Intracellular targeting of telomeric retrotransposon Gag proteins of distantly related Drosophila species.

abstract：:We construct a class of global exact solutions of the Einstein equations that extend the Oppeheimer-Snyder model to the case of nonzero pressure, inside the black hole, by incorporating a shock wave at the leading edge of the expansion of the galaxies, arbitrarily far beyond the Hubble length in the Friedmann-Robertso...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smoller J,Temple B

更新日期：2003-09-30 00:00:00

abstract：:Voltage-gated sodium (Na(V)) and potassium (K(V)) channels are critical components of neuronal action potential generation and propagation. Here, we report that Na(V)β1 encoded by SCN1b, an integral subunit of Na(V) channels, coassembles with and modulates the biophysical properties of K(V)1 and K(V)7 channels, but no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nguyen HM,Miyazaki H,Hoshi N,Smith BJ,Nukina N,Goldin AL,Chandy KG

更新日期：2012-11-06 00:00:00

abstract：:Activation of an anticancer innate immune response is highly desirable because of its inherent ability to generate an adaptive antitumor T-cell response. However, insufficient safety of innate immune modulators limits clinical use to topical applications. Toll-like receptor 5 (TLR5) agonists are favorably positioned a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brackett CM,Kojouharov B,Veith J,Greene KF,Burdelya LG,Gollnick SO,Abrams SI,Gudkov AV

更新日期：2016-02-16 00:00:00

abstract：:Green fluorescent protein (GFP) is widely used as a reporter gene in both prokaryotes and eukaryotes. However, the fluorescence levels of wild-type GFP (wtGFP) are not bright enough for fluorescence-activated cell sorting or flow cytometry. Several GFP variants were generated that are brighter or have altered excitati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson MT,Tjioe IM,Lorincz MC,Parks DR,Herzenberg LA,Nolan GP,Herzenberg LA

更新日期：1996-08-06 00:00:00

abstract：:High social status reduces stress responses in numerous species, but the stress-buffering effect of status may dissipate or even reverse during times of hierarchical instability. In an experimental test of this hypothesis, 118 participants (57.3% female) were randomly assigned to a high- or low-status position in a st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knight EL,Mehta PH

更新日期：2017-01-03 00:00:00

abstract：:We have developed an in vitro transcription system that uses nuclei isolated from Lemna gibba G-3. The in vitro transcripts include sequences homologous to hybridization probes for the small subunit of ribulose-1,5-bisphosphate carboxylase [3-phospho-D-glycerate carboxy-lyase (dimerizing), EC 4.1.1.39], the light-harv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silverthorne J,Tobin EM

更新日期：1984-02-01 00:00:00

abstract：:Leaf-cutting ants combine large-scale herbivory with fungus farming to sustain advanced societies. Their stratified colonies are major evolutionary achievements and serious agricultural pests, but the crucial adaptations that allowed this mutualism to become the prime herbivorous component of neotropical ecosystems ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Fine Licht HH,Schiøtt M,Rogowska-Wrzesinska A,Nygaard S,Roepstorff P,Boomsma JJ

更新日期：2013-01-08 00:00:00

abstract：:Cytotactin is an extracellular matrix protein that is dynamically and transiently expressed in a place-dependent fashion during development by glial cells, fibroblasts, and several other cell types. In the present study, the effects of cytotactin on cell proliferation were examined in fibroblastic cells in culture. NI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crossin KL

更新日期：1991-12-15 00:00:00

abstract：:In autotrophically grown Chlorella cells, glucose induces a hexose transport system but, at the same time, the synthesis of two amino acid transport systems is also induced. Thus, the rates of uptake of glycine, L-alanine, L-proline, and L-serine, all of which compete with each other for entry into the cells, increase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cho BH,Sauer N,Komor E,Tanner W

更新日期：1981-06-01 00:00:00

abstract：:Gyrate atrophy of the choroid and retina (GA) is an inherited chorioretinal degeneration caused by deficiency of ornithine delta-aminotransferase (OAT; L-ornithine: 2-oxo-acid aminotransferase; EC 2.6.1.13). GA is one of the "Finnish genetic diseases," a group of several rare monogenic disorders that occur with increa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitchell GA,Brody LC,Sipila I,Looney JE,Wong C,Engelhardt JF,Patel AS,Steel G,Obie C,Kaiser-Kupfer M

更新日期：1989-01-01 00:00:00

abstract：:Equine arteritis virus (EAV) is a positive-strand RNA virus that uses a discontinuous transcription mechanism to generate a nested set of six subgenomic mRNAs from which its structural genes are expressed. A stable bacterial plasmid (pEAV030) containing a full-length cDNA copy of the 12.7-kb EAV genome was constructed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Dinten LC,den Boon JA,Wassenaar AL,Spaan WJ,Snijder EJ

更新日期：1997-02-04 00:00:00

abstract：:The dramatic loss of Kilimanjaro's ice cover has attracted global attention. The three remaining ice fields on the plateau and the slopes are both shrinking laterally and rapidly thinning. Summit ice cover (areal extent) decreased approximately 1% per year from 1912 to 1953 and approximately 2.5% per year from 1989 to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson LG,Brecher HH,Mosley-Thompson E,Hardy DR,Mark BG

更新日期：2009-11-24 00:00:00

abstract：:The relative abundance of individual proteins shared among clones of lymphocytes provides a meaningful basis for cellular classification. Twelve clones of T cells (obtained by limiting dilution) were analyzed by two-dimensional gel electrophoresis for polypeptide content and then evaluated by the computational techniq...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lefkovits I,Kuhn L,Valiron O,Merle A,Kettman J

更新日期：1988-05-01 00:00:00

abstract：:It was recently demonstrated that amyloid beta (Abeta) peptide vaccination was effective in reducing the Abeta burden in Alzheimer model mice. However, the clinical trial was halted because of the development of meningoencephalitis in some patients. To overcome this problem, anti-Abeta antibody therapy and other types...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okura Y,Miyakoshi A,Kohyama K,Park IK,Staufenbiel M,Matsumoto Y

更新日期：2006-06-20 00:00:00

abstract：:Observations made during the last ten years with the Chandra X-ray Observatory have shed much light on the cooling gas in the centers of clusters of galaxies and the role of active galactic nucleus (AGN) heating. Cooling of the hot intracluster medium in cluster centers can feed the supermassive black holes found in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blanton EL,Clarke TE,Sarazin CL,Randall SW,McNamara BR

更新日期：2010-04-20 00:00:00

abstract：:We perform a generalized-ensemble simulation of a small peptide taking the interactions among all atoms into account. From this simulation we obtain thermodynamic quantities over a wide range of temperatures. In particular, we show that the folding of a small peptide is a multistage process associated with two charact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hansmann UH,Masuya M,Okamoto Y

更新日期：1997-09-30 00:00:00

abstract：:Fibronectin (FN) forms the primitive fibrillar matrix in both embryos and healing wounds. To study the matrix in living cell cultures, we have constructed a cell line that secretes FN molecules chimeric with green fluorescent protein. These FN-green fluorescent protein molecules were assembled into a typical matrix th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohashi T,Kiehart DP,Erickson HP

更新日期：1999-03-02 00:00:00

abstract：:We demonstrate ordered orientation of the hydration water at the surface of phospholipid bilayers by use of coherent anti-Stokes Raman scattering (CARS) microscopy, a highly sensitive vibrational imaging method recently developed. We investigated negatively charged POPS (1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-l-ser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng JX,Pautot S,Weitz DA,Xie XS

更新日期：2003-08-19 00:00:00

abstract：:Direct cell-cell communication is crucial for many processes in biology, particularly embryogenesis, interactions between hematopoetic cells, and in the nervous system. This communication is often mediated by the binding of receptors to cognate ligands at a cell-cell junction. One such interaction that is very importa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qi S,Krogsgaard M,Davis MM,Chakraborty AK

更新日期：2006-03-21 00:00:00

abstract：:Bacillus anthracis, the etiologic agent of anthrax, avoids immune surveillance and commandeers host macrophages as a vehicle for lymphatic spreading. Here, we show that B. anthracis edema toxin (ET), via its adenylyl cyclase activity, dramatically increases the motility of infected macrophages and the expression of va...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim C,Wilcox-Adelman S,Sano Y,Tang WJ,Collier RJ,Park JM

更新日期：2008-04-22 00:00:00

abstract：:The avian predentary is a small skeletal structure located rostral to the paired dentaries found only in Mesozoic ornithuromorphs. The evolution and function of this enigmatic element is unknown. Skeletal tissues forming the predentary and the lower jaws in the basal ornithuromorph Yanornis martini are identified usin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bailleul AM,Li Z,O'Connor J,Zhou Z

更新日期：2019-12-03 00:00:00

abstract：:Saccharomyces cerevisiae has a complex system for switching the mating type of haploid cells, requiring the genome to have three mating-type (MAT)-like loci and a mechanism for silencing two of them. How this system originated is unknown, because the three-locus system is present throughout the family Saccharomycetace...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hanson SJ,Byrne KP,Wolfe KH

更新日期：2014-11-11 00:00:00

abstract：:Embryonal rhabdomyosarcoma (ERMS) is a common pediatric malignancy of muscle, with relapse being the major clinical challenge. Self-renewing tumor-propagating cells (TPCs) drive cancer relapse and are confined to a molecularly definable subset of ERMS cells. To identify drugs that suppress ERMS self-renewal and induce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen EY,DeRan MT,Ignatius MS,Grandinetti KB,Clagg R,McCarthy KM,Lobbardi RM,Brockmann J,Keller C,Wu X,Langenau DM

更新日期：2014-04-08 00:00:00

abstract：:Measles virus (MeV) is the poster child for acute infection followed by lifelong immunity. However, recent work shows the presence of MeV RNA in multiple sites for up to 3 mo after infection in a proportion of infected children. Here, we use experimental infection of rhesus macaques to show that prolonged RNA presence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin WH,Kouyos RD,Adams RJ,Grenfell BT,Griffin DE

更新日期：2012-09-11 00:00:00

abstract：:Dendritic cell (DC) lectins mediate the recognition, uptake, and processing of antigens, but they can also be coopted by pathogens for infection. These distinct activities depend upon the routing of antigens within the cell. Antigens directed to endosomal compartments are degraded, and the peptides are presented on ma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jarvis CM,Zwick DB,Grim JC,Alam MM,Prost LR,Gardiner JC,Park S,Zimdars LL,Sherer NM,Kiessling LL

更新日期：2019-07-23 00:00:00

abstract：:The role of spliced leader RNA (SL RNA) in trans-splicing in Caenorhabditis elegans has been studied through a combination of in vitro mutagenesis and in vivo complementation of rrs-1 mutant nematodes, which lack endogenous SL1 RNA. Three classes of mutant SL1 RNAs have been found-those that rescue the lethal phenotyp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie H,Hirsh D

更新日期：1998-04-14 00:00:00

abstract：:Mitochondrial protein kinases (mPKs) are molecular switches that down-regulate the oxidation of branched-chain alpha-ketoacids and pyruvate. Elevated levels of these metabolites are implicated in disease states such as insulin-resistant Type II diabetes, branched-chain ketoaciduria, and primary lactic acidosis. We rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Machius M,Chuang JL,Wynn RM,Tomchick DR,Chuang DT

更新日期：2001-09-25 00:00:00

abstract：:Explanation of a process of development must ultimately be couched in the terms of the genomic regulatory code. Specification of an embryonic cell lineage is driven by a network of interactions among genes encoding transcription factors. Here, we present the gene regulatory network (GRN) that directs the specification...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oliveri P,Tu Q,Davidson EH

更新日期：2008-04-22 00:00:00

abstract：:BSC-1 cells, epithelial cells of African green monkey kidney origin, show pronounced density-dependent regulation of growth in cell culture. Growth of the cells is rapid to a density of approximately 1.5 x 10(5) cells/per cm(2) in Dulbecco-modified Eagle's medium supplemented with 10% calf serum. Above this "saturatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holley RW,Armour R,Baldwin JH

更新日期：1978-01-01 00:00:00

abstract：:Saccharomyces cerevisiae is one of the most important model organisms and has been a valuable asset to human civilization. However, despite its extensive use in the last 9,000 y, the existence of a seasonal cycle outside human-made environments has not yet been described. We demonstrate the role of social wasps as vec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stefanini I,Dapporto L,Legras JL,Calabretta A,Di Paola M,De Filippo C,Viola R,Capretti P,Polsinelli M,Turillazzi S,Cavalieri D

更新日期：2012-08-14 00:00:00