Glucose induces two amino acid transport systems in Chlorella.

abstract：:To create a universal system for the control of gene expression, we have studied methods for the construction of novel polydactyl zinc finger proteins that recognize extended DNA sequences. Elsewhere we have described the generation of zinc finger domains recognizing sequences of the 5'-GNN-3' subset of a 64-member zi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beerli RR,Segal DJ,Dreier B,Barbas CF 3rd

更新日期：1998-12-08 00:00:00

abstract：:Recent studies have highlighted the importance of peripheral induction of Foxp3-expressing regulatory T cells (Tregs) in the dominant control of immunological tolerance. However, Foxp3(+) Treg differentiation from naïve CD4(+) T cells occurs only under selective conditions, whereas the classical T helper (Th) 1 and 2 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei J,Duramad O,Perng OA,Reiner SL,Liu YJ,Qin FX

更新日期：2007-11-13 00:00:00

abstract：:The gene encoding latent-infection membrane protein 1 (LMP1) was specifically mutated in Epstein-Barr virus (EBV) recombinants by inserting a nonsense linker after codon 9 or codon 84 or into an intron 186 bp 3' to the latter insertion site. EBV recombinants with the LMP1 intron mutation were wild type for LMP1 expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaye KM,Izumi KM,Kieff E

更新日期：1993-10-01 00:00:00

abstract：:The Ipl (Tssc3) gene lies in an extended imprinted region of distal mouse chromosome 7, which also contains the Igf2 gene. Expression of Ipl is highest in placenta and yolk sac, where its mRNA is derived almost entirely from the maternal allele. Ipl encodes a small cytoplasmic protein with a pleckstrin-homology (PH) d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frank D,Fortino W,Clark L,Musalo R,Wang W,Saxena A,Li CM,Reik W,Ludwig T,Tycko B

更新日期：2002-05-28 00:00:00

abstract：:The expanding behavioral repertoire of the developing brain during childhood and adolescence is shaped by complex brain-environment interactions and flavored by unique life experiences. The transition into young adulthood offers opportunities for adaptation and growth but also increased susceptibility to environmental...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alnæs D,Kaufmann T,Marquand AF,Smith SM,Westlye LT

更新日期：2020-06-02 00:00:00

abstract：:The enormous complexity of biological networks has led to the suggestion that networks are built of modules that perform particular functions and are "reused" in evolution in a manner similar to reusable domains in protein structures or modules of electronic circuits. Analysis of known biological networks has revealed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spirin V,Gelfand MS,Mironov AA,Mirny LA

更新日期：2006-06-06 00:00:00

abstract：:Although the p53 network has been intensively studied, genetic analyses long hinted at the existence of components that remained elusive. Recent studies have shown regulation of p53 at the mRNA level mediated via both the 5' and the 3' untranslated regions and affecting the stability and translation efficiency of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Devany E,Zhang X,Park JY,Tian B,Kleiman FE

更新日期：2013-02-26 00:00:00

abstract：:Nonresolving chronic inflammation at the neoplastic site is consistently associated with promoting tumor progression and poor patient outcomes. However, many aspects behind the mechanisms that establish this tumor-promoting inflammatory microenvironment remain undefined. Using bladder cancer (BC) as a model, we found ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheah MT,Chen JY,Sahoo D,Contreras-Trujillo H,Volkmer AK,Scheeren FA,Volkmer JP,Weissman IL

更新日期：2015-04-14 00:00:00

abstract：:Two operators, spatially separated from each other and from the promoters, repress the gal operon when bound to Gal repressor. Conversion of either gal operator to a lac operator results in derepression, although both Gal and Lac repressors are present, suggesting that mere occupation of operator sites is not sufficie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haber R,Adhya S

更新日期：1988-12-01 00:00:00

abstract：:We have investigated the theory that the insulin-induced loss of insulin binding from adipocytes is due to internalization of insulin receptors. Cell-surface receptors were assessed by the binding capacity of intact cells at 16 degrees C. Total (i.e., cell-surface plus intracellular) receptors were assessed by solubil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Green A,Olefsky JM

更新日期：1982-01-01 00:00:00

abstract：:Malaria merozoite invasion of human erythrocytes depends on recognition of specific erythrocyte surface receptors by parasite ligands. Plasmodium vivax merozoite invasion is totally dependent on the recognition of the Duffy blood group antigen by the parasite ligand Duffy-binding protein (DBP). Receptor recognition by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： VanBuskirk KM,Sevova E,Adams JH

更新日期：2004-11-02 00:00:00

abstract：:Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs. TPMT genetic polymorphisms represent a striking example of the potential clinical value of pharmacogenetics. Subjects homozygous for TPMT*3A, the most common variant allele for low activity, an allele that encodes a protein with two...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang L,Nguyen TV,McLaughlin RW,Sikkink LA,Ramirez-Alvarado M,Weinshilboum RM

更新日期：2005-06-28 00:00:00

abstract：:Engaging mammalian Toll-like receptors (TLRs) activate both the NF-kappaB and mitogen-activated protein kinase signaling pathways. Here we establish that mitogen-activated protein 3 kinase Tpl2, levels of which are markedly reduced in nfkb1(-/-) cells, is required for extracellular signal-regulated kinase (ERK) activa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Banerjee A,Gugasyan R,McMahon M,Gerondakis S

更新日期：2006-02-28 00:00:00

abstract：:A target protein for nalidixic and oxolinic acids in Escherichia coli, the nalA gene product (Pnal), was purified to homogeneity as judged by gel electrophoresis, using an in vitro complementation assay. It is a dimer of identical 110,000-dalton subunits. A polypeptide of this molecular weight is uniquely induced by a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sugino A,Peebles CL,Kreuzer KN,Cozzarelli NR

更新日期：1977-11-01 00:00:00

abstract：:Fibrosis is caused by scar tissue formation in internal organs and is associated with 45% of deaths in the United States. Two closely related human serum proteins, serum amyloid P (SAP) and C-reactive protein (CRP), strongly affect fibrosis. In multiple animal models, and in Phase 1 and Phase 2 clinical trials, SAP af...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cox N,Pilling D,Gomer RH

更新日期：2015-07-07 00:00:00

abstract：:Glc3Man9GlcNAc2 is the preferred substrate of the oligosaccharyltransferase of N-linked glycosylation of proteins, but nonglucosylated oligosaccharides can be transferred to proteins in Saccharomyces cerevisiae. Mutations affecting the addition of the three terminal glucose residues lead to accumulation of Man9GlcNAc2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stagljar I,te Heesen S,Aebi M

更新日期：1994-06-21 00:00:00

abstract：:The precipitation and assembly of calcium carbonate skeletons by stony corals is a precisely controlled process regulated by the secretion of an ECM. Recently, it has been reported that the proteome of the skeletal organic matrix (SOM) contains a group of coral acid-rich proteins as well as an assemblage of adhesion a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mass T,Drake JL,Peters EC,Jiang W,Falkowski PG

更新日期：2014-09-02 00:00:00

abstract：:Murine fetal thymus lobes isolated from both normal and scid/scid mice can be colonized by donor cells from either human bone marrow or human umbilical cord blood in vitro. Subsequent organ culture results in a transient production of a few CD4+ CD8+ (double-positive) cells and then the accumulation of CD4+ or CD8+ (s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeoman H,Gress RE,Bare CV,Leary AG,Boyse EA,Bard J,Shultz LD,Harris DT,DeLuca D

更新日期：1993-11-15 00:00:00

abstract：:Digital droplet assays-in which biological samples are compartmentalized into millions of femtoliter-volume droplets and interrogated individually-have generated enormous enthusiasm for their ability to detect biomarkers with single-molecule sensitivity. These assays have untapped potential for point-of-care diagnosti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yelleswarapu V,Buser JR,Haber M,Baron J,Inapuri E,Issadore D

更新日期：2019-03-05 00:00:00

abstract：:The activity-regulated cytoskeleton-associated protein (Arc) gene is a neural immediate early gene that is involved in synaptic downscaling and is robustly induced by prolonged wakefulness in rodent brains. Converging evidence has led to the hypothesis that wakefulness potentiates, and sleep reduces, synaptic strength...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suzuki A,Yanagisawa M,Greene RW

更新日期：2020-05-12 00:00:00

abstract：:We have isolated an Arabidopsis thaliana gene that codes for a receptor related to antifungal pathogenesis-related (PR) proteins. The PR5K gene codes for a predicted 665-amino acid polypeptide that comprises an extracellular domain related to the PR5 proteins, a central transmembrane-spanning domain, and an intracellu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang X,Zafian P,Choudhary M,Lawton M

更新日期：1996-03-19 00:00:00

abstract：:Mutant I1A cells, lacking IL-1 receptor-associated kinase (IRAK) mRNA and protein, have been used to study the involvement of IRAK in NFkappaB and c-Jun N-terminal kinase (JNK) activation. A series of IRAK deletion constructs were expressed in I1A cells, which were then tested for their ability to respond to IL-1. Bot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Commane M,Jiang Z,Stark GR

更新日期：2001-04-10 00:00:00

abstract：:Deficiency in PTEN (phosphatase and tensin homolog deleted on chromosome 10) is the underlying cause of PTEN hamartoma tumor syndrome and a wide variety of human cancers. In skin epidermis, we have previously identified an autocrine FGF signaling induced by loss of Pten in keratinocytes. In this study, we demonstrate ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mathew G,Hannan A,Hertzler-Schaefer K,Wang F,Feng GS,Zhong J,Zhao JJ,Downward J,Zhang X

更新日期：2016-11-15 00:00:00

abstract：:Glycosylation is one of the most common posttranslational modifications to occur in protein biosynthesis, yet its effect on the thermodynamics and kinetics of proteins is poorly understood. A minimalist model based on the native protein topology, in which each amino acid and sugar ring was represented by a single bead...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shental-Bechor D,Levy Y

更新日期：2008-06-17 00:00:00

abstract：:Osteonectin is a prominent noncollagenous protein of developing bone. A 2150-base-pair cDNA coding for osteonectin, isolated from a bovine bone cell lambda gt11 expression library, was sequenced and identified by comparison with protein sequence data. The nucleotide sequence predicts that osteonectin contains 304 amin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bolander ME,Young MF,Fisher LW,Yamada Y,Termine JD

更新日期：1988-05-01 00:00:00

abstract：:Exposure of murine hepatoma (Hepa 1c1c7) cells to a variety of chemical agents known to protect animals against the neoplastic, mutagenic, and other toxic effects of chemical carcinogens results in dose- and time-dependent inductions of NAD(P)H:quinone reductase (EC 1.6.99.2). This enzyme protects against quinone toxi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Long MJ,Prochaska HJ,Talalay P

更新日期：1986-02-01 00:00:00

abstract：:Clonal expansion of premalignant lesions is an important step in the progression to cancer. This process is commonly considered to be a consequence of sustaining a proliferative mutation. Here, we investigate whether the growth trajectory of clones can be better described by a model in which clone growth does not depe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chao DL,Eck JT,Brash DE,Maley CC,Luebeck EG

更新日期：2008-09-30 00:00:00

abstract：:The cellular basis of the magnetic sense remains an unsolved scientific mystery. One theory that aims to explain how animals detect the magnetic field is the magnetite hypothesis. It argues that intracellular crystals of the iron oxide magnetite (Fe3O4) are coupled to mechanosensitive channels that elicit neuronal act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edelman NB,Fritz T,Nimpf S,Pichler P,Lauwers M,Hickman RW,Papadaki-Anastasopoulou A,Ushakova L,Heuser T,Resch GP,Saunders M,Shaw JA,Keays DA

更新日期：2015-01-06 00:00:00

abstract：:The autoimmune dermatologic disease pemphigus vulgaris (PV) is associated with the HLA serotypes DR4 and DRw6. Susceptibility to PV could be conferred either by sequences shared between the DR4 and DRw6 haplotypes or by different sequences in these haplotypes. We have examined the distribution of DR and DQ beta-chain ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scharf SJ,Friedmann A,Brautbar C,Szafer F,Steinman L,Horn G,Gyllensten U,Erlich HA

更新日期：1988-05-01 00:00:00

abstract：:We report a combined thermodynamic and structural characterization of a DNA tetraplex. Using spectroscopic and calorimetric techniques, we demonstrate that d(TG3T) and d(TG3T2G3T), in the presence of K+, form stable tetramolecular complexes. From differential scanning calorimetry measurements, we obtain the following ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin R,Gaffney BL,Wang C,Jones RA,Breslauer KJ

更新日期：1992-09-15 00:00:00