Tertiary structure of apolipoprotein A-I in nascent high-density lipoproteins.

abstract：:Benzophenones are among the most useful photocrosslinking agents in biology. We have evolved an orthogonal aminoacyl-tRNA synthetase/tRNA pair that makes possible the in vivo incorporation of p-benzoyl-l-phenylalanine into proteins in Escherichia coli in response to the amber codon, TAG. This unnatural amino acid was ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chin JW,Martin AB,King DS,Wang L,Schultz PG

更新日期：2002-08-20 00:00:00

abstract：:Class I major histocompatibility complex (MHC) antigens are confronted with an apparently insurmountable dilemma. Each should show a binding preference to a common enough variety of nonapeptides, so that one relevant nonapeptide can be found in at least every other viral protein to provoke a cytotoxic T-cell response....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohno S

更新日期：1992-05-15 00:00:00

abstract：:Human T lymphocytes were shown to proliferate in response to tetanus toxoid antigen only in the presence of macrophages. This response was inhibited by anti-DRw but not by anti-HLA (A and B loci) antisera added to the cultures and by pretreatment of macrophages but not of T cells with anti-DRw antisera and complement....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geha RS,Milgrom H,Broff M,Alpert S,Martin S,Yunis EJ

更新日期：1979-08-01 00:00:00

abstract：:Which network structures favor the rapid spread of new ideas, behaviors, or technologies? This question has been studied extensively using epidemic models. Here we consider a complementary point of view and consider scenarios where the individuals' behavior is the result of a strategic choice among competing alternati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Montanari A,Saberi A

更新日期：2010-11-23 00:00:00

abstract：:Previously, we showed using a computational agent-based model that a group of animals moving together can make a collective decision on direction of motion, even if there is a conflict between the directional preferences of two small subgroups of "informed" individuals and the remaining "uninformed" individuals have n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leonard NE,Shen T,Nabet B,Scardovi L,Couzin ID,Levin SA

更新日期：2012-01-03 00:00:00

abstract：:Mixing genomes of different species by hybridization can disrupt species-specific genetic interactions that were adapted and fixed within each species population. Such disruption can predispose the hybrids to abnormalities and disease that decrease the overall fitness of the hybrids and is therefore named as hybrid in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu Y,Sandoval A,Voss S,Lai Z,Kneitz S,Boswell W,Boswell M,Savage M,Walter C,Warren W,Schartl M,Walter R

更新日期：2020-11-24 00:00:00

abstract：:Noncompetitive inhibitors of the nicotinic acetylcholine (ACh) receptors suppress cation flux directly by binding in and blocking the open channel or indirectly by stabilizing closed states of the receptor. The lidocaine derivative QX-314 and the acridine derivative quinacrine act directly as open channel blockers, bu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu Y,Shi L,Karlin A

更新日期：2003-04-01 00:00:00

abstract：:Throughout three domains of life, alanyl-tRNA synthetases (AlaRSs) recognize a G3:U70 base pair in the acceptor stem of tRNAAla as the major identity determinant of tRNAAla The crystal structure of the archaeon Archaeoglobus fulgidus AlaRS in complex with tRNAAla provided the basis for G3:U70 recognition with residues...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chong YE,Guo M,Yang XL,Kuhle B,Naganuma M,Sekine SI,Yokoyama S,Schimmel P

更新日期：2018-07-17 00:00:00

abstract：:The occurrence and sequelae of disorders that lead to hypoxic spells such as asthma, chronic obstructive pulmonary disease, and obstructive sleep apnea (OSA) exhibit daily variance. This prompted us to examine the interaction between the hypoxic response and the circadian clock in vivo. We found that the global transc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manella G,Aviram R,Bolshette N,Muvkadi S,Golik M,Smith DF,Asher G

更新日期：2020-01-07 00:00:00

abstract：:Recent genome-wide nucleosome mappings along with bioinformatics studies have confirmed that the DNA sequence plays a more important role in the collective organization of nucleosomes in vivo than previously thought. Yet in living cells, this organization also results from the action of various external factors like D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milani P,Chevereau G,Vaillant C,Audit B,Haftek-Terreau Z,Marilley M,Bouvet P,Argoul F,Arneodo A

更新日期：2009-12-29 00:00:00

abstract：:Proparathyroid hormone (calcemic fraction-A) is a biosynthetic precursor of parathyroid hormone in bovine glands. Limited amounts of the isolated prohormone have been obtained for the purpose of initial structural studies. The results of automated sequence analysis on two separate preparations indicate that the N-term...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hamilton JW,Niall HD,Jacobs JW,Keutmann HT,Potts JT Jr,Cohn DV

更新日期：1974-03-01 00:00:00

abstract：:Tuberous sclerosis complex (TSC) is a tumor suppressor syndrome characterized by benign tumors in multiple organs, including the brain and kidney. TSC-associated tumors exhibit hyperactivation of mammalian target of rapamycin complex 1 (mTORC1), a direct inhibitor of autophagy. Autophagy can either promote or inhibit ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parkhitko A,Myachina F,Morrison TA,Hindi KM,Auricchio N,Karbowniczek M,Wu JJ,Finkel T,Kwiatkowski DJ,Yu JJ,Henske EP

更新日期：2011-07-26 00:00:00

abstract：:We address the stability of multicharged finite systems driven by Coulomb forces beyond the Rayleigh instability limit. Our exploration of the nuclear dynamics of heavily charged Morse clusters enabled us to vary the range of the pair potential and of the fissibility parameter, which results in distinct fragmentation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Last I,Levy Y,Jortner J

更新日期：2002-07-09 00:00:00

abstract：:Most organisms are evolutionary conservatives; they may subdivide their niches but tend to remain within them. Yet the fossil record shows many cases of breakthrough to a new mode of life. How may such evolutionary innovation be recognized at this time level? Three species of Drosophila have accomplished an innovation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carson HL

更新日期：1974-09-01 00:00:00

abstract：:We analyze the effects of an externally applied electric field on thermal fluctuations for a binary electrolyte fluid. We show that the fluctuating Poisson-Nernst-Planck (PNP) equations for charged multispecies diffusion coupled with the fluctuating fluid momentum equation result in enhanced charge transport via a mec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Péraud JP,Nonaka AJ,Bell JB,Donev A,Garcia AL

更新日期：2017-10-10 00:00:00

abstract：:A synthetic polymer has been prepared which contains dodecyl groups (to bind small substrate molecules) and methyleneimidazole side chains (as nucleophilic catalytic sites) linked to a polyethyleneimine framework. This macromolecule, with a high local concentration of binding and catalytic groups, catalyzes the hydrol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klotz IM,Royer GP,Scarpa IS

更新日期：1971-02-01 00:00:00

abstract：:ATP-binding cassette (ABC) transporters use ATP to drive solute transport across biological membranes. Members of this superfamily have crucial roles in cell physiology, and some of the transporters are linked to severe diseases. However, understanding of the transport mechanism, especially of human ABC exporters, is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zollmann T,Moiset G,Tumulka F,Tampé R,Poolman B,Abele R

更新日期：2015-02-17 00:00:00

abstract：:How did human cooperation evolve? Recent evidence shows that many people are willing to engage in altruistic punishment, voluntarily paying a cost to punish noncooperators. Although this behavior helps to explain how cooperation can persist, it creates an important puzzle. If altruistic punishment provides benefits to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fowler JH

更新日期：2005-05-10 00:00:00

abstract：:Dimers of bacteriochlorophyll a (Bchla) with optical absorption maximum at 853 nm and a nonconservative circular dichroism spectrum are formed in a solution of formamide/water that contains micelles of Triton X-100. The apparent equilibrium constant and the corresponding Gibbs energy change for the Bchl self-organizat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scherz A,Rosenbach-Belkin V

更新日期：1989-03-01 00:00:00

abstract：:Ventriculo-cisternal perfusion of horseradish peroxidase (HRP) in the mouse brain has demonstrated that a brain-blood barrier exists at the microvascular endothelium in brain parenchyma but not in the median eminence of the hypothalamus. The brain-blood barrier is similar to the blood-brain barrier in that: tight junc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Broadwell RD,Balin BJ,Salcman M,Kaplan RS

更新日期：1983-12-01 00:00:00

abstract：:Fish have somehow colonized isolated water bodies all over the world without human assistance. It has long been speculated that these colonization events are assisted by waterbirds, transporting fish eggs attached to their feet and feathers, yet empirical support for this is lacking. Recently, it was suggested that en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lovas-Kiss Á,Vincze O,Löki V,Pallér-Kapusi F,Halasi-Kovács B,Kovács G,Green AJ,Lukács BA

更新日期：2020-07-07 00:00:00

abstract：:Depolarization of isolated nerve terminals (synaptosomes) has been shown to stimulate neurotransmitter release and to increase the phosphorylation state of a number of proteins, including synapsin I, in a Ca2+-dependent manner. Synapsin I, a prominent nerve terminal phosphoprotein, interacts with the cytoplasmic surfa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sihra TS,Wang JK,Gorelick FS,Greengard P

更新日期：1989-10-01 00:00:00

abstract：:Traits that enable species to persist in ecological environments are often maintained over time, a phenomenon known as niche conservatism. Here we argue that ecological niches function at levels above species, notably at the level of genus for mammals, and that niche conservatism is also evident above the species leve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hadly EA,Spaeth PA,Li C

更新日期：2009-11-17 00:00:00

abstract：:Although it is now more than two decades since it was first reported that the imidazobenzodiazepine Ro15-4513 reverses behavioral alcohol effects, the molecular target(s) of Ro15-4513 and the mechanism of alcohol antagonism remain elusive. Here, we show that Ro15-4513 blocks the alcohol enhancement on recombinant "ext...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wallner M,Hanchar HJ,Olsen RW

更新日期：2006-05-30 00:00:00

abstract：:Serum RNase (ribonuclease) of normal persons and of patients with pancreatitis, carcinoma of pancreas, or other neoplasms was determined with poly(C) as substrate. Strikingly abnormal elevations occur in the serum RNase of patients with pancreatic cancer. There is no elevation in the serum RNase level of patients with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reddi KK,Holland JF

更新日期：1976-07-01 00:00:00

abstract：:Whether and how human populations exposed to the agricultural revolution are still affected by Darwinian selection remains controversial among social scientists, biologists, and the general public. Although methods of studying selection in natural populations are well established, our understanding of selection in hum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Courtiol A,Pettay JE,Jokela M,Rotkirch A,Lummaa V

更新日期：2012-05-22 00:00:00

abstract：:The C terminus of transcription factor NusA from Escherichia coli comprises two repeat units, which bind during antitermination to protein N from phage lambda. To delineate the structural basis of the NusA-lambdaN interaction, we attempted to crystallize the NusA C-terminal repeats in complex with a lambdaN peptide (r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonin I,Mühlberger R,Bourenkov GP,Huber R,Bacher A,Richter G,Wahl MC

更新日期：2004-09-21 00:00:00

abstract：:Molecular mechanisms that initiate meiosis have been studied in fungi and mammals, but little is known about the mechanisms directing the meiosis transition in other organisms. To elucidate meiosis initiation in plants, we characterized and cloned the ameiotic1 (am1) gene, which affects the transition to meiosis and p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pawlowski WP,Wang CJ,Golubovskaya IN,Szymaniak JM,Shi L,Hamant O,Zhu T,Harper L,Sheridan WF,Cande WZ

更新日期：2009-03-03 00:00:00

abstract：:Although a number of studies have highlighted the importance of offline processes for memory, how these mechanisms influence future learning remains unknown. Participants with established memories for a set of initial face-object associations were scanned during passive rest and during encoding of new related and unre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schlichting ML,Preston AR

更新日期：2014-11-04 00:00:00

abstract：:In animals, fatty acid desaturases catalyze key reactions in the synthesis of arachidonic acid and other polyunsaturated fatty acids. A search of the Caenorhabditis elegans DNA databases, using the sequences of Arabidopsis genes, identified several putative desaturases. Here we describe the characterization of the fir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spychalla JP,Kinney AJ,Browse J

更新日期：1997-02-18 00:00:00