High-density lipoprotein receptor SCARB1 is required for carotenoid coloration in birds.

abstract：:The two internal transcribed spacers (ITS1 and ITS2) of rDNA of three members of the Ixodes ricinus "complex" (Acari: Ixodidae) were sequenced. Sequence variation was assessed for the North American species I. scapularis, I. dammini, and I. pacificus at three levels: within individual/population, between individuals o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wesson DM,McLain DK,Oliver JH,Piesman J,Collins FH

更新日期：1993-11-01 00:00:00

abstract：:Mechanisms underlying age-related obesity and insulin resistance are generally unknown. Here, we report age-related adipose vascular changes markedly modulated fat mass, adipocyte functions, blood lipid composition, and insulin sensitivity. Notably, VEGF expression levels in various white adipose tissues (WATs) underw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Honek J,Seki T,Iwamoto H,Fischer C,Li J,Lim S,Samani NJ,Zang J,Cao Y

更新日期：2014-10-14 00:00:00

abstract：:Rhodopsin folding and assembly were investigated by expression of five bovine opsin gene fragments separated at points corresponding to proteolytic cleavage sites in the second or third cytoplasmic regions. The CH(1-146) and CH(147-348) gene fragments encode amino acids 1-146 and 147-348 of opsin, while the TH(1-240) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ridge KD,Lee SS,Yao LL

更新日期：1995-04-11 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1), released from gut endocrine L cells in response to glucose, regulates appetite, insulin secretion, and gut motility. How glucose given orally, but not systemically, induces GLP-1 secretion is unknown. We show that human duodenal L cells express sweet taste receptors, the taste G protei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jang HJ,Kokrashvili Z,Theodorakis MJ,Carlson OD,Kim BJ,Zhou J,Kim HH,Xu X,Chan SL,Juhaszova M,Bernier M,Mosinger B,Margolskee RF,Egan JM

更新日期：2007-09-18 00:00:00

abstract：:We determined the complete mtDNA sequence of the centipede Lithobius forficatus and found that only one of the 22 inferred tRNA genes encodes a fully paired aminoacyl acceptor stem. The other 21 genes encode tRNAs with up to five mismatches in these stems, and some of these overlap extensively with the downstream gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lavrov DV,Brown WM,Boore JL

更新日期：2000-12-05 00:00:00

abstract：:A general theory of the structure of complexes of the transition metals is developed on the basis of the enneacovalence of the metals and the requirements of the electroneutrality principle. An extra orbital may be provided through the small but not negligible amount of f and g character of spd bond orbitals, and an e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pauling L

更新日期：1977-12-01 00:00:00

abstract：:Six overlapping cosmid clones having an average insert size of 40 kilobase pairs were identified and isolated from a human genomic library by using a cDNA probe, Alu-7, specific for the amino acid sequence of C4d, a known region of the fourth component of human complement. Analysis of these genomic clones by restricti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carroll MC,Porter RR

更新日期：1983-01-01 00:00:00

abstract：:An important goal in biology is to predict from sequence data the high-resolution structures of proteins and the interactions that occur between them. In this paper, we describe a computational approach that can make these types of predictions for a series of coiled-coil dimers. Our method comprises a dual strategy th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keating AE,Malashkevich VN,Tidor B,Kim PS

更新日期：2001-12-18 00:00:00

abstract：:Rhythmic, spontaneously pulsating cardiac cells cultured from newborn rats are immediately stimulated to beat faster by addition of a number of tubulin-binding agents but not by their non-tubulin-binding analogues. The tubulin-binding agents tested include vinblastine, vincristine, navelbine, two analogs of vinblastin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lampidis TJ,Kolonias D,Savaraj N,Rubin RW

更新日期：1992-02-15 00:00:00

abstract：:Characterizing the entropy of a system is a crucial, and often computationally costly, step in understanding its thermodynamics. It plays a key role in the study of phase transitions, pattern formation, protein folding, and more. Current methods for entropy estimation suffer from a high computational cost, lack of gen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nir A,Sela E,Beck R,Bar-Sinai Y

更新日期：2020-12-01 00:00:00

abstract：:Intercropping, which grows at least two crop species on the same pieces of land at the same time, can increase grain yields greatly. Legume-grass intercrops are known to overyield because of legume nitrogen fixation. However, many agricultural soils are deficient in phosphorus. Here we show that a new mechanism of ove...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li L,Li SM,Sun JH,Zhou LL,Bao XG,Zhang HG,Zhang FS

更新日期：2007-07-03 00:00:00

abstract：:The ability to regulate gene expression through transcription initiation underlies the adaptability and survival of all bacteria. Recent work has revealed that the transcription machinery in many bacteria diverges from the paradigm that has been established in Escherichia coliMycobacterium tuberculosis (Mtb) encodes t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu DX,Garner AL,Galburt EA,Stallings CL

更新日期：2019-07-02 00:00:00

abstract：:Fast neurotransmission requires that docked synaptic vesicles be located near the presynaptic N-type or P/Q-type calcium channels. Specific protein-protein interactions between a synaptic protein interaction (synprint) site on N-type and P/Q-type channels and the presynaptic SNARE proteins syntaxin, SNAP-25, and synap...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim DK,Catterall WA

更新日期：1997-12-23 00:00:00

abstract：:The primary structure of the Escherichia coli hemolysin polypeptide (HlyA) is used to predict intramolecular structures involved in the secretion and cytolytic activity of the molecule. The C-terminal region of HlyA contains a repeated, 8-amino acid chain represented by the consensus sequence Leu-Xaa-Gly-Gly-Xaa-Gly-A...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Felmlee T,Welch RA

更新日期：1988-07-01 00:00:00

abstract：:The tails of newborn rats, consisting of slender continuous cones of avascular cartilage, were transplanted in subcutaneous spaces of allogeneic adolescents; colloidal carbon was injected in a vein before the transplants were harvested on days 7-28. Between 97 and 100% of the transplants were accepted, underwent diffe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huggins CB,Anderson KP

更新日期：1976-09-01 00:00:00

abstract：:Long-term synaptic plasticity requires both gene expression in the nucleus and local protein synthesis at synapses. The effector proteins that link molecular events in the cell body with local maintenance of synaptic strength are not known. We now show that treatment with serotonin (5-HT) that produces long-term facil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giustetto M,Hegde AN,Si K,Casadio A,Inokuchi K,Pei W,Kandel ER,Schwartz JH

更新日期：2003-11-11 00:00:00

abstract：:In savannas, predicting how vegetation varies is a longstanding challenge. Spatial patterning in vegetation may structure that variability, mediated by spatial interactions, including competition and facilitation. Here, we use unique high-resolution, spatially extensive data of tree distributions in an African savanna...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Staver AC,Asner GP,Rodriguez-Iturbe I,Levin SA,Smit IPJ

更新日期：2019-05-28 00:00:00

abstract：:Programmed cell death (apoptosis) is a normal physiological process, which could in principle be manipulated to play an important role in cancer therapy. The key importance of p53 expression in the apoptotic response to DNA-damaging agents has been stressed because mutant or deleted p53 is so common in most kinds of c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu C,Meikrantz W,Schlegel R,Sager R

更新日期：1995-08-15 00:00:00

abstract：:MicroRNAs (miRNAs) are small RNAs that play a regulatory role in numerous and diverse eukaryotic cellular processes. Virus-encoded miRNAs have garnered much interest, although the functions of most remain to be deciphered. To date, readily detectable, evolutionarily conserved natural miRNAs have only been identified f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kincaid RP,Burke JM,Sullivan CS

更新日期：2012-02-21 00:00:00

abstract：:Metabolic crossfeeding is an important process that can broadly shape microbial communities. However, little is known about specific crossfeeding principles that drive the formation and maintenance of individuals within a mixed population. Here, we devised a series of synthetic syntrophic communities to probe the comp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mee MT,Collins JJ,Church GM,Wang HH

更新日期：2014-05-20 00:00:00

abstract：:The memory for a new episode is formed immediately upon experience and can last up to a lifetime. It has been shown that the hippocampal network plays a fundamental role in the rapid acquisition of a memory of a one-time experience, in which the novelty component of the experience promotes the prompt formation of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagatsuma A,Okuyama T,Sun C,Smith LM,Abe K,Tonegawa S

更新日期：2018-01-09 00:00:00

abstract：:Seasonal changes of daylength (photoperiod) affect the expression of hormonal and behavioral circadian rhythms in a variety of organisms. In mammals, such effects might reflect photoperiodic changes in the circadian pace-making system [located in the suprachiasmatic nucleus (SCN) of the hypothalamus] that governs thes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sumová A,Trávnícková Z,Peters R,Schwartz WJ,Illnerová H

更新日期：1995-08-15 00:00:00

abstract：:Antibodies from three different lines of monoclonal hybridomas crossreact with both the beta subunit of spectrin and the 90-kDa peptide present in highly purified preparations of the heme-controlled eIF-2 alpha (initiation factor 2 alpha-subunit) kinase from rabbit reticulocytes. Antibodies from two of the three lines...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kudlicki W,Fullilove S,Kramer G,Hardesty B

更新日期：1985-08-01 00:00:00

abstract：:Fluoxetine (Prozac) inhibited the membrane currents elicited by serotonin (5-hydroxytryptamine; 5HT) in Xenopus oocytes expressing either cloned 5HT2C receptors or 5HT receptors encoded by rat cortex mRNA. Responses of 5HT2C receptors, elicited by nM concentrations of 5HT, were rapidly and reversibly blocked by microm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ni YG,Miledi R

更新日期：1997-03-04 00:00:00

abstract：:The cdc25 phosphatases play key roles in cell cycle progression by activating cyclin-dependent kinases. Two members of the 14-3-3 protein family have been isolated in a yeast two-hybrid screen designed to identify proteins that interact with the human cdc25A and cdc25B phosphatases. Genes encoding the human homolog of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Conklin DS,Galaktionov K,Beach D

更新日期：1995-08-15 00:00:00

abstract：:To identify genes important for hair-cell function, we conducted a mutagenic screen in zebrafish. Larvae from one mutant line, ru848, were unresponsive to acoustic stimuli and unable to balance. The mutation results in a 90% reduction in hair-cell number and partial retinal degeneration by 5 days postfertilization. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Starr CJ,Kappler JA,Chan DK,Kollmar R,Hudspeth AJ

更新日期：2004-02-24 00:00:00

abstract：:Combinatorial transcription codes generate the myriad of cell types during development and thus likely provide crucial insights into directed differentiation of stem cells to a specific cell type. The LIM complex composed of Isl1 and Lhx3 directs the specification of spinal motor neurons (MNs) in embryos. Here, we rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee S,Cuvillier JM,Lee B,Shen R,Lee JW,Lee SK

更新日期：2012-02-28 00:00:00

abstract：:Adrenocortical carcinomas (ACCs) are rare and highly malignant cancers associated with poor survival of patients. Currently, mitotane, a nonspecific derivative of the pesticide DDT (1,1-(dichlorobiphenyl)-2,2-dichloroethane), is used as the standard treatment, but its mechanism of action in ACCs remains elusive. Here ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belavgeni A,Bornstein SR,von Mässenhausen A,Tonnus W,Stumpf J,Meyer C,Othmar E,Latk M,Kanczkowski W,Kroiss M,Hantel C,Hugo C,Fassnacht M,Ziegler CG,Schally AV,Krone NP,Linkermann A

更新日期：2019-10-29 00:00:00

abstract：:We recently isolated an RNA polymerase II elongation factor from rat liver nuclei and found it to be homologous to the product of the human ELL gene, a frequent target for translocations in acute myeloid leukemia. To further our understanding of the possible role(s) of ELL in transcriptional regulation and human disea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shilatifard A,Duan DR,Haque D,Florence C,Schubach WH,Conaway JW,Conaway RC

更新日期：1997-04-15 00:00:00

abstract：:We completed the cDNA cloning and sequencing of gp330, the major kidney glomerular antigen for rat Heymann nephritis. The deduced 4660-aa sequence, expected to constitute a mature protein of M(r) 516,715, consists of a probable N-terminal signal peptide sequence (25 aa), an extracellular region (4400 aa), a single tra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saito A,Pietromonaco S,Loo AK,Farquhar MG

更新日期：1994-10-11 00:00:00