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Targeting p53 as a general tumor antigen.

Abstract：

:A major barrier to the design of immunotherapeutics and vaccines for cancer is the idiosyncratic nature of many tumor antigens and the possibility that T cells may be tolerant of broadly distributed antigens. We have devised an experimental strategy that exploits species differences in protein sequences to circumvent tolerance of high-affinity T cells. HLA transgenic mice were used to obtain cytotoxic T lymphocytes specific for peptides from the human p53 tumor-suppressor molecule presented in association with HLA-A2.1. Although such p53-specific cytotoxic T cells did not recognize nontransformed human cells, they were able to lyse a wide variety of human tumor cells lines, thus confirming the existence of broadly distributed determinants that may serve as targets for immunotherapy.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Theobald M,Biggs J,Dittmer D,Levine AJ,Sherman LA

doi

10.1073/pnas.92.26.11993

subject

Has Abstract

pub_date

1995-12-19 00:00:00

pages

11993-7

issue

26

eissn

0027-8424

issn

1091-6490

journal_volume

92

pub_type

杂志文章

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