Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer.

abstract：:We document male-biased sex ratios among U.S.-born children of Chinese, Korean, and Asian Indian parents in the 2000 U.S. Census. This male bias is particularly evident for third children: If there was no previous son, sons outnumbered daughters by 50%. By contrast, the sex ratios of eldest and younger children with a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Almond D,Edlund L

更新日期：2008-04-15 00:00:00

abstract：:All but two genes involved in the ergosterol biosynthetic pathway in Saccharomyces cerevisiae have been cloned, and their corresponding mutants have been described. The remaining genes encode the C-3 sterol dehydrogenase (C-4 decarboxylase) and the 3-keto sterol reductase and in concert with the C-4 sterol methyloxida...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gachotte D,Barbuch R,Gaylor J,Nickel E,Bard M

更新日期：1998-11-10 00:00:00

abstract：:Tobacco mosaic virus (TMV) was reconstituted from the RNA of a common strain (OM) and the protein of a watermelon strain of cucumber green mottle mosaic virus (CGMMV-W), which is a member of the tobamovirus group. In 0.25 M phosphate buffer at 25 degrees C, CGMMV-W protein existed mainly as 21S aggregates. When this p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fukuda M,Okada Y

更新日期：1982-10-01 00:00:00

abstract：:Cancers frequently arise as a result of an acquired genomic instability and the subsequent clonal evolution of neoplastic cells with variable patterns of genetic aberrations. Thus, the presence and behaviors of distinct clonal populations in each patient's tumor may underlie multiple clinical phenotypes in cancers. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruiz C,Lenkiewicz E,Evers L,Holley T,Robeson A,Kiefer J,Demeure MJ,Hollingsworth MA,Shen M,Prunkard D,Rabinovitch PS,Zellweger T,Mousses S,Trent JM,Carpten JD,Bubendorf L,Von Hoff D,Barrett MT

更新日期：2011-07-19 00:00:00

abstract：:Somatic crossing over in flies heterozygous for a dominant Minute mutant may result in two cells, homozygous for wild type and Minute, respectively. If both cells took part in development, a twin spot of two genotypes, different from the rest of the body, would result. Two-hundred wild type spots were found, none of w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stern C,Tokunaga C

更新日期：1971-02-01 00:00:00

abstract：:In the traditional Z scheme of photosynthesis the Emerson effects of red drop (decline in yield of photosynthesis in far-red light) and enhancement (of far-red yield by supplementary short-wavelength light) are taken to be evidence for the coupling in series of two photosystems that absorb unsymmetrically in the far-r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warner JW,Berry RS

更新日期：1987-06-01 00:00:00

abstract：:Staphylococcus aureus is a major cause of community-acquired and nosocomial infections including the life-threatening conditions endocarditis, necrotizing pneumonia, necrotizing fasciitis, and septicemia. Toll-like receptor (TLR)-2, a membrane-bound microbial sensor, detects staphylococcal components, but macrophages ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hruz P,Zinkernagel AS,Jenikova G,Botwin GJ,Hugot JP,Karin M,Nizet V,Eckmann L

更新日期：2009-08-04 00:00:00

abstract：:The spatiotemporal regulation of neurotransmitter transporters involves proteins that interact with their intracellular domains. Using a proteomic approach, we identified several proteins that interact with the C terminus of the serotonin transporter (SERT). These included neuronal nitric oxide synthase (nNOS), a PSD-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chanrion B,Mannoury la Cour C,Bertaso F,Lerner-Natoli M,Freissmuth M,Millan MJ,Bockaert J,Marin P

更新日期：2007-05-08 00:00:00

abstract：:It is generally believed that the old quantum theory, as presented by Niels Bohr in 1913, fails when applied to few electron systems, such as the H(2) molecule. Here, we find previously undescribed solutions within the Bohr theory that describe the potential energy curve for the lowest singlet and triplet states of H(...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Svidzinsky AA,Scully MO,Herschbach DR

更新日期：2005-08-23 00:00:00

abstract：:It is shown that polyphosphates are not generated in significant amounts in the phosphoglycerate kinase reaction; polyphosphate is more effective than ATP in the formation of glucose 6-P by glucokinase, but the rate with ATP may be adequate to meet the requirements of glucose metabolism; PPi is far more effective than...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wood HG,Goss NH

更新日期：1985-01-01 00:00:00

abstract：:Bacteria form colonies and secrete extracellular polymeric substances that surround the individual cells. These spatial structures are often associated with collaboration and quorum sensing between the bacteria. Here we investigate the mutual protection provided by spherical growth of a monoclonal colony during exposu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eriksen RS,Svenningsen SL,Sneppen K,Mitarai N

更新日期：2018-01-09 00:00:00

abstract：:Long interspersed nuclear elements 1 (L1) are active retrotransposons that reside in many species, including humans and rodents. L1 elements produce an RNA intermediate that is reverse transcribed to DNA and inserted in a new genomic location. We have tagged an active human L1 element (L1(RP)) with a gene encoding enh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prak ET,Dodson AW,Farkash EA,Kazazian HH Jr

更新日期：2003-02-18 00:00:00

abstract：:We have earlier reported conditions that support the axenic development in vitro of a complete asexual erythrocytic cycle of Plasmodium falciparum. Up to 30% of merozoites showed initial differentiation into trophic forms (rings) viable at 14 hr. However, only approximately 1% of the merozoites would develop further i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams JH,Gill GS,Trager W

更新日期：1995-01-17 00:00:00

abstract：:Human tuberculosis is caused by members of the Mycobacterium tuberculosis complex (MTBC) that vary in virulence and transmissibility. While genome-wide association studies have uncovered several mutations conferring drug resistance, much less is known about the factors underlying other bacterial phenotypes. Variation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Øyås O,Borrell S,Trauner A,Zimmermann M,Feldmann J,Liphardt T,Gagneux S,Stelling J,Sauer U,Zampieri M

更新日期：2020-04-14 00:00:00

abstract：:The bacterial pathogen Streptococcus pneumoniae is a major public health concern, being responsible for more than 1.5 million deaths annually through pneumonia, meningitis, and septicemia. Available vaccines target only a subset of serotypes, so vaccination is often accompanied by a rise in the frequency of nonvaccine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Obolski U,Lourenço J,Thompson C,Thompson R,Gori A,Gupta S

更新日期：2018-03-20 00:00:00

abstract：:Small ubiquitin modifier 1 (SUMO1) is shown to regulate K2P1 background channels in the plasma membrane (PM) of live mammalian cells. Confocal microscopy reveals native SUMO1, SAE1, and Ubc9 (the enzymes that activate and conjugate SUMO1) at PM where SUMO1 and expressed human K2P1 are demonstrated to colocalize. Silen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Plant LD,Dementieva IS,Kollewe A,Olikara S,Marks JD,Goldstein SA

更新日期：2010-06-08 00:00:00

abstract：:The phase transition for turbulent diffusion, reported by Avellaneda and Majda [Avellaneda, M. & Majda, A. J. (1994) Philos. Trans. R. Soc. London A 346, 205-233, and several earlier papers], is traced to a modeling assumption in which the energy spectrum of the turbulent fluid is singularly dependent on the viscosity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wallstrom TC

更新日期：1995-11-21 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) specifies in the infected cell a set of polypeptides (alpha) whose mRNAs are made in the absence of protein synthesis. The individual mRNAs specifying alpha polypeptides 0, 4, 22, and 27 were purified by hybridization to strand-separated or total HSV-1 DNA fragments cloned in pBR322 plas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mackem S,Roizman B

更新日期：1980-12-01 00:00:00

abstract：:This paper introduces the use of magnetic field tomography (MFT), a noninvasive technique based on distributed source analysis of magnetoencephalography data, which makes possible the three-dimensional reconstruction of dynamic brain activity in humans. MFT has a temporal resolution better than 1 msec and a spatial ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ribary U,Ioannides AA,Singh KD,Hasson R,Bolton JP,Lado F,Mogilner A,Llinás R

更新日期：1991-12-15 00:00:00

abstract：:The 4D organization of the interphase nucleus, or the 4D Nucleome (4DN), reflects a dynamical interaction between 3D genome structure and function and its relationship to phenotype. We present initial analyses of the human 4DN, capturing genome-wide structure using chromosome conformation capture and 3D imaging, and f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen H,Chen J,Muir LA,Ronquist S,Meixner W,Ljungman M,Ried T,Smale S,Rajapakse I

更新日期：2015-06-30 00:00:00

abstract：:Scientific journal publications, and their contributions to knowledge, can be described by their depth (specialized, domain-specific knowledge extensions) and breadth (topical scope, including spanning multiple knowledge domains). Toward generating hypotheses about how scientists' personal dispositions would uniquely ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bateman TS,Hess AM

更新日期：2015-03-24 00:00:00

abstract：:The organization and allelic recombination of the merozoite surface protein-1 gene of Plasmodium vivax (PvMsp-1), the most widely prevalent human malaria parasite, were evaluated in complete nucleotide sequences of 40 isolates from various geographic areas. Alignment of 31 distinct alleles revealed the mosaic organiza...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Putaporntip C,Jongwutiwes S,Sakihama N,Ferreira MU,Kho WG,Kaneko A,Kanbara H,Hattori T,Tanabe K

更新日期：2002-12-10 00:00:00

abstract：:To improve the efficiency of liposome-mediated DNA transfer as a tool for gene therapy, we have developed a fusigenic liposome vector based on principles of viral cell fusion. The fusion proteins of hemagglutinating virus of Japan (HVJ; also Sendai virus) are complexed with liposomes that encapsulate oligodeoxynucleot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dzau VJ,Mann MJ,Morishita R,Kaneda Y

更新日期：1996-10-15 00:00:00

abstract：:An electrophoretically slow albumin variant was detected with a phenotype frequency of about 1:1000 in Sweden and was also found in a family of Scottish descent from Kaikoura, New Zealand, and in five families in Tradate, Italy. Structural study established that the major variant component was arginyl-albumin, in whic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brennan SO,Arai K,Madison J,Laurell CB,Galliano M,Watkins S,Peach R,Myles T,George P,Putnam FW

更新日期：1990-05-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder and is strongly associated with obesity and type 2 diabetes. Currently, there is no approved pharmacological treatment for this disease, but improvement of insulin resistance using peroxisome proliferator-activated receptor-γ (PPARγ) ag...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu W,Struik D,Nies VJ,Jurdzinski A,Harkema L,de Bruin A,Verkade HJ,Downes M,Evans RM,van Zutphen T,Jonker JW

更新日期：2016-02-23 00:00:00

abstract：:High-resolution crystal structures of editing complexes of both duplex and single-stranded DNA bound to Escherichia coli DNA polymerase I large fragment (Klenow fragment) show four nucleotides of single-stranded DNA bound to the 3'-5' exonuclease active site and extending toward the polymerase active site. Melting of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freemont PS,Friedman JM,Beese LS,Sanderson MR,Steitz TA

更新日期：1988-12-01 00:00:00

abstract：:Management of the diverse fisheries of the world has had mixed success. While managing single species in data-rich environments has been largely effective, perhaps the greatest challenge facing fishery managers is how to deal with mixed stocks of fish with a range of life histories that reside in the same location. Be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hastings A,Gaines SD,Costello C

更新日期：2017-08-22 00:00:00

abstract：:We have long known that language is lateralized to the left hemisphere (LH) in most neurologically healthy adults. In contrast, findings on lateralization of function during development are more complex. As in adults, anatomical, electrophysiological, and neuroimaging studies in infants and children indicate LH latera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olulade OA,Seydell-Greenwald A,Chambers CE,Turkeltaub PE,Dromerick AW,Berl MM,Gaillard WD,Newport EL

更新日期：2020-09-22 00:00:00

abstract：:The cationic conductances of purified bovine retinal rod membranes were studied by incorporation of vesicles into planar lipid bilayers. When the membranes were stripped of all peripheral proteins [guanine nucleotide-binding protein (G protein) and cGMP phosphodiesterase (3',5'-cyclic-GMP 5'-nucleotidohydrolase), EC 3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bennett N,Ildefonse M,Crouzy S,Chapron Y,Clerc A

更新日期：1989-05-01 00:00:00

abstract：:In vitro T-cell receptor-induced programmed cell death in both activated T cells from human immunodeficiency virus-seronegative (HIV-) donors and resting T cells from HIV+ donors was substantially influenced by cytokines. Addition of exogenous recombinant "type 1" lymphokines interferon gamma and interleukin 2 (IL-2),...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clerici M,Sarin A,Coffman RL,Wynn TA,Blatt SP,Hendrix CW,Wolf SF,Shearer GM,Henkart PA

更新日期：1994-12-06 00:00:00