Abstract:
:The different isoforms of PDGF bind with different affinities to two different receptor types. Previously, these receptors have been demonstrated mainly on mesenchymal and glial cells. We show here that PDGF beta-type receptors are present also on rat brain neurons in vivo as well as in vitro. Immunohistochemical analysis of a sequentially sectioned brain of a newborn rat revealed the presence of PDGF beta receptors in neurons throughout the central nervous system. These beta-receptor-bearing cells were shown to contain neurofilaments by double immunofluorescence staining. Furthermore, the PDGF-BB isoform bound to cells in a neuron-enriched culture from newborn rat brains and induced c-Fos protein in these cells. Continuous PDGF-BB treatment of primary rat brain cell cultures resulted in outgrowth of neurites and prolonged survival. These results indicate a neurotrophic effect of PDGF-BB.
journal_name
Proc Natl Acad Sci U S Aauthors
Smits A,Kato M,Westermark B,Nistér M,Heldin CH,Funa Kdoi
10.1073/pnas.88.18.8159keywords:
subject
Has Abstractpub_date
1991-09-15 00:00:00pages
8159-63issue
18eissn
0027-8424issn
1091-6490journal_volume
88pub_type
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