Emergence of self-organized multivortex states in flocks of active rollers.

abstract：:IL-7 and thymic stromal lymphopoietin (TSLP) are two major cytokines controlling murine B cell development. IL-7 has been studied extensively, but only recently has it become possible to unravel the role of TSLP in detail. We studied the biological activities of TSLP in B cell development at distinct ages in the mouse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vosshenrich CA,Cumano A,Müller W,Di Santo JP,Vieira P

更新日期：2004-07-27 00:00:00

abstract：:Solution at 2.5-A resolution of the three-dimensional structure of H-2Ld with a single nine-residue peptide provides a structural basis for understanding its unique interaction with beta-2 microglobulin (beta2m) and peptide. Consistent with the biological data that show an unusually weak association of Ld with beta2m,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balendiran GK,Solheim JC,Young AC,Hansen TH,Nathenson SG,Sacchettini JC

更新日期：1997-06-24 00:00:00

abstract：:The different isoforms of PDGF bind with different affinities to two different receptor types. Previously, these receptors have been demonstrated mainly on mesenchymal and glial cells. We show here that PDGF beta-type receptors are present also on rat brain neurons in vivo as well as in vitro. Immunohistochemical anal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smits A,Kato M,Westermark B,Nistér M,Heldin CH,Funa K

更新日期：1991-09-15 00:00:00

abstract：:The recent emergence and reemergence of viruses in the human population has highlighted the need to develop broader panels of therapeutic molecules. High-throughput screening assays opening access to untargeted steps of the viral replication cycle will provide powerful leverage to identify innovative antiviral molecul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernandez J,Hassen-Khodja C,Georget V,Rose T,Jacob Y,Janin YL,Nisole S,Vidalain PO,Arhel NJ

更新日期：2021-01-12 00:00:00

abstract：:The molecular mechanism of growth hormone release by synthetic somatocrinin was investigated on purified hog anterior pituitary secretory granules; the granules were found to contain a cAMP-dependent protein kinase that catalyzed [gamma-32P]-ATP histone phosphorylation with maximal rates ranging from 1 to 5 nmol of Pi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lewin MJ,Reyl-Desmars F,Ling N

更新日期：1983-11-01 00:00:00

abstract：:Theoretical considerations predict that amplification of expressed gene transcripts by reverse transcription-PCR using arbitrarily chosen primers will result in the preferential amplification of the central portion of the transcript. Systematic, high-throughput sequencing of such products would result in an expressed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dias Neto E,Correa RG,Verjovski-Almeida S,Briones MR,Nagai MA,da Silva W Jr,Zago MA,Bordin S,Costa FF,Goldman GH,Carvalho AF,Matsukuma A,Baia GS,Simpson DH,Brunstein A,de Oliveira PS,Bucher P,Jongeneel CV,O'Hare MJ,

更新日期：2000-03-28 00:00:00

abstract：:At high altitude (HA), carbohydrate (CHO) is thought to be the preferred fuel because of its higher yield of ATP per mole of O2. We used indirect calorimetry and D-[6-3H]glucose infusions to determine total CHO and circulatory glucose utilization during exercise in HA-acclimated and sea level (SL) rats. We hypothesize...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McClelland GB,Hochachka PW,Weber JM

更新日期：1998-08-18 00:00:00

abstract：:CD4+ T cells recognize major histocompatibility complex (MHC) class II-bound peptides that are primarily obtained from extracellular sources. Endogenously synthesized proteins that readily enter the MHC class I presentation pathway are generally excluded from the MHC class II presentation pathway. We show here that en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanderson S,Frauwirth K,Shastri N

更新日期：1995-08-01 00:00:00

abstract：:A renin promoter-large tumor antigen (T antigen) fusion gene was constructed to provide a reporter function for renin expression in transgenic mice. These transgenic mice gave rise to tumors in subcutaneous soft tissue, which was attributed to transgene expression at this site. An immunohistochemical analysis of trans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sigmund CD,Jones CA,Mullins JJ,Kim U,Gross KW

更新日期：1990-10-01 00:00:00

abstract：:During differentiation of 3T3-L1 preadipocytes into adipocytes, transcription of the C/EBP alpha (CCA-AT/enhancer binding protein alpha) gene is activated. The promoter of the C/EBP alpha gene contains a bipartite cis element with binding sites for C/EBP alpha undifferentiated protein (CUP) and an Sp1-like GT box bind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vasseur-Cognet M,Lane MD

更新日期：1993-08-01 00:00:00

abstract：:Excitation of HbCO by a single 6-psec 530-nm pulse results in photodissociation with a first-order constant of 0.89 X 10(11) sec-1. The kinetics of photodissociation, monitored by following absorbance changes in the Soret band at 440 nm, are interpreted as corresponding to predissociation followed by a corssing into a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Noe LJ,Eisert WG,Rentzepis PM

更新日期：1978-02-01 00:00:00

abstract：:A strain of Escherichia coli, selected on the basis of its resistance to colicin N, reveals distinct structural and functional alterations in unspecific OmpF porin. A single mutation [Gly-119-->Asp (G119D)] was identified in the internal loop L3 that contributes critically to the formation of the construction inside t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jeanteur D,Schirmer T,Fourel D,Simonet V,Rummel G,Widmer C,Rosenbusch JP,Pattus F,Pagès JM

更新日期：1994-10-25 00:00:00

abstract：:In eukaryotes, microtubules are essential for cellular plasticity and dynamics. Here we show that P300/CBP-associated factor (PCAF), a kinetochore-associated acetyltransferase, acts as a negative modulator of microtubule stability through acetylation of EB1, a protein that controls the plus ends of microtubules. PCAF ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xia P,Wang Z,Liu X,Wu B,Wang J,Ward T,Zhang L,Ding X,Gibbons G,Shi Y,Yao X

更新日期：2012-10-09 00:00:00

abstract：:This study demonstrates the presence of an N-acetyl-D-galactosaminyltransferase in human serum and in erythrocyte membranes. This enzyme catalyzes the transfer of N-acetyl-D-galactosamine from UDP-N-acetyl-D-galactosamine to a mucin receptor and 2'-fucosyllactose that have blood group H activity and may be responsible...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim YS,Perdomo J,Bella A Jr,Nordberg J

更新日期：1971-08-01 00:00:00

abstract：:The murine-virus-infected erythroleukemia cell system provides an opportunity to examine regulatory mechanisms controlling cytodifferentiation. A cloned cell line (DR10c3) resistant to the erythropoiesis-inducing effect of dimethylsulfoxide (Me2SO) was isolated from the Me2SO-sensitive line DS19. DR10c3 is characteriz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohta Y,Tanaka M,Terada M,Miller OJ,Bank A,Marks P,Rifkind RA

更新日期：1976-04-01 00:00:00

abstract：:The poly(A) site of bovine prolactin (bPRL) mRNA was examined by phased priming of cDNA synthesis with oligodeoxynucleotides of the general sequence d(pT8-N-N'). The existence of multiple poly(A)-adjacent sequences in bPRL mRNA was indicated by the production of specific chain-termination fragments with at least three...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sasavage NL,Smith M,Gillam S,Woychik RP,Rottman FM

更新日期：1982-01-01 00:00:00

abstract：:Zinniol [1,2-bis(hydroxymethyl)-3-methoxy-4-methyl-5-(3-methyl-2-butenyloxy)benzene], a toxin produced by fungi of the Alternaria group, causes symptoms in plants that resemble those induced by the fungi. The phytotoxin binds to carrot protoplasts and isolated membranes in a saturable and reversible manner. Receptor o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thuleau P,Graziana A,Rossignol M,Kauss H,Auriol P,Ranjeva R

更新日期：1988-08-01 00:00:00

abstract：:Arylhydrazinopyrimidines inhibit DNA synthesis in Bacillus subtilis by promoting formation of a specific, long-lived ternary complex with DNA polymerase III and the template-primer DNA. DNA polymerase III contains an associated, single-strand-selective exonuclease which generates 5'-mononucleotides. Drug inhibition of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Low RL,Rashbaum SA,Cozzarelli NR

更新日期：1974-08-01 00:00:00

abstract：:Among 21 human mammary tumors analyzed for transforming genes by transfection of NIH/3T3 cells, only DNA of a carcinosarcoma cell line, HS578T, registered as positive. A Harvey (H)-ras oncogene identified in this line was cloned in biologically active form and the activating lesion was identified as a single nucleotid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kraus MH,Yuasa Y,Aaronson SA

更新日期：1984-09-01 00:00:00

abstract：:We previously developed a biological containment system using recombinant Salmonella Typhimurium strains that are attenuated yet capable of synthesizing protective antigens. The regulated delayed attenuation and programmed self-destructing features designed into these S. Typhimurium strains enable them to efficiently ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kong W,Brovold M,Koeneman BA,Clark-Curtiss J,Curtiss R 3rd

更新日期：2012-11-20 00:00:00

abstract：:Polymorphism may play an important role in speciation because new species could originate from the distinctive morphs observed in polymorphic populations. However, much remains to be understood about the process by which morphs found new species. To detail the steps of this mode of speciation, we studied the geographi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Corl A,Davis AR,Kuchta SR,Sinervo B

更新日期：2010-03-02 00:00:00

abstract：:Immediately after focal retinal lesions, receptive fields (RFs) in primary visual cortex expand considerably, even when the retinal damage is limited to the photoreceptor layer. The time course of these changes suggests that mere lack of stimulation in the vicinity of the RF accompanied by stimulation in the surroundi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pettet MW,Gilbert CD

更新日期：1992-09-01 00:00:00

abstract：:The ability to regulate gene expression through transcription initiation underlies the adaptability and survival of all bacteria. Recent work has revealed that the transcription machinery in many bacteria diverges from the paradigm that has been established in Escherichia coliMycobacterium tuberculosis (Mtb) encodes t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu DX,Garner AL,Galburt EA,Stallings CL

更新日期：2019-07-02 00:00:00

abstract：:The development of osteoclastic cell lines would greatly facilitate analysis of the cellular and molecular biology of bone resorption. Several cell lines have previously been reported to be capable of osteoclastic differentiation. However, such cell lines form at best only occasional excavations, suggesting that osteo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chambers TJ,Owens JM,Hattersley G,Jat PS,Noble MD

更新日期：1993-06-15 00:00:00

abstract：:Bovine proinsulin has been crystallized under a variety of conditions at both neutral and acid pH. Microtechniques were employed with sample weights of about 200 mug and volumes of 5-20 mul. The crystalline preparations all differ from each other morphologically.X-ray photographs of one form, tetragonal bipyramids gro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fullerton WW,Potter R,Low BW

更新日期：1970-08-01 00:00:00

abstract：:RNA interference (RNAi) is a widely used method for analysis of gene function in tissue culture cells. However, to date there has been no reliable method for testing the specificity of any particular RNAi experiment. The ideal experiment is to rescue the phenotype by expression of the target gene in a form refractory ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kittler R,Pelletier L,Ma C,Poser I,Fischer S,Hyman AA,Buchholz F

更新日期：2005-02-15 00:00:00

abstract：:T cell recognition typically involves both the engagement of a specific T cell receptor with a peptide/major histocompatibility complex (MHC) and a number of accessory interactions. One of the most important interactions is between the integrin lymphocyte function-associated antigen 1 (LFA-1) on the T cell and intrace...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wülfing C,Sjaastad MD,Davis MM

更新日期：1998-05-26 00:00:00

abstract：:Identifying potentially unique features of the human cerebral cortex is a first step to understanding how evolution has shaped the brain in our species. By analyzing MR images obtained from 177 humans and 73 chimpanzees, we observed a human-specific asymmetry in the superior temporal sulcus at the heart of the communi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leroy F,Cai Q,Bogart SL,Dubois J,Coulon O,Monzalvo K,Fischer C,Glasel H,Van der Haegen L,Bénézit A,Lin CP,Kennedy DN,Ihara AS,Hertz-Pannier L,Moutard ML,Poupon C,Brysbaert M,Roberts N,Hopkins WD,Mangin JF,Dehaene-

更新日期：2015-01-27 00:00:00

abstract：:The mammalian anx7 gene codes for a Ca(2+)-activated GTPase, which supports Ca(2+)/GTP-dependent secretion events and Ca(2+) channel activities in vitro and in vivo. To test whether anx7 might be involved in Ca(2+) signaling in secreting pancreatic beta cells, we knocked out the anx7 gene in the mouse and tested the i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Srivastava M,Atwater I,Glasman M,Leighton X,Goping G,Caohuy H,Miller G,Pichel J,Westphal H,Mears D,Rojas E,Pollard HB

更新日期：1999-11-23 00:00:00

abstract：:Transcriptional activation by steroid hormones is often associated with the appearance of a DNase I hypersensitive site resulting from a local alteration of the nucleoprotein structure of the promoter. For the mouse mammary tumor virus long terminal repeat, a viral promoter under glucocorticoid control, a model has be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carr KD,Richard-Foy H

更新日期：1990-12-01 00:00:00