in" PIK3CA mutations into human breast epithelial cells to identify new therapeutic targets associated with oncogenic PIK3CA. Mutant PIK3CA knockin cells were capable of epidermal growth facto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gustin JP,Karakas B,Weiss MB,Abukhdeir AM,Lauring J,Garay JP,Cosgrove D,Tamaki A,Konishi H,Konishi Y,Mohseni M,Wang G,Rosen DM,Denmeade SR,Higgins MJ,Vitolo MI,Bachman KE,Park BH

更新日期：2009-02-24 00:00:00