cAMP facilitates EDHF-type relaxations in conduit arteries by enhancing electrotonic conduction via gap junctions.

abstract：:Two issues long debated among Pacific and American prehistorians are (i) whether there was a pre-Columbian introduction of chicken (Gallus gallus) to the Americas and (ii) whether Polynesian contact with South America might be identified archaeologically, through the recovery of remains of unquestionable Polynesian or...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Storey AA,Ramírez JM,Quiroz D,Burley DV,Addison DJ,Walter R,Anderson AJ,Hunt TL,Athens JS,Huynen L,Matisoo-Smith EA

更新日期：2007-06-19 00:00:00

abstract：:The biological significance of DNA amplification in cancer is thought to be due to the selection of increased expression of a single or few important genes. However, systematic surveys of the copy number and expression of all genes within an amplified region of the genome have not been performed. Here we have used a c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Monni O,Barlund M,Mousses S,Kononen J,Sauter G,Heiskanen M,Paavola P,Avela K,Chen Y,Bittner ML,Kallioniemi A

更新日期：2001-05-08 00:00:00

abstract：:The reproductive activity of Trypanosoma lewisi was strikingly enhanced and sometimes prolonged for 2 days when sublethal doses of adenine were given to rats. The drug was effective when given for 5 or 7 days in the diet and/or intraperitoneally, starting one or two days before infection through two days after infecti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taliaferro WH,D'Alesandro PA

更新日期：1971-01-01 00:00:00

abstract：:The kinetics of electrogenic events associated with the different steps of the light-induced proton pump of bacteriorhodopsin is well studied in a wide range of time scales by direct electric methods. However, the investigation of the fundamental primary charge translocation phenomena taking place in the functional en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Groma GI,Hebling J,Kozma IZ,Váró G,Hauer J,Kuhl J,Riedle E

更新日期：2008-05-13 00:00:00

abstract：:Secretion of inflammatory mediators by rat mast cells (line RBL-2H3) was earlier shown to be inhibited upon clustering a membrane glycoprotein by monoclonal antibody G63. This glycoprotein, named mast cell function-associated antigen (MAFA), was also shown to interfere with the coupling cascade of the type 1 Fc epsilo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guthmann MD,Tal M,Pecht I

更新日期：1995-09-26 00:00:00

abstract：:Identifying the drivers and processes that determine globally the geographic range size of species is crucial to understanding the geographic distribution of biodiversity and further predicting the response of species to current global changes. However, these drivers and processes are still poorly understood, and no e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carvajal-Quintero J,Villalobos F,Oberdorff T,Grenouillet G,Brosse S,Hugueny B,Jézéquel C,Tedesco PA

更新日期：2019-07-02 00:00:00

abstract：:A series of monoclonal antibodies was used to define three discrete stages of human intrathymic T-cell differentiation. The earliest stage was confined to <10% of thymocytes, which were.reactive with both OKT9 and OKT10. Subsequently, approximately 70% of human thymocytes acquired a thymocyte-restricted antigen, OKT6,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reinherz EL,Kung PC,Goldstein G,Levey RH,Schlossman SF

更新日期：1980-03-01 00:00:00

abstract：:Previous reports of a relatively air-stable soluble hydrogenase from the photosynthetic anaerobe, Chromatium vinosum, have been substantiated. The properties of this enzyme, as seen in highly purified samples prepared by procedures that permit improved yields, are described. A possible role for flavin mediation is not...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kakuno T,Kaplan NO,Kamen MD

更新日期：1977-03-01 00:00:00

abstract：:The L-A double-stranded RNA virus of Saccharomyces cerevisiae makes a gag-pol fusion protein by a -1 ribosomal frameshift. The pol amino acid sequence includes consensus patterns typical of the RNA-dependent RNA polymerases (EC 2.7.7.48) of (+) strand and double-stranded RNA viruses of animals and plants. We have carr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ribas JC,Wickner RB

更新日期：1992-03-15 00:00:00

abstract：:The activity of cullin-containing ubiquitin protein ligase complexes is stimulated by linkage to cullin of the ubiquitin-like protein Nedd8 ("neddylation"). Neddylation is inhibited by the tight binding of cullins to CAND1 (cullin-associated and neddylation-dissociated 1) protein, and Nedd8 is removed from cullins by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bornstein G,Ganoth D,Hershko A

更新日期：2006-08-01 00:00:00

abstract：:Docosahexaenoic acid (DCHA), a major polyunsaturated acid component of fish lipid, is not a substrate for prostaglandin synthetase from ram seminal vesicles but is a strong competitive inhibitor (Ki, 0.36 microM) of the conversion by this enzyme of arachidonate (Km, 5.9 microM) to prostaglandins. In contrast, DCHA exh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Corey EJ,Shih C,Cashman JR

更新日期：1983-06-01 00:00:00

abstract：:Developmental constraint is indicated when one finds that similar genetic mechanisms are responsible for independent origins of the same derived phenotype. We studied three independent origins of rosette flowering within the mustard family and attempted to evaluate the extent to which the same mechanisms were involved...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoon HS,Baum DA

更新日期：2004-04-27 00:00:00

abstract：:The noninvasive detection and quantification of CD8(+) T cells in vivo are important for both the detection and staging of CD8(+) lymphomas and for the monitoring of successful cancer immunotherapies, such as adoptive cell transfer and antibody-based immunotherapeutics. Here, antibody fragments are constructed to targ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tavaré R,McCracken MN,Zettlitz KA,Knowles SM,Salazar FB,Olafsen T,Witte ON,Wu AM

更新日期：2014-01-21 00:00:00

abstract：:The 5'-phosphoinositol phosphatase SHIP negatively regulates signaling pathways triggered by antigen, cytokine and Fc receptors in both lymphocytes and myeloid cells. Mice with germ-line (null) deletion of SHIP develop a myeloproliferative-like syndrome that causes early lethality. Lymphocyte anomalies have been obser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tarasenko T,Kole HK,Chi AW,Mentink-Kane MM,Wynn TA,Bolland S

更新日期：2007-07-03 00:00:00

abstract：:In the T-cell somatic mutant J.CaM1, the T-cell antigen receptor complex is poorly coupled to the inositolphospholipid second messenger system; some antibodies against the invariant CD3 subunit of the receptor retain their agonist function in J.CaM1. Here we show by a combination of complementation assays that the mut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldsmith MA,Dazin PF,Weiss A

更新日期：1988-11-01 00:00:00

abstract：:Wnt signaling regulates many aspects of development by increasing the signaling activity of beta-catenin. Axin is a negative regulator of the Wnt signaling pathway, and it is responsible for the formation of the beta-catenin degradation complex. Genetic studies with Drosophila suggest that Axin promotes cytoplasmic lo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cong F,Varmus H

更新日期：2004-03-02 00:00:00

abstract：:The DC and DX subregions of the human major histocompatibility complex (MHC) have been cloned from a cosmid library made from a human B-cell line, Priess. The DC subregion, 48 kilobases, includes the DC alpha and DC beta genes. A second DC-like region, the DX subregion, 35 kilobases, contains the DX alpha gene and a n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okada K,Boss JM,Prentice H,Spies T,Mengler R,Auffray C,Lillie J,Grossberger D,Strominger JL

更新日期：1985-05-01 00:00:00

abstract：:Intracerebral hemorrhagic stroke and vascular dementia are age- and hypertension-associated manifestations of human cerebral small vessel disease (SVD). Cerebral microvessels are formed by endothelial cells (ECs), which are connected through tight junctions, adherens junctions, and stabilizing basement membrane struct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weinl C,Castaneda Vega S,Riehle H,Stritt C,Calaminus C,Wolburg H,Mauel S,Breithaupt A,Gruber AD,Wasylyk B,Olson EN,Adams RH,Pichler BJ,Nordheim A

更新日期：2015-08-11 00:00:00

abstract：:We have previously described a gene delivery system based upon the receptor-mediated endocytosis of DNA complexed with transferrin-polycation conjugates. This delivery system has been found to be very effective for both the internalization and the expression of genetic material in cells that have many transferrin rece...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner E,Cotten M,Foisner R,Birnstiel ML

更新日期：1991-05-15 00:00:00

abstract：:E2F is a heterodimeric transcription factor that regulates the expression of genes at the G1/S boundary and is composed of two related but distinct families of proteins, E2F and DP. E2F/DP heterodimers form complexes with the retinoblastoma (Rb) protein, the Rb-related proteins p107 and p130, and cyclins/cdks in a cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rogers KT,Higgins PD,Milla MM,Phillips RS,Horowitz JM

更新日期：1996-07-23 00:00:00

abstract：:The enhancer-binding factor NF-kappa B, which is found only in cells that transcribe immunoglobulin light chain genes, has been purified from nuclear extracts of Namalwa cells (human Burkitt lymphoma cells) by sequence-specific DNA affinity chromatography. The purified NF-kappa B has been identified as a 51-kDa polype...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawakami K,Scheidereit C,Roeder RG

更新日期：1988-07-01 00:00:00

abstract：:Explanations for primate brain expansion and the evolution of human cognition and culture remain contentious despite extensive research. While multiple comparative analyses have investigated variation in brain size across primate species, very few have addressed why primates vary in how much they use social learning. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Street SE,Navarrete AF,Reader SM,Laland KN

更新日期：2017-07-25 00:00:00

abstract：:Hearing loss is the main limitation of radiation therapy for vestibular schwannoma (VS), and identifying treatment options that minimize hearing loss are urgently needed. Treatment with bevacizumab is associated with tumor control and hearing improvement in neurofibromatosis type 2 (NF2) patients; however, its effect ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao X,Zhao Y,Stemmer-Rachamimov AO,Liu H,Huang P,Chin S,Selig MK,Plotkin SR,Jain RK,Xu L

更新日期：2015-11-24 00:00:00

abstract：:Down-regulation of mitogenic signaling in mammalian cells relies in part on endosomal trafficking of activated receptors into lysosomes, where the receptors are degraded. These events are mediated by ubiquitination of the endosomal cargo and its consequent sorting into multivesicular bodies that form at the surfaces o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu Q,Hope LW,Brasch M,Reinhard C,Cohen SN

更新日期：2003-06-24 00:00:00

abstract：:Electron micrographs are shown of the first component of human complement (C1) which has been crosslinked with a water-soluble carbodiimide to prevent dissociation into its C1q and C1r2C1s2 subunits. Two projections of the crosslinked molecule are seen in the electron micrographs, which are called "top" and "profile."...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strang CJ,Siegel RC,Phillips ML,Poon PH,Schumaker VN

更新日期：1982-01-01 00:00:00

abstract：:Intron removal from tRNA precursors involves cleavage by a tRNA splicing endonuclease to yield tRNA 3'-halves beginning with a 5'-hydroxyl, and 5'-halves ending in a 2',3'-cyclic phosphate. A tRNA ligase then incorporates this phosphate into the internucleotide bond that joins the two halves. Although this 3'-P RNA sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Englert M,Sheppard K,Aslanian A,Yates JR 3rd,Söll D

更新日期：2011-01-25 00:00:00

abstract：:Endothelium-derived relaxing factor (EDRF) activity has been attributed to the highly labile nitric oxide radical (NO). In view of the fact that the plasma and cellular milieux contain reactive species that can rapidly inactivate NO, it has been postulated that NO is stabilized by a carrier molecule that preserves its...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stamler JS,Simon DI,Osborne JA,Mullins ME,Jaraki O,Michel T,Singel DJ,Loscalzo J

更新日期：1992-01-01 00:00:00

abstract：:Familial adenomatous polyposis (FAP) is an autosomal-dominant disease characterized by the development of hundreds of adenomatous polyps of the colorectum. Approximately 80% of FAP patients can be shown to have truncating mutations of the APC gene. To determine the cause of FAP in the other 20% of patients, MAMA (mono...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laken SJ,Papadopoulos N,Petersen GM,Gruber SB,Hamilton SR,Giardiello FM,Brensinger JD,Vogelstein B,Kinzler KW

更新日期：1999-03-02 00:00:00

abstract：:Active matter, both synthetic and biological, demonstrates complex spatiotemporal self-organization and the emergence of collective behavior. A coherent rotational motion, the vortex phase, is of great interest because of its ability to orchestrate well-organized motion of self-propelled particles over large distances...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han K,Kokot G,Tovkach O,Glatz A,Aranson IS,Snezhko A

更新日期：2020-05-05 00:00:00

abstract：:The tumor microenvironment restrains conventional T cell (Tconv) activation while facilitating the expansion of Tregs. Here we showed that Tregs' advantage in the tumor milieu relies on supplemental energetic routes involving lipid metabolism. In murine models, tumor-infiltrating Tregs displayed intracellular lipid ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pacella I,Procaccini C,Focaccetti C,Miacci S,Timperi E,Faicchia D,Severa M,Rizzo F,Coccia EM,Bonacina F,Mitro N,Norata GD,Rossetti G,Ranzani V,Pagani M,Giorda E,Wei Y,Matarese G,Barnaba V,Piconese S

更新日期：2018-07-10 00:00:00