High-density lipoprotein receptor SCARB1 is required for carotenoid coloration in birds.

abstract：:The "disease-specific" (dsp) region next to the hrp gene cluster of Erwinia amylovora is required for pathogenicity but not for elicitation of the hypersensitive reaction. A 6.6-kb apparent operon, dspEF, was found responsible for this phenotype. The operon contains genes dspE and dspF and is positively regulated by h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bogdanove AJ,Kim JF,Wei Z,Kolchinsky P,Charkowski AO,Conlin AK,Collmer A,Beer SV

更新日期：1998-02-03 00:00:00

abstract：:We isolated erythroleukemic cell lines arrested at different levels of the erythroid differentiation pathway. One cell line (CB5), established from mice infected with the helper-independent Friend murine leukemia virus (F-MuLV), exhibited properties similar to those of the normal erythroid progenitor burst-forming cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shibuya T,Mak TW

更新日期：1983-06-01 00:00:00

abstract：:A de novo mutation in the KCND2 gene, which encodes the Kv4.2 K+ channel, was identified in twin boys with intractable, infant-onset epilepsy and autism. Kv4.2 channels undergo closed-state inactivation (CSI), a mechanism by which channels inactivate without opening during subthreshold depolarizations. CSI dynamically...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin MA,Cannon SC,Papazian DM

更新日期：2018-04-10 00:00:00

abstract：:Miraculin (MCL) is a homodimeric protein isolated from the red berries of Richadella dulcifica. MCL, although flat in taste at neutral pH, has taste-modifying activity to convert sour stimuli to sweetness. Once MCL is held on the tongue, strong sweetness is sensed over 1 h each time we taste a sour solution. Neverthel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koizumi A,Tsuchiya A,Nakajima K,Ito K,Terada T,Shimizu-Ibuka A,Briand L,Asakura T,Misaka T,Abe K

更新日期：2011-10-04 00:00:00

abstract：:Although(,) vascular remodeling is a hallmark of many chronic inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis, anti-vascular strategies to treat these conditions have received little attention to date. We investigated the anti-inflammatory activity of systemic blockade of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schonthaler HB,Huggenberger R,Wculek SK,Detmar M,Wagner EF

更新日期：2009-12-15 00:00:00

abstract：:Gyrate atrophy (GA), a recessive eye disease involving progressive loss of vision due to chorioretinal degeneration, is associated with a deficiency of the mitochondrial enzyme ornithine aminotransferase (OATase; ornithine-oxo-acid aminotransferase; L-ornithine:2-oxo-acid aminotransferase, EC 2.6.1.13) with consequent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramesh V,McClatchey AI,Ramesh N,Benoit LA,Berson EL,Shih VE,Gusella JF

更新日期：1988-06-01 00:00:00

abstract：:To examine the in vivo role(s) of type I interferons (IFNs) and to determine the role of a component of the type I IFN receptor (IFNAR1) in mediating responses to these IFNs, we generated mice with a null mutation (-/-) in the IFNAR1 gene. Despite compelling evidence for modulation of cell proliferation and differenti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang SY,Hertzog PJ,Holland KA,Sumarsono SH,Tymms MJ,Hamilton JA,Whitty G,Bertoncello I,Kola I

更新日期：1995-11-21 00:00:00

abstract：:The cDNA of the gene pds from tomato, encoding the carotenoid biosynthesis enzyme phytoene desaturase, was cloned, and its nucleotide sequence was determined. Cells of Escherichia coli that expressed the tomato pds gene could convert phytoene to zeta-carotene. This result suggests that one polypeptide, the product of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pecker I,Chamovitz D,Linden H,Sandmann G,Hirschberg J

更新日期：1992-06-01 00:00:00

abstract：:A debate has recently surfaced concerning the degree of precommitment attained by alpha beta and gamma delta T-cell precursors prior to T-cell receptor (TCR) gene rearrangement. It has been suggested that precursors may be precommitted to rearrange either alpha or delta genes, but not both, thus giving rise to alpha b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson SD,Pelkonen J,Hurwitz JL

更新日期：1990-07-01 00:00:00

abstract：:The ion transport properties of the rough endoplasmic reticulum (RER) from liver have been defined by using measurements of active and potential gradient-driven transport. The Ca2+ pump is shown to be electrogenic, and both ATP and potential difference is able to drive vanadate-inhibitable Ca2+ uptake into the RER. AT...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muallem S,Schoeffield M,Pandol S,Sachs G

更新日期：1985-07-01 00:00:00

abstract：:Single-stranded DNA oligonucleotides can achieve targeted base-pair substitution with modest efficiency but high precision. We show that "oligo targeting" can be used effectively to study missense mutations in DNA mismatch repair (MMR) genes. Inherited inactivating mutations in DNA MMR genes are causative for the canc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Houlleberghs H,Dekker M,Lantermans H,Kleinendorst R,Dubbink HJ,Hofstra RM,Verhoef S,Te Riele H

更新日期：2016-04-12 00:00:00

abstract：:Using a HeLa cell line stably transfected with the tat gene from human immunodeficiency virus type 1, we have found that the expression of the regulatory Tat protein suppresses the expression of cellular Mn-containing superoxide dismutase (Mn-SOD). This enzyme is one of the cell's primary defenses against oxygen-deriv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flores SC,Marecki JC,Harper KP,Bose SK,Nelson SK,McCord JM

更新日期：1993-08-15 00:00:00

abstract：:Nitrogen metabolism in bacteria and archaea is regulated by a ubiquitous class of proteins belonging to the P(II)family. P(II) proteins act as sensors of cellular nitrogen, carbon, and energy levels, and they control the activities of a wide range of target proteins by protein-protein interaction. The sensing mechanis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rajendran C,Gerhardt EC,Bjelic S,Gasperina A,Scarduelli M,Pedrosa FO,Chubatsu LS,Merrick M,Souza EM,Winkler FK,Huergo LF,Li XD

更新日期：2011-11-22 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) signals through a receptor complex containing the type I (TGF-beta RI) and type II (TGF-beta RII) receptors. We describe here biochemical studies on early events in the TGF-beta signaling pathways. TGF-beta RII is highly phosphorylated when expressed alone in COS-1 cells; its...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen F,Weinberg RA

更新日期：1995-02-28 00:00:00

abstract：:Modulation of cholesterol absorption in the intestine, the primary site of dietary cholesterol uptake in humans, can have profound clinical implications. We have undertaken a reverse genetic approach by disrupting putative cholesterol processing genes in zebrafish larvae by using morpholino (MO) antisense oligonucleot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smart EJ,De Rose RA,Farber SA

更新日期：2004-03-09 00:00:00

abstract：:The rat mammary cell line Rama 25 [Bennett, D.C., Peachey, L.A., Durbin, H. & Rudland, P.S. (1978) Cell 15, 283--298] differentiates morphologically in vitro from a cuboidal form to a fusiform cell resembling myoepithelial cells. This differentiation occurs in all clonal isolates of the line. By using three different ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lennon VA,Unger M,Dulbecco R

更新日期：1978-12-01 00:00:00

abstract：:Enzyme cytochemistry has been used, at the light and electron microscope levels, to "mark" cytoplasmic organelles of mammalian cells. Catalase cytochemistry permitted identification of microperoxisomes, apparently ubiquitous organelles that are attached by numerous slender connections to the endoplasmic reticulum. Thi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Novikoff AB

更新日期：1976-08-01 00:00:00

abstract：:We explore the question of what are the best ligands for macromolecular targets. A survey of experimental data on a large number of the strongest-binding ligands indicates that the free energy of binding increases with the number of nonhydrogen atoms with an initial slope of approximately -1.5 kcal/mol (1 cal = 4.18 J...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuntz ID,Chen K,Sharp KA,Kollman PA

更新日期：1999-08-31 00:00:00

abstract：:To improve the usefulness of in vivo mode for the investigation of the pathophysiology of human immunodeficiency virus (HIV) infection, we modified the construction of SCID mice implanted with human fetal thymus and liver (thy/liv-SCID-hu mice) so that the peripheral blood of the mice contained significant numbers of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kollmann TR,Pettoello-Mantovani M,Katopodis NF,Hachamovitch M,Rubinstein A,Kim A,Goldstein H

更新日期：1996-04-02 00:00:00

abstract：:Patients with chronic ulcerative colitis (UC) are at high risk for developing colorectal cancer. In this study, archival formalin-fixed paraffin-embedded colonic tissue from patients with UC who developed carcinoma (CA) or high-grade dysplasia (HGD) was examined for changes in expression of the proinflammatory and mit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gillespie E,Leeman SE,Watts LA,Coukos JA,O'Brien MJ,Cerda SR,Farraye FA,Stucchi AF,Becker JM

更新日期：2011-10-18 00:00:00

abstract：:The structure of the NH2-terminal, 20-residue membrane-bound portion of melittin has been computed with empirical energies (ECEPP, Empirical Conformational Energy Program for Peptides). First, a search was made for long stretches of nonpolar residues. Then, the low-energy conformations of these segments were built up ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pincus MR,Klausner RD,Scheraga HA

更新日期：1982-08-01 00:00:00

abstract：:Recent studies on proteins whose N and C termini are in close proximity have demonstrated that folding of polypeptide chains and assembly of oligomers can be accomplished with circularly permuted chains. As yet no methodical study has been conducted to determine how extensively new termini can be introduced and where ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graf R,Schachman HK

更新日期：1996-10-15 00:00:00

abstract：:Alzheimer's disease is a neurodegenerative disorder characterized by the accumulation of amyloid plaques in the brain. This amyloid primarily contains amyloid-beta (Abeta), a 39- to 43-aa peptide derived from the proteolytic cleavage of the endogenous amyloid precursor protein. The 42-residue-length Abeta peptide (Abe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang R,Hu X,Khant H,Ludtke SJ,Chiu W,Schmid MF,Frieden C,Lee JM

更新日期：2009-03-24 00:00:00

abstract：:Previous work has shown that nuclei of young embryos (to gastrula stage) promote normal development when transplanted into enucleated eggs. As development proceeds to later stages, the nuclei become increasingly restricted in their capacity to promote normal cleavage and development, and the majority of the embryos th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hennen S

更新日期：1970-07-01 00:00:00

abstract：:Several tissue culture cell lines that were transformed by a tumor virus have been found to react with an agglutinin, while under identical conditions their untransformed parent cell lines did not agglutinate. Since a short treatment of the parent cell line with low concentrations of proteases exposed the same aggluti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burger MM

更新日期：1969-03-01 00:00:00

abstract：:Because virtually all organisms compete with others in their social environment, mechanisms that reduce conflict between interacting individuals are crucial for the evolution of stable families, groups, and societies. Here, we tested whether costs of social conflict over territorial space between Seychelles warblers (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bebbington K,Kingma SA,Fairfield EA,Dugdale HL,Komdeur J,Spurgin LG,Richardson DS

更新日期：2017-10-24 00:00:00

abstract：:Gram-negative bacteria possess a characteristic outer membrane, of which the lipid A constituent elicits a strong host immune response through the Toll-like receptor 4 complex, and acts as a component of the permeability barrier to prevent uptake of bactericidal compounds. Lipid A species comprise the bulk of the oute...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dovala D,Rath CM,Hu Q,Sawyer WS,Shia S,Elling RA,Knapp MS,Metzger LE 4th

更新日期：2016-10-11 00:00:00

abstract：:It has recently been demonstrated that coupled enzymatic processes may possess, for a particular choice of the state variables, multidimensional inflection points in thermodynamic force-flow space. The conditions for reciprocity in the linear region near such a reference state, which may be far from equilibrium, are o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caplan SR

更新日期：1981-07-01 00:00:00

abstract：:Graphene superlattices were shown to exhibit high-temperature quantum oscillations due to periodic emergence of delocalized Bloch states in high magnetic fields such that unit fractions of the flux quantum pierce a superlattice unit cell. Under these conditions, semiclassical electron trajectories become straight agai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krishna Kumar R,Mishchenko A,Chen X,Pezzini S,Auton GH,Ponomarenko LA,Zeitler U,Eaves L,Fal'ko VI,Geim AK

更新日期：2018-05-15 00:00:00

abstract：:(2'-5')Oligoadenylate synthetase [(2'-5')A synthetase], which synthesizes a series of oligoadenylates ppp-(A2'p)n5'A [collectively referred to as (2'-5')A], has been described previously in rat liver cells, where its concentration varied with the growth status of this organ--i.e., it decreased during the early phase o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Etienne-Smekens M,Vandenbussche P,Content J,Dumont JE

更新日期：1983-08-01 00:00:00