Abstract:
:Zinniol [1,2-bis(hydroxymethyl)-3-methoxy-4-methyl-5-(3-methyl-2-butenyloxy)benzene], a toxin produced by fungi of the Alternaria group, causes symptoms in plants that resemble those induced by the fungi. The phytotoxin binds to carrot protoplasts and isolated membranes in a saturable and reversible manner. Receptor occupancy stimulates entry of calcium into protoplasts. Zinniol can partially reverse the effects and binding of the calcium-channel blockers desmethoxyverapamil and bepridil. Selected cell lines that are insensitive to zinniol lose part of their binding capacity and sensitivity to the action of the agonist-like compound but are still able to bind calcium-channel blockers. We conclude that zinniol acts on calcium entry but that the targets of the toxin and of calcium-channel blockers are dissimilar, suggesting the occurrence of sites affected both by zinniol and by channel blockers and of sites affected only by zinniol.
journal_name
Proc Natl Acad Sci U S Aauthors
Thuleau P,Graziana A,Rossignol M,Kauss H,Auriol P,Ranjeva Rdoi
10.1073/pnas.85.16.5932subject
Has Abstractpub_date
1988-08-01 00:00:00pages
5932-5issue
16eissn
0027-8424issn
1091-6490journal_volume
85pub_type
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