Single channel currents induced by complement in antibody-coated cell membranes.

abstract：:Thalassemia is a heritable human anemia caused by a variety of mutations that affect expression of the alpha- or the beta-chain of hemoglobin. The expressivity of the phenotype is likely to be influenced by unlinked modifying genes. Indeed, by using a mouse model of alpha-thalassemia, we find that its phenotype is str...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leder A,Wiener E,Lee MJ,Wickramasinghe SN,Leder P

更新日期：1999-05-25 00:00:00

abstract：:DsrA is an 87-nucleotide regulatory RNA of Escherichia coli that acts in trans by RNA-RNA interactions with two different mRNAs, hns and rpoS. DsrA has opposite effects on these transcriptional regulators. H-NS levels decrease, whereas RpoS (final sigma(s)) levels increase. Here we show that DsrA enhances hns mRNA tur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lease RA,Belfort M

更新日期：2000-08-29 00:00:00

abstract：:Individual cell types are defined by architecturally and functionally specialized cortical domains. The Ezrin, Radixin, and Moesin (ERM) proteins play a major role in organizing cortical domains by assembling membrane protein complexes and linking them to the cortical actin cytoskeleton. Many studies have focused on t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Casaletto JB,Saotome I,Curto M,McClatchey AI

更新日期：2011-07-19 00:00:00

abstract：:Animal development is remarkably robust; cell fates are specified with spatial and temporal precision despite physiological and environmental contingencies. Favorable conditions cause Caenorhabditis elegans to develop rapidly through four larval stages (L1-L4) to the reproductive adult. In unfavorable conditions, L2 l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hammell CM,Karp X,Ambros V

更新日期：2009-11-03 00:00:00

abstract：:Although prostate cancer (CaP) is the most frequently diagnosed malignant tumor and the second leading cause of cancer deaths in American men, the mechanisms explaining the development and progression of CaP remain largely unknown. Recent studies have shown that some aberrantly expressed microRNAs (miRNAs) are involve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shi XB,Xue L,Yang J,Ma AH,Zhao J,Xu M,Tepper CG,Evans CP,Kung HJ,deVere White RW

更新日期：2007-12-11 00:00:00

abstract：:Mutations in the gene encoding the endothelin receptor type B (EDNRB) produce congenital aganglionic megacolon and pigment abnormalities in mice and humans. Here we report a naturally occurring null mutation of the EDNRB gene in spotting lethal (sl) rats, which exhibit aganglionic megacolon associated with white coat ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gariepy CE,Cass DT,Yanagisawa M

更新日期：1996-01-23 00:00:00

abstract：:We investigated patterns of genetic diversity of Plasmodium falciparum associated with its two main African vectors: Anopheles gambiae and Anopheles funestus. We dissected 10,296 wild-caught mosquitoes from three tropical sites, two in Cameroon (Simbock and Tibati, separated by 320 km) and one in Kenya (Rota, >2,000 k...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Annan Z,Durand P,Ayala FJ,Arnathau C,Awono-Ambene P,Simard F,Razakandrainibe FG,Koella JC,Fontenille D,Renaud F

更新日期：2007-05-08 00:00:00

abstract：:We have previously proven that human macrophages can phagocytose porcine cells even in the absence of Ab or complement opsonization, indicating that macrophages present a pivotal immunological obstacle to xenotransplantation. A recent report indicates that the signal regulatory protein (SIRP)alpha is a critical immune...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ide K,Wang H,Tahara H,Liu J,Wang X,Asahara T,Sykes M,Yang YG,Ohdan H

更新日期：2007-03-20 00:00:00

abstract：:Understanding protein-protein interactions is central to our understanding of almost all complex biological processes. Computational tools exploiting rapidly growing genomic databases to characterize protein-protein interactions are urgently needed. Such methods should connect multiple scales from evolutionary conserv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gueudré T,Baldassi C,Zamparo M,Weigt M,Pagnani A

更新日期：2016-10-25 00:00:00

abstract：:Copper is a required metal nutrient for life, but global or local alterations in its homeostasis are linked to diseases spanning genetic and metabolic disorders to cancer and neurodegeneration. Technologies that enable longitudinal in vivo monitoring of dynamic copper pools can help meet the need to study the complex ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heffern MC,Park HM,Au-Yeung HY,Van de Bittner GC,Ackerman CM,Stahl A,Chang CJ

更新日期：2016-12-13 00:00:00

abstract：:Patients with chronic ulcerative colitis (UC) are at high risk for developing colorectal cancer. In this study, archival formalin-fixed paraffin-embedded colonic tissue from patients with UC who developed carcinoma (CA) or high-grade dysplasia (HGD) was examined for changes in expression of the proinflammatory and mit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gillespie E,Leeman SE,Watts LA,Coukos JA,O'Brien MJ,Cerda SR,Farraye FA,Stucchi AF,Becker JM

更新日期：2011-10-18 00:00:00

abstract：:The protein dystrophin, normally found on the cytoplasmic surface of skeletal muscle cell membranes, is absent in patients with Duchenne muscular dystrophy as well as mdx (X-linked muscular dystrophy) mice. Although its primary structure has been determined, the precise functional role of dystrophin remains the subjec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrof BJ,Shrager JB,Stedman HH,Kelly AM,Sweeney HL

更新日期：1993-04-15 00:00:00

abstract：:Linear hierarchies, the classical pecking-order structures, are formed readily in both nature and the laboratory in a great range of species including humans. However, the probability of getting linear structures by chance alone is quite low. In this paper we investigate the two hypotheses that are proposed most often...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chase ID,Tovey C,Spangler-Martin D,Manfredonia M

更新日期：2002-04-16 00:00:00

abstract：:Development of pharyngeal muscle in nematodes and cardiac muscle in vertebrates and insects involves the related homeobox genes ceh-22, nkx2.5, and tinman, respectively. To determine whether the nematode and vertebrate genes perform similar functions, we examined activity of the zebrafish nkx2.5 gene in transgenic Cae...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haun C,Alexander J,Stainier DY,Okkema PG

更新日期：1998-04-28 00:00:00

abstract：:Effects of previous strength training can be long-lived, even after prolonged subsequent inactivity, and retraining is facilitated by a previous training episode. Traditionally, such "muscle memory" has been attributed to neural factors in the absence of any identified local memory mechanism in the muscle tissue. We h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bruusgaard JC,Johansen IB,Egner IM,Rana ZA,Gundersen K

更新日期：2010-08-24 00:00:00

abstract：:We investigate the dynamics and spatial distribution of land use fragmentation in a rapidly urbanizing region of the United States to test key propositions regarding the evolution of sprawl. Using selected pattern metrics and data from 1973 and 2000 for the state of Maryland, we find significant increases in developed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Irwin EG,Bockstael NE

更新日期：2007-12-26 00:00:00

abstract：:Primary transcripts made in vitro on bacteriophage T4 DNA by RNA polymerase isolated from normal or T4-infected Escherichia coli were compared by gel electrophoresis. Bacteriophage-modified RNA polymerase fails to initiate transcription at certain promoters recognized by unmodified enzyme. In the T4tRNA gene region, o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldfarb A

更新日期：1981-06-01 00:00:00

abstract：:Seemingly similar individuals often experience drastically different success trajectories, with some repeatedly failing and others consistently succeeding. One explanation is preexisting variability along unobserved fitness dimensions that is revealed gradually through differential achievement. Alternatively, positive...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van de Rijt A,Kang SM,Restivo M,Patil A

更新日期：2014-05-13 00:00:00

abstract：:We previously identified a stromal cell-derived inducing activity (SDIA), which induces differentiation of neural cells, including midbrain tyrosine hydroxylase-positive (TH(+)) dopaminergic neurons, from mouse embryonic stem cells. We report here that SDIA induces efficient neural differentiation also in primate embr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawasaki H,Suemori H,Mizuseki K,Watanabe K,Urano F,Ichinose H,Haruta M,Takahashi M,Yoshikawa K,Nishikawa S,Nakatsuji N,Sasai Y

更新日期：2002-02-05 00:00:00

abstract：:CYP1B1-null mice, created by targeted gene disruption in embryonic stem cells, were born at the expected frequency from heterozygous matings with no observable phenotype, thus establishing that CYP1B1 is not required for mouse development. CYP1B1 was not detectable in cultured embryonic fibroblast (EF) or in different...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buters JT,Sakai S,Richter T,Pineau T,Alexander DL,Savas U,Doehmer J,Ward JM,Jefcoate CR,Gonzalez FJ

更新日期：1999-03-02 00:00:00

abstract：:A cDNA clone that hybridizes to an mRNA (1A10) that accumulates to a substantial level in the axis of the germinating soybean seed was sequenced. The amino acid sequence of the clone indicates an almost perfect repeat of Pro-Pro-Val-Tyr-Lys resulting in a protein containing 40% proline and lacking serine and histidine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Averyhart-Fullard V,Datta K,Marcus A

更新日期：1988-02-01 00:00:00

abstract：:Bathorhodopsin-rhodopsin difference spectra of native 11-cis-rhodopsin and regenerated 9-cis-rhodopsin were measured at room temperature with a double-beam laser spectrophotometer after excitation at 532 nm. A detailed analysis of data obtained at 85 psec after excitation suggests that the bathorhodopsins generated fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spalink JD,Reynolds AH,Rentzepis PM,Sperling W,Applebury ML

更新日期：1983-04-01 00:00:00

abstract：:The selection of a single molecular handedness, or homochirality across all living matter, is a mystery in the origin of life. Frank's seminal model showed in the '50s how chiral symmetry breaking can occur in nonequilibrium chemical networks. However, an important shortcoming in this classic model is that it consider...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laurent G,Lacoste D,Gaspard P

更新日期：2021-01-19 00:00:00

abstract：:Translocator protein (TSPO) is a key member of the mitochondrial cholesterol transport complex in steroidogenic tissues. To assess the function of TSPO, we generated two lines of Cre-mediated Tspo conditional knockout (cKO) mice. First, gonadal somatic cell-targeting Amhr2-Cre mice were crossed with Tspo-floxed mice t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fan J,Campioli E,Midzak A,Culty M,Papadopoulos V

更新日期：2015-06-09 00:00:00

abstract：:X-ray absorption spectra near the Kalpha edge have been measured in various iron group compounds using the intense synchrotron radiation at the Stanford Synchrotron Research Project. In the cubic compounds KMF3 where M = Mn+2, Fe+2, Co+2, Ni+2, and Zn+2, well resolved lines were observed and assigned to the 1s leads t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shulman GR,Yafet Y,Eisenberger P,Blumberg WE

更新日期：1976-05-01 00:00:00

abstract：:In the antennal lobe of Drosophila, information about odors is transferred from olfactory receptor neurons (ORNs) to projection neurons (PNs), which then send axons to neurons in the lateral horn of the protocerebrum (LHNs) and to Kenyon cells (KCs) in the mushroom body. The transformation from ORN to PN responses can...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luo SX,Axel R,Abbott LF

更新日期：2010-06-08 00:00:00

abstract：:We have employed a combination of temperature-dependent UV absorption spectroscopy, circular dichroism, and batch calorimetry to characterize the binding of actinomycin D to a series of oligomeric DNA duplexes. We find the duplex [d(CGTCGACG)]2 to be unique in its ability to bind actinomycin D strongly despite the abs...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Snyder JG,Hartman NG,D'Estantoit BL,Kennard O,Remeta DP,Breslauer KJ

更新日期：1989-06-01 00:00:00

abstract：:The transcription factor SRY (sex-determining region)-box 2 (SOX2) is an important functional marker of neural precursor cells (NPCs) and plays a critical role in self-renewal and neuronal differentiation; however, the molecular mechanisms underlying its functions are poorly understood. Using human embryonic stem cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cimadamore F,Amador-Arjona A,Chen C,Huang CT,Terskikh AV

更新日期：2013-08-06 00:00:00

abstract：:This report describes an unbiased method for systematically determining gene function in mammalian cells. A total of 20,704 predicted human full-length cDNAs were tested for induction of the IL-8 promoter. A number of genes, including those for cytokines, receptors, adapters, kinases, and transcription factors, were i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iourgenko V,Zhang W,Mickanin C,Daly I,Jiang C,Hexham JM,Orth AP,Miraglia L,Meltzer J,Garza D,Chirn GW,McWhinnie E,Cohen D,Skelton J,Terry R,Yu Y,Bodian D,Buxton FP,Zhu J,Song C,Labow MA

更新日期：2003-10-14 00:00:00

abstract：:In a search for Polo-like kinase 1 (Plk1)-interacting proteins using a yeast two-hybrid system, we have identified histone acetyltransferase binding to the origin recognition complex 1 (Hbo1) as a potential Plk1 target. Here, we show that the interaction between Plk1 and Hbo1 is mitosis-specific and that Plk1 phosphor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu ZQ,Liu X

更新日期：2008-02-12 00:00:00