Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells.

abstract：:The human cytokine I-309 is a small glycoprotein secreted by activated T lymphocytes and structurally related to a number of inflammatory cytokines. To investigate the biological activities of I-309 protein, we produced a stable Chinese hamster ovary cell transfectant, CDI.10, which constitutively secretes I-309 prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller MD,Krangel MS

更新日期：1992-04-01 00:00:00

abstract：:The role of intraspecific and interspecific interactions in structuring biotic communities at fine spatial scales is well documented, but the signature of species interactions at coarser spatial scales is unclear. We present evidence that species interactions may be a significant factor in mediating the regional assem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gotelli NJ,Graves GR,Rahbek C

更新日期：2010-03-16 00:00:00

abstract：:Radiation therapy is a widely used cancer treatment, but it causes side effects even when localized radiotherapy is used. Extensive apoptosis of microvascular endothelial cells of the lamina propria is the primary lesion initiating intestinal radiation damage after abdominal radiation therapy. Many in vitro studies su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cho CH,Kammerer RA,Lee HJ,Yasunaga K,Kim KT,Choi HH,Kim W,Kim SH,Park SK,Lee GM,Koh GY

更新日期：2004-04-13 00:00:00

abstract：:Human pluripotent stem cells have the potential to provide comprehensive model systems for the earliest stages of human ontogenesis. To serve in this capacity, these cells must undergo a targeted, stepwise differentiation process that follows a normal developmental timeline. Here we demonstrate the ability of both hum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyer JS,Shearer RL,Capowski EE,Wright LS,Wallace KA,McMillan EL,Zhang SC,Gamm DM

更新日期：2009-09-29 00:00:00

abstract：:The prgB gene encodes the surface protein, Asc10, which mediates cell aggregation, resulting in high-frequency conjugative transfer of the pheromone-inducible tetracycline-resistance plasmid pCF10 in Enterococcus faecalis. Messenger RNA analysis by Northern blot hybridization and primer extension indicates that prgB t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung JW,Dunny GM

更新日期：1992-10-01 00:00:00

abstract：:Purified influenza viral cores catalyze the entire process of viral RNA transcription, which includes the endonucleolytic cleavage of heterologous RNAs containing cap 1 (m(7)GpppNm) structures to generate capped primers 10-13 nucleotides long, the initiation of transcription via the incorporation of a guanosine residu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ulmanen I,Broni BA,Krug RM

更新日期：1981-12-01 00:00:00

abstract：:Photosynthesis relies on the delicate interplay between a specific set of membrane-bound pigment-protein complexes that harvest and transport solar energy, execute charge separation, and conserve the energy. We have investigated the organization of the light-harvesting (LH) and reaction-center (RC) complexes in native...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frese RN,Siebert CA,Niederman RA,Hunter CN,Otto C,van Grondelle R

更新日期：2004-12-28 00:00:00

abstract：:Chronic hypoxia causes pulmonary hypertension with smooth muscle cell proliferation and matrix deposition in the wall of the pulmonary arterioles. We demonstrate here that hypoxia also induces a pronounced inflammation in the lung before the structural changes of the vessel wall. The proinflammatory action of hypoxia ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Minamino T,Christou H,Hsieh CM,Liu Y,Dhawan V,Abraham NG,Perrella MA,Mitsialis SA,Kourembanas S

更新日期：2001-07-17 00:00:00

abstract：:A sequence of 14 nucleotides in one human diversity (D) minigene (D2) is identical with a sequence in complementarity-determining region 2 (CDR2) of one human gene for the variable region of the heavy chain of immunoglobulin. The finding that nucleotide segments present in a D minigene can appear in CDR2 raises the po...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu TT,Kabat EA

更新日期：1982-08-01 00:00:00

abstract：:Dimyristoyl lecithin liposomes, containing cytochrome b5 reductase (NADH:ferricytochrome b5 oxidoreductase, EC 1.6.2.2) and varying amounts of cytochrome b5, were used to measure flavoprotein catalysis alone and catalysis requiring electron transfer between the reductase and cytochrome as a function of temperature. Wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strittmatter P,Rogers MJ

更新日期：1975-07-01 00:00:00

abstract：:IDIOTYPY HAS BEEN STUDIED IN ANTIBODIES AGAINST A PROTEIN ANTIGEN: hen ovalbumin. Various fractions of antisera to hen ovalbumin have been compared from the standpoint of the idiotypic specificities found on the immunoglobulins that they contain. Idiotypic specificities were found to be common to (a) antibodies that w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oudin J,Cazenave PA

更新日期：1971-10-01 00:00:00

abstract：:The nucleic acid sequence of the 3' region of human T-cell leukemia virus type II (HTLV-II) proviral DNA was determined using a HTLV-II proviral clone that could be recovered as infectious, transforming virus. The sequence data indicate a region of unknown function of approximately equal to 1.6 kilobase pairs in the 3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimotohno K,Wachsman W,Takahashi Y,Golde DW,Miwa M,Sugimura T,Chen IS

更新日期：1984-11-01 00:00:00

abstract：:The pharmacokinetic analysis of dynamic-contrast-enhanced (DCE) MRI data yields K(trans) and k(ep), two parameters independently measuring the capillary wall contrast reagent transfer rate. The almost universally used standard model (SM) embeds the implicit assumption that equilibrium transcytolemmal water exchange is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang W,Li X,Morris EA,Tudorica LA,Seshan VE,Rooney WD,Tagge I,Wang Y,Xu J,Springer CS

更新日期：2008-11-18 00:00:00

abstract：:The archaeological record shows that typically human cultural traits emerged at different times, in different parts of the world, and among different hominin taxa. This pattern suggests that their emergence is the outcome of complex and nonlinear evolutionary trajectories, influenced by environmental, demographic, and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： d'Errico F,Banks WE,Warren DL,Sgubin G,van Niekerk K,Henshilwood C,Daniau AL,Sánchez Goñi MF

更新日期：2017-07-25 00:00:00

abstract：:Thioredoxins are 12-kDa proteins functional in the regulation of cellular processes throughout the animal, plant, and microbial kingdoms. Growing evidence with seeds suggests that an h-type of thioredoxin, reduced by NADPH via NADP-thioredoxin reductase, reduces disulfide bonds of target proteins and thereby acts as a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yano H,Wong JH,Lee YM,Cho MJ,Buchanan BB

更新日期：2001-04-10 00:00:00

abstract：:Staphylococcus aureus forms biofilms on indwelling medical devices using a variety of cell-surface proteins. There is growing evidence that specific homophilic interactions between these proteins represent an important mechanism of cell accumulation during biofilm formation, but the underlying molecular mechanisms are...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feuillie C,Formosa-Dague C,Hays LM,Vervaeck O,Derclaye S,Brennan MP,Foster TJ,Geoghegan JA,Dufrêne YF

更新日期：2017-04-04 00:00:00

abstract：:The protein complex formed by the Ca2+ sensor neuronal calcium sensor 1 (NCS-1) and the guanine exchange factor protein Ric8a coregulates synapse number and probability of neurotransmitter release, emerging as a potential therapeutic target for diseases affecting synapses, such as fragile X syndrome (FXS), the most co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mansilla A,Chaves-Sanjuan A,Campillo NE,Semelidou O,Martínez-González L,Infantes L,González-Rubio JM,Gil C,Conde S,Skoulakis EM,Ferrús A,Martínez A,Sánchez-Barrena MJ

更新日期：2017-02-07 00:00:00

abstract：:The photoaffinity herbicide azidoatrazine (2-azido-4-ethylamino-6-isopropylamino-s-triazine) selectively labels the L subunit of the reaction center of the photosynthetic bacterium Rhodopseudomonas sphaeroides. Herbicide-resistant mutants retain the L subunit and have altered binding properties for methylthio- and chl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown AE,Gilbert CW,Guy R,Arntzen CJ

更新日期：1984-10-01 00:00:00

abstract：:P201 is a short (eight-residue) nonacidic peptide that comprises a strong transcriptional activating region when tethered to DNA in yeast. Here we identify the mediator protein Gal11 as an essential target of P201. Deletion of Gal11, which modestly decreases activation elicited by the typical acidic yeast activator, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu Z,Ansari AZ,Lu X,Ogirala A,Ptashne M

更新日期：2002-06-25 00:00:00

abstract：:By employing the nuclear DNA of the African rice Oryza glaberrima as a reference genome, the timing, natures, mechanisms, and specificities of recent sequence evolution in the indica and japonica subspecies of Oryza sativa were identified. The data indicate that the genome sizes of both indica and japonica have increa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma J,Bennetzen JL

更新日期：2004-08-24 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is a neuropeptide that coexists with acetylcholine in spinal cord motoneurons. The effects of CGRP on the functional properties of the nicotinic acetylcholine receptor (AcChoR) were examined by electrophysiological methods. Using the whole-cell patch-clamp technique and a mouse c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mulle C,Benoit P,Pinset C,Roa M,Changeux JP

更新日期：1988-08-01 00:00:00

abstract：:We recognize, understand, and interact with objects through both vision and touch. Conceivably, these two sensory systems encode object shape in similar ways, which could facilitate cross-modal communication. To test this idea, we studied single neurons in macaque monkey intermediate visual (area V4) and somatosensory...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yau JM,Pasupathy A,Fitzgerald PJ,Hsiao SS,Connor CE

更新日期：2009-09-22 00:00:00

abstract：:Mesophyll protoplasts of Lycopersicon esculentum were treated with iodoacetamide to inactivate mitochondria, and protoplasts of Solanum acaule and Solanum tuberosum were irradiated with gamma- or x-rays to inactivate nuclei. Mixtures of protoplasts thus modified were treated with Ca2+ and polyethylene glycol to obtain...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Melchers G,Mohri Y,Watanabe K,Wakabayashi S,Harada K

更新日期：1992-08-01 00:00:00

abstract：:Picosecond studies of rhodopsin in low-temperature glasses have been carried out in order to observe directly the risetime of prelumirhodopsin, the first intermediate in the visual pathway. Only at 20 K or below can the risetime of this intermediate be resolved and even at 4 K it is astoundingly rapid, about 36 psec. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peters K,Applebury ML,Rentzepis PM

更新日期：1977-08-01 00:00:00

abstract：:Normal rat kidney cells infected with a temperature-sensitive mutant (LA23) of Rous sarcoma virus exhibit the transformed phenotype when grown at 33 degrees and the normal phenotype at 39 degrees. We have previously shown [Ash, J.F., Vogt, P.K. & Singer, S.J. (1976) Proc. Natl. Acad. Sci. USA 73, 3603-3607] that the a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carroll RC,Ash JF,Vogt PK,Singer SJ

更新日期：1978-10-01 00:00:00

abstract：:When the magnetic susceptibility of frozen aqueous solutions of human oxyhemoglobin was measured in the range between 25 and 250 K, it showed a temperature-dependent behavior typical of a thermal equilibrium between a ground singlet state and an excited triplet state for two electrons per heme, the energy separation b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cerdonio M,Congiu-Castellano A,Mogno F,Pispisa B,Romani GL,Vitale S

更新日期：1977-02-01 00:00:00

abstract：:Puf proteins bind RNA sequence specifically and regulate translation and stability of target mRNAs. A "code" for RNA recognition has been deduced from crystal structures of the Puf protein, human Pumilio1, where each of eight repeats binds an RNA base via a combination of three side chains at conserved positions. Here...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheong CG,Hall TM

更新日期：2006-09-12 00:00:00

abstract：:The α-proteobacterium Sinorhizobium meliloti establishes a chronic intracellular infection during the symbiosis with its legume hosts. Within specialized host cells, S. meliloti differentiates into highly polyploid, enlarged nitrogen-fixing bacteroids. This differentiation is driven by host cells through the productio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Penterman J,Abo RP,De Nisco NJ,Arnold MF,Longhi R,Zanda M,Walker GC

更新日期：2014-03-04 00:00:00

abstract：:The postdevelopmental basis of cellular identity and the unique cellular output of a particular neuron type are of particular interest in the nervous system because a detailed understanding of circuits responsible for complex processes in the brain is impeded by the often ambiguous classification of neurons in these c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schulz DJ,Goaillard JM,Marder EE

更新日期：2007-08-07 00:00:00

abstract：:The tumor suppressor protein p53 localizes to microtubules (MT) and, in response to DNA damage, is transported to the nucleus via the MT minus-end-directed motor protein dynein. Dynein is also responsible for MT-mediated nuclear targeting of adenovirus type 2 (Ad2). Here we show that treatment with low concentrations ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giannakakou P,Nakano M,Nicolaou KC,O'Brate A,Yu J,Blagosklonny MV,Greber UF,Fojo T

更新日期：2002-08-06 00:00:00