Abstract:
:DNA methylation at CpG dinucleotides is an important epigenetic regulator common to virtually all mammalian cell types, but recent evidence indicates that during early postnatal development neuronal genomes also accumulate uniquely high levels of two alternative forms of methylation, non-CpG methylation and hydroxymethylation. Here we discuss the distinct landscape of DNA methylation in neurons, how it is established, and how it might affect the binding and function of protein readers of DNA methylation. We review studies of one critical reader of DNA methylation in the brain, the Rett syndrome protein methyl CpG-binding protein 2 (MeCP2), and discuss how differential binding affinity of MeCP2 for non-CpG and hydroxymethylation may affect the function of this methyl-binding protein in the nervous system.
journal_name
Proc Natl Acad Sci U S Aauthors
Kinde B,Gabel HW,Gilbert CS,Griffith EC,Greenberg MEdoi
10.1073/pnas.1411269112subject
Has Abstractpub_date
2015-06-02 00:00:00pages
6800-6issue
22eissn
0027-8424issn
1091-6490pii
1411269112journal_volume
112pub_type
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