Abstract:
:Mononegaviruses are promising tools as oncolytic vectors and transgene delivery vectors for gene therapy and regenerative medicine. By using the Magnet proteins, which reversibly heterodimerize upon blue light illumination, photocontrollable mononegaviruses (measles and rabies viruses) were generated. The Magnet proteins were inserted into the flexible domain of viral polymerase, and viruses showed strong replication and oncolytic activities only when the viral polymerases were activated by blue light illumination.
journal_name
Proc Natl Acad Sci U S Aauthors
Tahara M,Takishima Y,Miyamoto S,Nakatsu Y,Someya K,Sato M,Tani K,Takeda Mdoi
10.1073/pnas.1906531116subject
Has Abstractpub_date
2019-06-11 00:00:00pages
11587-11589issue
24eissn
0027-8424issn
1091-6490pii
1906531116journal_volume
116pub_type
杂志文章abstract::In a previous study, we found that human neural stem cells (HNSCs) exposed to high concentrations of secreted amyloid-precursor protein (sAPP) in vitro differentiated into mainly astrocytes, suggesting that pathological alterations in APP processing during neurodegenerative conditions such as Alzheimer's disease (AD) ...
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更新日期:1972-09-01 00:00:00
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
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