当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > The neural basis of language development: Changes in lateralization over age.

The neural basis of language development: Changes in lateralization over age.

Abstract：

:We have long known that language is lateralized to the left hemisphere (LH) in most neurologically healthy adults. In contrast, findings on lateralization of function during development are more complex. As in adults, anatomical, electrophysiological, and neuroimaging studies in infants and children indicate LH lateralization for language. However, in very young children, lesions to either hemisphere are equally likely to result in language deficits, suggesting that language is distributed symmetrically early in life. We address this apparent contradiction by examining patterns of functional MRI (fMRI) language activation in children (ages 4 through 13) and adults (ages 18 through 29). In contrast to previous studies, we focus not on lateralization per se but rather on patterns of left-hemisphere (LH) and right-hemisphere (RH) activation across individual participants over age. Our analyses show significant activation not only in the LH language network but also in their RH homologs in all of the youngest children (ages 4 through 6). The proportion of participants showing significant RH activation decreases over age, with over 60% of adults lacking any significant RH activation. A whole-brain correlation analysis revealed an age-related decrease in language activation only in the RH homolog of Broca's area. This correlation was independent of task difficulty. We conclude that, while language is left-lateralized throughout life, the RH contribution to language processing is also strong early in life and decreases through childhood. Importantly, this early RH language activation may represent a developmental mechanism for recovery following early LH injury.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Olulade OA,Seydell-Greenwald A,Chambers CE,Turkeltaub PE,Dromerick AW,Berl MM,Gaillard WD,Newport EL

doi

10.1073/pnas.1905590117

subject

Has Abstract

pub_date

2020-09-22 00:00:00

pages

23477-23483

issue

38

eissn

0027-8424

issn

1091-6490

pii

1905590117

journal_volume

117

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Heparin-binding epidermal growth factor-like growth factor, a v-Jun target gene, induces oncogenic transformation.

    abstract：:Jun is a transcription factor belonging to the activator protein 1 family. A mutated version of Jun (v-Jun) transduced by the avian retrovirus ASV17 induces oncogenic transformation in avian cell cultures and sarcomas in young galliform birds. The oncogenicity of Jun probably results from transcriptional deregulation ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.10.5716

    authors： Fu Sl,Bottoli I,Goller M,Vogt PK

    更新日期：1999-05-11 00:00:00

  • The Drosophila homologue of vertebrate myogenic-determination genes encodes a transiently expressed nuclear protein marking primary myogenic cells.

    abstract：:We have isolated a cDNA clone, called Dmyd for Drosophila myogenic-determination gene, that encodes a protein with structural and functional characteristics similar to the members of the vertebrate MyoD family. Dmyd clone encodes a polypeptide of 332 amino acids with 82% identity to MyoD in the 41 amino acids of the p...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.9.3782

    authors： Paterson BM,Walldorf U,Eldridge J,Dübendorfer A,Frasch M,Gehring WJ

    更新日期：1991-05-01 00:00:00

  • Odd-skipped related-1 controls neural crest chondrogenesis during tongue development.

    abstract：:The tongue is a critical element of the feeding system in tetrapod animals for their successful adaptation to terrestrial life. Whereas the oral part of the mammalian tongue contains soft tissues only, the avian tongue has an internal skeleton extending to the anterior tip. The mechanisms underlying the evolutionary d...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1306495110

    authors： Liu H,Lan Y,Xu J,Chang CF,Brugmann SA,Jiang R

    更新日期：2013-11-12 00:00:00

  • Interplay between Drosophila Bloom's syndrome helicase and Ku autoantigen during nonhomologous end joining repair of P element-induced DNA breaks.

    abstract：:P transposable elements in Drosophila are mobilized via a cut-and-paste mechanism. The broken DNA ends generated during transposition can be repaired via the homology-directed synthesis-dependent strand annealing or by nonhomologous end joining (NHEJ). Genetic studies have demonstrated an interaction between the gene ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0403000101

    authors： Min B,Weinert BT,Rio DC

    更新日期：2004-06-15 00:00:00

  • Allele-specific B pocket transplant in class I major histocompatibility complex protein changes requirement for anchor residue at P2 of peptide.

    abstract：:To investigate the role of an anchoring pocket in allele-specific peptide presentation by a major histocompatibility complex class I molecule, we "transplanted" a B pocket from HLA-A*0201 into HLA-B*2705 by site-directed mutagenesis. The resulting protein, designated B27.A2B, binds a different set of endogenous peptid...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.90.14.6879

    authors： Colbert RA,Rowland-Jones SL,McMichael AJ,Frelinger JA

    更新日期：1993-07-15 00:00:00

  • Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation.

    abstract：:Stimulation of resting CD4(+) T lymphocytes leads to rapid proliferation and differentiation into effector (Teff) or inducible regulatory (Treg) subsets with specific functions to promote or suppress immunity. Importantly, Teff and Treg use distinct metabolic programs to support subset specification, survival, and fun...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1108856108

    authors： Michalek RD,Gerriets VA,Nichols AG,Inoue M,Kazmin D,Chang CY,Dwyer MA,Nelson ER,Pollizzi KN,Ilkayeva O,Giguere V,Zuercher WJ,Powell JD,Shinohara ML,McDonnell DP,Rathmell JC

    更新日期：2011-11-08 00:00:00

  • Ultrarapid mixing experiments shed new light on the characteristics of the initial conformational ensemble during the folding of ribonuclease A.

    abstract：:The earliest folding events in single-tryptophan mutants of RNase A were investigated by fluorescence measurements by using a combination of stopped-flow and continuous-flow mixing experiments covering the time range from 70 micros to 10 s. An ultrarapid double-jump mixing protocol was used to study refolding from an ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0407999101

    authors： Welker E,Maki K,Shastry MC,Juminaga D,Bhat R,Scheraga HA,Roder H

    更新日期：2004-12-21 00:00:00

  • Nucleotide sequence and predicted amino acid sequence of a protein encoded in a small herpes simplex virus DNA fragment capable of trans-inducing alpha genes.

    abstract：:The five alpha genes of herpes simplex virus 1 are the first set of genes to be expressed after infection. Previous studies have shown that alpha genes resident in eukaryotic cells are induced by infection with herpes simplex virus 1 or 2 but not by other herpesviruses and indicate that the alpha trans-inducing factor...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.82.17.5870

    authors： Pellett PE,McKnight JL,Jenkins FJ,Roizman B

    更新日期：1985-09-01 00:00:00

  • Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.

    abstract：:Pathway-specific therapy is the future of cancer management. The oncogenic phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in solid tumors; however, currently, no reliable test for PI3K pathway activation exists for human tumors. Taking advantage of the observation that loss of PTEN, the negative ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0702507104

    authors： Saal LH,Johansson P,Holm K,Gruvberger-Saal SK,She QB,Maurer M,Koujak S,Ferrando AA,Malmström P,Memeo L,Isola J,Bendahl PO,Rosen N,Hibshoosh H,Ringnér M,Borg A,Parsons R

    更新日期：2007-05-01 00:00:00

  • Land-use history impacts functional diversity across multiple trophic groups.

    abstract：:Land-use change is a major driver of biodiversity loss worldwide. Although biodiversity often shows a delayed response to land-use change, previous studies have typically focused on a narrow range of current landscape factors and have largely ignored the role of land-use history in shaping plant and animal communities...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1910023117

    authors： Le Provost G,Badenhausser I,Le Bagousse-Pinguet Y,Clough Y,Henckel L,Violle C,Bretagnolle V,Roncoroni M,Manning P,Gross N

    更新日期：2020-01-21 00:00:00

  • Quantitative expression profiling of identified neurons reveals cell-specific constraints on highly variable levels of gene expression.

    abstract：:The postdevelopmental basis of cellular identity and the unique cellular output of a particular neuron type are of particular interest in the nervous system because a detailed understanding of circuits responsible for complex processes in the brain is impeded by the often ambiguous classification of neurons in these c...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0705827104

    authors： Schulz DJ,Goaillard JM,Marder EE

    更新日期：2007-08-07 00:00:00

  • Identification of a serotonin receptor coupled to adenylyl cyclase involved in learning-related heterosynaptic facilitation in Aplysia.

    abstract：:Serotonin (5-HT) plays a critical role in modulating synaptic plasticity in the marine mollusc Aplysia and in the mammalian nervous system. In Aplysia sensory neurons, 5-HT can activate several signal cascades, including PKA and PKC, presumably via distinct types of G protein-coupled receptors. However, the molecular ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0907502106

    authors： Lee YS,Choi SL,Lee SH,Kim H,Park H,Lee N,Lee SH,Chae YS,Jang DJ,Kandel ER,Kaang BK

    更新日期：2009-08-25 00:00:00

  • Wolbachia as a bacteriocyte-associated nutritional mutualist.

    abstract：:Many insects are dependent on bacterial symbionts that provide essential nutrients (ex. aphid-Buchnera and tsetse-Wiglesworthia associations), wherein the symbionts are harbored in specific cells called bacteriocytes that constitute a symbiotic organ bacteriome. Facultative and parasitic bacterial symbionts like Wolba...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0911476107

    authors： Hosokawa T,Koga R,Kikuchi Y,Meng XY,Fukatsu T

    更新日期：2010-01-12 00:00:00

  • Reconstitution of thermostable ATPase capable of energy coupling from its purified subunits.

    abstract：:Purified dicyclohexylcarbodiimide-sensitive ATPase (TF0-F1) from thermophilic bacterium PS3 is composed of a water soluble part with ATP hydrolytic activity (TF1) and a water insoluble moiety (TF0). All of the five subunits (alpha, beta, gamma, delta, and epsilon) of TF1 were isolated. TF1 was reconstituted from the f...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.74.3.936

    authors： Yoshida M,Okamoto H,Sone N,Hirata H,Kagawa Y

    更新日期：1977-03-01 00:00:00

  • An early role for sonic hedgehog from foregut endoderm in jaw development: ensuring neural crest cell survival.

    abstract：:We have investigated the role of Sonic hedgehog (Shh) in the development of facial structures by depriving chicken embryos of the most anterior sources of this morphogen, including the prechordal plate and the anterior ventral endoderm of the foregut, before the onset of neural crest cell (NCC) migration to the first ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0604751103

    authors： Brito JM,Teillet MA,Le Douarin NM

    更新日期：2006-08-01 00:00:00

  • Binding of Drosophila Polo kinase to its regulator Matrimony is noncanonical and involves two separate functional domains.

    abstract：:Drosophila melanogaster Polo kinase physically interacts with, and is repressed by, the Matrimony (Mtrm) protein during oogenesis. Females heterozygous for a deletion of the mtrm gene display defects in chromosome segregation at meiosis I. However, a complete absence of Mtrm results in both meiotic catastrophe and fem...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1301690110

    authors： Bonner AM,Hughes SE,Chisholm JA,Smith SK,Slaughter BD,Unruh JR,Collins KA,Friederichs JM,Florens L,Swanson SK,Pelot MC,Miller DE,Washburn MP,Jaspersen SL,Hawley RS

    更新日期：2013-03-26 00:00:00

  • PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization.

    abstract：:Although peroxisome proliferator-activated receptor gamma (PPARgamma) agonists such as thiazolidinediones (TZDs) are widely used to treat type 2 diabetes, how its activation in individual tissues contributes to TZD's therapeutic action remains controversial. As TZDs are known to have receptor-independent effects, we s...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0912487106

    authors： Sugii S,Olson P,Sears DD,Saberi M,Atkins AR,Barish GD,Hong SH,Castro GL,Yin YQ,Nelson MC,Hsiao G,Greaves DR,Downes M,Yu RT,Olefsky JM,Evans RM

    更新日期：2009-12-29 00:00:00

  • Online purchasing creates opportunities to lower the life cycle carbon footprints of consumer products.

    abstract：:A major barrier to transitions to environmental sustainability is that consumers lack information about the full environmental footprints of their purchases. Sellers' incentives do not support reducing the footprints unless customers have such information and are willing to act on it. We explore the potential of moder...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1522211113

    authors： Isley SC,Stern PC,Carmichael SP,Joseph KM,Arent DJ

    更新日期：2016-08-30 00:00:00

  • Multibioinspired slippery surfaces with wettable bump arrays for droplets pumping.

    abstract：:Droplet manipulation is playing an important role in various fields, including scientific research, industrial production, and daily life. Here, inspired by the microstructures and functions of Namib desert beetles, Nepenthes pitcher plants, and emergent aquatic plants, we present a multibioinspired slippery surface f...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1912467116

    authors： Zhang X,Sun L,Wang Y,Bian F,Wang Y,Zhao Y

    更新日期：2019-10-15 00:00:00

  • Altered protein kinase C in a mast cell variant defective in exocytosis.

    abstract：:The murine mast cell line PB-3c is dependent on interleukin 3 (IL-3) with respect to survival and proliferation. These cells also require IL-3 to display antigen-mediated serotonin release, which is coupled to a transient increase of cytosolic free calcium ([Ca2+]i). The antigen-mediated exocytosis is inhibited by pho...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.84.5.1277

    authors： Mazurek N,Regazzi R,Borner C,Wyss R,Conscience JF,Erne P,Eppenberger U,Fabbro D

    更新日期：1987-03-01 00:00:00

  • A sulfated carbohydrate epitope inhibits axon regeneration after injury.

    abstract：:Chondroitin sulfate proteoglycans (CSPGs) represent a major barrier to regenerating axons in the central nervous system (CNS), but the structural diversity of their polysaccharides has hampered efforts to dissect the structure-activity relationships underlying their physiological activity. By taking advantage of our a...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1121318109

    authors： Brown JM,Xia J,Zhuang B,Cho KS,Rogers CJ,Gama CI,Rawat M,Tully SE,Uetani N,Mason DE,Tremblay ML,Peters EC,Habuchi O,Chen DF,Hsieh-Wilson LC

    更新日期：2012-03-27 00:00:00

  • Broad resistance to plant viruses in transgenic plants conferred by antisense inhibition of a host gene essential in S-adenosylmethionine-dependent transmethylation reactions.

    abstract：:S-Adenosylhomocysteine hydrolase (SAHH) is a key enzyme in transmethylation reactions that use S-adenosylmethionine as the methyl donor. Because of the importance of SAHH in a number of S-adenosylmethionine-dependent transmethylation reactions, particularly the 5' capping of mRNA during viral replication, SAHH has bee...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.13.6117

    authors： Masuta C,Tanaka H,Uehara K,Kuwata S,Koiwai A,Noma M

    更新日期：1995-06-20 00:00:00

  • Habituation of tobacco pith cells for factors promoting cell division is heritable and potentially reversible.

    abstract：:A type of heritable cellular change, known as habituation, occurs spontaneously in plant tissue and cell culture. This phenomenon is characterized by a newly acquired capacity of plant cells to produce growth regulatory substances. Using cloned lines of tobacco pith parenchyma cells, we demonstrated that a newly acqui...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.70.9.2660

    authors： Binns A,Meins F

    更新日期：1973-09-01 00:00:00

  • Cadmium and iron transport by members of a plant metal transporter family in Arabidopsis with homology to Nramp genes.

    abstract：:Metal cation homeostasis is essential for plant nutrition and resistance to toxic heavy metals. Many plant metal transporters remain to be identified at the molecular level. In the present study, we have isolated AtNramp cDNAs from Arabidopsis and show that these genes complement the phenotype of a metal uptake defici...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.97.9.4991

    authors： Thomine S,Wang R,Ward JM,Crawford NM,Schroeder JI

    更新日期：2000-04-25 00:00:00

  • A coherent framework for multiresolution analysis of biological networks with "memory": Ras pathway, cell cycle, and immune system.

    abstract：:Various biological processes exhibit characteristics that vary dramatically in response to different input conditions or changes in the history of the process itself. One of the examples studied here, the Ras-PKC-mitogen-activated protein kinase (MAPK) bistable pathway, follows two distinct dynamics (modes) depending ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0500554102

    authors： Barbano PE,Spivak M,Feng J,Antoniotti M,Mishra B

    更新日期：2005-05-03 00:00:00

  • Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons.

    abstract：:We have recently shown that the expression of nestin, the neural stem cell marker protein, is expressed in bulge-area stem cells of the hair follicle. We used transgenic mice with GFP expression driven by the nestin regulatory element [nestin-driven GFP (ND-GFP)]. The ND-GFP stem cells give rise to the outer-root shea...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0501263102

    authors： Amoh Y,Li L,Katsuoka K,Penman S,Hoffman RM

    更新日期：2005-04-12 00:00:00

  • Hippocampal long-term depression and depotentiation are defective in mice carrying a targeted disruption of the gene encoding the RI beta subunit of cAMP-dependent protein kinase.

    abstract：:The cAMP-dependent protein kinase (PKA) has been shown to play an important role in long-term potentiation (LTP) in the hippocampus, but little is known about the function of PKA in long-term depression (LTD). We have combined pharmacologic and genetic approaches to demonstrate that PKA activity is required for both h...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.19.8851

    authors： Brandon EP,Zhuo M,Huang YY,Qi M,Gerhold KA,Burton KA,Kandel ER,McKnight GS,Idzerda RL

    更新日期：1995-09-12 00:00:00

  • Dietary versatility of Early Pleistocene hominins.

    abstract：:New geochemical data from the Malawi Rift (Chiwondo Beds, Karonga Basin) fill a major spatial gap in our knowledge of hominin adaptations on a continental scale. Oxygen (δ18O), carbon (δ13C), and clumped (Δ47) isotope data on paleosols, hominins, and selected fauna elucidate an unexpected diversity in the Pleistocene ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 历史文章,杂志文章

    doi：10.1073/pnas.1809439115

    authors： Lüdecke T,Kullmer O,Wacker U,Sandrock O,Fiebig J,Schrenk F,Mulch A

    更新日期：2018-12-26 00:00:00

  • Changes in the composition of plasma membrane proteins during differentiation of embryonic chick erythroid cell.

    abstract：:Erythroid cells which are homogeneous with regard to stage of maturation are naturally available from the circulation of chick embryos at various times of development. This provides a convenient system for examining the changes in plasma membrane protein composition during red cell maturation. Plasma membranes are iso...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.74.3.1062

    authors： Chan LL

    更新日期：1977-03-01 00:00:00

  • Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase.

    abstract：:The later stages of cochlear differentiation and the developmental onset of hearing require thyroid hormone. Although thyroid hormone receptors (TRs) are a prerequisite for this process, it is likely that other factors modify TR activity during cochlear development. The mouse cochlea expresses type 2 deiodinase (D2), ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0307402101

    authors： Ng L,Goodyear RJ,Woods CA,Schneider MJ,Diamond E,Richardson GP,Kelley MW,Germain DL,Galton VA,Forrest D

    更新日期：2004-03-09 00:00:00