Differential expression of SNAP-25 protein isoforms during divergent vesicle fusion events of neural development.

abstract：:Attending to a stimulus is known to enhance the neural responses to that stimulus. Recent experiments on visual attention have shown that this modulation can have object-based characteristics, such that, when certain parts of a visual object are attended, other parts automatically also receive enhanced processing. Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Busse L,Roberts KC,Crist RE,Weissman DH,Woldorff MG

更新日期：2005-12-20 00:00:00

abstract：:Predicting climate change impact on ecosystem structure and services is one of the most important challenges in ecology. Until now, plant species response to climate change has been described at the level of fixed plant functional types, an approach limited by its inflexibility as there is much interspecific functiona...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Soudzilovskaia NA,Elumeeva TG,Onipchenko VG,Shidakov II,Salpagarova FS,Khubiev AB,Tekeev DK,Cornelissen JH

更新日期：2013-11-05 00:00:00

abstract：:A synthetic polyribonucleotide, poly(U5,G), was used to study the codon specificity of wild-type and UGA suppressor tRNATrp from Escherichia coli. Phe (UUU) incorporation directed by this synthetic messenger is reduced somewhat by omission from the incubation mixtures of Val (GUU), Leu (UUG), or Cys (UGU). In contrast...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buckingham RH,Kurland CG

更新日期：1977-12-01 00:00:00

abstract：:Two human 12-lipoxygenase enzyme (arachidonate:oxygen 12-oxidoreductase, EC 1.13.11.31)-related genes were characterized from 13 distinct clones isolated from three genomic bacteriophage and cosmid libraries. A complete gene (12-lipoxygenase gene 1) spanning approximately 17 kilobases and consisting of 14 exons with s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Funk CD,Funk LB,FitzGerald GA,Samuelsson B

更新日期：1992-05-01 00:00:00

abstract：:Antibodies to chromatin proteins of Novikoff hepatoma cells formed precipitin bands in the double-diffusion immunoprecipitation assay with chromatin proteins of Novikoff hepatoma, Walker 256 carcinosarcoma, and 18-day fetal rat liver. The antigen used for preparation of antiserum was the chromatin proteins initially e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeoman LC,Jordan JJ,Busch RK,Taylor CW,Savage HE,Busch H

更新日期：1976-09-01 00:00:00

abstract：:Procedures are described for the isolation of conditional lethal mutants of mouse L-60T cells. The mutant lines were temperature sensitive by the following criteria: (a) colony-forming ability, (b) growth in suspension culture, and (c) rate of uptake of tritiated-thymidine. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson LH,Mankovitz R,Baker RM,Till JE,Siminovitch L,Whitmore GF

更新日期：1970-06-01 00:00:00

abstract：:The three-dimensional structures of the inactive protein precursors (zymogens) of the serine, cysteine, aspartic, and metalloprotease classes of proteolytic enzymes are known. Comparisons of these structures with those of the mature, active proteases reveal that, in general, the preformed, active conformations of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khan AR,Khazanovich-Bernstein N,Bergmann EM,James MN

更新日期：1999-09-28 00:00:00

abstract：:Tiazofurin (2-beta-D-ribofuranosyl-4-thiazole-carboxamide; NSC 286193), an antitumor carbon-linked nucleoside that inhibits IMP dehydrogenase (IMP:NAD+ oxidoreductase; EC 1.1.1.205) and depletes guanylate levels, can activate the erythroid differentiation program of K-562 human leukemia cells. Tiazofurin-mediated cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olah E,Natsumeda Y,Ikegami T,Kote Z,Horanyi M,Szelenyi J,Paulik E,Kremmer T,Hollan SR,Sugar J

更新日期：1988-09-01 00:00:00

abstract：:Epitopes for 22 alloantibodies that inhibit factor VIII procoagulant protein (FVIII) from multitransfused individuals with severe hemophilia A and three autoantibodies from nonhemophilic individuals appeared to be restricted to two specific regions of the FVIII molecule. Immunoblotting of purified FVIII and purified t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fulcher CA,de Graaf Mahoney S,Roberts JR,Kasper CK,Zimmerman TS

更新日期：1985-11-01 00:00:00

abstract：:Caveolin, a 21- to 24-kDa integral membrane protein, is a principal component of caveolae membranes. Caveolin interacts directly with heterotrimeric guanine nucleotide binding proteins (G proteins) and can functionally regulate their activity. Here, an approximately 20-kDa caveolin-related protein, caveolin-2, was ide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scherer PE,Okamoto T,Chun M,Nishimoto I,Lodish HF,Lisanti MP

更新日期：1996-01-09 00:00:00

abstract：:Mouse beta-globin in encoded in a discontinuous structural gene interrupted by a 550-base pair intervening sequence of DNA. Correspondingly, the mature beta-globin mRNA appears to be synthesized via a 15S precursor, the length of which roughly equals the total length of the coding and intervening sequences of the beta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tilghman SM,Curtis PJ,Tiemeier DC,Leder P,Weissmann C

更新日期：1978-03-01 00:00:00

abstract：:Realizing the goal of the Paris Agreement to limit global warming to 2 °C by the end of this century will most likely require deployment of carbon-negative technologies. It is particularly important that China, as the world's top carbon emitter, avoids being locked into carbon-intensive, coal-fired power-generation te...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu X,Cao L,Wang H,Peng W,Xing J,Wang S,Cai S,Shen B,Yang Q,Nielsen CP,McElroy MB

更新日期：2019-04-23 00:00:00

abstract：:[3H]Puromycin and N-(ethyl-2-diazomalonyl)[3H]puromycin are incorporated into E. coli ribosomes on irradiation at 253.7 nm. Both compounds incorporate into both protein and nucleic acid. Two-dimensional gel electrophoresis of ribosomal protein shows that L23 is the major protein labeled by puromycin. Although incorpor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cooperman BS,Jaynes EN,Brunswick DJ,Luddy MA

更新日期：1975-08-01 00:00:00

abstract：:The generalized master equations (GMEs) that contain multiple time scales have been derived quantum mechanically. The GME method has then been applied to a model of charge migration in proteins that invokes the hole hopping between local amino acid sites driven by the torsional motions of the floppy backbones. This mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schlag EW,Yang DY,Sheu SY,Selzle HL,Lin SH,Rentzepis PM

更新日期：2000-08-29 00:00:00

abstract：:In the present article we describe the design and evaluation of a synthetic receptor that binds to the exterior surface of chymotrypsin and disrupts its interaction with proteinaceous inhibitors, such as soybean trypsin inhibitor, basic pancreatic trypsin inhibitor, ovomucoid turkey inhibitor, and Bowman-Birk inhibito...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park HS,Lin Q,Hamilton AD

更新日期：2002-04-16 00:00:00

abstract：:Synucleinopathies are a group of progressive disorders characterized by the abnormal aggregation and accumulation of α-synuclein (aSyn), an abundant neuronal protein that can adopt different conformations and biological properties. Recently, aSyn pathology was shown to spread between neurons in a prion-like manner. Pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Villar-Piqué A,Lopes da Fonseca T,Sant'Anna R,Szegö ÉM,Fonseca-Ornelas L,Pinho R,Carija A,Gerhardt E,Masaracchia C,Abad Gonzalez E,Rossetti G,Carloni P,Fernández CO,Foguel D,Milosevic I,Zweckstetter M,Ventura S,Outeiro

更新日期：2016-10-18 00:00:00

abstract：:Successful implementation of bone marrow transplantation for hematopoietic reconstitution is limited by the lack of suitably HLA-matched donors and by the occurrence of graft-versus-host disease that frequently accompanies this procedure. Recent clinical reports have implied that the use of umbilical cord blood as a s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harris DT,Schumacher MJ,Locascio J,Besencon FJ,Olson GB,DeLuca D,Shenker L,Bard J,Boyse EA

更新日期：1992-11-01 00:00:00

abstract：:As a consequence of recent developments in molecular phylogenomics, all extant orders of placental mammals have been grouped into 3 lineages: Afrotheria, Xenarthra, and Boreotheria, which originated in Africa, South America, and Laurasia, respectively. Despite this advancement, the order of divergence of these 3 linea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nishihara H,Maruyama S,Okada N

更新日期：2009-03-31 00:00:00

abstract：:Cells of the human embryonic stem (hES) cell line H9, when cultured in the form of embryoid bodies, give rise to cells with markers of the keratinocyte of stratified squamous epithelia. Keratinocytes also form in nodules produced in scid mice by injected H9 cells; the hES-derived keratinocytes could be recovered in cu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iuchi S,Dabelsteen S,Easley K,Rheinwald JG,Green H

更新日期：2006-02-07 00:00:00

abstract：:Marked hypoalphalipoproteinemia was found together with relatively low serum cholesterol, triacylglycerol, and LDL levels in a triose-phosphate isomerase (TPI; D-glyceraldehyde-3-phosphate ketol-isomerase, EC 5.3.1.1)-deficient Hungarian family, especially in the two compound-heterozygote brothers. Apart from a slight...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hollán S,Dey I,Szollár L,Horányi M,Magócsi M,Harsányi V,Farkas T

更新日期：1995-01-03 00:00:00

abstract：:Integrated assessment models of climate and the economy provide estimates of the social cost of carbon and inform climate policy. We create a variant of the Regional Integrated model of Climate and the Economy (RICE)-a regionally disaggregated version of the Dynamic Integrated model of Climate and the Economy (DICE)-i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dennig F,Budolfson MB,Fleurbaey M,Siebert A,Socolow RH

更新日期：2015-12-29 00:00:00

abstract：:L-Asparaginase (EC 3.5.1.1) inhibited respiration in sensitive, but not resistant, lines of murine lymphoma 6C3HED. Glucose, in these tumor lines, was principally converted to lactate, and very little was oxidized in the citric acid cycle or hexose monophosphate shunt. The cells derived 70-80% of their respiratory CO(...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lavietes BB,Regan DH,Demopoulos HB

更新日期：1974-10-01 00:00:00

abstract：:Cisplatin is a chemotherapeutic drug used to treat a variety of cancers. Both intrinsic and acquired resistance to cisplatin, as well as toxicity, limit its effectiveness. Molecular mechanisms that underlie cisplatin resistance are poorly understood. Here we demonstrate that deletion of the yeast CTR1 gene, which enco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishida S,Lee J,Thiele DJ,Herskowitz I

更新日期：2002-10-29 00:00:00

abstract：:During nervous system development, synapses undergo morphological change as a function of electrical activity. In Drosophila, enhanced activity results in the expansion of larval neuromuscular junctions. We have examined whether these structural changes involve the pre- or postsynaptic partner by selectively enhancing...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mosca TJ,Carrillo RA,White BH,Keshishian H

更新日期：2005-03-01 00:00:00

abstract：:Recent studies indicate that impairments in two cognitive domains characterize the cognitive abnormalities that appear earliest in the course of Alzheimer disease (AD). These cognitive domains pertain to memory and executive function ability; in particular, memory test scores reflecting the difference between immediat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Albert MS

更新日期：1996-11-26 00:00:00

abstract：:Global energy demand and environmental concerns have stimulated increasing efforts to produce carbon-neutral fuels directly from renewable resources. Microbially derived aliphatic hydrocarbons, the petroleum-replica fuels, have emerged as promising alternatives to meet this goal. However, engineering metabolic pathway...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu P,Li L,Zhang F,Stephanopoulos G,Koffas M

更新日期：2014-08-05 00:00:00

abstract：:Mitogen-activated protein (MAP) kinases are central components of signal transduction pathways for cell proliferation, stress responses, and differentiation. Signaling efficiency and specificity are modulated in large part by docking interactions between individual MAP kinase and the kinase interaction motif (KIM), (R...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu S,Sun JP,Zhou B,Zhang ZY

更新日期：2006-04-04 00:00:00

abstract：:This article considers replicability of the performance of predictors across studies. We suggest a general approach to investigating this issue, based on ensembles of prediction models trained on different studies. We quantify how the common practice of training on a single study accounts in part for the observed chal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patil P,Parmigiani G

更新日期：2018-03-13 00:00:00

abstract：:In rats fed the liver carcinogen 2-acetylaminofluorene (AAF), the two most abundant types of DNA adduct are N-(deoxyguanosin-8-yl)-2-acetylaminofluorene and its deacetylated derivative. When plasmids carrying AAF adducts replicate in bacteria, the predominant mutations are frameshifts, whereas with deacetylated (AF) a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mah MC,Boldt J,Culp SJ,Maher VM,McCormick JJ

更新日期：1991-11-15 00:00:00

abstract：:In this era of unprecedented biodiversity loss and increased zoonotic disease emergence, it is imperative to understand the effects of biodiversity on zoonotic pathogen dynamics in wildlife. Whether increasing biodiversity should lead to a decrease or increase in infection prevalence, termed the dilution and amplifica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luis AD,Kuenzi AJ,Mills JN

更新日期：2018-07-31 00:00:00