Abstract:
:The generalized master equations (GMEs) that contain multiple time scales have been derived quantum mechanically. The GME method has then been applied to a model of charge migration in proteins that invokes the hole hopping between local amino acid sites driven by the torsional motions of the floppy backbones. This model is then applied to analyze the experimental results for sequence-dependent long-range hole transport in DNA reported by Meggers et al. [Meggers, E., Michel-Beyerle, M. E., & Giese, B. (1998) J. Am. Chem. Soc. 120, 12950-12955]. The model has also been applied to analyze the experimental results of femtosecond dynamics of DNA-mediated electron transfer reported by Zewail and co-workers [Wan, C., Fiebig, T., Kelley, S. O., Treadway, C. R., Barton, J. K. & Zewail, A. H. (1999) Proc. Natl. Acad. Sci. USA 96, 6014-6019]. The initial events in the dynamics of protein folding have begun to attract attention. The GME obtained in this paper will be applicable to this problem.
journal_name
Proc Natl Acad Sci U S Aauthors
Schlag EW,Yang DY,Sheu SY,Selzle HL,Lin SH,Rentzepis PMdoi
10.1073/pnas.140196597keywords:
subject
Has Abstractpub_date
2000-08-29 00:00:00pages
9849-54issue
18eissn
0027-8424issn
1091-6490pii
140196597journal_volume
97pub_type
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