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Cognitive and neurobiologic markers of early Alzheimer disease.

Abstract：

:Recent studies indicate that impairments in two cognitive domains characterize the cognitive abnormalities that appear earliest in the course of Alzheimer disease (AD). These cognitive domains pertain to memory and executive function ability; in particular, memory test scores reflecting the difference between immediate and delayed recall and tasks that assess cognitive flexibility (e.g., set-shifting). Preliminary data indicate that tasks of this nature, along with specific genetic information (i.e., APOE-4 status), are important in identifying which individuals with recent cognitive changes (considered to have "questionable" disease) will progress to the point where they meet criteria for AD over time. When this cognitive and genetic information is combined with neuroimaging measures targeted at the brain regions demonstrating pathology early in AD, it may serve as specific and accurate prognostic markers of AD.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Albert MS

doi

10.1073/pnas.93.24.13547

subject

Has Abstract

pub_date

1996-11-26 00:00:00

pages

13547-51

issue

24

eissn

0027-8424

issn

1091-6490

journal_volume

93

pub_type

杂志文章,评审

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