Hierarchy stability moderates the effect of status on stress and performance in humans.

abstract：:Genetic recombination provides an important mechanism for the repair of DNA double-strand breaks. Homologous pairing and strand exchange lead to the formation of DNA intermediates, in which sister chromatids or homologous chromosomes are covalently linked by four-way Holliday junctions (HJs). Depending on the type of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shah Punatar R,Martin MJ,Wyatt HD,Chan YW,West SC

更新日期：2017-01-17 00:00:00

abstract：:Mesothelin is a differentiation antigen present on the surface of ovarian cancers, mesotheliomas, and several other types of human cancers. Because among normal tissues, mesothelin is present only on mesothelial cells, it represents a good target for antibody-mediated delivery of cytotoxic agents. In the present study...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chowdhury PS,Viner JL,Beers R,Pastan I

更新日期：1998-01-20 00:00:00

abstract：:The most frequent form of inherited amyloidoses is associated with mutations in the transthyretin (TTR) gene coding for 127-amino acid residues of four identical, noncovalently linked subunits that form a pair of dimers in the plasma protein complex. Amyloid fibrils containing the variant and to a lesser extent the wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jenne DE,Denzel K,Blätzinger P,Winter P,Obermaier B,Linke RP,Altland K

更新日期：1996-06-25 00:00:00

abstract：:KCNE β-subunits assemble with and modulate the properties of voltage-gated K+ channels. In the heart, KCNE1 associates with the α-subunit KCNQ1 to generate the slowly activating, voltage-dependent potassium current (IKs) in the heart that controls the repolarization phase of cardiac action potentials. By contrast, in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barro-Soria R,Ramentol R,Liin SI,Perez ME,Kass RS,Larsson HP

更新日期：2017-08-29 00:00:00

abstract：:The electrical block to fertilization of sea urchin eggs can be overcome by very brief periods of inside-negative egg membrane potential. Lytechinus pictus eggs whose membrane potentials have been clamped at +15 mV cannot be fertilized. If the membrane potential is repolarized to inside-negative voltages for a brief i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen SS,Steinhardt RA

更新日期：1984-03-01 00:00:00

abstract：:A comparison of the monoclinic and orthorhombic crystal structures of the uncomplexed double-stranded, antiparallel, left-handed beta-helix (5.6 amino acid residues per turn) (increases decreases beta 5.6) conformers of gramicidin A reveals marked differences in the tryptophan side-chain orientations and the degree of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Langs DA,Smith GD,Courseille C,Précigoux G,Hospital M

更新日期：1991-06-15 00:00:00

abstract：:The growth of a small number of cells from each of two chemically induced BALB/c sarcomas was enhanced when x-irradiated (15,000 rads) cells of the same sarcoma were mixed with the tumor inoculum. This enhancement did not occur if the recipients had been given a total body x-irradiation of 450 rads. Tumor neutralizati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hellström KE,Hellström I

更新日期：1978-01-01 00:00:00

abstract：:Our main goal is to analyze the geometric and spectral properties of the Picard modular group with Gaussian integer entries acting on the two-dimensional complex hyperbolic space. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Francsics G,Lax PD

更新日期：2006-07-25 00:00:00

abstract：:Cumulative distributions of the number of doublings undergone by mixed megakaryocytic/erythroblastic colonies and by pure megakaryocytic colonies were determined from plasma clot cultures of bone marrow (from C57BL/6 mice) supplemented with erythropoietin. Analysis of these distributions suggests that these colonies a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paulus JM,Prenant M,Deschamps JF,Henry-Amar M

更新日期：1982-07-01 00:00:00

abstract：:It has often been suggested that the frequently observed Watson-Crick base-pair compensatory substitutions in RNA helical structures occur mainly through a slightly deleterious G.U intermediate state. We have scored base substitutions in a set of 82 related Drosophila species for the D1 and D2 variable domains of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rousset F,Pélandakis M,Solignac M

更新日期：1991-11-15 00:00:00

abstract：:It is generally acknowledged that cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4/CD152) plays a pivotal role in the regulation of T-cell activation and the establishment of self-tolerance in the periphery. CTLA-4-deficient (CTLA-4KO) mice develop a lymphoproliferative disorder and die within 4 weeks of birth, sug...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Verhagen J,Gabrysová L,Minaee S,Sabatos CA,Anderson G,Sharpe AH,Wraith DC

更新日期：2009-03-03 00:00:00

abstract：:DNA methylation at CpG dinucleotides is an important epigenetic regulator common to virtually all mammalian cell types, but recent evidence indicates that during early postnatal development neuronal genomes also accumulate uniquely high levels of two alternative forms of methylation, non-CpG methylation and hydroxymet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kinde B,Gabel HW,Gilbert CS,Griffith EC,Greenberg ME

更新日期：2015-06-02 00:00:00

abstract：:DNA methylation is an epigenetic mark that silences transposable elements (TEs) and repeats. Whereas the establishment and maintenance of DNA methylation are relatively well understood, little is known about their dynamics and biological relevance in plant and animal innate immunity. Here, we show that some TEs are de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu A,Lepère G,Jay F,Wang J,Bapaume L,Wang Y,Abraham AL,Penterman J,Fischer RL,Voinnet O,Navarro L

更新日期：2013-02-05 00:00:00

abstract：:The corticotropin-releasing factor (CRF) ligand family has diverse effects on the CNS, including the modulation of the stress response. The ligands' effects are mediated by binding to CRF G protein-coupled receptors. We have determined the 3D NMR structure of the N-terminal extracellular domain (ECD1) of the mouse CRF...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grace CR,Perrin MH,DiGruccio MR,Miller CL,Rivier JE,Vale WW,Riek R

更新日期：2004-08-31 00:00:00

abstract：:Bioluminescence-based imaging of living cells has become an important tool in biological and medical research. However, many bioluminescence imaging applications are limited by the requirement of an externally provided luciferin substrate and the low bioluminescence signal which restricts the sensitivity and spatiotem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gregor C,Pape JK,Gwosch KC,Gilat T,Sahl SJ,Hell SW

更新日期：2019-12-02 00:00:00

abstract：:An epithelial cell line, designated COMMA-1D, was derived from mammary tissue of BALB/c mice in the middle of pregnancy. This line, in continuous cell culture for 12 months, exhibits several characteristics distinctive of normal mammary epithelial cells, including induction of casein synthesis in vitro and normal duct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Danielson KG,Oborn CJ,Durban EM,Butel JS,Medina D

更新日期：1984-06-01 00:00:00

abstract：:Antagonists of growth hormone-releasing hormone (GH-RH) inhibit the growth of various tumors through mechanisms that involve the suppression of the insulin-like growth factor I and/or insulin-like growth factor II levels or secretion. In the present study, we tested the hypothesis that the tumor inhibition is associat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kiaris H,Schally AV

更新日期：1999-01-05 00:00:00

abstract：:Natural-abundance (13)C nuclear magnetic resonance spectra of ten common nucleotides in neutral, aqueous solutions have been determined and interpreted. The spectra of two of these substances were also determined in acidic solutions, and several of the carbon chemical shifts were found to depend markedly on pH. Within...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dorman DE,Roberts JD

更新日期：1970-01-01 00:00:00

abstract：:To investigate the evolution of the mammalian sex chromosomes, we have compared the gene content of the X chromosomes in the mammalian groups most distantly related to man (marsupials and monotremes). Previous work established that genes on the long arm of the human X chromosome are conserved on the X chromosomes in a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watson JM,Spencer JA,Riggs AD,Graves JA

更新日期：1991-12-15 00:00:00

abstract：:In Xenopus oocytes injected with rat brain mRNA, as in neurons, glycine greatly potentiated responses of the N-methyl-D-aspartate (NMDA) type of excitatory amino acid receptor. Injected oocytes generated a partially desensitizing inward current in response to NMDA with 30 nM added glycine. As the added glycine concent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lerma J,Zukin RS,Bennett MV

更新日期：1990-03-01 00:00:00

abstract：:Ca(2+) signaling regulates cell function. This is subject to modulation by H(+) ions that are universal end-products of metabolism. Due to slow diffusion and common buffers, changes in cytoplasmic [Ca(2+)] ([Ca(2+)]i) or [H(+)] ([H(+)]i) can become compartmentalized, leading potentially to complex spatial Ca(2+)/H(+) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swietach P,Youm JB,Saegusa N,Leem CH,Spitzer KW,Vaughan-Jones RD

更新日期：2013-05-28 00:00:00

abstract：:Eukaryotic initiator proteins form origin recognition complexes (ORCs) that bind to replication origins during most of the cell cycle and direct assembly of prereplication complexes (pre-RCs) before the onset of S phase. In the eubacterium Escherichia coli, there is a temporally similar nucleoprotein complex comprisin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller DT,Grimwade JE,Betteridge T,Rozgaja T,Torgue JJ,Leonard AC

更新日期：2009-11-03 00:00:00

abstract：:Despite the recognized role of tumor necrosis factor (TNF) in inflammation and neuronal degeneration, anti-TNF therapeutics failed to treat neurodegenerative diseases. Animal disease models had revealed the antithetic effects of the two TNF receptors (TNFR) in the central nervous system, whereby TNFR1 has been associa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dong Y,Fischer R,Naudé PJ,Maier O,Nyakas C,Duffey M,Van der Zee EA,Dekens D,Douwenga W,Herrmann A,Guenzi E,Kontermann RE,Pfizenmaier K,Eisel UL

更新日期：2016-10-25 00:00:00

abstract：:The polymerase chain reaction was used to amplify DNA surrounding the codon 12 region of the c-Ki-ras gene from C3H/10T1/2 cells and from a number of 3-methylcholanthrene (MCA)-transformed derivatives of these cells. Sequence analysis demonstrated that tumorigenic MCAC116/39 cells, known by DNA-mediated transfection t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen AC,Herschman HR

更新日期：1989-03-01 00:00:00

abstract：:We report the discovery of mammalian tribosphenic teeth from the basal Cenomanian of southwestern France that we refer to a new primitive marsupial-like form identified as a basal taxon of Marsupialiformes, a new clade recognized here to include the crown group Marsupialia and primitive stem lineages more closely rela...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vullo R,Gheerbrant E,de Muizon C,Néraudeau D

更新日期：2009-11-24 00:00:00

abstract：:CCAAT enhancer-binding protein-alpha (C/EBPalpha) functions as a pleiotropic transcriptional activator of adipocyte genes during adipogenesis. Nuclear factor C/EBP undifferentiated protein (CUP), an isoform of activator protein-2alpha (AP-2alpha), binds to repressive elements in the C/EBPalpha gene promoter, silencing...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang MS,Lane MD

更新日期：2000-11-07 00:00:00

abstract：:The oxygen isotope record of the last million years, as provided by a deep sea core sediment, is analyzed by a method recently developed in the theory of dynamical systems. The analysis suggests that climatic variability is the manifestation of a chaotic dynamics described by an attractor of fractal dimensionality. A ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nicolis C,Nicolis G

更新日期：1986-02-01 00:00:00

abstract：:The requirement and influence of the peripheral nervous system on tissue replacement in mammalian appendages remain largely undefined. To explore this question, we have performed genetic lineage tracing and clonal analysis of individual cells of mouse hind limb tissues devoid of nerve supply during regeneration of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rinkevich Y,Montoro DT,Muhonen E,Walmsley GG,Lo D,Hasegawa M,Januszyk M,Connolly AJ,Weissman IL,Longaker MT

更新日期：2014-07-08 00:00:00

abstract：:Mouse granulocyte-macrophage progenitor cells were stimulated to divide by the granulocyte-macrophage colony-stimulating factor (GM-CSF). The two daughter cells were separated; one daughter was transferred to medium containing a high concentration of GM-CSF, the other to medium containing a low concentration. Daughter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metcalf D

更新日期：1980-09-01 00:00:00

abstract：:In Drosophila, Pumilio (Pum) is important for neuronal homeostasis as well as learning and memory. We have recently characterized a mammalian homolog of Pum, Pum2, which is found in discrete RNA-containing particles in the somatodendritic compartment of polarized neurons. In this study, we investigated the role of Pum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vessey JP,Schoderboeck L,Gingl E,Luzi E,Riefler J,Di Leva F,Karra D,Thomas S,Kiebler MA,Macchi P

更新日期：2010-02-16 00:00:00