Similar idiotypic specificities in immunoglobulin fractions with different antibody functions or even without detectable antibody function.

abstract：:mtDNA mutations occur in a wide variety of degenerative diseases and cancer. mtDNA seems to be more susceptible to DNA damage and consequently sustains higher rates of mutation than does nuclear DNA (nDNA). Many of the somatic mtDNA mutations in human cancers are located in the displacement loop (D-loop) and in partic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mambo E,Gao X,Cohen Y,Guo Z,Talalay P,Sidransky D

更新日期：2003-02-18 00:00:00

abstract：:Fast axoplasmic transport was studied in dorsal root ganglion cells of the cat. Proteins carried in the fast axoplasmic flow were labeled after an intraganglionic injection of (L)-[4,5-(3)H]leucine. The rate of transport was 380 +/- 26 mm/day in both the central and peripheral branches of the bifurcating axons that ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson LE,McClure WO

更新日期：1973-05-01 00:00:00

abstract：:Inhibitory gamma-aminobutyric acid-mediated synaptic currents were studied in dissociated primary cultures of neonatal rat cortex with the whole-cell patch-clamp technique. Immunocytochemical staining of the cultures showed the presence of a large number of glutamic acid decarboxylase-containing neurons, and electrica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vicini S,Alho H,Costa E,Mienville JM,Santi MR,Vaccarino FM

更新日期：1986-12-01 00:00:00

abstract：:Stability of the long noncoding-polyadenylated nuclear (PAN) RNA from Kaposi's sarcoma-associated herpesvirus is conferred by an expression and nuclear retention element (ENE). The ENE protects PAN RNA from a rapid deadenylation-dependent decay pathway via formation of a triple helix between the U-rich internal loop o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown JA,Valenstein ML,Yario TA,Tycowski KT,Steitz JA

更新日期：2012-11-20 00:00:00

abstract：:Despite growing evidence for perceptual interactions between motion and position, no unifying framework exists to account for these two key features of our visual experience. We show that percepts of both object position and motion derive from a common object-tracking system--a system that optimally integrates sensory...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwon OS,Tadin D,Knill DC

更新日期：2015-06-30 00:00:00

abstract：:Hepatitis B virus (HBV) is a major human pathogen. In addition to its importance in human health, there is growing interest in adapting HBV and other viruses for drug delivery and other nanotechnological applications. In both contexts, precise biophysical characterization of these large macromolecular particles is fun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uetrecht C,Versluis C,Watts NR,Roos WH,Wuite GJ,Wingfield PT,Steven AC,Heck AJ

更新日期：2008-07-08 00:00:00

abstract：:Protein tyrosine phosphorylation and dephosphorylation are key regulatory events in T-cell receptor (TCR) signaling. We investigated the role of the tyrosine phosphatase SHPTP1 in TCR signaling by analysis of TCR signal transduction in motheaten (me/me) mice, which lack SHPTP1 expression. As revealed by flow cytometri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lorenz U,Ravichandran KS,Burakoff SJ,Neel BG

更新日期：1996-09-03 00:00:00

abstract：:Control over the fluorescence of supramolecular assemblies is crucial for the development of chemosensors and light-emitting materials. Consequently, the postsynthetic modification of supramolecular structures via host-guest interactions has emerged as an efficient strategy in recent years that allows the facile tunin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang M,Yin S,Zhang J,Zhou Z,Saha ML,Lu C,Stang PJ

更新日期：2017-03-21 00:00:00

abstract：:The extinction of a species is inevitably preceded by the extirpation of a series of local populations. Ecological theory predicts that vulnerability to extirpation varies between populations and is ultimately linked to environmental heterogeneity. If populations of a species are present in multiple regions separated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yackulic CB,Sanderson EW,Uriarte M

更新日期：2011-03-08 00:00:00

abstract：:Highly purified preparations of trp repressor (TrpR) protein derived from Escherichia coli strains that were engineered to overexpress this material were found to contain another protein, of 21 kDa. The second protein, designated WrbA [for tryptophan (W) repressor-binding protein] remained associated with its namesake...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang W,Ni L,Somerville RL

更新日期：1993-06-15 00:00:00

abstract：:To investigate the mechanisms of asbestos-induced carcinogenesis, expression of c-fos and c-jun protooncogenes was examined in rat pleural mesothelial cells and hamster tracheal epithelial cells after exposure to crocidolite or chrysotile asbestos. In contrast to phorbol 12-myristate 13-acetate, which induces rapid an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heintz NH,Janssen YM,Mossman BT

更新日期：1993-04-15 00:00:00

abstract：:Saccharomyces cerevisiae strain PP5 has a phosphodiesterase (PDE) deficiency that results in heat-shock sensitivity due to the intracellular accumulation of cAMP. This strain also carries the cam mutation, which confers permeability to cAMP and, as shown here, to other compounds. Expression of rat type IV PDE in these...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pillai R,Kytle K,Reyes A,Colicelli J

更新日期：1993-12-15 00:00:00

abstract：:Using brain transcriptomic profiles from 853 individual honey bees exhibiting 48 distinct behavioral phenotypes in naturalistic contexts, we report that behavior-specific neurogenomic states can be inferred from the coordinated action of transcription factors (TFs) and their predicted target genes. Unsupervised hierar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chandrasekaran S,Ament SA,Eddy JA,Rodriguez-Zas SL,Schatz BR,Price ND,Robinson GE

更新日期：2011-11-01 00:00:00

abstract：:We have sequenced the mutant beta-actin gene of a tumorigenic human fibroblast cell line (HuT-14T) and found that it carries three mutations that alter the amino acids at positions 36, 83, and 244 as well as a 22-base-pair "insertion" sequence, in the 5' intron, not present in a wild-type gene. The less tumorigenic ce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin CS,Ng SY,Gunning P,Kedes L,Leavitt J

更新日期：1985-10-01 00:00:00

abstract：:Sinorhizobium meliloti is an alpha-proteobacterium that forms agronomically important N(2)-fixing root nodules in legumes. We report here the complete sequence of the largest constituent of its genome, a 62.7% GC-rich 3,654,135-bp circular chromosome. Annotation allowed assignment of a function to 59% of the 3,341 pre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Capela D,Barloy-Hubler F,Gouzy J,Bothe G,Ampe F,Batut J,Boistard P,Becker A,Boutry M,Cadieu E,Dréano S,Gloux S,Godrie T,Goffeau A,Kahn D,Kiss E,Lelaure V,Masuy D,Pohl T,Portetelle D,Pühler A,Purnelle B,Ramsper

更新日期：2001-08-14 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs selective for inhibition of COX-2 increase heart failure and elevate blood pressure. The COX-2 gene was floxed and crossed into merCremer mice under the alpha-myosin heavy-chain promoter. Tamoxifen induced selective deletion of COX-2 in cardiomyocytes depressed cardiac output, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang D,Patel VV,Ricciotti E,Zhou R,Levin MD,Gao E,Yu Z,Ferrari VA,Lu MM,Xu J,Zhang H,Hui Y,Cheng Y,Petrenko N,Yu Y,FitzGerald GA

更新日期：2009-05-05 00:00:00

abstract：:We have previously extracted a protein from inflammatory mouse granuloma that fully protects normal mice against lethal Listeria monocytogenes infection. We now report that polyclonal antibodies directed against this protein react with a human urinary fraction that also provides full protection of normal mice against ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fontan E,Saklani-Jusforgues H,Fauve RM

更新日期：1992-05-15 00:00:00

abstract：:Apolipoprotein(a) [apo(a)] is the distinguishing protein component of lipoprotein(a), a major inherited risk factor for atherosclerosis. Human apo(a) is homologous to plasminogen. It contains from 15 to 50 repeated domains closely related to plasminogen kringle four, plus single kringle five-like and inactive protease...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lawn RM,Schwartz K,Patthy L

更新日期：1997-10-28 00:00:00

abstract：:Whereas NF-kappaB has potent antiapoptotic function in most cell types, it was reported that in pancreatic beta cells it serves a proapoptotic function and may contribute to the pathogenesis of autoimmune type 1 diabetes. To investigate the role of beta cell NF-kappaB in autoimmune diabetes, we produced transgenic mic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim S,Millet I,Kim HS,Kim JY,Han MS,Lee MK,Kim KW,Sherwin RS,Karin M,Lee MS

更新日期：2007-02-06 00:00:00

abstract：:High-throughput metagenomic sequencing offers an unbiased approach to identify pathogens in clinical samples. Conventional metagenomic sequencing, however, does not integrate information about the host, which is often critical to distinguish infection from infectious disease, and to assess the severity of disease. Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng AP,Burnham P,Lee JR,Cheng MP,Suthanthiran M,Dadhania D,De Vlaminck I

更新日期：2019-09-10 00:00:00

abstract：:Although neurotrophins are primarily associated with long-term effects on neuronal survival and differentiation, recent studies have shown that acute changes in synaptic transmission can also be produced. In the hippocampus, an area critically involved in learning and memory, we have found that brain-derived neurotrop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levine ES,Dreyfus CF,Black IB,Plummer MR

更新日期：1995-08-15 00:00:00

abstract：:Yellow, orange, and red coloration is a fundamental aspect of avian diversity and serves as an important signal in mate choice and aggressive interactions. This coloration is often produced through the deposition of diet-derived carotenoid pigments, yet the mechanisms of carotenoid uptake and transport are not well-un...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toomey MB,Lopes RJ,Araújo PM,Johnson JD,Gazda MA,Afonso S,Mota PG,Koch RE,Hill GE,Corbo JC,Carneiro M

更新日期：2017-05-16 00:00:00

abstract：:The reactions catalyzed by Mo enzymes each find the product differing from the substrate by two electrons and two protons (or some multiple thereof). The coordination chemistry of Mo suggests that there is a distinct relationship between acid-base and redox properties of Mo complexes, and that a coupled electron-proto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stiefel EI

更新日期：1973-04-01 00:00:00

abstract：:The Bill and Melinda Gates Foundation supports an ambitious portfolio of novel vaccines, drug regimens, and diagnostic tools for tuberculosis (TB). We elicited the expected efficacies and improvements of the novel interventions in discussions with the foundations managing their development. Using an age-structured mat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abu-Raddad LJ,Sabatelli L,Achterberg JT,Sugimoto JD,Longini IM Jr,Dye C,Halloran ME

更新日期：2009-08-18 00:00:00

abstract：:Significant attention has focused on the role of low-density lipoprotein (LDL) in the pathogenesis of atherosclerosis. However, recent advances have identified triglyceride-rich lipoproteins [e.g., very LDL (VLDL)] as independent risk predictors for this disease. We have previously demonstrated peroxisome proliferator...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee CH,Kang K,Mehl IR,Nofsinger R,Alaynick WA,Chong LW,Rosenfeld JM,Evans RM

更新日期：2006-02-14 00:00:00

abstract：:We have investigated the role of cAMP in NO- and prostanoid-independent relaxations that are widely attributed to an endothelium-derived hyperpolarizing factor (EDHF). Under control conditions EDHF-type relaxations evoked by acetylcholine (ACh) in rabbit iliac arteries were transient, but in the presence of the cAMP p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Griffith TM,Chaytor AT,Taylor HJ,Giddings BD,Edwards DH

更新日期：2002-04-30 00:00:00

abstract：:We have developed an in situ hybridization assay capable of detecting enteroviral RNA in myocardial cells, using molecularly cloned coxsackievirus B3 cDNA as a diagnostic probe. Because of the high degree of nucleic acid sequence homology among the numerous enteroviral serotypes, including the group A and B coxsackiev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kandolf R,Ameis D,Kirschner P,Canu A,Hofschneider PH

更新日期：1987-09-01 00:00:00

abstract：:Conjugated linoleic acids (CLAs) affect body fat gain, carcinogenesis, insulin resistance, and lipid peroxidation in mammals. Several isomers of CLA exist, of which the (9Z, 11E) and (10E, 12Z) isomers have beneficial effects on human metabolism but are scarce in foods. Bacterial polyunsaturated fatty acid isomerases ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liavonchanka A,Hornung E,Feussner I,Rudolph MG

更新日期：2006-02-21 00:00:00

abstract：:The largest known DNA viruses infect Acanthamoeba and belong to two markedly different families. The Megaviridae exhibit pseudo-icosahedral virions up to 0.7 μm in diameter and adenine-thymine (AT)-rich genomes of up to 1.25 Mb encoding a thousand proteins. Like their Mimivirus prototype discovered 10 y ago, they enti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Legendre M,Bartoli J,Shmakova L,Jeudy S,Labadie K,Adrait A,Lescot M,Poirot O,Bertaux L,Bruley C,Couté Y,Rivkina E,Abergel C,Claverie JM

更新日期：2014-03-18 00:00:00

abstract：:The water channel aquaporin 1 (AQP1) and certain Rh-family members are permeable to CO(2) and NH(3). Here, we use changes in surface pH (pH(S)) to assess relative CO(2) vs. NH(3) permeability of Xenopus oocytes expressing members of the AQP or Rh family. Exposed to CO(2) or NH(3), AQP1 oocytes exhibit a greater maxima...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Musa-Aziz R,Chen LM,Pelletier MF,Boron WF

更新日期：2009-03-31 00:00:00