Autoimmune regulator (AIRE)-deficient CD8+CD28low regulatory T lymphocytes fail to control experimental colitis.

abstract：:Motifs of neural circuitry seem surprisingly conserved over different areas of neocortex or of paleocortex, while performing quite different sensory processing tasks. This apparent paradox may be resolved by the fact that seemingly different problems in sensory information processing are related by transformations (ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hopfield JJ

更新日期：1996-12-24 00:00:00

abstract：:Fumarase C was strongly induced by paraquat in a parental strain of Escherichia coli but was not induced in a strain lacking the soxRS response. Moreover, a strain that constitutively expresses the soxRS regulon contained more fumarase C than did the parental strain. The Mn-containing superoxide dismutase and glucose-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liochev SI,Fridovich I

更新日期：1992-07-01 00:00:00

abstract：:Sexual arousal is a dynamical, highly coordinated neurophysiological process that is often induced by visual stimuli. Numerous studies have proposed that the cognitive processing stage of responding to sexual stimuli is the first stage, in which sex differences occur, and the divergence between men and women has been ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitricheva E,Kimura R,Logothetis NK,Noori HR

更新日期：2019-07-30 00:00:00

abstract：:Evolution of an oxygenic atmosphere required primordial life to accommodate the toxicity associated with reactive oxygen species. We have characterized an archaeal antioxidant from the hyperthermophilic acidophile Sulfolobus solfataricus. The amino acid sequence of this approximately 22-kDa protein shares little seque...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wiedenheft B,Mosolf J,Willits D,Yeager M,Dryden KA,Young M,Douglas T

更新日期：2005-07-26 00:00:00

abstract：:Nerve cells depend on specific interactions with glial cells for proper function. Myelinating glial cells are thought to associate with neuronal axons, in part, via the cell-surface adhesion protein, myelin-associated glycoprotein (MAG). MAG is also thought to be a major inhibitor of neurite outgrowth (axon regenerati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang LJ,Zeller CB,Shaper NL,Kiso M,Hasegawa A,Shapiro RE,Schnaar RL

更新日期：1996-01-23 00:00:00

abstract：:Heterozygous mutations in the CD95 (APO-1/Fas) receptor occur in most individuals with autoimmune lymphoproliferative syndrome (ALPS) and dominantly interfere with apoptosis by an unknown mechanism. We show that local or global alterations in the structure of the cytoplasmic death domain from nine independent ALPS CD9...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martin DA,Zheng L,Siegel RM,Huang B,Fisher GH,Wang J,Jackson CE,Puck JM,Dale J,Straus SE,Peter ME,Krammer PH,Fesik S,Lenardo MJ

更新日期：1999-04-13 00:00:00

abstract：:Using [3H]quinuclidinyl benzilate as a specific cholinergic muscarinic ligand, it has been demonstrated that lymphocytes have muscarinic binding sites. There are approximately 200 sites per cell and the dissociation constant for quinuclidinyl benzilate is approximately 1 X 10(-9) M. Quinuclidinyl benzilate receptor bi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gordon MA,Cohen JJ,Wilson IB

更新日期：1978-06-01 00:00:00

abstract：:Infectious vesicular stomatitis virus (VSV), the prototypic nonsegmented negative-strand RNA virus, was recovered from a full-length cDNA clone of the viral genome. Bacteriophage T7 RNA polymerase expressed from a recombinant vaccinia virus was used to drive the synthesis of a genome-length positive-sense transcript o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Whelan SP,Ball LA,Barr JN,Wertz GT

更新日期：1995-08-29 00:00:00

abstract：:Polycomb-group (Pc-G) proteins ensure late maintenance of transcriptional repression outside the expression domain of target genes in flies and vertebrates. They act in complexes, presumably by modulating chromatin structure. In Drosophila, they have been found to be associated with transcriptionally inactive loci but...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： d Graaff W,Tomotsune D,Oosterveen T,Takihara Y,Koseki H,Deschamps J

更新日期：2003-11-11 00:00:00

abstract：:Antarctic ozone depletion is associated with enhanced chlorine from anthropogenic chlorofluorocarbons and heterogeneous chemistry under cold conditions. The deep Antarctic "hole" contrasts with the generally weaker depletions observed in the warmer Arctic. An unusually cold Arctic stratospheric season occurred in 2011...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Solomon S,Haskins J,Ivy DJ,Min F

更新日期：2014-04-29 00:00:00

abstract：:Hybridization of human T cells with an azaguanine-resistant human T cell line gave rise to T hybrid cell lines secreting several immunoregulatory molecules. Analyses of karyotypes, HLA phenotypes, and other surface phenotypes, such as T-cell-specific antigens or receptors for sheep erythrocytes and the patterns of mit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okada M,Yoshimura N,Kaieda T,Yamamura Y,Kishimoto T

更新日期：1981-12-01 00:00:00

abstract：:A polypeptide transforming growth factor (TGF) that induces anchorage-dependent rat kidney fibroblasts to grow in soft agar has been isolated from human placenta and purified to homogeneity. This polypeptide is classified as a type beta TGF because it does not compete with epidermal growth factor (EGF) for membrane re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frolik CA,Dart LL,Meyers CA,Smith DM,Sporn MB

更新日期：1983-06-01 00:00:00

abstract：:Negative cooperativity has been observed in CTP synthetase, an allosteric enzyme which contains a regulatory site. Thus, the same enzyme exhibits negative cooperativity for GTP (an effector) and glutamine (a substrate) and positive cooperativity for ATP and UTP (both substrates). In the process of the delineation of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levitzki A,Koshland DE Jr

更新日期：1969-04-01 00:00:00

abstract：:Immobilization antigens of stock 51 of Paramecium tetraurelia were subjected to electrophoresis in NaDodSO(4)/polyacrylamide gels. Type A is estimated to have a molecular size of 300,000 daltons; H is estimated to be 288,000, D to be 280,000, E to be 270,000, B to be 253,000, and C to be 250,000. Poly(A)(+)RNAs have b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Preer JR,Preer LB,Rudman BM

更新日期：1981-11-01 00:00:00

abstract：:The influence of the rare initiation triplet AUU on mRNA translation was investigated by comparing the activity of two pairs of model mRNAs that differ in the length of Shine-Dalgarno and spacer sequences. Irrespective of the initiation triplet (AUG or AUU), all mRNAs had similar template activity in vitro, but transl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： La Teana A,Pon CL,Gualerzi CO

更新日期：1993-05-01 00:00:00

abstract：:Na+ channels in chick brain and heart have been directly compared by measuring binding of tritium-labeled saxitoxin ([3H]STX) to the two tissues under identical conditions. Maximum saturable uptake and toxin affinity were considerably less in chick heart than in chick brain, requiring the development of an assay metho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rogart RB,Regan LJ,Dziekan LC,Galper JB

更新日期：1983-02-01 00:00:00

abstract：:Chronic gut inflammatory diseases are associated with disruption of intestinal epithelial barriers and impaired mucosal immunity. HIV-1 (HIV) causes depletion of mucosal CD4+ T cells early in infection and disruption of gut epithelium, resulting in chronic inflammation and immunodeficiency. Although antiretroviral the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crakes KR,Santos Rocha C,Grishina I,Hirao LA,Napoli E,Gaulke CA,Fenton A,Datta S,Arredondo J,Marco ML,Sankaran-Walters S,Cortopassi G,Giulivi C,Dandekar S

更新日期：2019-12-03 00:00:00

abstract：:Class I major histocompatibility complex (MHC) antigens are confronted with an apparently insurmountable dilemma. Each should show a binding preference to a common enough variety of nonapeptides, so that one relevant nonapeptide can be found in at least every other viral protein to provoke a cytotoxic T-cell response....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohno S

更新日期：1992-05-15 00:00:00

abstract：:Neuronal dynamics display a complex spatiotemporal structure involving the precise, context-dependent coordination of activation patterns across a large number of spatially distributed regions. Functional magnetic resonance imaging (fMRI) has played a central role in demonstrating the nontrivial spatial and topologica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zalesky A,Fornito A,Cocchi L,Gollo LL,Breakspear M

更新日期：2014-07-15 00:00:00

abstract：:We measured the M-N transition of wild-type bacteriorhodopsin (pH 9, 10 degrees C) by time-resolved x-ray diffraction study at SPring8 BL45XU-A. We confirmed the accumulation of M and N intermediates by absorbance measurements, and we found that the time resolution of x-ray diffraction experiments (244 ms) was suffici...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oka T,Yagi N,Fujisawa T,Kamikubo H,Tokunaga F,Kataoka M

更新日期：2000-12-19 00:00:00

abstract：:Of two closely related species of geese, one, the greylag goose, lives in the Indian plains all year round, while the other, the bar-headed goose, lives at the Tibetan lakes and migrates across the Himalayas to winter in India. Another species, the Andean goose, lives in the High Andes all year round. Possession of a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jessen TH,Weber RE,Fermi G,Tame J,Braunitzer G

更新日期：1991-08-01 00:00:00

abstract：:Sprouty proteins act as intracellular inhibitors of receptor tyrosine kinase signaling. Here we show that the mammalian Sprouty2 protein contains an iron-sulfur complex that can exist in an oxidized, reduced, or nitrosylated state. Purified Sprouty2 assembles into large monodisperse spheres containing approximately 24...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu X,Alexander PB,He Y,Kikkawa M,Vogel PD,McKnight SL

更新日期：2005-09-27 00:00:00

abstract：:Genome-wide association studies found that increased risk for atrial fibrillation (AF), the most common human heart arrhythmia, is associated with noncoding sequence variants located in proximity to PITX2 Cardiomyocyte-specific epigenomic and comparative genomics uncovered 2 AF-associated enhancers neighboring PITX2 w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang M,Hill MC,Kadow ZA,Suh JH,Tucker NR,Hall AW,Tran TT,Swinton PS,Leach JP,Margulies KB,Ellinor PT,Li N,Martin JF

更新日期：2019-11-05 00:00:00

abstract：:Whereas all mammals have one glutamate dehydrogenase gene (GLUD1), humans and apes carry an additional gene (GLUD2), which encodes an enzyme with distinct biochemical properties. We inserted a bacterial artificial chromosome containing the human GLUD2 gene into mice and analyzed the resulting changes in the transcript...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Q,Guo S,Jiang X,Bryk J,Naumann R,Enard W,Tomita M,Sugimoto M,Khaitovich P,Pääbo S

更新日期：2016-05-10 00:00:00

abstract：:There is no effective treatment for the cardiomyopathy of the most common autosomal recessive ataxia, Friedreich's ataxia (FA). The identification of potentially toxic mitochondrial (MIT) iron (Fe) deposits in FA suggests that Fe plays a role in its pathogenesis. This study used the muscle creatine kinase conditional ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Whitnall M,Suryo Rahmanto Y,Sutak R,Xu X,Becker EM,Mikhael MR,Ponka P,Richardson DR

更新日期：2008-07-15 00:00:00

abstract：:The enzyme tryptophan 2,3-dioxygenase [EC 1.13.11.11; L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)] first appears in the livers of young rats around the 15th postnatal day, and increases to the adult level by the 22nd day. Studies have shown that the appearance and subsequent development of the enzyme activity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Killewich LA,Feigelson P

更新日期：1977-12-01 00:00:00

abstract：:The Ig new antigen receptors (IgNARs) are single-domain antibodies found in the serum of sharks. Here, we report 2.2- and 2.8-A structures of the type 2 IgNAR variable domains 12Y-1 and 12Y-2. Structural features include, first, an Ig superfamily topology transitional between cell adhesion molecules, antibodies, and T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Streltsov VA,Varghese JN,Carmichael JA,Irving RA,Hudson PJ,Nuttall SD

更新日期：2004-08-24 00:00:00

abstract：:Quantitatively identifying direct dependencies between variables is an important task in data analysis, in particular for reconstructing various types of networks and causal relations in science and engineering. One of the most widely used criteria is partial correlation, but it can only measure linearly direct associ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao J,Zhou Y,Zhang X,Chen L

更新日期：2016-05-03 00:00:00

abstract：:The pore-forming peptide amoebapore is considered part of the cytolytic armament of pathogenic Entamoeba histolytica. Amoebapore is composed of 77 amino acid residues arranged in four alpha-helical domains. For structure-function analysis, synthetic peptides were constructed corresponding to these four domains: H1 (re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leippe M,Andrä J,Müller-Eberhard HJ

更新日期：1994-03-29 00:00:00

abstract：:Unit electrical activity was recorded from single neurons in the isolated lumbo-sacral spinal cord of 14- to 19-day chick embryos, in situ. Spinal cord transection was combined with transection of all lumbo-sacral dorsal roots. The spontaneous discharge of cells is confined, for the most part, to the lower two thirds ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharma SC,Provine RR,Hamburger V,Sandel TT

更新日期：1970-05-01 00:00:00