Avian reovirus mRNAs are nonfunctional in infected mouse cells: translational basis for virus host-range restriction.

abstract：:The primate gastrointestinal tract is home to trillions of bacteria, whose composition is associated with numerous metabolic, autoimmune, and infectious human diseases. Although there is increasing evidence that modern and Westernized societies are associated with dramatic loss of natural human gut microbiome diversit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clayton JB,Vangay P,Huang H,Ward T,Hillmann BM,Al-Ghalith GA,Travis DA,Long HT,Tuan BV,Minh VV,Cabana F,Nadler T,Toddes B,Murphy T,Glander KE,Johnson TJ,Knights D

更新日期：2016-09-13 00:00:00

abstract：:A fundamental property of ecosystems is a tradeoff between the number and size of habitats: as the number of habitats within a fixed area increases, the average area per habitat must decrease. This tradeoff is termed the "area-heterogeneity tradeoff." Theoretical models suggest that the reduction in habitat sizes unde...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ben-Hur E,Kadmon R

更新日期：2020-03-03 00:00:00

abstract：:Charcot-Marie-Tooth disease type 4C (CMT4C) is an early-onset, autosomal recessive form of demyelinating neuropathy. The clinical manifestations include progressive scoliosis, delayed age of walking, muscular atrophy, distal weakness, and reduced nerve conduction velocity. The gene mutated in CMT4C disease, SH3TC2/KIA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arnaud E,Zenker J,de Preux Charles AS,Stendel C,Roos A,Médard JJ,Tricaud N,Kleine H,Luscher B,Weis J,Suter U,Senderek J,Chrast R

更新日期：2009-10-13 00:00:00

abstract：:Although mathematical models and laboratory experiments have shown that species interactions can generate chaos, field evidence of chaos in natural ecosystems is rare. We report on a pristine rocky intertidal community located in one of the world's oldest marine reserves that has displayed a complex cyclic succession ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benincà E,Ballantine B,Ellner SP,Huisman J

更新日期：2015-05-19 00:00:00

abstract：:Most simian-human immunodeficiency viruses (SHIVs) bearing envelope (Env) glycoproteins from primary HIV-1 strains fail to infect rhesus macaques (RMs). We hypothesized that inefficient Env binding to rhesus CD4 (rhCD4) limits virus entry and replication and could be enhanced by substituting naturally occurring simian...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li H,Wang S,Kong R,Ding W,Lee FH,Parker Z,Kim E,Learn GH,Hahn P,Policicchio B,Brocca-Cofano E,Deleage C,Hao X,Chuang GY,Gorman J,Gardner M,Lewis MG,Hatziioannou T,Santra S,Apetrei C,Pandrea I,Alam SM,Liao HX,

更新日期：2016-06-14 00:00:00

abstract：:We hypothesized that a substantial portion of the mutagenic alterations produced in the basal layer of human skin by sunlight are induced by wavelengths in the UVA range. Using laser capture microdissection we examined separately basal and suprabasal keratinocytes from human skin squamous cell carcinomas and premalign...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agar NS,Halliday GM,Barnetson RS,Ananthaswamy HN,Wheeler M,Jones AM

更新日期：2004-04-06 00:00:00

abstract：:In both human patients and murine models, the progression from insulitis to diabetes is neither immediate nor inevitable, as illustrated by the innocuous versus destructive infiltrates of BDC2.5 transgenic mice on the nonobese diabetic (NOD) versus C57BL/6.H-2g7 genetic backgrounds. Natural killer (NK)-cell-specific t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poirot L,Benoist C,Mathis D

更新日期：2004-05-25 00:00:00

abstract：:CCR5 (R5)-tropic, but not CXCR4 (X4)-tropic, HIV-1 is associated with primary HIV-1 infection and transmission. Recent studies have shown that IFN-induced transmembrane (IFITM) proteins, including IFITM1, IFITM2, and IFITM3, restrict a broad range of viruses. Here, we demonstrate that an IFITM2 isoform (Δ20 IFITM2) la...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu WL,Grotefend CR,Tsai MT,Wang YL,Radic V,Eoh H,Huang IC

更新日期：2017-07-03 00:00:00

abstract：:Many marine bacteria have evolved to grow optimally at either high (copiotrophic) or low (oligotrophic) nutrient concentrations, enabling different species to colonize distinct trophic habitats in the oceans. Here, we compare the genome sequences of two bacteria, Photobacterium angustum S14 and Sphingopyxis alaskensis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lauro FM,McDougald D,Thomas T,Williams TJ,Egan S,Rice S,DeMaere MZ,Ting L,Ertan H,Johnson J,Ferriera S,Lapidus A,Anderson I,Kyrpides N,Munk AC,Detter C,Han CS,Brown MV,Robb FT,Kjelleberg S,Cavicchioli R

更新日期：2009-09-15 00:00:00

abstract：:The CH family of murine B-cell lymphomas includes several members that are sensitive to growth inhibition when their membrane IgM (mIgM) receptors are cross-linked by anti-mu chain, anti-kappa chain, or anti-idiotypic antibodies. These lymphomas are IgM+, Ia+, and IgD +/- and resemble neonatal B cells in terms of thei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alés-Martínez JE,Warner GL,Scott DW

更新日期：1988-09-01 00:00:00

abstract：:The first essential step in protein photoreception is the capture and storage of energy from a photon. We have recently identified and isolated, from the purple photoautotrophic bacterium, Ectothiorhodospira halophila, a 13,000-dalton photoactive yellow protein (PYP) that has a photocycle with kinetics similar to sens...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McRee DE,Tainer JA,Meyer TE,Van Beeumen J,Cusanovich MA,Getzoff ED

更新日期：1989-09-01 00:00:00

abstract：:The dendritic building blocks with a focal pyrene unit self-organize into vesicles in aqueous phase. The in situ inclusion of the focal pyrene units into the cavity of beta- or gamma-cyclodextrin (CD) induces self-assembled organic nanotubes with an average outer diameter of approximately 45 nm and inner diameter of 2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park C,Lee IH,Lee S,Song Y,Rhue M,Kim C

更新日期：2006-01-31 00:00:00

abstract：:We present the complete nucleotide and deduced amino acid sequences of a mouse epidermal keratin subunit of 60,000 Da. The keratin possesses a central alpha-helical domain of four tracts (termed 1A, 1B, 2A, and 2B) that can form coiled-coils, interspersed by short linker sequences, and has non-alpha-helical terminal d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steinert PM,Parry DA,Racoosin EL,Idler WW,Steven AC,Trus BL,Roop DR

更新日期：1984-09-01 00:00:00

abstract：:The transcription and processing of mitochondrial 21S rRNA in a petite strain of Saccharomyces cerevisiae has been examined by electron microscopic analysis of R-loop hybrids and by hybridization of labeled mitochondrial DNA probes to RNA transferred to diazobenzyloxymethyl paper. We have shown the presence of a large...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merten S,Synenki RM,Locker J,Christianson T,Rabinowitz M

更新日期：1980-03-01 00:00:00

abstract：:The number of x-irradiated mammalian cells surviving is markedly increased when the cells are incubated with an uncoupler of oxidative phosphorylation prior to or immediately after irradiation. This increase is greater in plateau-phase cells than in exponentially growing cells. The increase in survival is related to t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laval F

更新日期：1980-05-01 00:00:00

abstract：:We analyze the effects of an externally applied electric field on thermal fluctuations for a binary electrolyte fluid. We show that the fluctuating Poisson-Nernst-Planck (PNP) equations for charged multispecies diffusion coupled with the fluctuating fluid momentum equation result in enhanced charge transport via a mec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Péraud JP,Nonaka AJ,Bell JB,Donev A,Garcia AL

更新日期：2017-10-10 00:00:00

abstract：:The primitive neurohypophyseal nonapeptide oxytocin (OXT) has established functions in parturition, lactation, appetite, and social behavior. We have shown that OXT has direct actions on the mammalian skeleton, stimulating bone formation by osteoblasts and modulating the genesis and function of bone-resorbing osteocla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun L,Lizneva D,Ji Y,Colaianni G,Hadelia E,Gumerova A,Ievleva K,Kuo TC,Korkmaz F,Ryu V,Rahimova A,Gera S,Taneja C,Khan A,Ahmad N,Tamma R,Bian Z,Zallone A,Kim SM,New MI,Iqbal J,Yuen T,Zaidi M

更新日期：2019-12-16 00:00:00

abstract：:Plants have evolved adaptive strategies that involve transcriptional networks to cope with and survive environmental challenges. Key transcriptional regulators that mediate responses to environmental fluctuations in nitrate have been identified; however, little is known about how these regulators interact to orchestra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guan P,Ripoll JJ,Wang R,Vuong L,Bailey-Steinitz LJ,Ye D,Crawford NM

更新日期：2017-02-28 00:00:00

abstract：:Murine hematopoietic blast colony-forming cells (BL-CFCs) are able to generate up to 30,000 progeny blast cells within 10 d in agar cultures. Contained in these populations are large numbers of lineage-committed progenitor cells in the granulocytic and macrophage lineages. Sequential analyses of blast colonies reveale...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metcalf D,Ng A,Mifsud S,Di Rago L

更新日期：2010-09-14 00:00:00

abstract：:The retinoblastoma gene product (the RB protein) is phosphorylated in a cell cycle-dependent manner and this modification is believed to be important for cells to progress through the cell cycle. We found that purified cdk2 (cyclin-dependent kinase/cell division kinase 2) can phosphorylate the RB protein in vitro at t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akiyama T,Ohuchi T,Sumida S,Matsumoto K,Toyoshima K

更新日期：1992-09-01 00:00:00

abstract：:Aspartic acid in the second transmembrane domain is a highly conserved amino acid among the G protein-coupled receptors and is functionally important for agonist binding and G-protein coupling in beta 2-adrenergic and luteinizing hormone receptors. To determine whether this aspartic acid is also involved in the functi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bihoreau C,Monnot C,Davies E,Teutsch B,Bernstein KE,Corvol P,Clauser E

更新日期：1993-06-01 00:00:00

abstract：:The zinc finger protein LMO4 is overexpressed in a high proportion of breast carcinomas. Here, we report that overexpression of a mouse mammary tumor virus (MMTV)-Lmo4 transgene in the mouse mammary gland elicits hyperplasia and mammary intraepithelial neoplasia or adenosquamous carcinoma in two transgenic strains wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sum EY,Segara D,Duscio B,Bath ML,Field AS,Sutherland RL,Lindeman GJ,Visvader JE

更新日期：2005-05-24 00:00:00

abstract：:We developed two solid-phase reagent systems for microscopic visualization and characterization of melanocyte-stimulating hormone (MSH) receptors of melanoma cells. Multiple copies of [Nle-4,D-Phe-7]-alpha-MSH, a potent analog of alpha-MSH, were conjugated to microspheres (latex beads) or macrospheres (polyamide beads...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharma SD,Jiang J,Hadley ME,Bentley DL,Hruby VJ

更新日期：1996-11-26 00:00:00

abstract：:Superoxide dismutase from chicken-liver mitochondria (manganese enzyme) and the two dismutases from Escherichia coli (manganese and iron enzymes) were analyzed through 29 cycles of automated Edman degradations. The high degree of homology among the amino-terminal sequences of these three dismutases corroborates their ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steinman HM,Hill RL

更新日期：1973-12-01 00:00:00

abstract：:The retrotransposons that maintain telomeres in Drosophila melanogaster have unique features that are shared across all Drosophila species but are not found in other retrotransposons. Comparative analysis of these features provides insight into their importance for telomere maintenance in Drosophila. Gag proteins enco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Casacuberta E,Marín FA,Pardue ML

更新日期：2007-05-15 00:00:00

abstract：:Entamoeba histolytica is a single cell eukaryote that is the etiologic agent of amoebic colitis. Core promoter elements of E. histolytica protein encoding genes include a TATA-like sequence (GTATTTAAAG/C) at -30, a novel element designated GAAC (GAACT) that has a variable location between TATA and the site of transcri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Singh U,Rogers JB,Mann BJ,Petri WA Jr

更新日期：1997-08-05 00:00:00

abstract：:Molecular dynamics simulations show that the desolvation rates of isotopes of Li(+), K(+), Rb(+), Ca(2+), Sr(2+), and Ba(2+) may have a relatively strong dependence on the metal cation mass. This inference is based on the observation that the exchange rate constant, k(wex), for water molecules in the first hydration s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hofmann AE,Bourg IC,DePaolo DJ

更新日期：2012-11-13 00:00:00

abstract：:The androgen receptor (AR) plays an essential role in prostate cancer, and suppression of its signaling with androgen deprivation therapy (ADT) has been the mainstay of treatment for metastatic hormone-sensitive prostate cancer for more than 70 y. Chemotherapy has been reserved for metastatic castration-resistant pros...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Komura K,Jeong SH,Hinohara K,Qu F,Wang X,Hiraki M,Azuma H,Lee GS,Kantoff PW,Sweeney CJ

更新日期：2016-05-31 00:00:00

abstract：:Genes that are up- and down-regulated by thyroid hormone in the tail resorption program of Xenopus laevis have been isolated by a gene expression screen, sequenced, and identified in the GenBank data base. The entire program is estimated to consist of fewer than 35 up-regulated and fewer than 10 down-regulated genes; ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown DD,Wang Z,Furlow JD,Kanamori A,Schwartzman RA,Remo BF,Pinder A

更新日期：1996-03-05 00:00:00

abstract：:The need to assess subtle, potentially exploitable changes in serial structure is paramount in the analysis of financial data. Herein, we demonstrate the utility of approximate entropy (ApEn), a model-independent measure of sequential irregularity, toward this goal, by several distinct applications. We consider both e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pincus S,Kalman RE

更新日期：2004-09-21 00:00:00