Functional traits predict relationship between plant abundance dynamic and long-term climate warming.

abstract：:When light-grown seedlings of amaranth are transferred to total darkness, synthesis of the large subunit (LS) and small subunit (SS) of ribulose-1,5-bisphosphate carboxylase [RbuP(2)Case; 3-phospho-D-glycerate carboxylase (dimerizing), EC 4.1.1.39] is rapidly depressed. This reduction in RbuP(2)Case synthesis occurs i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berry JO,Carr JP,Klessig DF

更新日期：1988-06-01 00:00:00

abstract：:Myxococcus xanthus is a Gram-negative bacterium that aggregates to form fruiting bodies when nutrients are limiting. Previous studies showed that the frz mutants that are defective in chemotaxis exhibited irregular and infrequent patterns of cellular reversal. In contrast, wild-type cells, when examined individually, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shi W,Ngok FK,Zusman DR

更新日期：1996-04-30 00:00:00

abstract：:Helping and sharing among humans is often motivated by empathy and accompanied by a sense of satisfaction. To determine whether similar self-rewarding mechanisms may underpin assistance among nonhuman primates, eight female brown capuchin monkeys (Cebus apella) underwent testing in a simple choice paradigm. Paired wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Waal FB,Leimgruber K,Greenberg AR

更新日期：2008-09-09 00:00:00

abstract：:Infection of newborn rats with Borne disease virus (BDV) results in selective degeneration of granule cell neurons of the dentate gyrus (DG). To study cellular countermechanisms that might prevent this pathology, we screened for rat strains resistant to this BDV-induced neuronal degeneration. To this end, we infected ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu YJ,Schulz H,Lin CC,Saar K,Patone G,Fischer H,Hübner N,Heimrich B,Schwemmle M

更新日期：2013-01-29 00:00:00

abstract：:Melanomas occur mainly in sunlight-exposed skin. Xeroderma pigmentosum (XP) patients have 1,000-fold higher incidence of melanoma, suggesting that sunlight-induced "bulky" photoproducts are responsible for melanomagenesis. Sunlight induces a high level of reactive oxygen species in melanocytes (MCs); oxidative DNA dam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang HT,Choi B,Tang MS

更新日期：2010-07-06 00:00:00

abstract：:Achieving long-term pancellular expression of a transferred gene at therapeutic level in a given hematopoietic lineage remains an important goal of gene therapy. Advances have recently been made in the genetic correction of the hemoglobinopathies by means of lentiviral vectors and large locus control region (LCR) deri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Imren S,Payen E,Westerman KA,Pawliuk R,Fabry ME,Eaves CJ,Cavilla B,Wadsworth LD,Beuzard Y,Bouhassira EE,Russell R,London IM,Nagel RL,Leboulch P,Humphries RK

更新日期：2002-10-29 00:00:00

abstract：:Cytochrome P450 enzymes are monooxygenases that contain a functional heme b group linked to a conserved cysteine with a thiolate bond. In the native state, the central iron atom is hexacoordinated with a covalently bound water molecule. The exclusion of solvent molecules from the active site is essential for efficient...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oprea TI,Hummer G,Garcia AE

更新日期：1997-03-18 00:00:00

abstract：:CD4(+) T cells producing IL-17 [T helper (Th)17], as distinct from Th1 or Th2 cells, have recently been shown to be associated with autoimmunity, but it is not entirely clear how Th17 cells are generated from naïve T cells. We demonstrate here that IL-6, but not TNF-alpha or IL-1beta, can, in combination with TGF-beta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kimura A,Naka T,Kishimoto T

更新日期：2007-07-17 00:00:00

abstract：:Cyclic AMP (cAMP) and calcium are ubiquitous, interdependent second messengers that regulate a wide range of cellular processes. During development of neuronal networks they are critical for the first step of circuit formation, transducing signals required for axon pathfinding. Surprisingly, the spatial and temporal c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nicol X,Hong KP,Spitzer NC

更新日期：2011-08-16 00:00:00

abstract：:The affinity of the Escherichia coli phage 434 operator for phage 434 repressor is affected by changes in the sequence of the noncontacted base pairs near the operator's center. The results presented here show that base composition near the center of the operator affects the operator's affinity for repressor by alteri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koudelka GB,Harbury P,Harrison SC,Ptashne M

更新日期：1988-07-01 00:00:00

abstract：:The C-terminal domains of the two alpha-subunits (alphaCTD) in Escherichia coli RNA polymerase (RNAP) recognize specific sequences called UP elements in some promoters. These interactions can increase transcription dramatically. Previously, effects of upstream DNA-alphaCTD interactions on transcription were quantified...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ross W,Gourse RL

更新日期：2005-01-11 00:00:00

abstract：:Antibodies may bind to bacterial pathogens or their toxins to control infections, and their effector activity is mediated through the recruitment of complement component C1q or the engagement with Fcγ receptors (FcγRs). For bacterial pathogens that rely on a single toxin to cause disease, immunity correlates with toxi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen X,Shi M,Tong X,Kim HK,Wang LX,Schneewind O,Missiakas D

更新日期：2020-09-15 00:00:00

abstract：:Fms-like tyrosine kinase 1 (Flt1)/vascular endothelial growth factor (VEGF) receptor 1, a receptor for VEGF-A and placental growth factor, is expressed in the spongiotrophoblast layer that segregates the maternal and fetal vasculature in the mouse placenta. A soluble form of Flt1 (sFlt1) produced in the mouse and huma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirashima M,Lu Y,Byers L,Rossant J

更新日期：2003-12-23 00:00:00

abstract：:Sex differences influence brain morphology and physiology during both development and aging. Here we apply a machine learning algorithm to a multiparametric brain PET imaging dataset acquired in a cohort of 20- to 82-year-old, cognitively normal adults (n = 205) to define their metabolic brain age. We find that throug...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goyal MS,Blazey TM,Su Y,Couture LE,Durbin TJ,Bateman RJ,Benzinger TL,Morris JC,Raichle ME,Vlassenko AG

更新日期：2019-02-19 00:00:00

abstract：:Declining biodiversity and ecosystem functions put many of nature's contributions to people at risk. We review and synthesize the scientific literature to assess 50-y global trends across a broad range of nature's contributions. We distinguish among trends in potential and realized contributions of nature, as well as ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brauman KA,Garibaldi LA,Polasky S,Aumeeruddy-Thomas Y,Brancalion PHS,DeClerck F,Jacob U,Mastrangelo ME,Nkongolo NV,Palang H,Pérez-Méndez N,Shannon LJ,Shrestha UB,Strombom E,Verma M

更新日期：2020-12-22 00:00:00

abstract：:Interleukin 1 (IL-1) is a two-member family of proteins (IL-1 alpha and IL-1 beta) that mediates a diverse series of immune and inflammatory responses. These two proteins have only 26% amino acid homology yet bind to the same receptor. It is of importance to define the active sites of these molecules in order to under...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mosley B,Dower SK,Gillis S,Cosman D

更新日期：1987-07-01 00:00:00

abstract：:We have found that poly(L-lysine) can be a very effective agent in preventing the growth of Ehrlich ascites tumors in mice. When given optimal doses of poly(L-lysine) (Mr 60 x 10(3)) intraperitoneally for 5 consecutive days, beginning on day 1 after inoculation with Ehrlich ascites cells. White Swiss mice show nearly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arnold LJ Jr,Dagan A,Gutheil J,Kaplan NO

更新日期：1979-07-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is characterized by impaired social interactions and communication. The pathogenesis of ASD is not known, but it involves activation of microglia. We had shown that the peptide neurotensin (NT) is increased in the serum of children with ASD and stimulates cultured adult human microglia t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsilioni I,Pantazopoulos H,Conti P,Leeman SE,Theoharides TC

更新日期：2020-07-14 00:00:00

abstract：:Nucleotide sequences that direct transcription of the human 5-lipoxygenase gene have been examined by ligation to the chloramphenicol acetyltransferase gene and determination of chloramphenicol acetyltransferase activity in transfected HeLa and HL-60 cells. Various lengths of 5'-flanking sequences up to 5.9 kilobase p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoshiko S,Rådmark O,Samuelsson B

更新日期：1990-12-01 00:00:00

abstract：:T7 gene 5 DNA polymerase (gp5) and its processivity factor, Escherichia coli thioredoxin, together with the T7 gene 4 DNA helicase, catalyze strand displacement synthesis on duplex DNA processively (>17,000 nucleotides per binding event). The processive DNA synthesis is resistant to the addition of a DNA trap. However...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson DE,Takahashi M,Hamdan SM,Lee SJ,Richardson CC

更新日期：2007-03-27 00:00:00

abstract：:Pyramidal cells in piriform cortex receive excitatory inputs from two different sources that are segregated onto adjacent segments of their apical dendrites. The present studies show that excitatory postsynaptic potentials (EPSPs) evoked by primary olfactory tract afferents that terminate on distal apical segments dis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bower JM,Haberly LB

更新日期：1986-02-01 00:00:00

abstract：:Single-molecule manipulation techniques reveal that stretching unravels individually folded domains in the muscle protein titin and the extracellular matrix protein tenascin. These elastic proteins contain tandem repeats of folded domains with beta-sandwich architecture. Herein, we propose by stretching two model sequ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klimov DK,Thirumalai D

更新日期：2000-06-20 00:00:00

abstract：:Genomic clones of the human non-N-methyl-D-aspartate (non-NMDA) glutamate receptor subunit GluR5 were isolated by high-stringency screening of a cosmid library using the rat cDNA as a probe. The chromosomal localization of the human GluR5 gene has been established. Southern hybridization of DNA isolated from mapping p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eubanks JH,Puranam RS,Kleckner NW,Bettler B,Heinemann SF,McNamara JO

更新日期：1993-01-01 00:00:00

abstract：:We derive more than 80 embeddings of 2D hyperbolic honeycombs in Euclidean 3 space, forming 3-periodic infinite polyhedra with cubic symmetry. All embeddings are "minimally frustrated," formed by removing just enough isometries of the (regular, but unphysical) 2D hyperbolic honeycombs [Formula: see text], [Formula: se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pedersen MC,Hyde ST

更新日期：2018-07-03 00:00:00

abstract：:The mechanism by which cells recognize and complete replicated regions at their precise doubling point must be remarkably efficient, occurring thousands of times per cell division along the chromosomes of humans. However, this process remains poorly understood. Here we show that, in Escherichia coli, the completion of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wendel BM,Courcelle CT,Courcelle J

更新日期：2014-11-18 00:00:00

abstract：:NAPVSIPQ (NAP), an active fragment of the glial-derived activity-dependent neuroprotective protein, is protective at femtomolar concentrations against a wide array of neural insults and prevents ethanol-induced fetal wastage and growth retardation in mice. NAP also antagonizes ethanol inhibition of L1-mediated cell ad...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilkemeyer MF,Chen SY,Menkari CE,Brenneman DE,Sulik KK,Charness ME

更新日期：2003-07-08 00:00:00

abstract：:The selection of a single molecular handedness, or homochirality across all living matter, is a mystery in the origin of life. Frank's seminal model showed in the '50s how chiral symmetry breaking can occur in nonequilibrium chemical networks. However, an important shortcoming in this classic model is that it consider...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laurent G,Lacoste D,Gaspard P

更新日期：2021-01-19 00:00:00

abstract：:Long interspersed nuclear elements 1 (L1) are active retrotransposons that reside in many species, including humans and rodents. L1 elements produce an RNA intermediate that is reverse transcribed to DNA and inserted in a new genomic location. We have tagged an active human L1 element (L1(RP)) with a gene encoding enh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prak ET,Dodson AW,Farkash EA,Kazazian HH Jr

更新日期：2003-02-18 00:00:00

abstract：:A simple model is described for calculating the electrostatic energy of lipid domains at the air-water interface, taking account of dipole-dipole repulsions between the lipid molecules themselves, as well as interactions between the molecular dipoles and image dipoles in the subphase. The model assumes that the molecu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McConnell HM,Bazaliy YB

更新日期：1995-09-12 00:00:00

abstract：:Mutations in the gene encoding the transcription factor autoimmune regulator (AIRE) are responsible for autoimmune polyendocrinopathy candidiasis ectodermal dystrophy syndrome. AIRE directs expression of tissue-restricted antigens in the thymic medulla and in lymph node stromal cells and thereby substantially contribu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pomié C,Vicente R,Vuddamalay Y,Lundgren BA,van der Hoek M,Enault G,Kagan J,Fazilleau N,Scott HS,Romagnoli P,van Meerwijk JP

更新日期：2011-07-26 00:00:00